Psilocybin clinical trials
Also written PEX010, COMP360 and Indocybin.
Includes 1 study of Psilocybin trihydrate.
How each study uses Psilocybin is sorted by a rule, right about nine times in ten. Readers can ask us to read every study one by one.Ask us to read each study
Get an email when these change. Save the Psilocybin studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
See an example email
Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
One email a week for all your saved searches. Stop any time.
Approvals
The first approval found in each region, with its record
- United States
- Not in FDA's approval records
- European Union
- Not in EMA's list of EU-wide authorisations
From FDA's Drugs@FDA and Purple Book (through openFDA) and the European Medicines Agency, files of Sept 2026 and 27 Oct 2026. National approvals in Europe and other countries are not included. How this is worked out
How studies write it
Studies that test it under each name
Studies by the year they started
232 studies that test it; most in 2026 (51); 9 more planned to start later
| Year | Studies |
|---|---|
| 2004 | 1 |
| 2007 | 1 |
| 2009 | 2 |
| 2012 | 2 |
| 2013 | 2 |
| 2014 | 2 |
| 2015 | 3 |
| 2017 | 3 |
| 2018 | 4 |
| 2019 | 6 |
| 2020 | 5 |
| 2021 | 19 |
| 2022 | 20 |
| 2023 | 31 |
| 2024 | 39 |
| 2025 | 41 |
| 2026 | 51 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it, so a study counts once.
Who runs them
Industry 20 · Other 221
Johns Hopkins University (24) · Yale University (13) · NYU Langone Health (9) · COMPASS Pathways (8) · Centre for Addiction and Mental Health (7) · University of Wisconsin, Madison (6) · University of Washington (5) · University Health Network, Toronto (4)
Often tested with
Tested in the same studies.
N-Methyl-3,4-methylenedioxyamphetamine (4) · Lysergic Acid Diethylamide (3) · Risperidone (2) · Psychotherapy (1) · Psilocin (1) · Methylphenidate (1) · Midazolam (1) · Trazodone (1)
Related medicines
As reviewed, each with the page that says it.
- One of Psychedelics source
- One of Serotonin receptor agonists source
Coming up
From the study records. Dates are the sponsors’ own estimates and often move.
Reaching primary completion within a year · 51, 2 in phase 3
Studies that test Psilocybin, phase 3 first.
- Aug 2027Psilocybin Microdose for Psychological and Existential Distress in Palliative Care (PSYCHED-PAL-RCT)Phase 3 · Bruyère Health Research Institute.
- Oct 2027Effect of Psilocybin and Structured Integrated Reframing Therapy on Gut-Brain Axis Biomarkers and Depression in Major Depressive DisorderPhase 3 · Khyber Medical University Peshawar
- Nov 2026Safety and Psychological Effects of Psilocybin and D-Serine Formulation in Healthy VolunteersPhase 1 · Hadassah Medical Organization
- Nov 2026PsiloStudy: Psilocybin With Psychological Support (Psi-PS) for Military Veterans and First Responders With Co-occurring PTSD & Alcohol Use Disorder (AUD)Phase 2 · Nathan Brashares Sackett
- Dec 2026Psilocybin in the Treatment of Cannabis Use Disorder: A-Proof-of-Concept StudyPhase 2 · McMaster University
- Dec 2026Psilocybin-Assisted Psychotherapy in Treating Irritable Bowel Syndrome (IBS)Early Phase 1 · NYU Langone Health
- Dec 2026Study of Psilocybin Assisted Psychotherapy to Address Fear of RecurrencePhase 1 · University of Colorado, Denver
- Dec 20265-HT2A Agonist Psilocybin in the Treatment of Tobacco Use DisorderPhase 2 · Johns Hopkins University
- Dec 2026Cancer Related Major Depression Treated With a Single Dose of PsilocybinPhase 2 · Section for Affective Disorders; Northern Stockholm Psychiatry
- Dec 2026Group Retreat Psilocybin Therapy for the Treatment of Anxiety and Depression in Patients With Metastatic Solid Tumors or Incurable Hematologic MalignanciesPhase 2 · University of Washington
Studies
Open first, then newest update. How each study uses Psilocybin is read from its arms, and is right about nine times in ten. Ask us to read each study. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.
