Urinary Bladder Neoplasms clinical trials
The registry lists 1,798 studies for Urinary Bladder Neoplasms across more than 10 countries. 445 are recruiting or about to start. 1,196 of them are mainly about Urinary Bladder Neoplasms (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its narrower condition Non-Muscle Invasive Bladder Neoplasms too: 1,944 studies, 517 open.
ClinicalTrials.gov finds 2,162 studies for Urinary Bladder Neoplasms. How that becomes 1,795 here
This page counts the studies the registry files under Urinary Bladder Neoplasms, and those it files under no condition that list Urinary Bladder Neoplasmsthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 2,162Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −139Filed under a narrower condition, counted on its own pageNon-Muscle Invasive Bladder Neoplasms 138
- −52List Urinary Bladder Neoplasms as a condition, but the registry did not file them under itMost often written as “Gall Bladder Cancer” (26), “Muscle Invasive Bladder Cancer” (4), and “Biliary Cancer (Cholangiocarcinoma, Gall Bladder Cancer)” (3). The registry filed them under other conditions only, most often Gallbladder Neoplasms (30) and Cholangiocarcinoma (15).
- −236Match it another way48 name it in the title, 8 in a keyword, and 180 by a synonym or other text the search reads.
- 1,735Counted here and found by its search5 of them list Urinary Bladder Neoplasms in their own words; the registry filed them under no condition.
- +60
Counted here, but its search does not find them
- Trastuzumab Rezetecan and Adebrelimab as Neoadjuvant Therapy for HER2-Positive Muscle-Invasive Bladder CancerNCT07624201
- Open-Label, Randomised, Multi-Drug, Biomarker-Directed, Phase 1b Study in Pts w/ Muscle Invasive Bladder CancerNCT02546661
- A Study of Atezolizumab Versus Placebo as Adjuvant Therapy in Participants With High-risk Muscle-invasive Bladder Cancer (MIBC) Who Are ctDNA Positive Following CystectomyNCT04660344
- Pembrolizumab (MK3475), Gemcitabine, and Concurrent Hypofractionated Radiation Therapy for Muscle-Invasive Urothelial Cancer of the BladderNCT02621151
- Evaluation of the Role of Early Second Look TURBT in Management of High Risk Non Muscle Invasive Bladder CancerNCT07642102
- Multiparametric MRI for Bladder Cancer: Validation of VI-RADS for the Detection of Muscle Invasive Bladder CancerNCT07578233
- Trimodality Bladder PreservationNCT07402317
- BCG for Therapeutic Use Phase I Clinical TrialNCT06100653
- Avelumab as Neoadjuvant Therapy in Subjects With Urothelial Muscle Invasive Bladder Cancers (AURA Trial)NCT03674424
- Durvalumab Plus Tremelimumab With Concurrent Radiotherapy for Localized Muscle Invasive Bladder Cancer Treated With a Selective Bladder Preservation ApproachNCT03702179
- Study of Tislelizumab in Participants With Locally Advanced or Metastatic Urothelial Bladder CancerNCT04004221
- PRS-343 in Combination With Atezolizumab in HER2-Positive Solid TumorsNCT03650348
- PRS-343 in HER2-Positive Solid TumorsNCT03330561
- HIPEC After Radical Cystectomy for High Risk Bladder CancerNCT03514888
- Paclitaxel and Radiation Therapy With or Without Trastuzumab in Treating Patients Who Have Undergone Surgery for Bladder CancerNCT00238420
- Intravenous Lidocaine for Cystectomy ProceduresNCT02924480
- Testing the Utilization of a Mobile Health App for Patients Undergoing Cystectomy Surgery for Bladder CancerNCT03862105
- Mechanism of Action Trial of ColoAd1NCT02053220
- Adjuvant Post-radical Cystectomy Treatment for Bladder CancerNCT01734798
- Observational Study of Subjects Having Routine Recurrence Screening for Bladder CancerNCT00903240
- 1,795The count on this page
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Status
Who runs them
National Cancer Institute (NCI) (67) · Memorial Sloan Kettering Cancer Center (47) · M.D. Anderson Cancer Center (32) · Mansoura University (27) · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University (21) · Assiut University (20) · AstraZeneca (19) · Merck Sharp & Dohme LLC (17)
What is being tested here
Drugs under test in Urinary Bladder Neoplasms studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Gemcitabine | 12 | 13 | 100 |
| Pembrolizumab | 10 | 7 | 35 |
| Enfortumab vedotin | 10 | 5 | 19 |
| Cisplatin | 5 | 11 | 66 |
| Mitomycin | 5 | 8 | 26 |
| Docetaxel | 5 | 0 | 20 |
| Disitamab vedotin | 5 | 2 | 7 |
| Durvalumab | 4 | 3 | 19 |
| Nivolumab | 3 | 4 | 25 |
| BCG Vaccine | 3 | 8 | 19 |
Drug classes tested here Immune checkpoint inhibitors 35 open · Antibody-drug conjugates (ADCs) 23 open · Antimetabolites 15 open · Tyrosine kinase inhibitors (TKIs) 6 open · Antimitotic agents 6 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Nov 2026A Study of Adjuvant Cretostimogene Grenadenorepvec for Treatment of Intermediate Risk NMIBC Following TURBT · Phase 3 · CG Oncology, Inc.
