Drug
Temozolomide clinical trials
Also written Temodar, Temodal, SCH 52365 and Methazolastone.
- studies test it
- 659
- open now
- 91
- in phase 3
- 43
- first study started
- 1997
Keep track of what changes. Save the Temozolomide studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Name
- Temozolomide
- 533
- TMZ
- 100
- Temcad
- 56
Development codes
- RP-46161
- 53
Other names
Combined with it in one product
Studies by the year they started
655 studies that test it; most in 2007 (41); 2 more planned to start later
| Year | Studies |
|---|---|
| 1997 | 3 |
| 1998 | 10 |
| 1999 | 9 |
| 2000 | 22 |
| 2001 | 9 |
| 2002 | 17 |
| 2003 | 11 |
| 2004 | 23 |
| 2005 | 39 |
| 2006 | 32 |
| 2007 | 41 |
| 2008 | 39 |
| 2009 | 37 |
| 2010 | 32 |
| 2011 | 14 |
| 2012 | 19 |
| 2013 | 19 |
| 2014 | 23 |
| 2015 | 25 |
| 2016 | 21 |
| 2017 | 27 |
| 2018 | 28 |
| 2019 | 21 |
| 2020 | 23 |
| 2021 | 21 |
| 2022 | 22 |
| 2023 | 17 |
| 2024 | 15 |
| 2025 | 23 |
| 2026 | 13 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 13
- Phase 1
- 269
- Phase 2
- 435
- Phase 3
- 43
- Phase 4
- 4
- No phase
- 11
What it is tested for
Each study’s main condition, where its own words name it.
- Glioblastoma
- 237
- Glioma
- 72
- Melanoma
- 61
- Lymphoma
- 13
Who runs them
Industry 99 · Other 560
National Cancer Institute (NCI) (46) · M.D. Anderson Cancer Center (23) · Duke University (22) · Memorial Sloan Kettering Cancer Center (20) · Merck Sharp & Dohme LLC (17) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (16) · European Organisation for Research and Treatment of Cancer - EORTC (12) · Children's Oncology Group (11)
Often tested with
Tested in the same studies.
Irinotecan (65) · Bevacizumab (45) · Carboplatin (24) · Vincristine (19) · Cisplatin (18) · Veliparib (17) · Capecitabine (17) · Topotecan (15)
Studies
Open first, then newest update. How each study uses Temozolomide is read from its arms, and is right about nine times in ten.
Testing it · 659
- Phase I Trial of rhIL-15 Plus Dinutuximab Plus Irinotecan/Temozolomide for Children and Young Adults With Relapsed/Refractory NeuroblastomaRecruitingPhase 1National Cancer Institute (NCI)NCT06995872Written as Temozolomide
- Temozolomide and Survivin Long Peptide Vaccine (SurVaxM) for the Treatment of Patients With Progressing Metastatic Neuroendocrine CarcinomasNot yet recruitingPhase 2Roswell Park Cancer InstituteNCT06202066Written as Temozolomide
- Temozolomide, With or Without WSD0922-FU, for the Treatment of EGFR-Mutant, IDH-Wildtype GlioblastomaRecruitingPhase 2Mayo ClinicNCT07708961Written as Temozolomide
- Antiangiogenic Therapy for Children With Recurrent Medulloblastoma, Ependymoma, ATRT and Rare CNS TumorsRecruitingPhase 2Medical University of ViennaNCT01356290Written as Temozolomide (TMZ)
- CapTemY90 for Grade 2/3 NET Liver MetastasesRecruitingPhase 2Abramson Cancer Center at Penn MedicineNCT04339036Written as Temozolomide Oral Product
- PEEL-224, Vincristine and Temozolomide in Pediatric Solid TumorsRecruitingPhase 1/2Theodore LaetschNCT06721689Written as Temozolomide (TMZ)
- Metronomic Temozolomide With Dexbrompheniramine for Recurrent High-Grade Glioma/GlioblastomaNot yet recruitingPhase 1/2University of NebraskaNCT07859059Written as Temozolomide
- Medication Combinations of Dasatinib, Quercetin, Fisetin, Temozolomide, LMP744, and Autologous TLPO Vaccine for the Treatment of Previously Treated Glioma With Residual DiseaseRecruitingEarly Phase 1Mayo ClinicNCT07025226Written as Temozolomide
- Preoperative Radiosurgery for the Treatment of High Grade Glioma, NeoGlioma TrialRecruitingPhase 1Mayo ClinicNCT05030298Written as Temozolomide
