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Trastuzumab clinical trials

Also written Herceptin, RO0452317 and HD201.

Includes 3 studies of CT-P6, 2 studies of Trastuzumab/Hyaluronidase-oysk and 1 study of ABP-980.

studies test it
531
open now
89
in phase 3
79
first study started
1997
Related medicines add 9 studies

Counted the way a researcher would: Trastuzumab with its salts, dosage forms, brands and biosimilars. Looking for a trial to join? Including related medicines shows more you could take part in.

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ClinicalTrials.gov finds 1,754 studies for Trastuzumab. How that becomes 531 here

Every study that search finds has been read, apart from the 10 newest, to see whether and how it gives Trastuzumab. ClinicalTrials.gov counts as of Nov 14, 2026. How drug pages count

  1. 1,754Found by its intervention search · See all 1,754 hereIt also reads titles, arm labels, keywords and descriptions, and counts the drug’s other names. Of these, 1,287 name it in an intervention entry. The counts it shows beside each synonym overlap: a study writing two names counts under both.
  2. −448
    Mention it without giving it — earlier treatment, a protocol code, a title naming another drug
  3. −7New since the last reading, not read yet
  4. +3Give it under a name that search misses: a biosimilar’s code or a misspelling
  5. 1,302Give Trastuzumab to participants
  6. −142Observe patients on it, or give it outside a trial
  7. −21Use it as a tool: an imaging tracer or a test of drug response
  8. −90Compare another treatment with it
  9. −518Give it beside what is tested
  10. 531Test it: the count on this site

Get an email when these change. Save the Trastuzumab studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.

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Example · made-up studies

Breast cancer · Recruiting: 2 came in, 3 changed

What changed in your saved searches, Oct 31 – Nov 6:

A study of drug A after surgery for early breast cancer

Came in · now Recruiting

Drug B with hormone therapy in advanced breast cancer

Changed

· Sites: 4 added, including Seoul and Busan

· Enrollment: 300 → 450 participants

Exercise during chemotherapy

Now Active, not recruiting

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Approvals

The first approval found in each region, with its record

United States
25 Sept 1998 · HERCEPTIN · BLA 103792 (FDA, Drugs@FDA)
European Union
28 Aug 2000 · Herceptin · EMEA/H/C/000278 (EMA)

From FDA's Drugs@FDA and Purple Book (through openFDA) and the European Medicines Agency, files of Sept 2026 and 27 Oct 2026. National approvals in Europe and other countries are not included. How this is worked out

How studies write it

Studies that test it under each name

Name

Trastuzumab
320
anti-c-erB-2
20
MOAB HER2
20
trastuzumab [Herceptin]
11
Trastuzumab (Herceptin)
6

Brand

Herceptin
161

Development codes

RO0452317
3
HD201
2
rhuMAb HER2
1
BCD-022
1
DMB-3111
1
Ro 45-2317
1

In one entry with another drug

Given together, or one or the other

capecitabine and trastuzumab
2
oxaliplatin, capecitabine, trastuzumab
2
Trastuzumab + NK cells
2

Biosimilars

Herzuma
5
PF-05280014
4
HLX02
3
EG12014
2
SB3
2
Ontruzant
1
QL1701
1
SIBP-01
1

Studies by the year they started

528 studies that test it; most in 2011 (35); 1 more planned to start later

Studies that test Trastuzumab, by start year
YearStudies
19971
19985
199917
200016
200116
200212
200310
200414
200519
200619
200721
200817
200918
201014
201135
20127
201332
201430
201518
201612
201712
201811
201923
202020
202126
202230
202322
202421
202519
202611

By phase

A phase 1/2 study counts in both.

Early Phase 1
4
Phase 1
79
Phase 2
385
Phase 3
79
Phase 4
10
No phase
19

What it is tested for

Each study’s main condition, where its own words name it, so a study counts once.

Breast Neoplasms
309
Stomach Neoplasms
24
Colorectal Neoplasms
9
Carcinoma, Non-Small-Cell Lung
6
Biliary Tract Neoplasms
5
Colonic Neoplasms
4
Breast Neoplasms, Male
4
Adenocarcinoma
4
Urinary Bladder Neoplasms
4
Neoplasms
4
Prostatic Neoplasms
3
Esophageal Neoplasms
3

Who runs them

Industry 106 · Other 425

Hoffmann-La Roche (43) · National Cancer Institute (NCI) (27) · Dana-Farber Cancer Institute (13) · Memorial Sloan Kettering Cancer Center (12) · Fudan University (11) · SCRI Development Innovations, LLC (8) · City of Hope Medical Center (7) · Genentech, Inc. (6)

Often tested with

Tested in the same studies.

