An interventional study of Immediate Laparoscopic Appendectomy and Interval Laparoscopic Appendectomy in Appendicular Mass, Acute Appendicitis and Appendiceal Phlegmon, sponsored by Assiut University. Not yet recruiting. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-23.
Sponsored by Assiut University · Not applicable, Interventional, and Treatment
This study compares two standard treatment approaches for patients presenting with an appendicular mass, an inflammatory lump that forms when the appendix becomes severely inflamed and walled off by surrounding abdominal tissues.
The traditional treatment involves conservative medical therapy using intravenous antibiotics followed by an elective interval surgery to remove the appendix 6 to 8 weeks later. Alternatively, advances in minimally invasive surgery allow for an immediate keyhole operation (laparoscopic appendectomy) performed during the initial hospital admission. The goal of this study is to evaluate which approach leads to shorter total hospital stays, faster recovery, and fewer complications.
Participants will be assigned to one of two treatment groups:
Participants in both groups will be monitored throughout their hospital stay and will attend follow-up visits at 1, 3, and 6 months postoperatively to assess recovery, wound healing, and any potential complications.
419 studies on the registry are indexed under Appendicitis; 67 are open to participants now.
This study's planned enrollment of 100 is close to the median of 111 across 252 interventional studies indexed under Appendicitis.
Browse Appendicitis studies →Assiut University is the lead sponsor of 5,078 studies on the registry; 2,178 are open to participants now.
Of its 14 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.
Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
ASA physical status
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Cancer (malignancy)
Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.
Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Patients undergo immediate laparoscopic appendectomy within 24 hours of admission. The procedure utilizes a standard 3-port laparoscopic technique (one 10 mm umbilical camera port and two 5 mm working ports), blunt and sharp adhesiolysis to isolate the inflamed appendix, appendix resection via endoloop or endoscopic stapler, warm saline peritoneal lavage (3-5 L), and abdominal drain placement if indicated.
Procedure: Immediate Laparoscopic Appendectomy
Patients receive initial conservative medical treatment with intravenous antibiotics (third-generation cephalosporin, metronidazole, and amikacin) along with analgesics, monitored via clinical examination and ultrasound every 48 hours until symptom resolution and discharge. Patients subsequently undergo elective interval laparoscopic appendectomy 6 to 8 weeks later using the same standard 3-port technique.
Procedure: Interval Laparoscopic Appendectomy
Laparoscopic appendectomy performed within 24 hours of admission. The procedure is executed using a standard 3-port technique (one 10 mm umbilical camera port and two 5 mm working ports). It includes careful blunt and sharp adhesiolysis to identify and mobilize the appendix, appendectomy using an endoloop ligature or endoscopic stapler, peritoneal lavage with 3-5 liters of warm normal saline, and abdominal drain placement when clinically indicated.
Initial conservative medical management with intravenous antibiotics (third-generation cephalosporin, metronidazole, and amikacin) and analgesics, monitored clinically and via ultrasonography every 48 hours until clinical improvement and discharge. Patients undergo elective interval laparoscopic appendectomy 6 to 8 weeks later using the standard 3-port laparoscopic technique.
Total Length of Hospital Stay
Time frame: Up to 3 months
No study locations are listed for this record.
Start is estimated for Oct 2026; primary completion for Oct 2027, 12 months later.
Of 89 non-industry interventional studies with no phase under Appendicitis, half reached primary completion within 18 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 36. This study's planned 12 months is below that.
Counting every sponsor, half of 91 studies reached it within 18 months; a quarter within 10 and three quarters within 36.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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