Brain Death clinical trials
The registry lists 74 studies for Brain Death across more than 10 countries. 10 are recruiting or about to start. 66 of them are mainly about Brain Death (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
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Who runs them
University Hospital, Basel, Switzerland (3) · Institut d'Anesthesiologie des Alpes Maritimes (2) · Nova Scotia Health Authority (2) · Chinese Academy of Medical Sciences (2) · Centre Hospitalier Régional d'Orléans (2) · Washington University School of Medicine (2) · Kiskunhalas Semmelweis Hospital the Teaching Hospital of the University of Szeged (2) · Brno University Hospital (2)
What is being tested here
Drugs under test in Brain Death studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Atorvastatin | 1 | 0 | 1 |
| Thyroxine | 0 | 1 | 3 |
| Naloxone | 0 | 1 | 2 |
| Tacrolimus | 0 | 0 | 1 |
| Cyclosporine | 0 | 0 | 1 |
| Liraglutide | 0 | 1 | 1 |
| Methylprednisolone | 0 | 0 | 1 |
| Albuterol | 0 | 0 | 1 |
| Acetylcysteine | 0 | 1 | 1 |
| Hydrocortisone | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The study
- Nov 2026Automated Screening for Clinically Ascertained Loss of Cerebral Functions · Technische Universität Dresden
Who these studies take
Of the 5 Brain Death studies recruiting now, 4 (80%) set no upper age limit and 1 (20%) stop at 75 or younger. 0 (0%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 5 (100%) | 5 (100%) |
| 30 | 5 (100%) | 5 (100%) |
| 40 | 5 (100%) | 5 (100%) |
| 50 | 5 (100%) | 5 (100%) |
| 65 | 5 (100%) | 5 (100%) |
| 75 | 5 (100%) | 5 (100%) |
| 85 | 4 (80%) | 4 (80%) |
Across all 74 studies, recruiting or not: 18% stop at 75 or younger and 9% at 65; 28% take children; 1% are for women only and 0% for men only; 15% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Brain Death studies take
Of 14 interventional studies with no phase under Brain Death, half reached primary completion within 29 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 29 mo24–52 · 14 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 74. Browse all 74 → or search them.
- Miniature In-line RespiratorNot yet recruitingNCT07768215Not applicable1 country
- Efficacy of High-Flow Humidified Oxygen (HFHO) in Apneic Oxygenation for Apnea Testing: A Comparison With Continuous Positive Airway Pressure (CPAP)Not yet recruitingNCT07640009Not applicable1 country
- Pupillometric Evaluation in Patients Declared Brain Dead - a Prospective Quality Control StudyRecruitingNCT062799751 country
- Non-Invasive Detection and Preservation of Neurocognitive Signals in the Peri-Death Period Using Brain-Computer Interface and Artificial IntelligenceNot yet recruitingNCT07477028
- CT-Angiography Versus Angiogram as Ancillary Tests in the Determination of Death by Neurologic CriteriaRecruitingNCT073414901 country
- Atorvastatin Pretreatment in Cerebrovascular Events (APICES) After Flow Diverter ImplantationRecruitingNCT06308952Phase 41 country
- Anesthesia sTrategy foR Organ Procurement In braiN dEathRecruitingNCT07166991Phase 31 country
- ICU Management of Brain-Dead Donors Before Multi-Organ Procurement and Factors Associated With the Number of Organs RetrievedRecruitingNCT067685151 country
- Implementation of Apnoea Test for Patients With Suspected Brain DeathNot yet recruitingNCT06359119
- Automated Screening for Clinically Ascertained Loss of Cerebral FunctionsNot yet recruitingNCT06293170Not applicable1 country
- Therapeutic Hypothermia in "Expanded Criteria" Brain-dead Donors and Kidney-graft FunctionCompletedNCT03098706Not applicable1 country
- Cyclosporine A Pretreatment and Kidney Graft FunctionCompletedNCT02907554Phase 41 country
- The Anticipated Organ Donation ApproachCompletedNCT037658141 country
- Determining ICU Staffs Conceptions, Opinions, Views, Experiences and Reflection of Brain Death and Organ DonationCompletedNCT066400881 country
