Colonic Neoplasms clinical trials
The registry lists 2,457 studies for Colonic Neoplasms across more than 10 countries. 458 are recruiting or about to start. 1,347 of them are mainly about Colonic Neoplasms (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its narrower condition Sigmoid Neoplasms too: 2,474 studies, 461 open.
ClinicalTrials.gov finds 8,359 studies for Colonic Neoplasms. How that becomes 2,458 here
This page counts the studies the registry files under Colonic Neoplasms, and those it files under no condition that list Colonic Neoplasmsthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 8,359Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −17Filed under a narrower condition, counted on its own pageSigmoid Neoplasms 17
- −65List Colonic Neoplasms as a condition, but the registry did not file them under itMost often written as “Liver Metastasis Colon Cancer” (31), “Colon Cancer Screening” (6), and “Colon Cancer Liver Metastasis” (5). The registry filed them under other conditions only, most often Colorectal Neoplasms (31) and Liver Neoplasms (8).
- −5,819Match it another way150 name it in the title, 25 in a keyword, and 5,644 by a synonym or other text the search reads.
- 2,458The count on this page76 of them list Colonic Neoplasms in their own words; the registry filed them under no condition.
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A study of drug A after surgery for early breast cancer
Came in · now Recruiting
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· Enrollment: 300 → 450 participants
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Status
Who runs them
National Cancer Institute (NCI) (114) · Memorial Sloan Kettering Cancer Center (53) · Alliance for Clinical Trials in Oncology (40) · M.D. Anderson Cancer Center (33) · City of Hope Medical Center (30) · Fudan University (19) · GERCOR - Multidisciplinary Oncology Cooperative Group (18) · Case Comprehensive Cancer Center (18)
What is being tested here
Drugs under test in Colonic Neoplasms studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Cetuximab | 6 | 12 | 57 |
| Bevacizumab | 5 | 13 | 71 |
| Tislelizumab | 5 | 2 | 8 |
| Oxaliplatin | 4 | 28 | 108 |
| Irinotecan | 4 | 20 | 89 |
| Pembrolizumab | 4 | 1 | 7 |
| Iparomlimab/Tuvonralimab | 4 | 1 | 4 |
| Dostarlimab | 4 | 1 | 4 |
| Capecitabine | 3 | 11 | 52 |
| Nivolumab | 3 | 2 | 15 |
Drug classes tested here Immune checkpoint inhibitors 43 open · Antimetabolites 7 open · Tyrosine kinase inhibitors (TKIs) 6 open · Angiogenesis inhibitors 5 open · Alkylating agents 2 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Dec 2026Identification and Treatment Of Micrometastatic Disease in Stage III Colon Cancer · Phase 3 · Massachusetts General Hospital
- Mar 2027Evaluation of NuvastaticTM in Reducing Cancer-Related Fatigue in Colon Cancer Patients Undergoing First-Line Chemotherapy · Phase 3 · Natureceuticals Sdn Bhd
- Apr 2027Xian-Lian-Jie-Du Optimization Decoction As an Adjuvant Treatment for Prevention of Recurrence of Colon Cancer · Phase 3 · Jiangsu Famous Medical Technology Co., Ltd.
- Apr 2027CompariSon Between the EuroPeAn and Japanese pathologiCal InvEstigation for Colon Cancer (SPACE) · Phase 3 · Russian Society of Colorectal Surgeons
- May 2027A Phase Ⅱ/Ⅲ Clinical Trial of RC148 Plus Chemotherapy as 1L Therapy for Unresectable or Metastatic Colorectal Cancer · Phase 3 · RemeGen Co., Ltd.