- Dec 2026A Study of TAR-200 in Combination With Cetrelimab Versus Concurrent Chemoradiotherapy in Participants With Muscle-invasive Bladder Cancer (MIBC) of the Bladder · Phase 3 · Janssen Research & Development, LLC
- Jan 2027Outcomes of High-risk Non-muscle Invasive Bladder Cancer Treated With Blue Light Resection · Phase 3 · Johns Hopkins University
- Jan 2027Disitamab Vedotin With Pembrolizumab vs Chemotherapy in Previously Untreated Urothelial Cancer Expressing HER2 · Phase 3 · Seagen, a wholly owned subsidiary of Pfizer
- Jan 2027Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Chemoradiotherapy (CRT) Versus CRT Alone in Muscle-invasive Bladder Cancer (MIBC) (MK-3475-992/KEYNOTE-992) · Phase 3 · Merck Sharp & Dohme LLC
- Apr 2027A Clinical Trail to Determine the Safety and Efficacy of the Combination of Tislelizumab With Cisplatin and Gemcitabine, With or Without Trilaciclib for Patients With Untreated Unresectable and Metastatic Urothelial Carcinoma. · Phase 3 · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
- Jun 2027Chemoradiotherapy With or Without Atezolizumab in Treating Patients With Localized Muscle Invasive Bladder Cancer · Phase 3 · National Cancer Institute (NCI)
- Aug 2027Sequential Chemotherapy Followed by Ultrahypofractionated Radiotherapy for Muscle-Invasive Bladder Cancer · Phase 3 · Assiut University
- Nov 2026Mannitol Versus Nitroglycerin for Kidney Injury Prevention in Robotic-assisted Radical Prostatectomy or Cystectomy · Nazmy Edward Seif
- Nov 2026Safety and Preliminary Anti-Tumor Activity of TYRA-300 in Advanced Urothelial Carcinoma and Other Solid Tumors With FGFR3 Gene Alterations · Tyra Biosciences, Inc
Who these studies take
Of the 336 Urinary Bladder Neoplasms studies recruiting now, 256 (76%) set no upper age limit and 22 (7%) stop at 75 or younger. 22 (7%) take children under 18. 3 (1%) are for women only and 7 (2%) for men only; 21 (6%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 20 (6%) | 20 (6%) |
| 18 | 304 (90%) | 306 (91%) |
| 30 | 315 (94%) | 318 (95%) |
| 40 | 320 (95%) | 323 (96%) |
| 50 | 324 (96%) | 328 (98%) |
| 65 | 329 (98%) | 333 (99%) |
| 75 | 327 (97%) | 330 (98%) |
| 85 | 290 (86%) | 293 (87%) |
Across all 1,798 studies, recruiting or not: 6% stop at 75 or younger and 1% at 65; 7% take children; 1% are for women only and 3% for men only; 6% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Urinary Bladder Neoplasms studies take
Of 194 phase 2 interventional studies under Urinary Bladder Neoplasms, half reached primary completion within 52 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 43 mo29–66 · 145 studies | 43 mo30–66 · 80 studies | 47 mo26–65 · 65 studies |
| Phase 1/2 | 52 mo35–78 · 67 studies | 45 mo32–74 · 39 studies | — |
| Phase 2 | 52 mo36–91 · 194 studies | 36 mo25–52 · 39 studies | 58 mo39–103 · 155 studies |
| Phase 3 | 65 mo40–87 · 73 studies | 54 mo24–74 · 39 studies | — |
| Interventional, no phase | 39 mo20–69 · 244 studies | — | 40 mo21–70 · 235 studies |
| Observational | 60 mo32–… · 202 studies | — | 60 mo30–… · 167 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 11, 2026.
