Retinoblastoma clinical trials
The registry lists 124 studies for Retinoblastoma across more than 10 countries. 23 are recruiting or about to start. 87 of them are mainly about Retinoblastoma (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-16.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
Memorial Sloan Kettering Cancer Center (10) · Children's Oncology Group (10) · St. Jude Children's Research Hospital (10) · Sun Yat-sen University (9) · National Cancer Institute (NCI) (5) · Amsterdam UMC, location VUmc (4) · Institut Curie (4) · Stanford University (3)
What is being tested here
Drugs under test in Retinoblastoma studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Melphalan | 3 | 1 | 13 |
| Carboplatin | 1 | 3 | 14 |
| Etoposide | 1 | 2 | 10 |
| Topotecan | 1 | 1 | 7 |
| Vincristine | 1 | 2 | 7 |
| Topotecan Sustained-Release Episcleral Plaque | 1 | 0 | 3 |
| Abemaciclib | 1 | 0 | 1 |
| Nitroglycerin | 1 | 0 | 1 |
| Thiotepa | 0 | 0 | 6 |
| Cyclophosphamide | 0 | 0 | 4 |
Drug classes tested here Alkylating agents 3 open · Antimitotic agents 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 5
- Nov 2026Early Check: Expanded Screening in Newborns · RTI International
- Mar 2027Retinoblastoma Survivor Study: Assessment of General Health and Quality of Life · Memorial Sloan Kettering Cancer Center
- May 2027Retinoblastoma Consolidation in Egyptians · Assiut University
- May 2027Determining Whether Multiple Anesthesia Exposures Affect Cognitive Function for Retinoblastoma Patients · Memorial Sloan Kettering Cancer Center
- Jun 2027Abemaciclib for Bone and Soft Tissue Sarcoma With Cyclin-Dependent Kinase (CDK) Pathway Alteration · Medical College of Wisconsin
Who these studies take
Of the 20 Retinoblastoma studies recruiting now, 11 (55%) set no upper age limit and 9 (45%) stop at 75 or younger. 19 (95%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 3 (15%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 16 (80%) | 16 (80%) |
| 18 | 15 (75%) | 15 (75%) |
| 30 | 11 (55%) | 11 (55%) |
| 40 | 11 (55%) | 11 (55%) |
| 50 | 11 (55%) | 11 (55%) |
| 65 | 11 (55%) | 11 (55%) |
| 75 | 11 (55%) | 11 (55%) |
| 85 | 11 (55%) | 11 (55%) |
Across all 124 studies, recruiting or not: 64% stop at 75 or younger and 62% at 65; 97% take children; 0% are for women only and 0% for men only; 8% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 50 of 124. Browse all 124 → or search them.
- Comprehensive Omics Analysis of Pediatric and Adult Solid Tumors and Establishment of a Repository for Related Biological StudiesRecruitingNCT011093941 country
- A Study to Give Treatment Inside the Eye to Treat RetinoblastomaRecruitingNCT05504291Phase 23 countries
- GPC2 CAR T Cells for Relapsed or Refractory Neuroblastoma and Metastatic RetinoblastomaEnrolling by invitationNCT05650749Phase 11 country
- Abemaciclib for Bone and Soft Tissue Sarcoma With Cyclin-Dependent Kinase (CDK) Pathway AlterationRecruitingNCT04040205Phase 21 country
- Familial Investigations of Childhood Cancer PredispositionRecruitingNCT030502681 country
- Determining Whether Multiple Anesthesia Exposures Affect Cognitive Function for Retinoblastoma PatientsRecruitingNCT035463871 country
- Retinoblastoma Phase II Expanded Access Clinical TrialRecruitingNCT06679634Phase 21 country
- Retinoblastoma Patient Clinical Database and Tissue RepositoryRecruitingNCT049590972 countries
- Retinoblastoma Consolidation in EgyptiansNot yet recruitingNCT07530458
- Detailed Phenotypic and Genotype Study to Correlate RB1 Mutations Relating to Primary Ocular Tumors and Secondary Extra-ocular Metastasis.RecruitingNCT067251731 country
- Therapeutic Recommendations For The Treatment Of Children With A RetinoblastomaRecruitingNCT044254346 countries
- Can Pretreatment MRI be Used to Predict Intra-arterial Chemotherapy Response in Retinoblastoma?RecruitingNCT032674591 country
- Cognitive Functioning and Health Related Quality of Life in Retinoblastoma SurvivorsEnrolling by invitationNCT062279621 country
- Ocular Conservative Treatment for Retinoblastoma : Efficacy of the New Management Strategies and Visual OutcomeRecruitingNCT04681417Phase 2/31 country
