An observational study in Aortic Dissection, Stroke and Paraplegia, sponsored by China Medical University Hospital. Completed at 1 site in Taiwan. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-12-26.
Sponsored by China Medical University Hospital · Observational
Single-center retrospective cohort at China Medical University Hospital (Taichung, Taiwan) using fully de-identified electronic health records. Consecutive adults who underwent emergency repair of acute type A aortic dissection between 2021-01-01 and 2025-04-30 were pooled into one cohort. The study measures the incidence and patterns of early postoperative neurological complications and evaluates their association with intensive care unit (ICU) resource use, focusing on prolonged ICU length of stay (LOS ≥ 10 days), ICU and hospital LOS, and duration of mechanical ventilation (MV). No new data collection or patient contact occurs. Institutional Review Board (IRB) approval: CMUH114-REC1-139.
Adults (≥ 18 years) undergoing emergency repair for acute type A aortic dissection (ATAAD) at China Medical University Hospital (CMUH) during 2021-01-01 to 2025-04-30 were screened. Exclusions: missing key variables, preoperative stroke within 30 days or modified Rankin Scale (mRS) ≥ 4, pregnancy. The analytic cohort included 274 of 309 screened patients. Neurological complications comprise radiology-confirmed stroke, other focal neurological deficits, paraplegia, or sustained coma/encephalopathy recorded by neurology consultation. Prolonged ICU stay is prespecified as ICU LOS ≥ 10 days in the index admission. Outcomes: primary outcomes are prolonged ICU stay and any postoperative neurological complication; secondary outcomes are ICU LOS (days), duration of mechanical ventilation (hours), hospital LOS (days), in-hospital mortality, and in-hospital death within 30 days of the index surgery. Analyses are performed in R version 4.5.1. Continuous variables are summarized as medians with interquartile ranges (IQRs) and compared using the Mann-Whitney U test; categorical variables are presented as counts and percentages and compared using chi-square or Fisher exact tests. Multivariable logistic regression identifies factors associated with prolonged ICU stay (ICU LOS ≥ 10 days) among hospital survivors using a priori covariates (age, sex, chronic kidney disease stage 4-5, operation time, cardiopulmonary bypass [CPB] time, intraoperative red blood cell [RBC] units transfused, postoperative acute kidney injury [AKI], any postoperative neurological complication). A prespecified sensitivity analysis in the full cohort treats the endpoint as ICU LOS ≥ 10 days or in-hospital death using the same prespecified covariates. Data were de-identified before analysis and stored on secure hospital servers; the study is minimal risk and does not involve United States Food and Drug Administration (US FDA) regulated products.
205 studies on the registry are indexed under Aortic Dissection; 73 are open to participants now.
This study's enrollment of 274 is above the median of 230 across 115 observational studies indexed under Aortic Dissection.
Browse Aortic Dissection studies →China Medical University Hospital is the lead sponsor of 479 studies on the registry; 115 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Consecutive adults undergoing emergency repair of acute type A aortic dissection at a single tertiary centre ICU in Taichung, Taiwan (2021-01-01 to 2025-04-30).
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Single-center retrospective cohort of consecutive adults (≥18 years) who underwent emergency repair of acute type A aortic dissection at China Medical University Hospital between 2021-01-01 and 2025-04-30; all participants are pooled into one cohort with no protocol-assigned interventions; outcomes are obtained from de-identified records to assess neurological complications and ICU resource use.
Prolonged ICU length of stay (LOS ≥10 days)
Proportion of participants with ICU LOS ≥10 days during the index ICU admission. Unit of measure: percent.
Time frame: Through ICU discharge during the index admission (up to 30 days).
Any postoperative neurological complication
Proportion with stroke (CT/MRI confirmed), other focal neurological deficits, paraplegia, or sustained coma/encephalopathy recorded by neurology consultation. Unit of measure: percent.
Time frame: Through hospital discharge during the index admission (up to 30 days).
ICU length of stay (days)
ICU LOS summarized as median and IQR; larger values indicate greater resource use. Unit of measure: days.
Time frame: Through ICU discharge during the index admission (up to 30 days).
Duration of mechanical ventilation (hours)
Cumulative hours of invasive ventilation from ICU arrival to final extubation. Unit of measure: hours.
Time frame: Through final extubation during the index hospitalization (up to 40 days).
Hospital length of stay (days)
Days from hospital admission to discharge; deaths counted up to date of death. Unit of measure: days.
Time frame: Through hospital discharge during the index admission (up to 65 days).
In-hospital mortality
All-cause death before discharge from the index hospitalization. Unit of measure: percent.
Time frame: Through hospital discharge during the index admission (up to 30 days).
In-hospital mortality within 30 days
All-cause death occurring during the index hospitalization within 30 days after the index surgery (deaths after hospital discharge were not captured).
Time frame: Up to 30 days after index surgery, during the index hospitalization.
Plan to share: No — Individual participant data will not be shared. The dataset consists of de-identified electronic health records governed by CMUH institutional policy and IRB approval (CMUH114-REC1-139), which restrict external transfer. Aggregate results or summary tables may be provided on reasonable request, subject to additional REC approval and data-use agreements.
This study is completed, as verified in Dec 2025. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
China Medical University Hospital →