Neuroblastoma clinical trials
The registry lists 675 studies for Neuroblastoma across more than 10 countries. 127 are recruiting or about to start. 393 of them are mainly about Neuroblastoma (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its 2 narrower conditions too, such as Esthesioneuroblastoma, Olfactory: 750 studies, 131 open.
ClinicalTrials.gov finds 772 studies for Neuroblastoma. How that becomes 675 here
This page counts the studies the registry files under Neuroblastoma, and those it files under no condition that list Neuroblastomathemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 772Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −75Filed under a narrower condition, counted on its own pageEsthesioneuroblastoma, Olfactory 72 · Ganglioneuroblastoma 2
- −11List Neuroblastoma as a condition, but the registry did not file them under itMost often written as “Disseminated Neuroblastoma” (3), “Localized Resectable Neuroblastoma” (1), and “Neuroblastoma. CNS” (1). The registry filed them under other conditions only, most often Recurrence (5) and Pdgfra-Associated Chronic Eosinophilic Leukemia (3).
- −11Match it another way7 name it in the title and 4 in a keyword.
- 675The count on this page22 of them list Neuroblastoma in their own words; the registry filed them under no condition.
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Who runs them
National Cancer Institute (NCI) (69) · Children's Oncology Group (59) · Memorial Sloan Kettering Cancer Center (51) · St. Jude Children's Research Hospital (24) · New Approaches to Neuroblastoma Therapy Consortium (24) · Giselle Sholler (19) · Baylor College of Medicine (14) · Fred Hutchinson Cancer Center (14)
What is being tested here
Drugs under test in Neuroblastoma studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Dinutuximab | 7 | 4 | 22 |
| Naxitamab | 7 | 0 | 14 |
| Cyclophosphamide | 5 | 6 | 39 |
| Temozolomide | 5 | 1 | 22 |
| Irinotecan | 5 | 1 | 21 |
| Melphalan | 4 | 3 | 21 |
| Carboplatin | 3 | 7 | 26 |
| Vincristine | 3 | 2 | 15 |
| Etoposide | 2 | 6 | 27 |
| Topotecan | 2 | 1 | 19 |
Drug classes tested here Alkylating agents 10 open · Tyrosine kinase inhibitors (TKIs) 4 open · Antimitotic agents 3 open · Antimetabolites 2 open · HDAC inhibitors 2 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Nov 2026High-Risk Neuroblastoma Study 2 of SIOP-Europa-Neuroblastoma (SIOPEN) · Phase 3 · Gustave Roussy, Cancer Campus, Grand Paris
- Dec 2026Chemoimmunotherapy Combined With Autologous NK Cell Therapy for Pediatric Patients With Refractory and Relapsed High-Risk Neuroblastoma and Ganglioneuroblastoma · Phase 3 · Federal Research Institute of Pediatric Hematology, Oncology and Immunology
- Nov 2026PET Imaging of Solid Tumors Using 124I-Humanized 3F8: A Pilot Study · Memorial Sloan Kettering Cancer Center
- Nov 2026Safety and Efficacy of Systemic Allogenic NK Cells in R/R Neuroblastoma · Marzieh Ebrahimi
- Nov 2026Pediatric Long-Term Follow-up and Rollover Study · Novartis Pharmaceuticals
- Nov 2026Phase I Study of Umbilical Cord Blood Natural Killer (NK) Cell Therapy for Children With High-risk, R/R Neuroblastoma. · Sun Yat-sen University
- Dec 2026Anti-GD2 CAR T Cells in Pediatric Patients Affected by High Risk and/or Relapsed/Refractory Neuroblastoma or Other GD2-positive Solid Tumors · Bambino Gesù Hospital and Research Institute
- Dec 2026NK Cells Infusions With Irinotecan, Temozolomide, and Dinutuximab · Nationwide Children's Hospital
- Dec 2026Flavored, Oral Irinotecan VAL-413 (Orotecan®) Given With Temozolomide for Treatment of Recurrent Pediatric Solid Tumors · Valent Technologies, LLC
- Dec 2026Multi-modular Chimeric Antigen Receptor Targeting GD2 in Neuroblastoma · University College, London
Who these studies take
Of the 104 Neuroblastoma studies recruiting now, 25 (24%) set no upper age limit and 74 (71%) stop at 75 or younger. 101 (97%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 3 (3%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 100 (96%) | 100 (96%) |
| 18 | 99 (95%) | 99 (95%) |
| 30 | 53 (51%) | 53 (51%) |
| 40 | 35 (34%) | 35 (34%) |
| 50 | 33 (32%) | 33 (32%) |
| 65 | 31 (30%) | 31 (30%) |
| 75 | 30 (29%) | 30 (29%) |
| 85 | 29 (28%) | 29 (28%) |
Across all 675 studies, recruiting or not: 70% stop at 75 or younger and 68% at 65; 94% take children; 0% are for women only and <1% for men only; 2% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Neuroblastoma studies take
Of 86 phase 1 interventional studies under Neuroblastoma, half reached primary completion within 83 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 83 mo60–114 · 86 studies | — | 89 mo65–117 · 73 studies |
| Phase 1/2 | 80 mo62–115 · 35 studies | — | — |
| Phase 2 | 74 mo52–99 · 67 studies | — | 74 mo52–99 · 62 studies |
| Phase 3 | 96 mo80–122 · 19 studies | — | — |
| Observational | 213 mo74–304 · 34 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting2
Results posted1
Newly registered2
Studies
Recruiting first, then most recently updated. Showing 50 of 675. Browse all 675 → or search them.