- ORI and ETCO₂ Relationship With Arterial Blood Gas During Apnea TestCompletedNCT069839901 country
- Prone vs Supine Position in Potential Organ Donors: Multicenter Clinical TrialCompletedNCT07251777Not applicable1 country
- Potassium Canrenoate in Brain-dead Organ Donors: Randomized Controlled Clinical TrialActive, not recruitingNCT04714710Phase 21 country
- Calcineurin Inhibitor in NEuRoloGically Deceased Donors to Decrease Kidney delaYed Graft Function (CINERGY)Active, not recruitingNCT05148715Phase 21 country
- Etiology and Hemodynamic Instability in Brain DeathCompletedNCT065699921 country
- Rapid Reversal of CNS-Depressant Drug Effect Prior to Brain Death DeterminationWithdrawnNCT03743805Early Phase 11 country
- Computed Tomography Perfusion in Patients With Severe Head InjuryCompletedNCT02756585Not applicable1 country
- Special Imaging Technique to Aid in the Diagnosis of Patients in Coma After Cardiac ArrestCompletedNCT02102945Not applicable1 country
- Validation of the Apnea Test Performed by High-flow Oxygen Therapy in Patients With Clinical Brain DeathCompletedNCT05950178Not applicable1 country
- The Use of Liraglutide in Brain DeathCompletedNCT03672812Phase 31 country
- Electrical Impedance Tomography Measurements During Apnea Test in Patients With Suspected Brain DeathCompletedNCT04857242Not applicable1 country
- Orbital Artery Doppler Ultrasound in Brain DeathCompletedNCT06229782Not applicable1 country
- Intravenous Thyroxine for Heart-Eligible Organ DonorsCompletedNCT04415658Phase 31 country
- Research on the Brain Death Determination in ChinaCompletedNCT059034431 country
- Methods of Confirmation of Brain DeathStatus unknownNCT047345741 country
- Incidence of Complications of Brain DeathStatus unknownNCT044049721 country
- Does Venous pCO2 Increase by 20 mmHg or More During Apnea Challenge Test?CompletedNCT02503813Not applicable1 country
- Deceased Organ Donor Interventions to Protect Kidney Graft FunctionCompletedNCT02525510Not applicable1 country
- "LiverColor": Machine Learning in Liver PhotographsStatus unknownNCT05202886Not applicable1 country
- Safeguarding the Brain of Our Smallest Infants Phase IIICompletedNCT03770741Not applicable1 country
- Resting Energy Needs in Brain Dead Patients (reSting EneRgy nEeds iN brAin DEad Patients)CompletedNCT050701821 country
- Evaluation of CTA on the Assessment of Brain DeathStatus unknownNCT049140391 country
- Brain Death Diagnosis at an Academic Tertiary Medical Care CenterCompletedNCT039849811 country
- Goal of Open Lung Ventilation in DonorsTerminatedNCT03439995Not applicable1 country
- Online Noninvasive Assessment of Human Brain Death and Deep Coma by Near-infrared SpectroscopyStatus unknownNCT046232941 country
- Donation Network to Optimize Organ Recovery StudyCompletedNCT03179020Not applicable1 country
- Non-randomized, Open-labeled, Interventional, Single Group, Proof of Concept Study With Multi-modality Approach in Cases of Brain Death Due to Traumatic Brain Injury Having Diffuse Axonal InjuryCompletedNCT02742857Phase 11 country
- Thyroid and Adrenocortical Hormone Replacement in Organ DonorsCompletedNCT04528797Not applicable
- Naloxone for Optimizing Hypoxemia Of Lung DonorsCompletedNCT02581111Phase 2/31 country
- Understanding Family RefusalCompletedNCT04303624
- Organ Procurement : Usefulness of a Guide for Meeting With the Next of KinCompletedNCT028542671 country
- Expanding Pancreas Donor Pool by Evaluation of Unallocated Organs After Brain Death - The EXPLORE StudyStatus unknownNCT041272661 country
- Evaluation of Liver Grafts With FibroScan® Before Organ Retrieval in Patients With Brain DeathCompletedNCT02460250Not applicable1 country
- Organ Donation and End-of-life DecisionsCompletedNCT041311401 country
- Neurophysiological Examination in Patients With Brain DeathCompletedNCT032628961 country
- Computed Tomography Angiography Accuracy in Brain Death DiagnosisCompletedNCT020454071 country