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RecruitingNCT07115303Updated Aug 11, 2025

Results of Laparoscopic Appendectomy With Application of Clips Versus Ligature for Stump Closure

An interventional study of Laparoscopic Appendectomy with application of clips for stump closure and Laparoscopic Appendectomy with ligature for stump closure in Appendicitis, sponsored by Sohag University. Recruiting at 1 site in Egypt. Per ClinicalTrials.gov, last updated 2025-08-11.

Sponsored by Sohag University · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Primary completion was expected by Feb 2026, 8 months ago, but the record still lists the study as recruiting.
  • Started Jul 2025; still recruiting 1 year 3 months later.
Phase
Not applicable
Study type
Interventional
Enrollment
80
Allocation
Randomized
Sex
All
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Study summary

This a prospective study to compare between clipping and ligation of appendicular stump in laparoscopic appendectomies regarding ;technical feasibility , post operative complications as fecal fistula and economic consideration.

02

Conditions studied

  • Appendicitis

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03

In context

Appendicitis

419 studies on the registry are indexed under Appendicitis; 67 are open to participants now.

This study's planned enrollment of 80 is below the median of 111 across 252 interventional studies indexed under Appendicitis.

Browse Appendicitis studies →

Lead sponsor

Sohag University is the lead sponsor of 1,230 studies on the registry; 636 are open to participants now.

Browse Sohag University studies →

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Any patient diagnosed with acute appendicitis of any age and of any sex presented to ER of the Department of General, Laparoscopic and Oncologic Surgery Department, Sohag University Hospital will be enrolled in this study.

Exclusion criteria

Exclusion Criteria:

  • Patients with complicated appendicitis.
  • Patients with unstable cardiac or pulmonary condition.
  • Patients with suspicious crhon's disease or mass intraoperative.
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Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
80 participants (estimated)

Study arms

  • Active comparator
    Laparoscopic Appendectomy with application of clips for stump closure

    Procedure: Laparoscopic Appendectomy with application of clips for stump closure

  • Active comparator
    Laparoscopic Appendectomy with ligature for stump closure

    Procedure: Laparoscopic Appendectomy with ligature for stump closure

Interventions

  • ProcedureLaparoscopic Appendectomy with application of clips for stump closure

    in patients who will undergo Laparoscopic Appendectomy, appendicular stump will be closed by application of clips

  • ProcedureLaparoscopic Appendectomy with ligature for stump closure

    in patients who will undergo Laparoscopic Appendectomy, appendicular stump will be closed by ligation

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What researchers measure

Primary outcomes

  1. Results of Laparoscopic Appendectomy with application of clips versus ligature for stump closure

    postoperative hospital stay

    Time frame: 24 hours postoperative

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Study locations

1 of 1 sites recruiting
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References and documents

Publications

  • Makaram N, Knight SR, Ibrahim A, Patil P, Wilson MSJ. Closure of the appendiceal stump in laparoscopic appendectomy: A systematic review of the literature. Ann Med Surg (Lond). 2020 Aug 4;57:228-235. doi: 10.1016/j.amsu.2020.07.058. eCollection 2020 Sep. PubMed 32802324 ↗
  • Farahani PK, Safaei N. Comparison of two methods: Clipping and suturing in laparoscopic appendectomy. Surg Open Sci. 2024 May 3;19:162-165. doi: 10.1016/j.sopen.2024.04.007. eCollection 2024 Jun. PubMed 38764557 ↗
  • Poon SHT, Law SY, Lai ATY. Clips closure versus endoloop ligation in laparoscopic appendectomy: a systematic review and meta-analysis of comparative studies. Ann Med Surg (Lond). 2023 Sep 6;85(10):5011-5021. doi: 10.1097/MS9.0000000000001260. eCollection 2023 Oct. PubMed 37811063 ↗
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Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Started Jul 2025 (actual). Primary completion is estimated for Feb 2026, 7 months after the start.

Of 89 non-industry interventional studies with no phase under Appendicitis, half reached primary completion within 18 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 36. This study's planned 7 months is below that.

Counting every sponsor, half of 91 studies reached it within 18 months; a quarter within 10 and three quarters within 36.

How these figures are worked out, and which studies are left out of them.

Registered
Aug 4, 2025
First posted
Aug 11, 2025
StartActual
Jul 14, 2025
Primary completionEst.
Feb 28, 2026
CompletionEst.
Feb 28, 2026
Last update
Aug 11, 2025
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Aug 11, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07115303
Lead sponsor
Sohag University
Responsible party
Ahmed Amer Abdelraheem (Resident of General, Oncologic& Laparscopic Surgery Faculty of Medicine, Sohag University, Sohag University) — Principal investigator
First posted
Aug 11, 2025
Start date
Jul 14, 2025
Primary completion
Feb 28, 2026 (estimated)
Completion
Feb 28, 2026 (estimated)
Last update
Aug 11, 2025

Study contacts

Ahmed A Abdelreheem, Resident
Contact
ahmeddd_amerrr@yahoo.com
01026675749
Mohamed M Ali, Professor
Contact
01004564240

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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