Drug
Macitentan clinical trials
Also written ACT-064992, Opsumit and JNJ-67896062.
- studies test it
- 56
- open now
- 3
- in phase 3
- 23
- first study started
- 2008
Keep track of what changes. Save the macitentan studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Studies by the year they started
56 studies that test it; most in 2015 (6)
| Year | Studies |
|---|---|
| 2008 | 2 |
| 2009 | 1 |
| 2011 | 4 |
| 2012 | 1 |
| 2013 | 4 |
| 2014 | 4 |
| 2015 | 6 |
| 2016 | 2 |
| 2017 | 5 |
| 2018 | 5 |
| 2019 | 2 |
| 2020 | 5 |
| 2021 | 3 |
| 2022 | 6 |
| 2024 | 4 |
| 2025 | 2 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 2
- Phase 1
- 16
- Phase 2
- 12
- Phase 3
- 23
- Phase 4
- 5
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 46 · Other 10
Actelion (41) · Janssen Pharmaceutical K.K. (2) · Janssen Research & Development, LLC (2) · University of California, Los Angeles (2) · China-Japan Friendship Hospital (2) · Assistance Publique - Hôpitaux de Paris (1) · University of Giessen (1) · Humanis Saglık Anonim Sirketi (1)
Often tested with
Tested in the same studies.
Tadalafil (7) · Riociguat (3) · Rosuvastatin (2) · Sildenafil (1) · Moxifloxacin (1) · Selexipag (1)
Studies
Open first, then newest update. How each study uses macitentan is read from its arms, and is right about nine times in ten.
Testing it · 56
- A Study Providing Treatment Access in Participants With Pulmonary Hypertension Completing a Parent Study and Having no Other OptionRecruitingPhase 3ActelionNCT05179876Written as Macitentan
- Efficacy and Mechanisms of Macitentan for Non-Coronary Obstructive AnginaRecruitingEarly Phase 1China-Japan Friendship HospitalNCT07392281Written as Macitentan 10 mg tablet, once daily.
- Evaluation of the Efficacy of MACitentan in the Treatment of CoronaryMICrovascular Angina (MACMIC)RecruitingEarly Phase 1China-Japan Friendship HospitalNCT06811831Written as Macitentan 10 mg tablet, once daily.
- Outcome Study Assessing a 75 Milligrams (mg) Dose of Macitentan in Patients With Pulmonary Arterial HypertensionActive, not recruitingPhase 3ActelionNCT04273945Written as Macitentan 10 mg
- Effects of Combination Medical Therapy Followed by BPA on Right Ventricular-PA Coupling and Hemodynamics in CTEPHTerminatedPhase 3Dr Sudarshan RajagopalNCT05140525Written as Macitentan Tablets
- A Study of Macitentan in Japanese Pediatric Participants With Pulmonary Arterial HypertensionCompletedPhase 3Janssen Pharmaceutical K.K.NCT05167825Written as Macitentan
- A Study to Assess Whether Macitentan Delays Disease Progression in Children With Pulmonary Arterial Hypertension (PAH)CompletedPhase 3ActelionNCT02932410Written as Macitentan
- Initial Dual Oral Combination Therapy Versus Standard-of-care Initial Oral Monotherapy Prior to Balloon Pulmonary Angioplasty in Patients With Inoperable Chronic Thromboembolic Pulmonary HypertensionCompletedPhase 2/3Assistance Publique - Hôpitaux de ParisNCT04780932Written as Macitentan 10mg
- A Study to Evaluate Efficacy and Safety of Macitentan 75 mg in Inoperable or Persistent/Recurrent Chronic Thromboembolic Pulmonary HypertensionTerminatedPhase 3ActelionNCT04271475Written as Macitentan
- Clinical Study to Investigate the Effect of Macitentan on the Concentrations of Rosuvastatin in the Blood of Healthy Male SubjectsCompletedPhase 1ActelionNCT03359291Written as Macitentan