- Molecular Analysis Of Solid TumorsRecruitingNCT010502961 country
- Studying Health Outcomes After Treatment in Patients With RetinoblastomaRecruitingNCT039327862 countries
- Targeting NUDT21 siRNA Drugs for Patients With Refractory RetinoblastomaRecruitingNCT06424301Early Phase 11 country
- High-dose Topotecan for Retinoblastoma With Recurrent or Refractory Vitreous SeedRecruitingNCT06972602Early Phase 11 country
- Intrathecal Chemotherapy for Central Nervous System Metastasis in RetinoblastomaRecruitingNCT04903678Not applicable1 country
- Trilateral Retinoblastoma: Incidence and OutcomesRecruitingNCT063675301 country
- Nitroglycerin for Intra-arterial Chemotherapy in Pediatric Retinoblastoma.RecruitingNCT04564521Not applicable1 country
- Adjuvant Chemotherapy for High-risk Postenucleation RetinoblastomaRecruitingNCT05080010Phase 31 country
- Topotecan and Melphalan for RetinoblastomaRecruitingNCT04799002Phase 31 country
- EGFR806 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young AdultsActive, not recruitingNCT03618381Phase 11 country
- Determination of the Sensitivity and Specificity of a Smartphone Application to Detect RetinoblastomaTerminatedNCT03016156Not applicable1 country
- Early Check: Expanded Screening in NewbornsActive, not recruitingNCT036552231 country
- Protocol for the Study and Treatment of Participants With Intraocular RetinoblastomaActive, not recruitingNCT01783535Phase 21 country
- B7H3 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young AdultsActive, not recruitingNCT04483778Phase 11 country
- A Study Evaluating the Safety and Efficacy of ENV-101 (Taladegib) in Patients With Advanced Solid Tumors Harboring PTCH1 Loss of Function MutationsCompletedNCT05199584Phase 21 country
- Retinoblastoma Survivor Study: Assessment of General Health and Quality of LifeActive, not recruitingNCT006393011 country
- Adjuvant Treatment in Extensive Unilateral Retinoblastoma Primary Enucleated (RB SFCE 2009)Active, not recruitingNCT02870907Phase 21 country
- Conservative Treatments of RetinoblastomaActive, not recruitingNCT02866136Phase 21 country
- Photoscreening for RetinoblastomaWithdrawnNCT04344652Not applicable
- MRI Screening of Second Primary Cancer Occurring Within Radiation Fields After Treatment by External Beam Radiation Therapy for Hereditary Retinoblastoma (DepiSCARRH)Active, not recruitingNCT03026998Not applicable1 country
- Study of Treatment for Patients With Cancer of the Eye -RetinoblastomaCompletedNCT00186888Phase 31 country
- Baby Detect : Genomic Newborn ScreeningCompletedNCT056874741 country
- 131I-omburtamab for the Treatment of Central Nervous System/Leptomeningeal Neoplasms in Children and Young AdultsNo longer availableNCT050643061 country
- Intra-arterial Chemotherapy for RetinoblastomaCompletedNCT04342572Phase 11 country
- Collecting and Storing Tissue From Young Patients With CancerCompletedNCT008987552 countries
- Treatment Protocol for Non-Metastatic Unilateral RetinoblastomaCompletedNCT03475121Phase 31 country
- Combination Chemotherapy, Autologous Stem Cell Transplant, and/or Radiation Therapy in Treating Young Patients With Extraocular RetinoblastomaCompletedNCT00554788Phase 36 countries
- Topotecan Episcleral Plaque for Treatment of RetinoblastomaCompletedNCT04428879Phase 11 country
- Evaluate Safety and the Oncolitic Adenovirus VCN-01 Activity in Patients With Refractory RetinoblastomaCompletedNCT03284268Not applicable1 country
- Combination Chemotherapy and Cyclosporine Followed by Focal Therapy for Bilateral RetinoblastomaActive, not recruitingNCT00110110Phase 24 countries
- Evaluation of MRI of the Pineal Gland in RetinoblastomaCompletedNCT063675691 country
- Adjuvant Chemotherapy for High-risk Retinoblastoma After EnucleationActive, not recruitingNCT01906814Phase 31 country
- Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal CancerCompletedNCT00445965Phase 21 country
- Retinoblastoma Biomarker StudyCompletedNCT003427971 country
- Auto Transplant for High Risk or Relapsed Solid or CNS TumorsCompletedNCT01505569Not applicable1 country
- Anti-Angiogenic Therapy Post Transplant (ASCR) for Pediatric Solid TumorsCompletedNCT01661400Phase 11 country