- Jun 2027Borderline of CME/D3 Dissection for Local Advanced Right-sided Colon Cancer · Phase 3 · Haixing Ju, MD
- Sep 2027Neoadjuvant CAPOX Plus Tislelizumab vs CAPOX in MSS High-Risk Locally Advanced Colon Cancer · Phase 3 · First Affiliated Hospital of Guangxi Medical University
- Nov 2026A Study of Neoadjuvant Dostarlimab Plus Capecitabine Plus Oxaliplatin (CAPEOX) Vs CAPEOX With Previously Untreated T4N0 or Stage III Mismatch Repair Proficient (MMRp)/Microsatellite Stable (MSS) Colon Cancer · GlaxoSmithKline
- Nov 2026IMProving Adherence to Colonoscopy Through Teams and Technology · University of California, San Francisco
- Nov 2026A Study to Evaluate ARV-806 in Adults With Advanced Cancer That Has the KRAS G12D Mutation · Arvinas Inc.
Who these studies take
Of the 326 Colonic Neoplasms studies recruiting now, 203 (62%) set no upper age limit and 71 (22%) stop at 75 or younger. 19 (6%) take children under 18. 3 (1%) are for women only and 0 (0%) for men only; 34 (10%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 13 (4%) | 13 (4%) |
| 18 | 290 (89%) | 288 (88%) |
| 30 | 304 (93%) | 302 (93%) |
| 40 | 308 (94%) | 306 (94%) |
| 50 | 313 (96%) | 311 (95%) |
| 65 | 314 (96%) | 312 (96%) |
| 75 | 307 (94%) | 305 (94%) |
| 85 | 237 (73%) | 237 (73%) |
Across all 2,457 studies, recruiting or not: 17% stop at 75 or younger and 3% at 65; 8% take children; 1% are for women only and <1% for men only; 13% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Colonic Neoplasms studies take
Of 135 phase 2 interventional studies under Colonic Neoplasms, half reached primary completion within 43 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 48 mo32–69 · 116 studies | 49 mo30–64 · 51 studies | 46 mo32–69 · 65 studies |
| Phase 1/2 | 65 mo41–93 · 60 studies | — | — |
| Phase 2 | 43 mo30–66 · 135 studies | — | 43 mo29–66 · 122 studies |
| Phase 3 | 55 mo37–119 · 72 studies | — | 87 mo39–123 · 55 studies |
| Phase 4 | 29 mo20–105 · 16 studies | — | — |
| Interventional, no phase | 30 mo16–51 · 404 studies | — | 31 mo17–55 · 382 studies |
| Observational | 50 mo24–116 · 224 studies | — | 54 mo24–116 · 186 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting4
- Biopsy-Resection Agreement of Peritoneal Histopathological Growth Patterns in Colorectal Peritoneal Metastases: A Prospective Observational Pilot StudyOct 26, 2026NCT07474025
- Neoadjuvant Pembrolizumab and Porustobart in Resectable pMMR/MSS Colon CancerOct 22, 2026NCT07808151
- A Phase 1 Study of DEM301 in Participants With Metastatic Colorectal CancerOct 15, 2026NCT07805369
- A Study of Imaging, Blood, and Tissue Samples to Guide Treatment of Colon Cancer and Related Liver TumorsOct 13, 2026NCT03432806
Results posted2
Stopped1
- Cryptosporidium Infection and Human Colorectal CancerTerminatedNov 6, 2026NCT04332705
Newly registered10
- Personalized Ultrafractionated Stereotactic Adaptive Radiotherapy Combined With Penpulimab and Fruquintinib for Advanced Colorectal CancerOct 29, 2026NCT07904130
- Study of Varsetatug Masetecan in Combination With Anti-Cancer Therapies in Colorectal CancerOct 28, 2026NCT07900165
- T1 Colorectal Cancer After Local Excision: Decision Between Surgery and Active Surveillance (T1LDA Trial)Oct 28, 2026NCT07900620
- Toripalimab Plus Cetuximab and Irinotecan for Second-Line Right-Sided RAS/BRAF Wild-Type Advanced Colon Cancer Phase II StudyOct 27, 2026NCT07896681
- A Study to Learn About the Study Medicine Called PF-08165784 in People With PIK3CA-Mutated Advanced or Metastatic Solid TumorsOct 27, 2026NCT07897721
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- Effect of ACTIVE-Care on Cancer-Related Fatigue, Hope, and Psychological Resilience in Adolescents With Acute Lymphoblastic LeukemiaOct 20, 2026NCT07882069
- Perioperative Biomarkers in Colorectal and Gastric Cancer SurgeryOct 19, 2026NCT07881133
- Chemotherapy Combined With or Without Short-Course Radiotherapy Versus Chemotherapy Alone as Neoadjuvant Therapy for High-Risk Locally Advanced Colon Cancer With pMMR/MSSOct 16, 2026NCT07877597
- This is a Phase 1/1b Study to Evaluate the Safety and Preliminary Antitumor Activity of LTZ-232 in Participants With Advanced/Metastatic Colorectal Cancer and Other Solid TumorsOct 16, 2026NCT07878988
- NURSE-led Geriatric Assessment in Older Colorectal Cancer PatientsOct 14, 2026NCT07872787
Studies
Recruiting first, then most recently updated. Showing 50 of 2,457. Browse all 2,457 → or search them.
