Topotecan: all 270 studies that test it

Page 1 of 3. Open to participants first (17), then studies with results posted, then the rest; newest registration first within each.

• Metastatic Ewing's Trial Testing Schedule Enhancement to Improve OutcomesRecruitingNCT07194044Phase 1
• An Umbrella Study of Recurrent, Extensive Stage Small Cell Lung Cancer Based on Molecular TypingNot yet recruitingNCT07141771Phase 1/2
• High-dose Topotecan for Retinoblastoma With Recurrent or Refractory Vitreous SeedRecruitingNCT06972602Early Phase 1
• Intravitreal Topotecan for Prevention or Treatment of Proliferative Vitreoretinopathy in Retinal DetachmentNot yet recruitingNCT06818721Phase 2
• Study of Sacituzumab Govitecan Versus Standard of Care in Participants With Previously Treated Extensive Stage Small Cell Lung CancerRecruitingNCT06801834Phase 3
• Chronic CED of TPT for Recurrent Malignant GliomaRecruitingNCT06666712Phase 1
• Testing a Standardized Approach to Surgery and Chemotherapy for Type I Pleuropulmonary Blastoma or the Addition of an Anti-cancer Drug, Topotecan, to the Usual Treatment for Types II and III Pleuropulmonary BlastomaRecruitingNCT06647953Phase 3
• Oral Topotecan With Toripalimab for Patients With Endometrial CancerNot yet recruitingNCT06548763Phase 2
• N10: A Study of Reduced Chemotherapy and Monoclonal Antibody (mAb)-Based Therapy in Children With NeuroblastomaRecruitingNCT06528496Phase 2
• The Safety and Efficacy of Intravitreal Topotecan for the Treatment of Proliferative VitreoretinopathyNot yet recruitingNCT06425419Phase 1
• Dose Attenuated Chemotherapy in Compromised Patients With Lung CancerRecruitingNCT05800587Phase 2
• Molecular and Clinical Risk-Directed Therapy for Infants and Young Children With Newly Diagnosed MedulloblastomaRecruitingNCT05535166Phase 2
• Intravitreal Topotecan in the Repair of Rhegmatogenous Retinal Detachment with Proliferative VitreoretinopathyRecruitingNCT05523869Phase 2
• Targeting Pediatric Brain Tumors and Relapsed/Refractory Solid Tumors With Sodium Glucose Cotransporter 2 Inhibitors (SGLT2i)RecruitingNCT05521984Phase 1
• Allogeneic Hematopoietic Stem Cell Transplantation for 4/M NeuroblastomaNot yet recruitingNCT05303727Phase 2
• A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWTRecruitingNCT04322318Phase 2
• European Proof-of-Concept Therapeutic Stratification Trial of Molecular Anomalies in Relapsed or Refractory TumorsRecruitingNCT02813135Phase 1/2
• A Study of MORAb-202 Versus Investigator's Choice Chemotherapy in Female Participants With Platinum-resistant High-grade Serous (HGS) Ovarian, Primary Peritoneal, or Fallopian Tube CancerCompletedNCT05613088Phase 2Results posted
• Intra-Arterial Chemotherapy for Newly Diagnosed, Residual, or Recurrent Atypical Choroid Plexus Papilloma and Choroid Plexus Carcinoma Prior to Second-Look SurgeryTerminatedNCT04994977Phase 1Results posted
• Berzosertib + Topotecan in Relapsed Platinum-Resistant Small-Cell Lung Cancer (DDRiver SCLC 250)CompletedNCT04768296Phase 2Results posted
• Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid TumorsCompletedNCT03709680Phase 2Results posted
• M7824 and Topotecan or Temozolomide in Relapsed Small Cell Lung CancersCompletedNCT03554473Phase 1/2Results posted
• High-Risk Neuroblastoma Chemotherapy Without G-CSFCompletedNCT02786719Not applicableResults posted
• A Study of Mirvetuximab Soravtansine vs. Investigator's Choice of Chemotherapy in Women With Folate Receptor (FR) Alpha Positive Advanced Epithelial Ovarian Cancer (EOC), Primary Peritoneal or Fallopian Tube CancerCompletedNCT02631876Phase 3Results posted
