Cleft Palate clinical trials
The registry lists 123 studies for Cleft Palate across more than 10 countries. 35 are recruiting or about to start. 79 of them are mainly about Cleft Palate (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its narrower condition Van der Woude syndrome too: 159 studies, 44 open.
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Who runs them
Cairo University (6) · Assiut University (6) · Fayoum University (4) · University Hospital, Basel, Switzerland (4) · University of Pittsburgh (3) · Sohag University (3) · University of Florida (3) · AZ Sint-Jan AV (3)
What is being tested here
Drugs under test in Cleft Palate studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Bupivacaine | 2 | 4 | 4 |
| Methadone | 1 | 0 | 1 |
| Fentanyl | 1 | 0 | 1 |
| Hydromorphone | 1 | 0 | 1 |
| Liposomal Bupivacaine | 1 | 1 | 1 |
| Dexmedetomidine | 0 | 1 | 3 |
| Acetaminophen | 0 | 0 | 2 |
| Ropivacaine | 0 | 0 | 1 |
| Botulinum toxin type A | 0 | 0 | 1 |
| Sultamicillin | 0 | 0 | 1 |
Drug classes tested here Local anesthetics 2 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Nov 2026Nebulized Bupivacaine Analgesia for Cleft Palate Repair · Phase 3 · Assiut University
- Dec 2026MRI Assessment of Velopharyngeal Anatomy After Modified Furlow-Buccinator Flap in Late Primary Palate Repair · Cairo University
- Dec 2026Early Intervention in Infants With Unrepaired Cleft Palate: Language, Palatal Function, and Articulation. · Old Dominion University
- Jan 2027QL vs LAI for Palatoplasty · Medical University of South Carolina
- May 2027Expiratory Muscle Strength Training for Hypernasal Speech in Children · Noel Jabbour
- May 2027Perioperative Respiratory Adverse Events in Cleft Lip and Palate Surgery: Incidence, Risk Factors, and Clinical Scoring · Marmara University Pendik Training and Research Hospital
- May 2027Evaluation of Trigeminal Nerve Blockade · University of Florida
- Jun 2027Optimizing Perioperative Analgesia to Lower Pain Following Cleft Palate Surgery · Duke University
- Sep 2027Furlow With Buccinator and Fistula Formation · Fayoum University
- Oct 2027Effect of Infant Sign Training on Speech-language Development · University Hospital, Ghent
Who these studies take
Of the 21 Cleft Palate studies recruiting now, 3 (14%) set no upper age limit and 18 (86%) stop at 75 or younger. 20 (95%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 2 (10%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 10 (48%) | 10 (48%) |
| 18 | 7 (33%) | 7 (33%) |
| 30 | 4 (19%) | 4 (19%) |
| 40 | 3 (14%) | 3 (14%) |
| 50 | 3 (14%) | 3 (14%) |
| 65 | 3 (14%) | 3 (14%) |
| 75 | 3 (14%) | 3 (14%) |
| 85 | 3 (14%) | 3 (14%) |
Across all 123 studies, recruiting or not: 78% stop at 75 or younger and 78% at 65; 96% take children; 2% are for women only and 0% for men only; 24% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Cleft Palate studies take
Of 34 interventional studies with no phase under Cleft Palate, half reached primary completion within 18 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 18 mo12–45 · 34 studies | — | 18 mo12–45 · 34 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 12, 2026.
Newly registered2
Studies
Recruiting first, then most recently updated. Showing 50 of 123. Browse all 123 → or search them.
- Assessing the Effect of Infant-directed Unidirectional Feeding Valves on Milk Volume Intake in Infants With Cleft PalateRecruitingNCT07927933Not applicable1 country
- Risk of Caries and Enamel Abnormalities in Patients With Cleft PalateNot yet recruitingNCT07926646Not applicable1 country
- Furlow With Buccinator and Fistula FormationNot yet recruitingNCT07840911Not applicable
- Nebulized Bupivacaine Analgesia for Cleft Palate RepairRecruitingNCT04928352Phase 31 country
- Palatoplasty Techniques Using PRF and Gentamicin-Loaded PRF in Cleft PalateRecruitingNCT07752849Not applicable1 country
- Expiratory Muscle Strength Training for Hypernasal Speech in ChildrenRecruitingNCT05492266Not applicable1 country
- Speech Intervention Frameworks in Cantonese-speaking Children and Adolescences With Cleft Palate +/- LipEnrolling by invitationNCT07692061Not applicable1 country
- QL vs LAI for PalatoplastyRecruitingNCT06420336Not applicable1 country
- Perioperative Respiratory Adverse Events in Cleft Lip and Palate Surgery: Incidence, Risk Factors, and Clinical ScoringNot yet recruitingNCT07651904
- Etiological Study of Persistent Velopharyngeal Insufficiency in Children With Operated Velopalatine Cleft by Analysis of Velopharyngeal Motor Skills in Static and Dynamic MRIRecruitingNCT06072495Not applicable1 country
- Optimizing Perioperative Analgesia to Lower Pain Following Cleft Palate SurgeryRecruitingNCT06962306Phase 41 country
- MRI Assessment of Velopharyngeal Anatomy After Modified Furlow-Buccinator Flap in Late Primary Palate RepairNot yet recruitingNCT07514091Not applicable1 country
- Speech Intervention Via Telepractice for Children With Repaired Cleft PalateNot yet recruitingNCT07434375Not applicable1 country