- Liothyronine in Combination With BIT Regimen for Medulloblastoma With or Without Minimal Residual DiseaseRecruitingPhase 1/2Sabine Mueller, MD, PhDNCT07346157Written as Temozolomide (TMZ)
- Metastatic Ewing's Trial Testing Schedule Enhancement to Improve OutcomesRecruitingPhase 1H. Lee Moffitt Cancer Center and Research InstituteNCT07194044Written as Temozolomide
- A Study of Temodar With Abexinostat (PCI-24781) for Patients With Recurrent GliomaRecruitingPhase 1University of NebraskaNCT05698524Written as Temozolomide
- Combination of Tarlatamab and Temozolomide in Patients With Central Nervous System TumorsRecruitingPhase 1/2Centre Leon BerardNCT07243470Written as Temozolomide (TMZ)
- hSTAR GBM (Hematopoetic Stem Cell (HPC) Rescue for GBM)RecruitingPhase 2Leland MethenyNCT05052957Written as temozolomide
- Study of ABBV-637 or ABBV-155 With ERAS-801 for People With GlioblastomaRecruitingPhase 1Memorial Sloan Kettering Cancer CenterNCT06934889Written as Temozolomide
- Trial of Temozolomide in BAP1 Mutated Patients With Advanced or Metastatic Cutaneous MelanomaNot yet recruitingPhase 2Assistance Publique Hopitaux De MarseilleNCT07807878Written as Temozolomide (TMZ)
- Study of Olutasidenib and Temozolomide in HGGRecruitingPhase 2Rigel PharmaceuticalsNCT06161974Written as Olutasidenib + TMZ
- N10: A Study of Reduced Chemotherapy and Monoclonal Antibody (mAb)-Based Therapy in Children With NeuroblastomaRecruitingPhase 2Memorial Sloan Kettering Cancer CenterNCT06528496Written as Temozolomide
- INdividualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT)RecruitingPhase 2David Reardon, MDNCT02977780Written as Temozolomide
- Implantable Microdevice for the Delivery of Drugs and Their Effect on Tumors in Patients With Metastatic or Recurrent SarcomaRecruitingNot applicableM.D. Anderson Cancer CenterNCT04199026Written as Temozolomide
See all 659 studies that test Temozolomide →
Given in every arm · 178 — Temozolomide is usual care beside what is tested
- Testing the Addition of an Anti-cancer Drug, Selinexor, to the Usual Chemotherapy Treatment (Temozolomide) for Brain Tumors That Have Returned After Previous TreatmentRecruitingPhase 1/2National Cancer Institute (NCI)NCT05432804Written as Temozolomide
- Pembrolizumab + Chemotherapy in Newly Diagnosed PCNSLRecruitingPhase 1Dana-Farber Cancer InstituteNCT06475235Written as Temozolomide
- IDH1-vac in Patients With Newly Diagnosed IDH1R132H-positive High-grade AstrocytomasNot yet recruitingPhase 2German Cancer Research CenterNCT07888647Written as Temozolomide (TMZ)
- Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk NeuroblastomaRecruitingPhase 3National Cancer Institute (NCI)NCT06172296Written as Temozolomide
- Tris-CAR-T Cell Therapy Targeting CD44 and CD133 in Newly Diagnosed GlioblastomaNot yet recruitingPhase 2/3Beijing Tiantan HospitalNCT07873996Written as Temozolomide (TMZ)
- ONO-4538 Phase II Rollover Study (ONO-4538-98)RecruitingPhase 2Ono Pharmaceutical Co., Ltd.NCT04566380Written as temozolomide
- Silmitasertib (CX-4945) in Combination With Chemotherapy for Relapsed Refractory Solid TumorsRecruitingPhase 1/2Milton S. Hershey Medical CenterNCT06541262Written as Temozolomide
- A Study of BMS-986504 Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5)RecruitingPhase 2Bristol-Myers SquibbNCT07492680Written as Temozolomide
- Study of AZD9574 as Monotherapy and in Combination With Anti-cancer Agents in Participants With Advanced Solid MalignanciesRecruitingPhase 1/2AstraZenecaNCT05417594Written as Temozolomide (TMZ)
- Beginning Radiation Immediately With GammaTile at GBM Excision Versus Standard of CareRecruitingPhase 3GT Medical Technologies, Inc.NCT07195591Written as Temozolomide