- A Study to Compare the Macitentan-tadalafil Fixed Dose Combination Tablet Relative to the Concomitant Administration of the Reference Tablets of Macitentan and Tadalafil in Healthy SubjectsCompletedPhase 1ActelionNCT03215966Written as Macitentan / tadalafil FDC
- Safety and Tolerability Study of Macitentan in Patients With Idiopathic Pulmonary FibrosisWithdrawnPhase 2ActelionNCT01346930Written as Macitentan
- A Clinical Study to Investigate the Long-term Safety of the Drug Macitentan in Patients With Pulmonary Hypertension Who Were Previously Treated With Macitentan in Clinical Studies.CompletedPhase 3ActelionNCT03422328Written as macitentan
- A Study of Fixed Dose Combination of Macitentan/Tadalafil (10 mg/20 mg) Compared to the Reference Free Combination of Macitentan and Tadalafil in Healthy Adult ParticipantsCompletedPhase 1ActelionNCT05236231Written as Macitentan 10 mg
- A Study of Two Different Test Formulations Compared to the Reference Formulation of Macitentan in Healthy Adult ParticipantsCompletedPhase 1ActelionNCT05392530Written as Macitentan
- A Study of Macitentan/Tadalafil Combination Administered a Fixed-dose Combination Formulation Compared to the Reference Free Combination of Macitentan and TadalafilCompletedPhase 1Janssen Research & Development, LLCNCT04540744Written as FDC of macitentan/tadalafil (10 mg/20 mg)
- A 2-part Study to Investigate the Effect of Macitentan in Healthy Male ParticipantsCompletedPhase 1ActelionNCT04211272Written as Macitentan
- Clinical Study to Assess the Efficacy, Safety and Tolerability of Macitentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary HypertensionCompletedPhase 2ActelionNCT02021292Written as Macitentan
- REPAIR: Right vEntricular Remodeling in Pulmonary ArterIal hypeRtensionCompletedPhase 4ActelionNCT02310672Written as Macitentan
- A Study of Two Macitentan Pediatric Formulations in Healthy Adult ParticipantsCompletedPhase 1ActelionNCT04963439Written as Macitentan
See all 56 studies that test macitentan →
Given in every arm · 3 — macitentan is usual care beside what is tested
- The Efficacy and Safety of Initial Triple Versus Initial Dual Oral Combination Therapy in Patients With Newly Diagnosed Pulmonary Arterial HypertensionCompletedPhase 3ActelionNCT02558231Written as Macitentan
- Comparison of the Pharmacokinetic Properties of Two Tablet Formulations of Macitentan in Healthy AdultsCompletedPhase 1ActelionNCT02476864Written as Treatment A (adult formulation)
- Bioequivalence Study of Macitentan and Tadalafil Film-coated Tablets 10 Mg/40 Mg and 'PrOpsynvi®' Macitentan and Tadalafil Film-coated Tablets 10 Mg/40 MgCompletedPhase 1Humanis Saglık Anonim SirketiNCT06553937Written as Macitentan and Tadalafil
As the comparator · 1 — what is tested is compared with macitentan
Codes
What other systems call macitentan · ClinicalTrials.gg INT005368
- MeSH (NLM) C533860macitentanConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) Z9K9Y9WMVLMACITENTANConfirmed FDA, NLM, Wikidata
- RxNorm 1442132Confirmed FDA, Wikidata
- Wikidata Q6724151macitentanConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C87728MacitentanOne source FDA
- DrugBank DB08932One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | C533860 | macitentan | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | Z9K9Y9WMVL | MACITENTAN | Confirmed FDA, NLM, Wikidata |
| RxNorm | 1442132 | — | Confirmed FDA, Wikidata |
| Wikidata | Q6724151 | macitentan | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C87728 | Macitentan | One source FDA |
| DrugBank | DB08932 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.