- Allied Cleft & Craniofacial Quality-Improvement and Research Network (ACCQUIREnet)Enrolling by invitationNCT027028692 countries
- Length of Hospital Stay and Postoperative Analgesic Requirements After Introduction of a Specific Maxillary Nerve Block in Children Undergoing Cleft Palate SurgeryRecruitingNCT072798831 country
- Early Intervention in Infants With Unrepaired Cleft Palate: Language, Palatal Function, and Articulation.Not yet recruitingNCT07219901Not applicable1 country
- Nebulized Dexmedetomidine Combined With Ketamine Versus Nebulized Dexmedetomidine for Cleft PalateRecruitingNCT05821972Phase 41 country
- Effect of Furlow Palatoplasty With Buccal Myomucosal Flap on the Speech DevelopmentRecruitingNCT068563301 country
- Aesthetic and Functional Self-Assessment Following Rhinoseptoplasty in Patients With Unilateral Cleft Lip and PalateRecruitingNCT070484181 country
- Book Sharing for Toddlers With CleftsEnrolling by invitationNCT06338319Not applicable1 country
- Effects of AlignBabyCleft (ABaCleft)Not yet recruitingNCT05357092Not applicable
- The Financial and Emotional Impact of Cleft PalateRecruitingNCT069056781 country
- Neural Network to Calculate Morphology of the Cleft Palate to Reduce Cleft Lip and Palate Treatment Burden.RecruitingNCT043422341 country
- Role of Plasma Rich Growth Factor in Repair Primary Cleft PalateNot yet recruitingNCT06889181Not applicable1 country
- Otological Study of Facial Cleft Patients Over 10 Years of Age (Excluding Isolated Cleft Lip) (EFEOF)Not yet recruitingNCT067389271 country
- Detection of Single Nucleotide Polymorphism (SNP) Rs2235371 of IRF6 Gene in Egyptian Patients with Non-Syndromic Cleft Lip and PalateNot yet recruitingNCT06730880
- Respiratory Tract Microbiome and Probiotics in Children With Cleft PalateRecruitingNCT06505330Not applicable1 country
- Liposomal Bupivacaine Use in Alveolar Bone Graft PatientsRecruitingNCT06284434Phase 31 country
- Velopharyngeal Insufficiency Evaluation Post Cleft Palate Repair. Furlow With Buccinator Myomucosal Flap Versus Two Flap PalatoplastyNot yet recruitingNCT06477679Not applicable1 country
- Prospective Evaluation of Speech Function Through Patient- and Parent-response Outcome Measurements in Velopharyngeal InsufficiencyRecruitingNCT058382611 country
- Maxillary Nerve Blocks in Children - An MRI Study of the Suprazygomatic ApproachRecruitingNCT05778903Not applicable1 country
- Effect of Infant Sign Training on Speech-language DevelopmentRecruitingNCT06143254Not applicable1 country
- Comparing the Side-lying Sleep Positioning to Back-lying in Infants With Cleft PalateRecruitingNCT04478201Not applicable1 country
- Genetics of Reproductive Disorders (Including Kallmann Syndrome) and Cleft Lip and/or PalateRecruitingNCT016011711 country
- A Comparison of Speech Outcome in Pediatric Cleft Patients, After Modified Furlow-Sommerlad Palatoplasty in Comparison to Modified Furlow Palatoplasty AloneRecruitingNCT039951991 country
- Study of Smith-Lemli-Opitz SyndromeCompletedNCT000017211 country
- Repair of Oronasal Fistula Using Interpositional Buccal Pad of Fat as a Free Graft in a Cleft Palate PatientCompletedNCT06807450Not applicable1 country
- Improving the Outcomes of Nasoalveolar Molding in Complete Bilateral Cleft Lip and Palate Neonates Using a Modification in the Design of the Conventional Molding Appliance.CompletedNCT07814625Not applicable1 country
- Timing of Primary Surgery for Cleft PalateCompletedNCT00993551Not applicable5 countries
- Description of Pain in Pediatric Patients With Cleft Lip and Palate Undergoing Alveolar Grafting Using Two Surgical Strategies: Stem Cells and Autogenous Iliac Crest Bone (Pain Evaluation in Children Undergoing Alveolar Grafting: Stem Cells vs. Iliac Crest Bone)CompletedNCT07734974Phase 1/21 country
- Evaluation of Trigeminal Nerve BlockadeActive, not recruitingNCT03632044Phase 41 country
- Suprazygomatic Maxillary Nerve Block in Cleft Palate OutcomesCompletedNCT04909619Not applicable1 country
- Analgesic Contribution of the Suprazygomatic Maxillary Nerve Block for Cleft Palate Surgery in ChildrenWithdrawnNCT04023825Not applicable
- Evaluating Salivary α - Amylase Levels Following Trigona Sp Honey Application To Post Palatoplasty Patients: A Pilot Randomized Clinical StudyCompletedNCT07610993Not applicable1 country
- Evaluation of Quality of Life After Orthognathic Surgery in a Cleft Lip and Palate ContextTerminatedNCT040490581 country
- Alveolar Cleft Repair Using Osteoinductive CeramicsCompletedNCT05331456Not applicable1 country
- A Single Bolus of Dexmedetomidine Versus Normal Saline in Postoperative AgitationCompletedNCT04928391Phase 31 country
- Assessment of the Influence of Cleft Repair on Microcirculation of the PalateCompletedNCT038776661 country
- Three Dimensional Evaluation of Dento-Skeletal Effects of Leaf Self Expander in Cleft Lip and Palate PatientsCompletedNCT07384338Not applicable1 country
- LIMA Protocol Towards Palatal Fistula and Maxillary Growth in Cleft PalateCompletedNCT07137169Not applicable1 country