• Trial of Topotecan With VX-970 (M6620), an ATR Kinase Inhibitor, in Small Cell Cancers and Extrapulmonary Small Cell CancersCompletedNCT02487095Phase 1/2Results posted
• Avatar-Directed Chemotherapy in Treating Patients With Ovarian, Primary Peritoneal, or Fallopian Tube CancerCompletedNCT02312245Phase 2Results posted
• ME-344 Given in Combination With Hycamtin® in Patients With Solid TumorsTerminatedNCT02100007Phase 1/2Results posted
• Oral Pazopanib Plus Oral Topotecan Metronomic Antiangiogenic Therapy for Recurrent Glioblastoma Multiforme (A) Without Prior Bevacizumab Exposure and (B) After Failing Prior BevacizumabCompletedNCT01931098Phase 2Results posted
• Therapy for Children With Advanced Stage NeuroblastomaCompletedNCT01857934Phase 2Results posted
• Protocol for the Study and Treatment of Participants With Intraocular RetinoblastomaActive, not recruitingNCT01783535Phase 2Results posted
• Pertuzumab in Platinum-Resistant Low Human Epidermal Growth Factor Receptor 3 (HER3) Messenger Ribonucleic Acid (mRNA) Epithelial Ovarian Cancer (PENELOPE)CompletedNCT01684878Phase 3Results posted
• Veliparib, Topotecan Hydrochloride, and Filgrastim or Pegfilgrastim in Treating Patients With Persistent or Recurrent Cervical CancerCompletedNCT01266447Phase 2Results posted
• Combination Chemotherapy in Treating Patients With Non-Metastatic Extracranial Ewing SarcomaCompletedNCT01231906Phase 3Results posted
• Veliparib and Topotecan Hydrochloride in Treating Patients With Solid Tumors, Relapsed or Refractory Ovarian Cancer, or Primary Peritoneal CancerActive, not recruitingNCT01012817Phase 1/2Results posted
• Avastin/Radiation (XRT)/Temozolomide (Temodar) Followed by Avastin/Temodar/Topotecan for GlioblastomaCompletedNCT01004874Phase 2Results posted
• Topotecan With Erlotinib for Topotecan Pretreated Ovarian CancerTerminatedNCT01003938Phase 2Results posted
• Neuroblastoma Protocol 2008: Therapy for Children With Advanced Stage High Risk NeuroblastomaTerminatedNCT00808899Phase 2Results posted
• Paclitaxel and Cisplatin or Topotecan With or Without Bevacizumab in Treating Patients With Stage IVB, Recurrent, or Persistent Cervical CancerCompletedNCT00803062Phase 3Results posted
• Phase I Trial of Oral Metronomic Topotecan and Oral Pazopanib to Treat Recurrent/Persistent Gynecologic TumorsCompletedNCT00800345Phase 1Results posted
• Genomic Directed Salvage Chemotherapy With Either Liposomal Doxorubicin Or TopotecanTerminatedNCT00720096Not applicableResults posted
• Study of Oral Topotecan With Bevacizumab for Recurrent Small Cell Lung CancerCompletedNCT00698516Phase 2Results posted
• Comparing Three Different Combination Chemotherapy Regimens in Treating Patients With Relapsed or Refractory Acute Myeloid LeukemiaCompletedNCT00634244Phase 2Results posted
• Two Regimens of Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed Localized Ewing Sarcoma Family of TumorsCompletedNCT00618813Not applicableResults posted
• Phase I, Dosage-finding and PK Study of IV Topotecan and Erlotinib With Refractory Solid TumorsCompletedNCT00611468Phase 1Results posted
• Topotecan, Cisplatin and Bevacizumab for Recurrent/Persistent Cervical CancerCompletedNCT00548418Phase 2Results posted
• Sorafenib + Topotecan for Platinum-Resistant Recurrent Ovarian CancerTerminatedNCT00526799Phase 1/2Results posted
• Obatoclax Mesylate and Topotecan Hydrochloride in Treating Patients With Relapsed or Refractory Small Cell Lung Cancer or Advanced Solid TumorsCompletedNCT00521144Phase 1/2Results posted
• Combination Chemotherapy and Surgery With or Without Isotretinoin in Treating Young Patients With NeuroblastomaCompletedNCT00499616Phase 3Results posted
