Drug
Topotecan clinical trials
Also written Hycamtin, Hycamptamine, Evotopin and SKF-104864.
- studies test it
- 270
- open now
- 17
- in phase 3
- 27
- first study started
- 1993
Keep track of what changes. Save the Topotecan studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Studies by the year they started
265 studies that test it; most in 2004 (23)
| Year | Studies |
|---|---|
| 1993 | 2 |
| 1994 | 2 |
| 1995 | 3 |
| 1996 | 7 |
| 1997 | 9 |
| 1998 | 14 |
| 1999 | 17 |
| 2000 | 11 |
| 2001 | 15 |
| 2002 | 14 |
| 2003 | 7 |
| 2004 | 23 |
| 2005 | 15 |
| 2006 | 14 |
| 2007 | 18 |
| 2008 | 14 |
| 2009 | 10 |
| 2010 | 2 |
| 2011 | 4 |
| 2012 | 4 |
| 2013 | 5 |
| 2014 | 4 |
| 2015 | 8 |
| 2016 | 7 |
| 2017 | 1 |
| 2018 | 5 |
| 2019 | 2 |
| 2020 | 3 |
| 2021 | 4 |
| 2022 | 4 |
| 2023 | 5 |
| 2024 | 4 |
| 2025 | 5 |
| 2026 | 3 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 6
- Phase 1
- 124
- Phase 2
- 135
- Phase 3
- 27
- Phase 4
- 1
- No phase
- 6
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 39 · Other 231
National Cancer Institute (NCI) (25) · GlaxoSmithKline (16) · H. Lee Moffitt Cancer Center and Research Institute (11) · Gynecologic Oncology Group (11) · SCRI Development Innovations, LLC (11) · Children's Oncology Group (10) · Alliance for Clinical Trials in Oncology (9) · St. Jude Children's Research Hospital (7)
Often tested with
Tested in the same studies.
Carboplatin (40) · Paclitaxel (35) · Cyclophosphamide (31) · Etoposide (29) · Cisplatin (23) · Doxorubicin (20) · Temozolomide (15) · Vincristine (14)
Studies
Open first, then newest update. How each study uses Topotecan is read from its arms, and is right about nine times in ten.
Testing it · 270
- Study of Sacituzumab Govitecan Versus Standard of Care in Participants With Previously Treated Extensive Stage Small Cell Lung CancerRecruitingPhase 3Gilead SciencesNCT06801834Written as Topotecan
- The Safety and Efficacy of Intravitreal Topotecan for the Treatment of Proliferative VitreoretinopathyNot yet recruitingPhase 1Massachusetts Eye and Ear InfirmaryNCT06425419Written as Topotecan
- Metastatic Ewing's Trial Testing Schedule Enhancement to Improve OutcomesRecruitingPhase 1H. Lee Moffitt Cancer Center and Research InstituteNCT07194044Written as Topotecan
- Molecular and Clinical Risk-Directed Therapy for Infants and Young Children With Newly Diagnosed MedulloblastomaRecruitingPhase 2St. Jude Children's Research HospitalNCT05535166Written as Topotecan
- N10: A Study of Reduced Chemotherapy and Monoclonal Antibody (mAb)-Based Therapy in Children With NeuroblastomaRecruitingPhase 2Memorial Sloan Kettering Cancer CenterNCT06528496Written as Topotecan
- A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWTRecruitingPhase 2Children's Oncology GroupNCT04322318Written as Topotecan
- Testing a Standardized Approach to Surgery and Chemotherapy for Type I Pleuropulmonary Blastoma or the Addition of an Anti-cancer Drug, Topotecan, to the Usual Treatment for Types II and III Pleuropulmonary BlastomaRecruitingPhase 3Children's Oncology GroupNCT06647953Written as Topotecan
- European Proof-of-Concept Therapeutic Stratification Trial of Molecular Anomalies in Relapsed or Refractory TumorsRecruitingPhase 1/2Gustave Roussy, Cancer Campus, Grand ParisNCT02813135Written as Topotecan
- Chronic CED of TPT for Recurrent Malignant GliomaRecruitingPhase 1Jeffrey N. BruceNCT06666712Written as Topotecan
- Targeting Pediatric Brain Tumors and Relapsed/Refractory Solid Tumors With Sodium Glucose Cotransporter 2 Inhibitors (SGLT2i)RecruitingPhase 1Washington University School of MedicineNCT05521984Written as Topotecan