- Analysis of Circulating Tumor Markers in BloodRecruitingNCT04025541Not applicable1 country
- Follow-Up Study of Subjects Previously Enrolled in Poxviral Vector Gene Transfer StudiesRecruitingNCT004510221 country
- Collection of Blood From Patients With CancerRecruitingNCT000342161 country
- Genomic Services Research ProgramRecruitingNCT025959571 country
- Improving Colorectal Cancer Screening Uptake Through Education and Stool-Based Testing OutreachNot yet recruitingNCT07781774Not applicable1 country
- Cemiplimab With Fianlimab for Resectable Non-Metastatic Colon CancerNot yet recruitingNCT07224022Phase 2
- A Multilevel Approach to Connecting Underrepresented Populations to Clinical TrialsRecruitingNCT056554941 country
- Anti-Mesothelin TNaive/SCM hYP218 (TNhYP218) CAR T Cells in Participants With Mesothelin-Expressing Solid Tumors Including MesotheliomaRecruitingNCT06885697Phase 11 country
- A Study to Learn About the Study Medicine Called PF-08032562 in People With Advanced or Metastatic Solid TumorsRecruitingNCT07318805Phase 13 countries
- A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)RecruitingNCT06997497Phase 329 countries
- Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous PolypsRecruitingNCT05080673Not applicable2 countries
- Distance-Based Exercise to Preserve Function and Prevent DisabilityRecruitingNCT07059884Not applicable1 country
- Colon Adjuvant Chemotherapy Based on Evaluation of Residual DiseaseRecruitingNCT05174169Phase 2/33 countries
- Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment DelaysRecruitingNCT07283939Not applicable3 countries
- Regorafenib in Combination With Multimodal Metronomic Chemotherapy for Chemo-resistant Metastatic Colorectal CancersRecruitingNCT06425133Phase 21 country
- Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 PatientsRecruitingNCT03190941Phase 1/21 country
- This is a Phase 1/1b Study to Evaluate the Safety and Preliminary Antitumor Activity of LTZ-232 in Participants With Advanced/Metastatic Colorectal Cancer and Other Solid TumorsRecruitingNCT07878988Phase 11 country
- Family Communications After Genetic TestingRecruitingNCT07143487Not applicable2 countries
- Artificial Intelligence to Implement Cost-saving Strategies for Colonoscopy Screening Based on in Vivo Prediction of Polyp HistologyRecruitingNCT06041945Not applicable1 country
- Mainstreaming Genetics: Evaluation of a Digital Application to Scale and Spread Oncologist-initiated Genetic TestingRecruitingNCT07387263Not applicable1 country
- A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal CancerRecruitingNCT07284849Phase 322 countries
- Personalized Ultrafractionated Stereotactic Adaptive Radiotherapy Combined With Penpulimab and Fruquintinib for Advanced Colorectal CancerNot yet recruitingNCT07904130Phase 2
- A Phase 1 Study of DEM301 in Participants With Metastatic Colorectal CancerRecruitingNCT07805369Phase 11 country
- Study of Varsetatug Masetecan in Combination With Anti-Cancer Therapies in Colorectal CancerNot yet recruitingNCT07900165Phase 1/2
- T1 Colorectal Cancer After Local Excision: Decision Between Surgery and Active Surveillance (T1LDA Trial)Not yet recruitingNCT07900620Not applicable1 country
- Avera Cancer Sequencing and Analytics Protocol (ASAP)RecruitingNCT051420331 country