- A Study of a Vaccine in Combination With β-glucan and GM-CSF in People With NeuroblastomaRecruitingNCT04936529Phase 21 country
- Pencil Beam Scanning Proton Beam Radiotherapy for the Management of Abdominal NeuroblastomaRecruitingNCT06804447Not applicable1 country
- 177Lutetium-DOTATATE in Children With Primary Refractory or Relapsed High-risk NeuroblastomaRecruitingNCT04903899Phase 27 countries
- A Study of a Vaccine in Combination With Beta-glucan in People With NeuroblastomaRecruitingNCT06057948Phase 21 country
- A First-in-Human Phase I Trial With Antibody Drug Conjugate ADCT-701 in Neuroendocrine Tumors, Carcinomas and Malignant Peripheral Nerve Sheath TumorsRecruitingNCT06041516Phase 11 country
- Testing the Addition of Iberdomide to Therapy in People With Neuroblastoma That Has Come Back, Not Responded to Treatment, or Gotten WorseRecruitingNCT07437963Phase 1/21 country
- Prospective Comprehensive Molecular Analysis of Endocrine NeoplasmsRecruitingNCT010056541 country
- PEACH TRIAL- Precision Medicine and Adoptive Cellular TherapyRecruitingNCT04837547Phase 11 country
- GD2IL18CART Combined With Bevacizumab for Relapsed and Refractory GD2-positive Solid TumorsNot yet recruitingNCT07897968Phase 11 country
- A Safety and Efficacy Study of hu14 in High-Risk Neuroblastoma PatientsRecruitingNCT07549321Phase 2/37 countries
- Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post ConsolidationRecruitingNCT06942039Early Phase 11 country
- Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk NeuroblastomaRecruitingNCT06172296Phase 35 countries
- Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)RecruitingNCT06395103Phase 1/223 countries
- 4SCAR-T Therapy Targeting GD2, PSMA and CD276 for Treating NeuroblastomaNot yet recruitingNCT04637503Phase 1/21 country
- Myeloablative Consolidation Therapy and Tandem Autologous Stem Cell Rescue in Patients With High-Risk NeuroblastomaRecruitingNCT02605421Phase 21 country
- Alpha/Beta CD19+ Depleted Haploidentical Transplantation + Zometa for Pediatric Hematologic Malignancies and Solid TumorsRecruitingNCT02508038Phase 11 country
- International PPB/DICER1 RegistryRecruitingNCT033821581 country
- Phase I Trial of rhIL-15 Plus Dinutuximab Plus Irinotecan/Temozolomide for Children and Young Adults With Relapsed/Refractory NeuroblastomaRecruitingNCT06995872Phase 11 country
- Prospective Multicenter Study of the Genomic, Transcriptomic, and Biological Profile of Patients With NeuroblastomaRecruitingNCT078811721 country
- Comprehensive Omics Analysis of Pediatric and Adult Solid Tumors and Establishment of a Repository for Related Biological StudiesRecruitingNCT011093941 country
- Phase 1 Dose-escalating Study of MM-398 (Irinotecan Sucrosofate Liposome Injection) Plus Intravenous Cyclophosphamide in Recurrent or Refractory Pediatric Solid TumorsRecruitingNCT02013336Phase 11 country
- Dinutuximab-beta and Chemotherapy in Newly Diagnosed High-Risk NeuroblastomaRecruitingNCT07688252Phase 11 country
- PEEL-224, Vincristine and Temozolomide in Pediatric Solid TumorsRecruitingNCT06721689Phase 1/21 country
- Silmitasertib (CX-4945) in Combination With Chemotherapy for Relapsed Refractory Solid TumorsRecruitingNCT06541262Phase 1/22 countries
- Molecular Characterization of Neuroblastic Tumor: Correlation With Clinical OutcomeRecruitingNCT005880681 country