Pertuzumab (88) · Paclitaxel (76) · Docetaxel (43) · Capecitabine (37) · Cyclophosphamide (33) · Doxorubicin (31) · Carboplatin (30) · Pyrotinib (27)

Related medicines

As reviewed, each with the page that says it.

Coming up

From the study records. Dates are the sponsors’ own estimates and often move.

Tested against it · 29 phase 3 studies under way

Trastuzumab is the comparator. A study of two new drugs counts under both.

  • 4Trastuzumab deruxtecan · AstraZeneca, Daiichi Sankyo · next primary completion May 2027
  • 3Anbenitamab · Shanghai JMT-Bio Inc. · next primary completion Dec 2026
  • 3Docetaxel · Shanghai JMT-Bio Inc. · next primary completion Dec 2026
  • 2Pertuzumab · AstraZeneca, Helsinki University Central Hospital · next primary completion May 2027
  • 2Zanidatamab · Jazz Pharmaceuticals · next primary completion Apr 2028
  • 2Trastuzumab rezetecan · Jiangsu HengRui Medicine Co., Ltd. · next primary completion Dec 2027
  • 2Disitamab vedotin · Fudan University, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · next primary completion Jan 2028
  • 2Pyrotinib · Shengjing Hospital, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · next primary completion Aug 2027
New treatments tested with it · 8 most studied

New when their studies opened, with Trastuzumab beside them; studies of each.

Reaching primary completion within a year · 37, 4 in phase 3

Studies that test Trastuzumab, phase 3 first.

Studies

Open first, then newest update. How each study uses Trastuzumab has had a first review, but it may not be perfect: check the study record before relying on it for anything important, and report a problem from its row. Some give it without naming it in an intervention entry: those were found by reading the record.

Testing it · 531

See all 531 studies that test Trastuzumab →

Tested on its own · 81 — no other medicine in its arm

Showing 20 of 81. See all 81 →

Tested with established drugs · 68 — they are given beside it

Showing 20 of 68. See all 68 →

Tested in a combination · 382 — another drug in the study is under test too

Showing 20 of 382. See all 382 →

Beside an established treatment under test · 192 — an approved drug, surgery or radiation is what the study tests

Tested with Trastuzumab: Surgery or a procedure 28 · Carboplatin 18 · Radiation 14 · Docetaxel 12 · tucatinib 12 · pembrolizumab 12 · Paclitaxel 11 · pertuzumab 10

Showing 20 of 192. See all 192 →

Beside a new treatment under test · 261 — a new drug, cell therapy or vaccine is what the study tests

New treatments tested with Trastuzumab: pyrotinib 21 · pertuzumab 10 · Lapatinib 6 · trastuzumab rezetecan 6 · Everolimus 5 · neratinib 5 · dulpatatug 4 · tucatinib 4

Showing 20 of 261. See all 261 →

Beside supportive care · 46 — a supportive treatment or test is studied

Showing 20 of 46. See all 46 →

One option of several · 17 — a test or a strategy chooses among drugs
Given beside what is tested · 2 — usual care or a partner of the new treatment
As the comparator · 90 — what is tested is compared with Trastuzumab

Showing 20 of 90. See all 90 →

Observed · 142 — patients on it are followed, or it is given outside a trial

Showing 20 of 142. See all 142 →

As a tool · 21 — an imaging tracer or a test of drug response

Showing 20 of 21. See all 21 →

What changed recently

From the registry's own updates since Oct 15, 2026.

Started recruiting1

Results posted1

Codes

What other systems call Trastuzumab · ClinicalTrials.gg INT006553

  • MeSH (NLM) D000068878TrastuzumabConfirmed ClinicalTrials.gov, NLM, Wikidata
  • UNII (FDA) P188ANX8CKTRASTUZUMABConfirmed FDA, NLM, Wikidata
  • RxNorm 224905Confirmed FDA, Wikidata
  • Wikidata Q412616trastuzumabConfirmed FDA, NLM, Wikidata
  • NCI Thesaurus C1647TrastuzumabOne source FDA
  • DrugBank DB00072One source Wikidata

“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.

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