Testing it · 241
- Neuroplasticity Enhancement From Cognitive Training Reinforced by PsilocybinRecruitingPhase 2National Institute on Aging (NIA)NCT07721467Written as Psilocybin
- The Effects of Psilocybin on Social ConnectednessNot yet recruitingPhase 1Yale UniversityNCT07693153Written as Psilocybin
- NeuroGuard: Psilocybin Trial for Preventing Chemo-induced NeuropathyNot yet recruitingPhase 2M.D. Anderson Cancer CenterNCT07227909Written as Psilocybin (drug)
- Redefine Study: A Study Evaluating the Efficacy, Safety, and Tolerability of COMP360 in Participants With Post-traumatic Stress DisorderRecruitingPhase 2/3COMPASS PathwaysNCT07570654Written as COMP360 psilocybin
- Effects of Psilocybin on Speech Fluency, Struggle, and Brain Activity in People Who StutterRecruitingPhase 2NYU Langone HealthNCT07296328Written as Psilocybin
- Psilocybin Therapy for Methamphetamine Use Disorder and HIVRecruitingPhase 2Nicky Mehtani, MD, MPHNCT07756736Written as Psilocybin 5 mg
- The RECAP2 Study: Midazolam and PsilocybinRecruitingPhase 1University of Wisconsin, MadisonNCT06692192Written as Psilocybin
- Psilocybin With Psychotherapy for Improving Chronic Pain in Cancer Patients Requiring OpioidsNot yet recruitingPhase 2Roswell Park Cancer InstituteNCT06827054Written as Psilocybine
- Psilocybin-Assisted Psychotherapy in Patients With Advanced Cancer on Maintenance TherapyRecruitingPhase 2M.D. Anderson Cancer CenterNCT06200155Written as Psilocybin
- TRIPS - Treatment to Improve Depression and/or Anxiety Using Psilocybin-assisted Psychotherapy in Cancer SurvivorsRecruitingPhase 2M.D. Anderson Cancer CenterNCT06801041Written as Psilocybin
- Psilocybin FCR Early-Stage Breast CancerNot yet recruitingPhase 2NYU Langone HealthNCT07909408Written as Psilocybin 25 mg
- Consciousness and Psilocybin Effects on Well-Being: The CoPEWell StudyNot yet recruitingPhase 1University of Wisconsin, MadisonNCT07360301Written as Psilocybin
- Assessing of Behavioral Risk and Response to Electromagnetic and Psychedelic TherapiesNot yet recruitingPhase 2University of New MexicoNCT07745569Written as Psilocybin (drug)
- Open-Label Psilocybin Study in Transdiagnostic PopulationRecruitingPhase 1Yale UniversityNCT06442423Written as Psilocybin
- Psilocybin-Assisted Psychotherapy in Cancer Patients With Adjustment DisorderRecruitingPhase 2Psyence Australia Pty LtdNCT07072728Written as Psilocybin therapy
- Psilocybin-Assisted Physical Therapy in Chronic Low Back PainNot yet recruitingPhase 2Yale UniversityNCT07306364Written as Psilocybin 10 mg
- Psilocybin for Depression in VeteransNot yet recruitingPhase 2VA Office of Research and DevelopmentNCT07895134Written as Psilocybin
- Psilocybin-assisted Therapy for Comorbid Major Depressive Disorder and Alcohol Use DisorderRecruitingPhase 2Centre for Addiction and Mental HealthNCT07405606Written as Psilocybin 25 mg
- Psilocybin Assisted Psychotherapy for Treatment Resistant Depression and Co-occurring Substance Use DisorderNot yet recruitingPhase 1/2Indiana UniversityNCT07499583Written as Psilocybin
- Psilocybin Intervention for Veterans Overcoming Treatment-Resistant DepressionRecruitingPhase 3VA Office of Research and DevelopmentNCT07226232Written as Psilocybin
See all 241 studies that test Psilocybin →
Given beside what is tested · 14 — Psilocybin is usual care or a partner of the new treatment
- Psilocybin With Pimavanserin Compared to Psilocybin Alone for the Treatment of Major Depressive DisorderRecruitingPhase 2Icahn School of Medicine at Mount SinaiNCT06592833Written as Psilocybin
- Psilocybin Efficacy With or Without Pimavanserin PretreatmentRecruitingPhase 1/2Johns Hopkins UniversityNCT07610135Written as Psilocybin
- The ENHANCE Study: taVNS and PsilocybinRecruitingPhase 1University of Wisconsin, MadisonNCT05866471Written as Psilocybin
- Imaging the Effects of Serotonin 2A Receptor Modulation on Synaptic Density in Treatment-resistant Depression (SYNVEST)RecruitingPhase 2Centre for Addiction and Mental HealthNCT06512220Written as Psilocybin 25 mg
