An observational study in Traumatic Brain Injury, Intracerebral Haemorrhage and Subarachnoid Haemorrhagic Stroke, sponsored by University of Miami. Recruiting at 2 sites in United States. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-08.
Sponsored by University of Miami · Observational
The purpose of this research study to find out if clinically unconscious acute brain injury patients that show brain activation to music and language on electroencephalogram (EEG) (bedside test) have better outcomes and wake up in the future.
1,721 studies on the registry are indexed under Brain Injuries, Traumatic; 447 are open to participants now.
This study's planned enrollment of 300 is above the median of 117 across 557 observational studies indexed under Brain Injuries, Traumatic.
Browse Brain Injuries, Traumatic studies →University of Miami is the lead sponsor of 840 studies on the registry; 164 are open to participants now.
Of its 115 completed or terminated interventional studies of FDA-regulated products, 97 (84%) have results posted.
Counted across the registry records on this site, refreshed daily.
Patients who present to the intensive care unit after ABI and are unconscious. Additionally, healthy volunteers will be recruited.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
For ABI Participants
For Healthy Volunteers:
Exclusion Criteria:
For All Participants:
Acute brain injury (ABI) patients will be recruited and studied using electroencephalogram (EEG) to monitor their brain response to auditory and visual stimuli.
Diagnostic Test: Auditory stimuli
Healthy volunteers will serve as the control group and will undergo electroencephalogram (EEG) to monitor their brain response to auditory and visual stimuli.
Diagnostic Test: Auditory stimuli
Auditory stimuli (passive, active perturbations)
Glasgow Outcome Scale-Extended (GOSE) Scale
The GOSE is an outcome scale, range 1-8 evaluating the patients' functional outcomes - higher score indicates better recovery
Time frame: Up to 5 years
Coma Recovery Scale - Revised (CRS-R)
The CRS-R will evaluate the patients' conscious state, range 0-23 -higher score indicates a better conscious state
Time frame: Up to 5 years
Plan to share: No
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