- Dose Attenuated Chemotherapy in Compromised Patients With Lung CancerRecruitingPhase 2Fox Chase Cancer CenterNCT05800587Written as Topotecan
- An Umbrella Study of Recurrent, Extensive Stage Small Cell Lung Cancer Based on Molecular TypingNot yet recruitingPhase 1/2Cancer Institute and Hospital, Chinese Academy of Medical SciencesNCT07141771Written as Topotecan/Irinotecan/Paclitaxel/Temozolomide
- High-dose Topotecan for Retinoblastoma With Recurrent or Refractory Vitreous SeedRecruitingEarly Phase 1Eye & ENT Hospital of Fudan UniversityNCT06972602Written as Topotecan
- Intravitreal Topotecan for Prevention or Treatment of Proliferative Vitreoretinopathy in Retinal DetachmentNot yet recruitingPhase 2Unity Health TorontoNCT06818721Written as Intravitreal topotecan
- Intravitreal Topotecan in the Repair of Rhegmatogenous Retinal Detachment with Proliferative VitreoretinopathyRecruitingPhase 2Unity Health TorontoNCT05523869Written as Intravitreal topotecan
- Oral Topotecan With Toripalimab for Patients With Endometrial CancerNot yet recruitingPhase 2Fudan UniversityNCT06548763Written as Topotecan
- Allogeneic Hematopoietic Stem Cell Transplantation for 4/M NeuroblastomaNot yet recruitingPhase 2Sun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityNCT05303727Written as Topotecan
- Bortezomib and Topotecan Hydrochloride in Treating Patients With Advanced Solid TumorsCompletedPhase 1City of Hope Medical CenterNCT00541359Written as topotecan hydrochloride
- Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid TumorsCompletedPhase 2PfizerNCT03709680Written as Topotecan
- Therapy for Children With Advanced Stage NeuroblastomaCompletedPhase 2St. Jude Children's Research HospitalNCT01857934Written as topotecan
See all 270 studies that test Topotecan →
Given in every arm · 47 — Topotecan is usual care beside what is tested
- Testing the Addition of Iberdomide to Therapy in People With Neuroblastoma That Has Come Back, Not Responded to Treatment, or Gotten WorseRecruitingPhase 1/2National Cancer Institute (NCI)NCT07437963Written as Topotecan
- Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk NeuroblastomaRecruitingPhase 3National Cancer Institute (NCI)NCT06172296Written as Topotecan
- Eflornithine (DFMO) for Ewing Sarcoma and OsteosarcomaRecruitingPhase 2Milton S. Hershey Medical CenterNCT07321912Written as Topotecan
- A Study of PHST001 in Advanced Solid TumorsRecruitingPhase 1Pheast TherapeuticsNCT06840886Written as Topotecan
- Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)RecruitingPhase 3Children's Oncology GroupNCT03126916Written as Topotecan Hydrochloride
- A Study of Peluntamig (PT217) in Patients With Neuroendocrine Carcinomas Expressing DLL3 (the SKYBRIDGE Study)RecruitingPhase 1/2Phanes TherapeuticsNCT05652686Written as Topotecan
- Study of NMS-03305293 in Adult Patients With Relapsed Ovarian CancerRecruitingPhase 1Nerviano Medical SciencesNCT06930755Written as Topotecan
- Study of Talazoparib in Combination With Chemotherapy in Relapsed Pediatric AML to Determine Safety and EfficacyRecruitingPhase 1Norman J. LacayoNCT05101551Written as Topotecan
- A Multi-Arm, Platform Trial For Relapsed NeuroblastomaRecruitingPhase 1/2University of BirminghamNCT07334301Written as Topotecan
- A Phase II/III Study of IBB0979 in Combination With Topotecan Versus Topotecan in Relapsed Small Cell Lung CancerNot yet recruitingPhase 2SUNHO（China）BioPharmaceutical CO., Ltd.NCT07076095Written as topotecan hydrochloride for injection