Started recruiting5
- Evaluation of the Clinical Utility of Online Adaptive Radiotherapy in Bladder Cancer (BLADAPT-GETUG V11)Nov 9, 2026NCT07043543
- A Real-world Study in Participants With High-risk Non-Muscle-Invasive Bladder Cancer After Bacillus Calmette-Guérin Therapy in KoreaNov 9, 2026NCT07735793
- A Clinical Trial of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) and Pembrolizumab (MK-3475A) in Participants With Bladder Cancer (MK-2870-055)Nov 6, 2026NCT07829783
- Calcium Electroporation for Urinary Bladder Tumors: A First-in-Human Feasibility, Safety, and Early Response TrialOct 27, 2026NCT07555769
- Role of ERBT Plus Intravesical BCG in Intermediate-Risk or High-Risk NMBCOct 27, 2026NCT07724886
Results posted2
Stopped2
- Gemcitabine/Cisplatin Plus Cemiplimab With or Without Fianlimab in Localized Muscle-invasive Bladder Cancer (NeoSTOP-IT)TerminatedNov 3, 2026NCT06571708
- Evaluation of Naloxegol in the Prevention of POI After CystectomyWithdrawnOct 14, 2026NCT04219046
Newly registered13
- MyPatientPal+: A Smartphone App and a Provider Dashboard to Manage Patient Care While on TreatmentNov 10, 2026NCT07928154
- Diagnostic Performance of Multiparametric Magnetic Resonance Imaging After Transurethral Resection of Bladder Tumour for Prediction of Muscle Invasion and Detection of Residual Tumour in Non-muscle-invasive Bladder Cancer PatientsNov 9, 2026NCT07924046
- EHR Integrated Remote Patient Monitoring to Reduce Readmission for Patients With Bladder Cancer Undergoing CystectomyNov 3, 2026NCT07912034
- Sequential Chemotherapy Followed by Ultrahypofractionated Radiotherapy for Muscle-Invasive Bladder CancerNov 3, 2026NCT07914101
- Remote Screening and Navigation to Increase Trial Enrollment, INVITE TrialNov 2, 2026NCT07908407
Show 8 moreShow fewer
- Risk-Enabled Therapy After Initiating EV/Pembro for Bladder CancerNov 2, 2026NCT07908979
- The Role of ERBT Plus Adjuvant Intravesical Induction and Maintenance Chemotherapy for Intermediate-Risk NMIBCOct 30, 2026NCT07907575
- A Real-world Study to Learn About of the Characteristics and Outcomes of Advanced or Metastatic Bladder Cancer Patients With Different HistologiesOct 27, 2026NCT07897669
- Outcomes for IR and High Risk (HR) Non-muscle Invasive Bladder Cancer (NMIBC) and ctDNA-based Biomarkers for Response and Recurrence in Muscle Invasive Bladder Cancer (MIBC)Oct 26, 2026NCT07893509
- Urinary Cell-Free DNA Liquid Biopsy for Urothelial Cancer Diagnosis and Origin IdentificationOct 22, 2026NCT07888374
- Inactivated UPEC-FimON for Non Muscle Invasive Bladder Cancer After BCG or Intravesical Chemotherapy FailureOct 19, 2026NCT07881666
- The Role of Definitive Radiotherapy in Non Muscle Invasive Bladder CancerOct 14, 2026NCT07873333
- BL-M07D1 (Trastuzumab Brengitecan T-bren) vs Standard of Care Platinum-based Chemotherapy (PBC) for HER2-expressing Metastatic Urothelial Cancer After Progression on Anti-PD-(L)1-based TherapyOct 13, 2026NCT07869836
Studies
Recruiting first, then most recently updated. Showing 50 of 1,798. Browse all 1,798 → or search them.
