An interventional study of Laparoscopic Appendectomy and Open Appendectomy in Appendicitis, Perforated Appendicitis and Gangrenous Appendicitis, sponsored by Assiut University. Not yet recruiting. Open to participants aged 1 Year to 18 Years. Per ClinicalTrials.gov, last updated 2026-10-16.
Sponsored by Assiut University · Not applicable, Interventional, and Treatment
Acute appendicitis is one of the most common surgical emergencies in children. In complicated cases, where the appendix has perforated, become gangrenous, or caused peritonitis and purulent contamination, determining the optimal surgical approach remains an important clinical question. While laparoscopic appendectomy is widely used for uncomplicated cases, this study aims to evaluate its safety, clinical effectiveness, and postoperative outcomes compared with conventional open appendectomy in children with complicated appendicitis.
A total of 100 pediatric patients diagnosed with complicated acute appendicitis will participate in this prospective comparative study, divided into two groups:
The primary goal is to compare the overall rate of postoperative complications between the two operative techniques. Researchers will also assess secondary outcomes, including operative time, intraoperative complications, conversion to open surgery, postoperative pain, time to resume oral feeding, duration of intravenous antibiotics, length of hospital stay, wound infections, intra-abdominal abscesses, bowel obstruction, readmissions, and reoperations. All participants will be evaluated during their hospital admission and followed up for 30 days postoperatively.
417 studies on the registry are indexed under Appendicitis; 63 are open to participants now.
This study's planned enrollment of 100 is close to the median of 111 across 248 interventional studies indexed under Appendicitis.
Browse Appendicitis studies →Assiut University is the lead sponsor of 5,050 studies on the registry; 2,174 are open to participants now.
Of its 14 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Pediatric patients undergoing laparoscopic appendectomy under general anesthesia using a standard 3-port technique (periumbilical camera port, 5 mm right lower quadrant port, and 10 mm suprapubic port). The mesoappendix and appendicular artery are clipped and divided, the appendicular base is secured with three endoloops, and the specimen is retrieved in an endobag through the umbilical port. Peritoneal lavage, aspiration of pus, and drain insertion are performed as indicated based on operative findings.
Procedure: Laparoscopic Appendectomy
Pediatric patients undergoing conventional open appendectomy under general anesthesia through a standard right lower-quadrant incision. The appendix is mobilized, the mesoappendix and appendicular base are ligated and divided by standard surgical technique, and peritoneal contamination is addressed with peritoneal toilet and drain insertion as indicated based on operative findings.
Procedure: Open Appendectomy
Laparoscopic appendectomy performed under general anesthesia via a three-port technique (periumbilical camera port using Hasson open technique, 5 mm right lower quadrant port, and 10 mm suprapubic port). The mesoappendix is dissected, and the appendicular artery is skeletonized, secured with clips, and divided. The appendicular base is secured using three endoloops and divided between the second and third loop. The appendix is extracted in an endobag through the umbilical port. Peritoneal lavage, pus aspiration, and drain placement are performed based on operative findings. Incisions are closed in layers.
Conventional open appendectomy performed under general anesthesia through a standard right lower-quadrant incision (e.g., McBurney or Lanz). The cecum and appendix are mobilized into the field. The mesoappendix and appendicular artery are ligated and divided, followed by ligation and division of the appendicular base. Peritoneal contamination is managed with peritoneal toilet, suction, and drainage as indicated by operative findings. The wound is closed in anatomical layers.
Percentage of Participants With Postoperative Complications
Calculated as the percentage of pediatric patients who develop at least one postoperative complication (including surgical-site infection, intra-abdominal abscess or collection, prolonged postoperative ileus, mechanical bowel obstruction, or need for reoperation) following appendectomy.
Time frame: 30 days postoperatively
No study locations are listed for this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.