- Trilaciclib vs Placebo in Patients With Extensive Stage Small Cell Lung Cancer (ES-SCLC) Receiving TopotecanActive, not recruitingPhase 4Pharmacosmos A/SNCT05874401Written as Topotecan
- DAREON™-9: A Study to Test How Well Different Doses of BI 764532 Are Tolerated by People With Small Cell Lung Cancer When Taken Together With a Single Agent ChemotherapyActive, not recruitingPhase 1Boehringer IngelheimNCT05990738Written as Topotecan
- Testing the Addition of an Anti-cancer Drug, BAY 1895344, to Usual Chemotherapy for Advanced Stage Solid Tumors, With a Specific Focus on Patients With Small Cell Lung Cancer, Poorly Differentiated Neuroendocrine Cancer, and Pancreatic CancerActive, not recruitingPhase 1National Cancer Institute (NCI)NCT04514497Written as Topotecan Hydrochloride
- Phase 2 Study of Alisertib Therapy for Rhabdoid TumorsActive, not recruitingPhase 2St. Jude Children's Research HospitalNCT02114229Written as topotecan
- A Study of LY3295668 Erbumine in Participants With Relapsed/Refractory NeuroblastomaActive, not recruitingPhase 1Eli Lilly and CompanyNCT04106219Written as Topotecan
- Randomized Trial of Topotecan With M6620, an ATR Kinase Inhibitor, in Small Cell Lung Cancers and Small Cell Cancers Outside of the LungsActive, not recruitingPhase 2National Cancer Institute (NCI)NCT03896503Written as Topotecan Hydrochloride
- Topotecan Hydrochloride and Carboplatin With or Without Veliparib in Treating Advanced Myeloproliferative Disorders and Acute Myeloid Leukemia or Chronic Myelomonocytic LeukemiaActive, not recruitingPhase 2National Cancer Institute (NCI)NCT03289910Written as Topotecan
- Dinutuximab, Sargramostim, and Combination Chemotherapy in Treating Patients With Newly Diagnosed High-Risk NeuroblastomaCompletedPhase 2National Cancer Institute (NCI)NCT03786783Written as Topotecan
- Induction Therapy Including 131 I-MIBG and Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma Undergoing Stem Cell Transplant, Radiation Therapy, and Maintenance Therapy With IsotretinoinCompletedPhase 1Children's Oncology GroupNCT01175356Written as Topotecan Hydrochloride
- Trilaciclib (G1T28) in Patients With Previously Treated Extensive Stage SCLC Receiving Topotecan ChemotherapyCompletedPhase 1/2G1 Therapeutics, Inc.NCT02514447Written as Topotecan
Showing 20 of 47.
As the comparator · 64 — what is tested is compared with Topotecan
- A Study of GSK5764227 in Participants With Relapsed Small Cell Lung Cancer (SCLC) [EMBOLD SCLC-301]RecruitingPhase 3GlaxoSmithKlineNCT07099898Written as Topotecan
- A Study to Investigate Mocertatug Rezetecan Compared With Standard of Care in Participants With Platinum-resistant Ovarian Cancer (BEHOLD-Ovarian01)RecruitingPhase 3GlaxoSmithKlineNCT07286266Written as Topotecan
- A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian CancerRecruitingPhase 3Eli Lilly and CompanyNCT07213804Written as Topotecan
- An Extension Study to Assess the Efficacy of Rina-S Compared to Treatment of Investigator's Choice in Participants With Platinum Resistant Ovarian Cancer in ChinaRecruitingPhase 3GenmabNCT07604766Written as Topotecan
- A Study to Evaluate Adverse Events and Change in Disease Activity of Intravenous ABBV-706 Versus Standard of Care in Adult Participants With Relapsed/Refractory Small Cell Lung CancerRecruitingPhase 3AbbVieNCT07365241Written as Topotecan
- JSKN033 Versus Investigator's Choice of Chemotherapy in Recurrent or Metastatic Cervical CancerNot yet recruitingPhase 3Jiangsu Alphamab Biopharmaceuticals Co., LtdNCT07797153Written as Topotecan
- A Study of Ifinatamab Deruxtecan Versus Treatment of Physician's Choice in Subjects With Relapsed Small Cell Lung CancerRecruitingPhase 3Daiichi SankyoNCT06203210Written as Topotecan