• Brain Metastases In ErbB2-Positive Breast CancerTerminatedNCT00437073Phase 2Results posted
• Lapatinib and Topotecan in Treating Patients With Ovarian Epithelial Cancer or Primary Peritoneal Cancer That Did Not Respond to Cisplatin or CarboplatinCompletedNCT00436644Phase 2Results posted
• Oral HYCAMTIN Plus Whole Brain Radiation Therapy In Treatment Of Brain Metastases Resulting From Non-Small Lung CancerCompletedNCT00390806Phase 3Results posted
• Oral Topotecan to Treat Recurrent or Persistent Solid TumorsCompletedNCT00382733Phase 1/2Results posted
• Topotecan and Bevacizumab in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer That Did Not Respond to Previous Systemic ChemotherapyCompletedNCT00365547Phase 2Results posted
• Ph II Study of Wkly Topotecan + Bevacizumab in Plat. Resistant/Recurrent Gyn CancersCompletedNCT00343044Phase 2Results posted
• Study of Melphalan and Topotecan (MT) Followed by Autologous Stem Cell Rescue in Patients With Multiple Myeloma.CompletedNCT00325416Phase 1/2Results posted
• Topotecan and Gefitinib (Iressa) for Ovarian, Peritoneal, or Fallopian Tube CancerCompletedNCT00317772Phase 1/2Results posted
• Oxaliplatin and Topotecan in Advance Ovarian CancerTerminatedNCT00313612Phase 2Results posted
• Topotecan by Intracerebral Clysis for Recurrent Primary Malignant Brain TumorsCompletedNCT00308165Phase 1Results posted
• Topotecan and Carboplatin in the First-Line Treatment of Patients With Extensive Stage Small Cell Lung CancerCompletedNCT00305942Phase 2Results posted
• Intravenous Weekly Topotecan In Subjects With Recurrent Or Persistent Endometrial CancerCompletedNCT00267488Phase 2Results posted
• Study of Treatment for Patients With Cancer of the Eye -RetinoblastomaCompletedNCT00186888Phase 3Results posted
• Therapy With Topotecan and Carboplatin by Patients With Relapsed Ovarian CancerCompletedNCT00170625Phase 1/2Results posted
• Topotecan in Treating Patients With Recurrent Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal CancerCompletedNCT00114166Phase 2Results posted
• 7-hydroxystaurosporine and Topotecan Hydrochloride in Treating Patients With Relapsed or Progressed Small Cell Lung CancerCompletedNCT00098956Phase 2Results posted
• Topotecan in Treating Women With Persistent or Recurrent Cervical CancerCompletedNCT00087126Phase 2Results posted
• Comparison of Four Combination Chemotherapy Regimens Using Cisplatin in Treating Patients With Stage IVB, Recurrent, or Persistent Cancer of the CervixCompletedNCT00064077Phase 3Results posted
• Comparison of Two Combination Chemotherapy Regimens in Treating Patients With Extensive-Stage Small Cell Lung CancerCompletedNCT00057837Phase 2Results posted
• A Study Comparing BL-B01D1 With Topotecan in Patients With Recurrent Small Cell Lung Cancer(PANKU-Lung03)Active, not recruitingNCT06500026Phase 3
• Safety, Preliminary Effectiveness of BNT327, an Investigational Therapy for Patients With Small-cell Lung Cancer in Combination With ChemotherapyActive, not recruitingNCT06449209Phase 2
• Study of Efficacy and Safety of Ribociclib (LEE011) in Combination With Topotecan and Temozolomide (TOTEM) in Pediatric Patients With Relapsed or Refractory Neuroblastoma and Other Solid TumorsTerminatedNCT05429502Phase 1
• Testing of Tazemetostat in Combination With Topotecan and Pembrolizumab in Patients With Recurrent Small Cell Lung CancerActive, not recruitingNCT05353439Phase 1
• Reducing Hypoxia in Patients With Coronavirus Disease (COVID-19) Using Topotecan With Standard of CareStatus unknownNCT05083000Phase 1