- Ruxolitinib With Radiation and Temozolomide Compared to Radiation and Temozolomide for Newly Diagnosed GlioblastomaRecruitingPhase 2Baptist Health South FloridaNCT06991101Written as Temozolomide
- Testing Addition of an Anti-cancer Drug, Vorasidenib to Temozolomide, After Radiation for Advanced Brain CancerRecruitingPhase 3Alliance for Clinical Trials in OncologyNCT07215910Written as Temozolomide
- A Study of the Efficacy and Safety of Lisocabtagene Maraleucel (Liso-cel) as First-Line Therapy in Adults With Transplant-Ineligible Primary Central Nervous System LymphomaRecruitingPhase 2Juno Therapeutics, Inc., a Bristol-Myers Squibb CompanyNCT07015242Written as Temozolomide
- Pan Tumor Rollover StudyRecruitingPhase 2Bristol-Myers SquibbNCT03899155Written as Temozolomide
- A Study of Debio 0123 in Combination With Temozolomide in Adult Participants With Recurrent or Progressive Glioblastoma and of Debio 0123 in Combination With Temozolomide and Radiotherapy in Adult Participants With Newly Diagnosed GlioblastomaRecruitingPhase 1/2Debiopharm International SANCT05765812Written as Temozolomide
- Trial of Glioblastoma Immunotherapy Advancement With Nivolumab and RelatlimabRecruitingPhase 2Duke UniversityNCT06816927Written as TMZ
- Combination ADI-PEG 20, TMZ, and RT for Treatment of Newly Diagnosed High-grade Glioma (HGG)Not yet recruitingPhase 1/2Sabine Mueller, MD, PhDNCT07389278Written as Temozolomide (TMZ)
- Comparison of Cerebraca Wafer Plus Temozolomide Versus Temozolomide Alone in Recurrent GlioblastomaNot yet recruitingPhase 2/3Everfront Biotech Co., Ltd.NCT07349693Written as Temozolomide (for relapsed malignant glioma)
- A Study of Catequentinib Hydrochloride (AL3818) in Endometrial, LGSOC, STS or GBM CancersNot yet recruitingPhase 1/2Advenchen Pharmaceuticals, LLC.NCT07811297Written as Temozolomide (TMZ)
- Temporally-Modulated Pulsed Radiation Therapy Versus Standard Radiation Therapy for the Treatment of Newly Diagnosed, IDH Wildtype, MGMT-Unmethylated GlioblastomaRecruitingPhase 3NRG OncologyNCT07452458Written as Temozolomide
Showing 20 of 178.
As the comparator · 33 — what is tested is compared with Temozolomide
- A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent GlioblastomaRecruitingPhase 2/3Global Coalition for Adaptive ResearchNCT03970447Written as Temozolomide
- Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIIIRecruitingPhase 2Black Diamond Therapeutics, Inc.NCT07326566Written as temozolomide (TMZ)
- IGNITE: Study of Tirabrutinib vs Rituximab and Temozolomide for Relapsed/Refractory Primary Central Nervous System Lymphoma (PCNSL)RecruitingPhase 3Ono Pharmaceutical Co., Ltd.NCT07104032Written as Temozolomide
- Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBMRecruitingPhase 3CarTheraNCT05902169Written as Temozolomide
- A Phase II Trial of LM103 in Advanced MelanomaRecruitingPhase 2Suzhou BlueHorse Therapeutics Co., Ltd.NCT07310784Written as Dacarbazine, temozolomide, paclitaxel, carboplatin/cisplatin
- SUPRAME-ACTengine® IMA203 vs. Investigator's Choice of Treatment in Previously Treated, Unresectable or Metastatic Cutaneous MelanomaRecruitingPhase 3Immatics US, Inc.NCT06743126Written as temozolomide
- Doxorubicin Hydrochloride Liposome Combined With Irinotecan (AI Regimen) Versus VIT Regimen in the Treatment of Relapsed and Refractory Pediatric Rhabdomyosarcoma: a Prospective, Open-label, Randomized Controlled, Multicenter, Phase II Clinical StudyRecruitingPhase 2Sun Yat-sen UniversityNCT05457829Written as Temozolomide+Irinotecan+Vincristine