- An Exploratory Study of the Efficacy and Safety of SBRT Following Induction Therapy With Neoadjuvant Immunotherapy Combined With Chemotherapy in Muscle-Invasive Bladder CancerNot yet recruitingNCT07927400Not applicable
- A Clinical Study of MK-3120 in People With Bladder Cancer (MK-3120-003)RecruitingNCT07222488Phase 1/212 countries
- A Clinical Trial of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) to Treat Urothelial Cancer (MK-2870-031)RecruitingNCT07419295Phase 317 countries
- MyPatientPal+: A Smartphone App and a Provider Dashboard to Manage Patient Care While on TreatmentNot yet recruitingNCT07928154Not applicable1 country
- BL-M07D1 (Trastuzumab Brengitecan T-bren) vs Standard of Care Platinum-based Chemotherapy (PBC) for HER2-expressing Metastatic Urothelial Cancer After Progression on Anti-PD-(L)1-based TherapyRecruitingNCT07869836Phase 31 country
- A Real-world Study in Participants With High-risk Non-Muscle-Invasive Bladder Cancer After Bacillus Calmette-Guérin Therapy in KoreaRecruitingNCT077357931 country
- Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to Radiation Therapy Compared to the Usual Chemotherapy Treatment During Radiation Therapy for Bladder Cancer, PARRC TrialRecruitingNCT06770582Phase 22 countries
- Evaluation for NCI Surgery Branch Clinical Research ProtocolsRecruitingNCT000018231 country
- Collection of Serum and Tissue Samples From Patients With Biopsy-Proved or Suspected Malignant DiseaseRecruitingNCT000268841 country
- Whole-slide Image and CT Radiomics Based Deep Learning System for Prognostication Prediction in Bladder CancerRecruitingNCT063890191 country
- Evaluation of the Clinical Utility of Online Adaptive Radiotherapy in Bladder Cancer (BLADAPT-GETUG V11)RecruitingNCT07043543Not applicable1 country
- Diagnostic Performance of Multiparametric Magnetic Resonance Imaging After Transurethral Resection of Bladder Tumour for Prediction of Muscle Invasion and Detection of Residual Tumour in Non-muscle-invasive Bladder Cancer PatientsNot yet recruitingNCT07924046Not applicable
- Remote Screening and Navigation to Increase Trial Enrollment, INVITE TrialNot yet recruitingNCT07908407Not applicable1 country
- The Vanguard Study: Testing a New Way to Screen for CancerRecruitingNCT06995898Not applicable1 country
- A Clinical Trial of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) and Pembrolizumab (MK-3475A) in Participants With Bladder Cancer (MK-2870-055)RecruitingNCT07829783Phase 32 countries
- A Study to Learn About the Study Medicine PF-08052667 in People With Bladder CancerRecruitingNCT07206225Phase 16 countries
- DV Plus Toripalimab With Cetirizine and Mecobalamin Pretreatment in Patients With Locally Advanced Unresectable or Metastatic Bladder CancerNot yet recruitingNCT07853053Phase 11 country
- A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid TumorsRecruitingNCT07090499Phase 16 countries
- Evaluating Safety and Efficacy of Prostate-sparing Radical CystectomyRecruitingNCT05792722Not applicable1 country
- cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual DiseaseRecruitingNCT053668811 country
- A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)RecruitingNCT06760819Phase 211 countries
- A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid TumorsRecruitingNCT06465069Phase 18 countries
- FORAGER-1: A Study of Vepugratinib (LY3866288; LOXO-435) in Participants With Cancer With a Change in a Gene Called FGFR3RecruitingNCT05614739Phase 114 countries
- Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer DetectionRecruitingNCT053340691 country
- Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary TumorsRecruitingNCT03866382Phase 22 countries
