Appendicitis clinical trials
The registry lists 419 studies for Appendicitis across more than 10 countries. 67 are recruiting or about to start. 368 of them are mainly about Appendicitis (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-09.
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Who runs them
Assiut University (9) · Turku University Hospital (8) · Children's Mercy Hospital Kansas City (8) · Mansoura University (5) · Helsinki University Central Hospital (5) · Fatih Sultan Mehmet Training and Research Hospital (4) · National Taiwan University Hospital (4) · Herlev Hospital (4)
What is being tested here
Drugs under test in Appendicitis studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Ertapenem | 2 | 0 | 5 |
| Metronidazole | 1 | 2 | 9 |
| Amoxicillin | 1 | 1 | 5 |
| Clavulanic Acid | 1 | 0 | 4 |
| Ketorolac Tromethamine | 1 | 3 | 3 |
| Ketorolac | 1 | 3 | 3 |
| Moxifloxacin | 1 | 0 | 2 |
| Levofloxacin | 1 | 0 | 2 |
| Magnesium | 1 | 0 | 1 |
| Ropivacaine | 0 | 0 | 4 |
Drug classes tested here Beta-lactamase inhibitors 2 open · NSAIDs 1 open · Local anesthetics 11
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Nov 2026Primary Versus Delayed Wound Closure in Complicated Appendectomy (The HIEDI-Yemen Trial) · Sana'a University
- Dec 2026Use of Antibiotic Irrigation to Decrease Wound Infections in Pediatric Perforated Appendicitis · Prisma Health-Upstate
- Dec 2026Direct Visualization ERAT Versus Laparoscopic Appendectomy in Adults With Acute Uncomplicated Appendicitis · Changhai Hospital
- Dec 2026Effect Of Specimen Extraction Site And Local Anesthesia On Postoperative Pain In Laparoscopic Appendectomy · YUNUS YÜKSEL
- Dec 2026Prevention of Postoperative Hernias in Emergency Surgery · Jan Kochanowski University
- Jan 2027Systemic and Tissue Inflammatory Biomarkers in Acute Appendicitis · Haydarpasa Numune Training and Research Hospital
- Jan 2027Comparison of Diagnostic Methods in Patients Operated for Suspected Appendicitis · Sanliurfa Education and Research Hospital
- Feb 2027Clinical Study of PEG Bowel Preparation in Appendectomy Patients · Huaping Xie
- Apr 2027Feasibility and Safety of a Pediatric ERAS Protocol for Laparoscopic Appendectomy · Ahmet Burak Doğan, MD
- Apr 2027Diagnosis of Abdominal Pain Using RNA Levels: The NATURAL Study · True Bearing Diagnostics, Inc.
Who these studies take
Of the 39 Appendicitis studies recruiting now, 18 (46%) set no upper age limit and 19 (49%) stop at 75 or younger. 23 (59%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 7 (18%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 20 (51%) | 20 (51%) |
| 18 | 31 (79%) | 31 (79%) |
| 30 | 25 (64%) | 25 (64%) |
| 40 | 25 (64%) | 25 (64%) |
| 50 | 24 (62%) | 24 (62%) |
| 65 | 24 (62%) | 24 (62%) |
| 75 | 21 (54%) | 21 (54%) |
| 85 | 20 (51%) | 20 (51%) |
Across all 419 studies, recruiting or not: 47% stop at 75 or younger and 41% at 65; 58% take children; 3% are for women only and 1% for men only; 12% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Appendicitis studies take
Of 91 interventional studies with no phase under Appendicitis, half reached primary completion within 18 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 18 mo10–36 · 91 studies | — | 18 mo10–36 · 89 studies |
| Observational | 23 mo7–56 · 56 studies | — | 23 mo7–56 · 54 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 11, 2026.