- Study on The Sensitizing Effect of Sonodynamic Therapy on The Treatment of Brainstem Glioma With Radiotherapy and Chemotherapy and Survival AnalysisEnrolling by invitationPhase 2Yingjuan ZhengNCT06999148Written as Radiotherapy plus temozolomide
- Clinical Trial of VIM With VIT in Children With Relapsed and Refractory Soft Tissue Sarcoma.RecruitingPhase 2Yizhuo ZhangNCT06514313Written as Temozolomide+Irinotecan+Vincristine
- FaR-RMS: An Overarching Study for Children and Adults With Frontline and Relapsed RhabdoMyoSarcomaRecruitingPhase 1/2University of BirminghamNCT04625907Written as Temozolomide
- A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated GlioblastomaActive, not recruitingPhase 3Ivy Brain Tumor CenterNCT06388733Written as Temozolomide
- Testing the Use of the Immunotherapy Drugs Ipilimumab and Nivolumab Plus Radiation Therapy Compared to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Unmethylated GlioblastomaCompletedPhase 2/3National Cancer Institute (NCI)NCT04396860Written as Temozolomide
- A Study to Assess Naporafenib (ERAS-254) Administered With Trametinib in Patients With NRAS-mutant Melanoma (SEACRAFT-2)Active, not recruitingPhase 3Erasca, Inc.NCT06346067Written as Temozolomide
- A Study of PLB1001 Enteric Capsules in the Treatment of sGBM/IDH Mutant Glioblastoma Patients With the ZM Fusion Gene (FUGEN).Active, not recruitingPhase 2/3Beijing Pearl Biotechnology Limited Liability CompanyNCT06105619Written as Temozolomide
- Evaluation of Fluoxetine and Cytotoxic Lysosomal Stress in Glioma (FLIRT)Active, not recruitingEarly Phase 1Duke UniversityNCT05634707Written as Temozolomide
- Glioblastoma Treatment With Irradiation and Olaptesed Pegol (NOX-A12) in MGMT Unmethylated PatientsActive, not recruitingPhase 1/2TME Pharma AGNCT04121455Written as Temozolomide (TMZ)
- Study on Tailored Treatment in Elderly Patients With Newly Diagnosed Primary Lymphoma of Central Nervous SystemCompletedPhase 2International Extranodal Lymphoma Study Group (IELSG)NCT03495960Written as Temozolomide
- An Open-Label, Multicenter, Phase 1/2 Study of Poly(ADP-Ribose) Polymerase (PARP) Inhibitor E7449 as Single Agent in Subjects With Advanced Solid Tumors or With B-cell Malignancies and in Combination With Temozolomide (TMZ) or With Carboplatin and Paclitaxel in Subjects With Advanced Solid TumorsCompletedPhase 1/2Eisai LimitedNCT01618136Written as E7449 plus TMZ
- An Investigational Immuno-therapy Study of Nivolumab Compared to Temozolomide, Each Given With Radiation Therapy, for Newly-diagnosed Patients With Glioblastoma (GBM, a Malignant Brain Cancer)CompletedPhase 3Bristol-Myers SquibbNCT02617589Written as Temozolomide
- PPX and Concurrent Radiation for Newly Diagnosed Glioblastoma Without MGMT MethylationCompletedPhase 2Brown UniversityNCT01402063Written as Temozolomide
Showing 20 of 33.
Codes
What other systems call Temozolomide · ClinicalTrials.gg INT006660
- MeSH (NLM) D000077204TemozolomideConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) YF1K15M17YTEMOZOLOMIDEConfirmed FDA, NLM, Wikidata
- RxNorm 37776Confirmed FDA, Wikidata
- Wikidata Q425088temozolomideConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C1244TemozolomideOne source FDA
- DrugBank DB00853One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D000077204 | Temozolomide | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | YF1K15M17Y | TEMOZOLOMIDE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 37776 | — | Confirmed FDA, Wikidata |
| Wikidata | Q425088 | temozolomide | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C1244 | Temozolomide | One source FDA |
| DrugBank | DB00853 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.