- EHR Integrated Remote Patient Monitoring to Reduce Readmission for Patients With Bladder Cancer Undergoing CystectomyNot yet recruitingNCT07912034Not applicable1 country
- Sequential Chemotherapy Followed by Ultrahypofractionated Radiotherapy for Muscle-Invasive Bladder CancerNot yet recruitingNCT07914101Phase 3
- Outcomes of High-risk Non-muscle Invasive Bladder Cancer Treated With Blue Light ResectionRecruitingNCT06525571Phase 31 country
- Study of [177Lu]Lu-DWJ155 and [68Ga]Ga-DWJ155 in Patients With Solid TumorsRecruitingNCT07660055Phase 14 countries
- Guiding Value of Urinary Tumor DNA Testing in Repeat Transurethral Resection of Non-Muscle-Invasive Bladder CancerRecruitingNCT07187635Not applicable1 country
- Performance, Feasibility, and Safety Study for a Novel Endoluminal Robotic System for En-Bloc Resection of Bladder Tumours: First-In-Human TrialRecruitingNCT06281080Not applicable1 country
- Combining Immunotherapy and Radiation Therapy to Help Patients Avoid Bladder Removal After Treatment Shrinks Muscle Invasive Bladder Cancer, BRIGHT TrialRecruitingNCT07061964Phase 21 country
- A Study to Find Out if Enfortumab Vedotin Given With Pembrolizumab Helps People With Muscle-invasive Bladder Cancer Keep Their BladderRecruitingNCT07475806Phase 212 countries
- Risk-Enabled Therapy After Initiating EV/Pembro for Bladder CancerRecruitingNCT07908979Phase 21 country
- The Role of ERBT Plus Adjuvant Intravesical Induction and Maintenance Chemotherapy for Intermediate-Risk NMIBCNot yet recruitingNCT07907575Not applicable1 country
- Study Investigating Intravesical HDAC Inhibition to Improve Response to Immuno-Oncology AgentsRecruitingNCT06963346Phase 11 country
- Inactivated UPEC-FimON for Non Muscle Invasive Bladder Cancer After BCG or Intravesical Chemotherapy FailureRecruitingNCT07881666Phase 11 country
- Gender Related Coping and Survivorship for Genitourinary CancersRecruitingNCT056493061 country
- Exploration of Novel AI-enabled Blue Light Enhanced CystoscopyRecruitingNCT071443195 countries
- En-bloc Transurethral Resection of Bladder Tumor (En-bloc TURBT) Specimens Using a Redesigned Surgical Resectoscope DeviceRecruitingNCT042357641 country
- Tetra-modality Bladder Preservation Strategies in Muscle-invasive Bladder Cancer: TURBT+ Chemo/Immunotherapy+ Radiation Therapy+ Maintenance Immunotherapy vs. W&WRecruitingNCT06686381Phase 21 country
- 18F-Fibroblast Activation Protein Inhibitor ([18F]FAPI-74) PET Imaging for Cancer DetectionRecruitingNCT06503146Phase 21 country
- Radical CystEctomy or RaDio-chEMotherapy as Preferred Treatment for invasivE blaDder CancerNot yet recruitingNCT07008833Not applicable1 country
- Cancer Experience Registry (CER) for Cancer Patients and CaregiversRecruitingNCT023336041 country
- A Study of a Side Effects and Resource Navigation Program for People With CancerRecruitingNCT07646847Not applicable1 country
- A Study of MGC026 in Participants With Advanced Solid TumorsRecruitingNCT06242470Phase 13 countries
- Enfortumab Vedotin in Combination With Pembrolizumab vs. Concurrent Chemoradiotherapy (cCRT) in People With Muscle Invasive Bladder Cancer (EV-309)RecruitingNCT07566156Phase 34 countries
- Artificial Intelligence-assisted Uro-Cam Catheter Assessment System for Diagnosing Bladder CancerNot yet recruitingNCT07095751Not applicable1 country
- Role of ERBT Plus Intravesical BCG in Intermediate-Risk or High-Risk NMBCRecruitingNCT07724886Not applicable1 country
- Calcium Electroporation for Urinary Bladder Tumors: A First-in-Human Feasibility, Safety, and Early Response TrialRecruitingNCT07555769Phase 11 country