Results posted1
Newly registered3
- Systemic and Tissue Inflammatory Biomarkers in Acute AppendicitisNov 9, 2026NCT07926165
- Prospective Comparison of Pro-Adrenomedullin, C-Reactive Protein, and Neutrophil-to-Lymphocyte Ratio for Diagnosing Acute AppendicitisOct 22, 2026NCT07889544
- Comparative Study Between Laparoscopic and Open Appendectomy of Complicated AppendicitisOct 16, 2026NCT07879235
Studies
Recruiting first, then most recently updated. Showing 50 of 419. Browse all 419 → or search them.
- Systemic and Tissue Inflammatory Biomarkers in Acute AppendicitisRecruitingNCT079261651 country
- Prospective Comparison of Pro-Adrenomedullin, C-Reactive Protein, and Neutrophil-to-Lymphocyte Ratio for Diagnosing Acute AppendicitisRecruitingNCT078895441 country
- Comparative Study Between Laparoscopic and Open Appendectomy of Complicated AppendicitisNot yet recruitingNCT07879235Not applicable
- Feasibility and Safety of a Pediatric ERAS Protocol for Laparoscopic AppendectomyRecruitingNCT07643285Not applicable1 country
- Piperacillin/Tazobactam Versus Ceftriaxone and Metronidazole for Children With Perforated AppendicitisNot yet recruitingNCT07869095Phase 3
- Patient Choice Between Antibiotics and Appendectomy in Uncomplicated Appendicitis (FRENCH 47 - ALACARTE)Not yet recruitingNCT07857252Phase 21 country
- Immediate Laparoscopic Appendectomy Versus Interval Laparoscopic Appendectomy for Early Appendicular MassNot yet recruitingNCT07837531Not applicable
- Protocol Based Selective Imaging Versus Routine Computed Tomography or Ultrasound in Suspected AppendicitisRecruitingNCT06083064Not applicable1 country
- Perforated Appendicitis and Postoperative Antibiotics Pilot TrialNot yet recruitingNCT07656636Not applicable
- Effect Of Specimen Extraction Site And Local Anesthesia On Postoperative Pain In Laparoscopic AppendectomyRecruitingNCT07824908Not applicable1 country
- Laparoscopic vs Open Appendectomy in Obese PatientsNot yet recruitingNCT07822503Not applicable
- Fast Track Therapeutic Model in Acute Complicated Appendicitis in PediatricsRecruitingNCT05761080Phase 41 country
- Direct Visualization ERAT Versus Laparoscopic Appendectomy in Adults With Acute Uncomplicated AppendicitisRecruitingNCT07230379Not applicable1 country
- Video-Based Grading of Intraoperative Adverse Events in Pediatric Laparoscopic AppendectomyRecruitingNCT077946181 country
- Magnesium Sulfate in Children Undergoing Laparoscopic AppendectomyRecruitingNCT06563349Phase 41 country
- Laparoscopic Appendectomy: Outcomes of 10 mmHg Versus 15 mmHg Intra-abdominal PressureNot yet recruitingNCT07727499Not applicable1 country
- The Impact of a Diagnostic Strategy for Acute Appendicitis in Children With Acute Abdominal Pain in Primary CareRecruitingNCT06762275Not applicable1 country
- Primary Versus Delayed Wound Closure in Complicated Appendectomy (The HIEDI-Yemen Trial)Not yet recruitingNCT07688109Not applicable1 country
- Effect of Endotracheal Tube Cuff Pressure Management on Postoperative Sore Throat in Pediatric Laparoscopic AppendectomyRecruitingNCT07678086Not applicable1 country
- Oral Lactulose for Gastrointestinal Recovery After Complex AppendectomyRecruitingNCT07589465Not applicable1 country
- Effects of Cartoons and Mobile Games on Preoperative Anxiety and Fear in Children With Appendicitis: An RCTRecruitingNCT07640230Not applicable1 country
- Efficacy of Non Operative Treatment With Amoxicillin/Clavulanic Acid Versus Surgical Treatment in Acute Uncomplicated Appendicitis in ChildrenNot yet recruitingNCT07587450Phase 31 country
