An observational study in Post-Resuscitation Syndrome, Critical Illness and Cardiac Arrest, sponsored by Ahmet Düzgün. Completed at 1 site in Turkey (Türkiye). Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-05-08.
Sponsored by Ahmet Düzgün · Observational
This retrospective observational cohort study aims to identify early predictors of short- and mid-term mortality in adult patients who achieved return of spontaneous circulation (ROSC) after cardiac arrest. Eligible patients admitted to the intensive care unit between January 1, 2024 and May 31, 2025 were identified retrospectively from electronic medical records following institutional ethics approval. Clinical, biochemical, and resuscitation-related parameters recorded within the first 24 hours of ICU admission were analyzed. The primary objective was to determine factors independently associated with short-term mortality. Six-month mortality was additionally assessed using hospital records and the national death registry. The findings are expected to improve risk stratification and clinical decision-making in post-cardiac arrest care.
This retrospective observational cohort study was conducted in the intensive care unit (ICU) of Gazi Yaşargil Training and Research Hospital, Turkey. Adult patients (≥18 years) who achieved return of spontaneous circulation (ROSC) after cardiac arrest and were admitted to the ICU between January 1, 2024 and May 31, 2025 were identified retrospectively from electronic medical records following institutional ethics approval.
Baseline demographic, clinical, laboratory, and resuscitation-related variables recorded within the first 24 hours of ICU admission were extracted from hospital records. These variables included arrest characteristics, time to ROSC, initial rhythm, hemodynamic parameters, neurological status, laboratory biomarkers, and therapeutic interventions routinely performed in ICU practice.
The primary outcome was 30-day all-cause mortality. Secondary outcomes included 24-hour, 7-day, and 6-month mortality, neurological outcome at hospital discharge, and ICU length of stay. Six-month mortality status was confirmed using hospital records and the national death registry.
A total of 168 eligible patients were identified during the study period. Multivariate logistic regression analysis was performed to identify independent predictors of mortality. No interventions beyond routine clinical care were conducted.
926 studies on the registry are indexed under Heart Arrest; 226 are open to participants now.
This study's enrollment of 168 is below the median of 200 across 376 observational studies indexed under Heart Arrest.
Browse Heart Arrest studies →This is the only study on the registry with Ahmet Düzgün as lead sponsor.
Compared within Heart Arrest, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Critical Illness. The counts are of registry records indexed under each term, refreshed daily. How we classify →
Adult patients (≥18 years old) who achieved return of spontaneous circulation (ROSC) after cardiac arrest and were admitted to the intensive care unit (ICU) at Gazi Yaşargil Training and Research Hospital, Turkey. Patients are consecutively enrolled and observed for outcomes related to in-hospital and 6-month mortality.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Adult patients (≥18 years old) who achieved return of spontaneous circulation (ROSC) after cardiac arrest and were admitted to the intensive care unit. These patients are prospectively followed to evaluate clinical and biochemical predictors of in-hospital mortality.
30-Day Mortality
All-cause mortality within 30 days of ICU admission following ROSC.
Time frame: 30 days after ICU admission
In-Hospital Mortality
All-cause mortality recorded during the index hospital stay following return of spontaneous circulation (ROSC).
Time frame: From ICU admission to hospital discharge (up to 60 days)
6-Month Mortality
All-cause mortality assessed at 6 months following the initial cardiac arrest event. Mortality status is confirmed through hospital records and national death registry.
Time frame: 6 months after ICU admission
A total of 168 adult patients admitted to the intensive care unit after return of spontaneous circulation following cardiac arrest were included in this retrospective cohort study.
| Milestone | Overall Cohort |
|---|---|
| Started | 168 |
| Completed | 168 |
| Not completed | 0 |
All-cause mortality within 30 days of ICU admission following ROSC.
| participants | Overall Cohort |
|---|---|
| 30-Day Mortality | 112 |
All-cause mortality recorded during the index hospital stay following return of spontaneous circulation (ROSC).
| participants | Overall Cohort |
|---|---|
| In-Hospital Mortality | 87 |
All-cause mortality assessed at 6 months following the initial cardiac arrest event. Mortality status is confirmed through hospital records and national death registry.
| participants | Overall Cohort |
|---|---|
| 6-Month Mortality | 130 |
Collected over Up to 180 days after ICU admission. Non-serious events are listed at a 0% frequency threshold.
| Group | Deaths | Serious | Other |
|---|---|---|---|
| Overall Cohort | 130/168 (77.4%) | 0/168 (0%) | 0/168 (0%) |
| Age, Continuous(years) | Overall Cohort |
|---|---|
| Mean | 69.5 ± 16.2 |
| Sex: Female, Male(Participants) | Overall Cohort |
|---|---|
| Female | 77 |
| Male | 91 |
| Race and Ethnicity Not Collected(Participants) | Overall Cohort |
|---|
| APACHE II score(score) | Overall Cohort |
|---|---|
| Mean | 24.3 ± 6.3 |
| SOFA score(score) | Overall Cohort |
|---|---|
| Mean | 8.6 ± 2.5 |
| SAPS 3 score(score) | Overall Cohort |
|---|---|
| Mean | 83.6 ± 16.4 |
| Charlson Comorbidity Index(score) | Overall Cohort |
|---|---|
| Mean | 5.5 ± 2.3 |
PDFs hosted by the registry, ClinicalTrials.gov.
Plan to share: Undecided — At this stage, no final decision has been made regarding individual participant data (IPD) sharing. The possibility of sharing anonymized IPD will be evaluated after the study is completed and initial results are published, taking into account ethical, legal, and institutional considerations.
This study is completed, as verified in Apr 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.