• A Study of N9 Chemotherapy in Children With NeuroblastomaActive, not recruitingNCT04947501Early Phase 1
• Cabozantinib With Topotecan-CyclophosphamideCompletedNCT04661852Phase 1
• A Prospective International Multicenter Clinical Trial for Eyes With Relapsed RetinoblastomaTerminatedNCT04455139Phase 2
• 9-ING-41 in Pediatric Patients With Refractory Malignancies.TerminatedNCT04239092Phase 1
• Intratumorally-Administered Topotecan Using Convection-Enhanced Delivery in Patients With Grade III/ IV GliomaTerminatedNCT03927274Early Phase 1
• Clinical Trial of SP-2577 (Seclidemstat) in Patients With Relapsed or Refractory Ewing or Ewing-related SarcomasActive, not recruitingNCT03600649Phase 1
• Treatment Protocol for Non-Metastatic Unilateral RetinoblastomaCompletedNCT03475121Phase 3
• Study in Patients With SCLC of Veliparib in Combination With TopotecanStatus unknownNCT03227016Phase 1
• Intratumorally-Administered Topotecan Using CED in High Grade Glioma Undergoing Stereotactic BiopsyWithdrawnNCT03193463Early Phase 1
• Evaluation of 2 Intensification Treatment Strategies for Neuroblastoma Patients With a Poor Response to InductionTerminatedNCT03165292Phase 2
• Chronic Convection Enhanced Delivery of TopotecanCompletedNCT03154996Phase 1
• Phase II Study of Intraventricular Methotrexate in Children With Recurrent or Progressive Malignant Brain TumorsTerminatedNCT02684071Phase 2
• LCL161 Plus Topotecan for Patients With Relapsed/Refractory Small Cell Lung Cancer and Select Gynecologic MalignanciesTerminatedNCT02649673Phase 1
• Phase 1/2a/3 Evaluation of Adding AL3818 to Standard Platinum-Based Chemotherapy in Subjects With Recurrent or Metastatic Endometrial, Ovarian, Fallopian, Primary Peritoneal or Cervical Carcinoma (AL3818-US-002)Active, not recruitingNCT02584478Phase 3
• Topotecan in Glioma Undergoing A Clinically-Indicated Surgical ResectionTerminatedNCT02500459Early Phase 1
• Simvastatin With Topotecan and Cyclophosphamide in Relapsed and/or Refractory Pediatric Solid and CNS TumorsCompletedNCT02390843Phase 1
• A Study of SGT-53 in Children With Refractory or Recurrent Solid TumorsSuspendedNCT02354547Phase 1
• Phase II Study of Pazopanib and Topotecan in Cervical CancerWithdrawnNCT02348398Phase 2
• Activity Study of Bevacizumab With Temozolomide ± Irinotecan for Neuroblastoma in ChildrenCompletedNCT02308527Phase 2
• Phase I Dose Escalation Study of Topotecan and Pazopanib in Children With Recurrent/Refractory Solid TumoursCompletedNCT02303028Phase 1/2
• Sorafenib and Cyclophosphamide/Topotecan in Patients With Relapsed and Refractory NeuroblastomaActive, not recruitingNCT02298348Phase 1
• Topotecan Using Convection-Enhanced Delivery (CED) in High Grade GliomaCompletedNCT02278510Early Phase 1
• N2012-01: Phase 1 Study of Difluoromethylornithine (DFMO) and Celecoxib With Cyclophosphamide/TopotecanCompletedNCT02030964Phase 1
• Whole-Body Radiation Therapy, Systemic Chemotherapy, and High-Dose Chemotherapy Followed By Stem Cell Rescue in Treating Patients With Poor-Risk Ewing SarcomaWithdrawnNCT01795430Not applicable
• Phase II Trial of Chemotherapy With Temodar With Topotecan for CNS Metastasis of Solid TumorsWithdrawnNCT01736800Phase 2
• Veliparib and Topotecan for Relapsed Ovarian Cancer With Negative or Unknown BRCA StatusCompletedNCT01690598Phase 1/2
• Sorafenib and Topotecan in Refractory/Recurrent Pediatric MalignanciesCompletedNCT01683149Phase 1
• Sirolimus With Cyclophosphamide and Topotecan for Pediatric/Adolescent Relapsed and Refractory Solid TumorsCompletedNCT01670175Phase 1

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