- MCT for the Harvard/UCSF ROBIN CenterRecruitingNCT06000787Not applicable1 country
- Phase II Study of Chidamide-Dinutuximab Beta-Irinotecan-Temozolomide for Refractory/Relapsed Neuroblastoma in ChildrenRecruitingNCT07318831Phase 21 country
- Patients Between the Ages of 12 Months to 21 Years With Newly-Diagnosed High-Risk Neuroblastoma Will Receive Children's Oncology Group (COG) Type Recommended Therapy With the Addition of Naxitamab and Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) to Induction Cycles 1-5RecruitingNCT07537400Phase 21 country
- Testing the Addition of an Anti-Cancer Drug, Daraxonrasib, for Relapsed or Refractory Solid Tumors With RAS MutationsNot yet recruitingNCT07819838Phase 1/2
- Biomarkers of Resiliency In Childhood Cancer SurgeryRecruitingNCT066748111 country
- Pediatric Precision Laboratory Advanced Neuroblastoma TherapyRecruitingNCT02559778Phase 22 countries
- B7-H3.CD28Z.CART in Solid TumorsRecruitingNCT07358260Phase 11 country
- Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and SarcomasRecruitingNCT06465199Phase 1/21 country
- Tipifarnib and Naxitamab for Relapsed/Refractory NeuroblastomaRecruitingNCT06540963Phase 21 country
- International Congenital Central Hypoventilation Syndrome (CCHS) Registry and CCHS SHARERecruitingNCT030880201 country
- N10: A Study of Reduced Chemotherapy and Monoclonal Antibody (mAb)-Based Therapy in Children With NeuroblastomaRecruitingNCT06528496Phase 21 country
- Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid TumorsRecruitingNCT04851119Phase 1/21 country
- Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)RecruitingNCT03126916Phase 33 countries
- Haploidentical Donor Cytokine-Induced Memory-Like Natural Killer Cells (CIML-NK) for Relapsed & Refractory NeuroblastomaRecruitingNCT07635056Phase 21 country
- APG-115 Alone or in Combination With APG-2575 in Recurrent or Refractory Neuroblastoma or Solid TumorsRecruitingNCT05701306Phase 1/21 country
- NANT 2021-02: Randomized MIBG With Vorinostat/Dinutuximab/Vorinostat + DinutuximabNot yet recruitingNCT07261241Phase 21 country
- Safety, Tolerability, and Preliminary Efficacy of [211At]MABG in Patients With Relapsed or Refractory NeuroblastomaRecruitingNCT07767630Early Phase 11 country
- GPC2 CAR T Cells for Relapsed or Refractory Neuroblastoma and Metastatic RetinoblastomaEnrolling by invitationNCT05650749Phase 11 country
- Selective Antigen Specific T Cells and CAR T Cells in Subjects With Relapsed/Refractory Embryonal Tumors (SABRE)RecruitingNCT07172958Phase 11 country
- Naxitamab Added to Induction for Newly Diagnosed High-Risk NeuroblastomaRecruitingNCT05489887Phase 24 countries
- SPEARHEAD-3 Pediatric StudyRecruitingNCT05642455Phase 1/21 country
- Clinical Trial of GAIA-102 for Refractory/Relapse Neuroblastomas and Other Malignant Pediatric Solid TumorsRecruitingNCT05608148Phase 11 country
- A Compassionate Use/Expanded Access Protocol Using 131I-MIBG Therapy for Patients With Refractory Neuroblastoma and Metastatic PheochromocytomaAvailableNCT030158441 country
- 131I-Labeled MIBG for Refractory Neuroblastoma: A Compassionate Use ProtocolAvailableNCT013703301 country
- NKG2D.Zeta-NK Cell Conditioning With C7R.GD2.CAR-T Cells for Patients With Relapsed or Refractory Osteosarcoma or NeuroblastomaRecruitingNCT07211737Phase 11 country