An interventional study of Discharge on oral antibiotics in Appendicitis Acute, Appendicitis Perforated and Appendicitis With Perforation, sponsored by Cedars-Sinai Medical Center. Recruiting at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-04-29.
Sponsored by Cedars-Sinai Medical Center · Not applicable, Interventional, and Treatment
The exploratory objective of this pilot study is to evaluate the feasibility and safety of an enhanced recovery protocol that will allow adult patients to be discharged to home on an oral antibiotic regimen for three days following a laparoscopic appendectomy for complicated appendicitis. Feasibility will be determined by high compliance and adherence of patients to the postoperative instructions, while safety will be assessed by the incidence of postoperative infectious complications and requirement for re-admission.
419 studies on the registry are indexed under Appendicitis; 67 are open to participants now.
This study's planned enrollment of 20 is below the median of 111 across 252 interventional studies indexed under Appendicitis.
Browse Appendicitis studies →Cedars-Sinai Medical Center is the lead sponsor of 456 studies on the registry; 107 are open to participants now.
Of its 65 completed or terminated interventional studies of FDA-regulated products, 49 (75%) have results posted.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A weakened immune system. It can come from an illness, such as HIV or some blood cancers, or from medicines that turn the immune system down, for example after an organ transplant or for an autoimmune disease; steroids at higher doses count.
Read whether the line is about a condition or about medicines, and which medicines and doses it means.
Immunosuppression
A weakened immune system. It can come from an illness, such as HIV or some blood cancers, or from medicines that turn the immune system down, for example after an organ transplant or for an autoimmune disease; steroids at higher doses count.
Read whether the line is about a condition or about medicines, and which medicines and doses it means.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Patients with intraoperative diagnosis of complicated appendicitis as determined by the operating surgeon.
Other: Discharge on oral antibiotics
Patients will be discharged to home on an oral antibiotic regimen for 3 days instead of being admitted for intravenous antibiotics.
Readmission rate
Feasibility will be determined by the readmission within 30 days rate for any reason
Time frame: 30 days
Postoperative infections
Safety will be assessed by the incidence of postoperative infectious complications
Time frame: 30 days
Plan to share: Undecided
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