- Psilocybin-Assisted TherapyRecruitingPhase 2Emory UniversityNCT07332143Written as psilocybin
- Psilocybin Administration With 5-HT1a BlockadeRecruitingEarly Phase 1Johns Hopkins UniversityNCT07565493Written as Psilocybin
- Psilocybin-Assisted Therapy for Physician Well-Being and BurnoutRecruitingPhase 1/2University of California, San DiegoNCT06814522Written as Psilocybin, [3-[2-(dimethylamino)ethyl]-1H-indol-4-yl] dihydrogen phosphate
- Investigation to Understand and Optimize PsilocybinRecruitingPhase 2Charles RaisonNCT06512194Written as Psilocybin
- Psilocybe Cubensis Mushrooms With or Without Fluoxetine for Refractory DepressionRecruitingPhase 1/2Federal University of Latin American IntegrationNCT06898606Written as Psilocybin and Psilocyn
- RCT of Psilocybin-assisted CBT for DepressionRecruitingPhase 1/2University of California, Los AngelesNCT07281352Written as Psilocybin (drug)
- The Neurobiological Effect of 5-HT2AR ModulationRecruitingPhase 1Gitte Moos KnudsenNCT03289949Written as Psilocybine
- A Study of Psilocybin for PTSDActive, not recruitingPhase 1Johns Hopkins UniversityNCT06407635Written as Psilocybin
- Optimizing Microdosing and MeditationWithdrawnNot applicableNational University of Natural MedicineNCT06560658Written as Psilocybin
- Consciousness, Psilocybin, and Well-BeingCompletedPhase 1University of Wisconsin, MadisonNCT05592379Written as Psilocybin
As the comparator · 6 — what is tested is compared with Psilocybin
- Psilocybin-assisted Therapy for Post-Traumatic Stress Disorder in Survivors of Intimate Partner ViolenceNot yet recruitingPhase 2University of CalgaryNCT06885996Written as Psilocybin
- Mindfulness-Assisted Psychedelic TherapyRecruitingPhase 2University of Southern CaliforniaNCT06233344Written as Psilocybin
- Investigation of Psychedelic Effects in Psychoactive SubstancesRecruitingPhase 1Johns Hopkins UniversityNCT06772753Written as Psilocybin
- Acute Effects of 2C-B Compared With MDMA and Psilocybin in Healthy SubjectsCompletedPhase 1University Hospital, Basel, SwitzerlandNCT05523401Written as Psilocybin
- Psilocybin vs Escitalopram for Major Depressive Disorder: Comparative MechanismsCompletedPhase 2Imperial College LondonNCT03429075Written as Psilocybin + Escitalopram
- Comparative Acute Effects of LSD, Psilocybin and MescalineCompletedPhase 1University Hospital, Basel, SwitzerlandNCT04227756Written as Psilocybin
What changed recently
From the registry's own updates since Oct 16, 2026.
Started recruiting3
- Effects of Psilocybin on Speech Fluency, Struggle, and Brain Activity in People Who StutterNov 10, 2026NCT07296328
- Psilocybin Therapy for Methamphetamine Use Disorder and HIVNov 9, 2026NCT07756736
- Psilocybin-assisted Therapy for Comorbid Major Depressive Disorder and Alcohol Use DisorderOct 26, 2026NCT07405606
Results posted2
- Psilocybin in Co-occuring Major Depressive Disorder and Borderline Personality DisorderOct 29, 2026NCT05399498
- Efficacy of Psilocybin in OCD: a Double-Blind, Placebo-Controlled Study.Oct 16, 2026NCT03356483
Stopped1
- Psilocybin With Intracranial Neural SensingWithdrawnNov 12, 2026NCT06919640
Newly registered2
- Psilocybin FCR Early-Stage Breast CancerNov 2, 2026NCT07909408
- Psilocybin for Depression in VeteransOct 26, 2026NCT07895134
Codes
What other systems call Psilocybin · ClinicalTrials.gg INT008125
- MeSH (NLM) D011562PsilocybinConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 2RV7212BP0PSILOCYBINConfirmed FDA, NLM, Wikidata
- Wikidata Q208118psilocybinConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C62529PsilocybineOne source FDA
- DrugBank DB11664One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D011562 | Psilocybin | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 2RV7212BP0 | PSILOCYBIN | Confirmed FDA, NLM, Wikidata |
| Wikidata | Q208118 | psilocybin | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C62529 | Psilocybine | One source FDA |
| DrugBank | DB11664 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.