- A Study of Raludotatug Deruxtecan (R-DXd) in Subjects With Platinum-resistant, High-grade Ovarian, Primary Peritoneal, or Fallopian Tube CancerRecruitingPhase 2/3Daiichi SankyoNCT06161025Written as Topotecan
- AZD5335 vs. Mirvetuximab Soravtansine in FRα-high and AZD5335 vs. Chemotherapy in FRα-low Platinum-resistant Ovarian CancerRecruitingPhase 3AstraZenecaNCT07218809Written as Topotecan
- A Study Comparing BL-M07D1 With Physician's Choice of Chemotherapy in Patients With HER2-Expressing Platinum-Resistant Recurrent Epithelial Ovarian Cancer, Fallopian Tube Cancer, and Primary Peritoneal CancerNot yet recruitingPhase 3Sichuan Baili Pharmaceutical Co., Ltd.NCT07545460Written as Topotecan
- A Study of SHR-A1811 in Subjects With Ovarian CancerRecruitingPhase 3Jiangsu HengRui Medicine Co., Ltd.NCT06828354Written as Topotecan Hydrochloride for Injection
- A Study of SHR-A2102 Versus Investigator's Choice of Chemotherapy in Patients With Platinum-based Chemotherapy and PD-(L)1 Inhibitor Treatment Failed Recurrent or Metastatic Cervical CancerRecruitingPhase 3Suzhou Suncadia Biopharmaceuticals Co., Ltd.NCT07418749Written as Topotecan Hydrochloride for Injection
- Study Comparing ZG006 With Investigator-Selected Chemotherapy in Participants With Relapsed Small Cell Lung CancerRecruitingPhase 3Suzhou Zelgen Biopharmaceuticals Co.,LtdNCT07189455Written as Topotecan
- HS-20089 for Injection in Patients With Platinum-Resistant Recurrent Epithelial Ovarian CancerRecruitingPhase 3Hansoh BioMedical R&D CompanyNCT06855069Written as Topotecan
- Organoid-guided vs Topotecan Therapy in Relapsed Extensive-Stage Small Cell Lung CancerNot yet recruitingPhase 2/3Peking Union Medical College HospitalNCT07106528Written as Topotecan
- A Study of MHB088C Injection Versus Treatment of Physician's Choice in Subjects With Relapsed Small Cell Lung CancerRecruitingPhase 3Qilu Pharmaceutical Co., Ltd.NCT06954246Written as Topotecan
- JSKN003 in Platinum-Resistant, Relapsed Epithelial Ovarian CancerNot yet recruitingPhase 3Jiangsu Alphamab Biopharmaceuticals Co., LtdNCT06751485Written as Topotecan
- Lurbinectedin or in Combination with Irinotecan Versus Topotecan in Patients with Relapsed SCLCRecruitingPhase 3Luye Pharma Group Ltd.NCT06496048Written as Topotecan
- JK-1201I Compared with Topotecan in Patients with Relapsed Extensive Stage Small Cell Lung CancerNot yet recruitingPhase 3JenKem Technology Co., Ltd.NCT06581380Written as Topotecan
- SHR-A1921 for Injection in Patients With Platinum-Resistant Recurrent Epithelial Ovarian CancerRecruitingPhase 3Suzhou Suncadia Biopharmaceuticals Co., Ltd.NCT06394492Written as Topotecan
Showing 20 of 64.
Codes
What other systems call Topotecan · ClinicalTrials.gg INT008712
- MeSH (NLM) D019772TopotecanConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 7M7YKX2N15TOPOTECANConfirmed FDA, NLM, Wikidata
- RxNorm 57308Confirmed FDA, Wikidata
- Wikidata Q419953topotecanConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C1413TopotecanOne source FDA
- DrugBank DB01030One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D019772 | Topotecan | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 7M7YKX2N15 | TOPOTECAN | Confirmed FDA, NLM, Wikidata |
| RxNorm | 57308 | — | Confirmed FDA, Wikidata |
| Wikidata | Q419953 | topotecan | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C1413 | Topotecan | One source FDA |
| DrugBank | DB01030 | — | One source Wikidata |
Also registered as topotecan hydrochloride (UNII 956S425ZCY · RxNorm 266573).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.