- A Study to Learn About the Study Medicine Called PF-08165784 in People With PIK3CA-Mutated Advanced or Metastatic Solid TumorsNot yet recruitingNCT07897721Phase 1
- Toripalimab Plus Cetuximab and Irinotecan for Second-Line Right-Sided RAS/BRAF Wild-Type Advanced Colon Cancer Phase II StudyRecruitingNCT07896681Phase 21 country
- Neoadjuvant Pembrolizumab and Porustobart in Resectable pMMR/MSS Colon CancerRecruitingNCT07808151Phase 26 countries
- A Study to Learn About Study Medicine ALTA3263 in Adults With Advanced Solid Tumors With KRAS MutationsRecruitingNCT06835569Phase 11 country
- Biopsy-Resection Agreement of Peritoneal Histopathological Growth Patterns in Colorectal Peritoneal Metastases: A Prospective Observational Pilot StudyRecruitingNCT074740251 country
- A Study of SHY-ONC6, a Novel Proteasome Inhibitor, in Adults With Advanced or Metastatic Solid TumorsRecruitingNCT07705334Phase 11 country
- Optimised Post-discharge Care in Older Patients After Surgery for Colon Cancer (ERAS 3.0)RecruitingNCT06802991Not applicable1 country
- Phase 1/2 Study of BHB810 in Advanced Gastric and GEJ AdenocarcinomaRecruitingNCT07529808Phase 1/21 country
- T Cell Receptor T Cells for Advanced KRAS G12V-mutant Non-small Cell Lung Cancer, Pancreas Cancer, Colon CancerRecruitingNCT06043713Phase 11 country
- Neoadjuvant Botensilimab and Balstilimab for the Treatment of Advanced Resectable Colorectal Cancer NEST3RecruitingNCT07595874Phase 21 country
- Perioperative Biomarkers in Colorectal and Gastric Cancer SurgeryRecruitingNCT07881133Not applicable1 country
- Simultaneous vs. Staged Resection of Colorectal Cancer With Synchronous Liver MetastasesRecruitingNCT06200831Not applicable1 country
- Chemotherapy Combined With or Without Short-Course Radiotherapy Versus Chemotherapy Alone as Neoadjuvant Therapy for High-Risk Locally Advanced Colon Cancer With pMMR/MSSNot yet recruitingNCT07877597Phase 31 country
- Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid TumorsRecruitingNCT06239194Phase 1/21 country
- A Phase 1 Dose Escalation and Dose Expansion Trial of KST-6051 in Participants With Advanced Solid Tumors With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) MutationRecruitingNCT07458347Phase 11 country
- Mesogastrium Metastasis in Colon CancerRecruitingNCT049802871 country
- Cancer Awareness Among Syrian MigrantsNot yet recruitingNCT07541105Not applicable
- NURSE-led Geriatric Assessment in Older Colorectal Cancer PatientsNot yet recruitingNCT07872787Not applicable1 country
- Collagenase Biobank StudyNot yet recruitingNCT072112301 country
- A Study of Imaging, Blood, and Tissue Samples to Guide Treatment of Colon Cancer and Related Liver TumorsRecruitingNCT034328061 country
- Delayed Systemic Therapy Following Destructive Local Treatment of Pulmonary Oligometastases After No Evidence of Disease (NED) in Colorectal Cancer.RecruitingNCT06778382Phase 21 country
- Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal CancerRecruitingNCT07222800Phase 317 countries
- Oncology, Undernutrition and Sensoriality: Links, Mechanisms and Levers for ActionRecruitingNCT066002951 country
- ctDNA and TEP Levels in Colon CancerNot yet recruitingNCT07701408Not applicable1 country