- Early Detection of Infection Using the Fitbit in Pediatric Surgical PatientsRecruitingNCT06395636Not applicable1 country
- Diagnosis of Abdominal Pain Using RNA Levels: The NATURAL StudyRecruitingNCT075793121 country
- One Versus Five Days of Antibiotics After AppendectomyNot yet recruitingNCT07563933Not applicable1 country
- Out-patiente Management for Gangrenous Acute Appendicitis: The PENDI-CSI II Randomized Clinical Trial.RecruitingNCT07521969Not applicable1 country
- Re-assessment of Appendicitis Evaluation During Laparoscopic Appendectomy, Peritoneal Irrigation During Laparoscopic Appendectomy Does the Grade of Contamination Matter?RecruitingNCT050752521 country
- Comparison of Diagnostic Methods in Patients Operated for Suspected AppendicitisRecruitingNCT074967231 country
- Same Day Ambulatory Appendectomy (SAMBA)RecruitingNCT05691348Not applicable2 countries
- TACTILE : Validation of a Teleconsultation-Based Predictive Score for the Diagnosis of Acute Appendicitis in Children Using Artificial Intelligence MethodsNot yet recruitingNCT07479849Not applicable1 country
- Clinical Study of PEG Bowel Preparation in Appendectomy PatientsRecruitingNCT074780291 country
- First Appendectomy Using Revolve Surgical Robotic ArmNot yet recruitingNCT07455487Not applicable
- APPI-Cost Trial for Perforated AppendicitisRecruitingNCT06705842Phase 41 country
- Operative Versus Non-Operative Management for Appendicitis With Abscess or PhlegmonRecruitingNCT04168866Not applicable1 country
- Benefit of Hypnosis on Smartphone for Acute Post-operative Pain (HYPNO-APP)RecruitingNCT05854914Not applicable1 country
- Comparison Between Metallic Clip Ligation and Suture Ligation of Appendicular Stump in Laparoscopic AppendectomyNot yet recruitingNCT07129746Not applicable1 country
- Results of Laparoscopic Appendectomy With Application of Clips Versus Ligature for Stump ClosureRecruitingNCT07115303Not applicable1 country
- Early vs Conventional Enteral Nutrition After Uncomplicated Paediatric Open AppendectomyRecruitingNCT07016919Not applicable1 country
- Prevention of Postoperative Hernias in Emergency SurgeryRecruitingNCT068158221 country
- Prostaglandin-E Urinary Metabolite (PGE-M) as a Predictor of Acute Appendicitis in ChildrenRecruitingNCT070080921 country
- Comparison of Outcome of Open Appendectomy With and Without Transversus Abdominis Plane (TAP) BlockNot yet recruitingNCT06943456Not applicable
- Enhanced Recovery After Surgery (ERAS) for Complicated AppendicitisRecruitingNCT06948071Not applicable1 country
- A Global Prospective Cohort Study on Outcomes of Appendicectomy for AppendicitisRecruitingNCT067740017 countries
- Risk Factors of Failure of Conservative Treatment in Acute Non Complicated AppendicitisNot yet recruitingNCT068289521 country
- Povidone-iodine Irrigation for Prevention of Intra-abdominal Abscess in Pediatric Perforated Appendicitis: a Multi-center Stepped Wedge Cluster Randomized StudyNot yet recruitingNCT04200729Phase 41 country
- Textbook Outcomes in Urgent AppendectomyNot yet recruitingNCT06765044
- Artificial Intelligence-driven Virtual Standardized Pediatric Patients TrialRecruitingNCT06699433Not applicable1 country
- Laparoscopic Versus Open Appendectomy Plus Peritoneal Lavage for Acute Complicated Appendicitis Patients With Diffuse PeritonitisNot yet recruitingNCT06633744
- Transumbilical Laparoscopic AppendectomyRecruitingNCT06177418Not applicable1 country
- Appendicoliths in Acute Complicated Appendicitis Patients With AbscessNot yet recruitingNCT06469086