Drug
Riociguat clinical trials
Also written Adempas and MK-4836.
- studies test it
- 48
- open now
- 2
- in phase 3
- 7
- first study started
- 2007
Keep track of what changes. Save the riociguat studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Studies by the year they started
48 studies that test it; most in 2014 (7)
| Year | Studies |
|---|---|
| 2007 | 1 |
| 2008 | 3 |
| 2009 | 3 |
| 2010 | 6 |
| 2012 | 2 |
| 2013 | 1 |
| 2014 | 7 |
| 2015 | 3 |
| 2016 | 5 |
| 2017 | 3 |
| 2018 | 3 |
| 2020 | 2 |
| 2021 | 1 |
| 2022 | 3 |
| 2023 | 3 |
| 2024 | 1 |
| 2025 | 1 |
By phase
A phase 1/2 study counts in both.
- Phase 1
- 12
- Phase 2
- 18
- Phase 3
- 7
- Phase 4
- 9
- No phase
- 2
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 30 · Other 18
Bayer (27) · Actelion (2) · Medical University of Vienna (2) · Maastricht University (2) · Heidelberg University (2) · Sheffield Teaching Hospitals NHS Foundation Trust (1) · University of Colorado, Denver (1) · Danish Headache Center (1)
Often tested with
Tested in the same studies.
Macitentan (3) · Sildenafil (2) · Propylthiouracil (2) · Perphenazine (2) · Selexipag (1) · Sotatercept (1) · Rosuvastatin (1) · Ethinyl estradiol, levonorgestrel drug combination (1)
Studies
Open first, then newest update. How each study uses riociguat is read from its arms, and is right about nine times in ten.
Testing it · 48
- Switching of Sildenafil to Riociguat in CTEPH PatientsRecruitingPhase 4Chinese University of Hong KongNCT06715280Written as Riociguat (Adempas)
- Networked Drug REpurposing for Mechanism-based neuroPrOtection in Acute Ischaemic STROKERecruitingPhase 2Maastricht UniversityNCT05762146Written as Riociguat
- Riociguat in Children With Pulmonary Arterial Hypertension (PAH)Active, not recruitingPhase 3BayerNCT02562235Written as Riociguat (Adempas, BAY63-2521)
- Effects of Combination Medical Therapy Followed by BPA on Right Ventricular-PA Coupling and Hemodynamics in CTEPHTerminatedPhase 3Dr Sudarshan RajagopalNCT05140525Written as Riociguat
- A Study to Test the Effects of Riociguat in Patients With Pulmonary Hypertension Associated With Left Ventricular Systolic DysfunctionTerminatedPhase 2BayerNCT01065454Written as Riociguat (Adempas, BAY63-2521)
- Pulmonary Hypertension: Intensification and Personalisation of Combination RxActive, not recruitingPhase 4Sheffield Teaching Hospitals NHS Foundation TrustNCT05825417Written as Riociguat
- Effects of Riociguat on RIght VEntricular Size and Function in PAH and CTEPHTerminatedPhase 4Heidelberg UniversityNCT04954742Written as Riociguat
- Treatment of Exercise-Induced Pulmonary Vascular Dysfunction After Pulmonary Thromboendarterectomy or Balloon Pulmonary AngioplastyCompletedPhase 2University of Colorado, DenverNCT03409588Written as Adempas
- Efficacy and Safety of Riociguat in Incipient Pulmonary Vascular Disease as an Indicator for Early PAHTerminatedPhase 2Heidelberg UniversityNCT05339087Written as Riociguat Oral Tablet
- A Long-term Extension Study of Riociguat in Patients With Symptomatic Pulmonary Arterial Hypertension.CompletedPhase 4BayerNCT02759419Written as Adempas (Riociguat, BAY63-2521)
- A 2-part Study to Investigate the Effect of Macitentan in Healthy Male ParticipantsCompletedPhase 1ActelionNCT04211272Written as Riociguat
- Effect of Riocigaut on Migraine Attack Induction in People With MigraineCompletedNot applicableDanish Headache CenterNCT05750446Written as Riociguat (BAY 63-2521)
- Bioequivalence Study of Riociguat 2.5 mg Film Coated Tablets and Adempas (Riociguat) 2.5 mg Film Coated TabletsCompletedPhase 1Humanis Saglık Anonim SirketiNCT06180096Written as Riociguat film coated tablets
- A Study to Evaluate Efficacy and Safety of Oral BAY63-2521 in Patients With Pulmonary Arterial Hypertension (PAH)CompletedPhase 3BayerNCT00810693Written as Riociguat (Adempas, BAY63-2521)
- A Study to Evaluate Efficacy and Safety of Oral BAY63-2521 in Patients With CTEPH.CompletedPhase 3BayerNCT00855465Written as Riociguat (Adempas, BAY63-2521)
- BAY63-2521 - Long-term Extension Study in Patients With Chronic Thromboembolic Pulmonary HypertensionCompletedPhase 3BayerNCT00910429Written as Riociguat (Adempas, BAY63-2521)
- BAY63-2521:Long-term Extension Study in Patients With Pulmonary Arterial HypertensionCompletedPhase 3BayerNCT00863681Written as Riociguat (BAY63-2521)
- Early Signs of Efficacy Study With Riociguat in Adult Homozygous Delta F508 Cystic Fibrosis PatientsTerminatedPhase 2BayerNCT02170025Written as Riociguat (Adempas, BAY63-2521)
- A Multi-Center Study of Riociguat in Patients With Sickle Cell DiseasesCompletedPhase 2Mark GladwinNCT02633397Written as Riociguat
- Sleep-Disordered Breathing in Chronic Thromboembolic Pulmonary HypertensionCompletedNot applicableMedical University of ViennaNCT03074539Written as Riociguat
See all 48 studies that test riociguat →
Given in every arm · 1 — riociguat is usual care beside what is tested
As the comparator · 3 — what is tested is compared with riociguat
- Riociguat-Discontinue Effects on Right HEART in CTEPH (RED-HEART)RecruitingPhase 3Suqiao YangNCT06922240Written as Riociguat
- Effect of Riocigaut on Cerebral Vasodilation and Headache Induction in Healthy VolunteersCompletedNot applicableDanish Headache CenterNCT05582811Written as Riociguat
- Riociguat Versus Balloon Pulmonary Angioplasty in Non-operable Chronic thromboEmbolic Pulmonary HypertensionCompletedNot applicableAssistance Publique - Hôpitaux de ParisNCT02634203Written as Riociguat
Codes
What other systems call riociguat · ClinicalTrials.gg INT005474
- MeSH (NLM) C542595riociguatConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) RU3FE2Y4XIRIOCIGUATConfirmed FDA, NLM, Wikidata
- RxNorm 1439816Confirmed FDA, Wikidata
- Wikidata Q2154494riociguatConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C152225RiociguatOne source FDA
- DrugBank DB08931One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | C542595 | riociguat | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | RU3FE2Y4XI | RIOCIGUAT | Confirmed FDA, NLM, Wikidata |
| RxNorm | 1439816 | — | Confirmed FDA, Wikidata |
| Wikidata | Q2154494 | riociguat | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C152225 | Riociguat | One source FDA |
| DrugBank | DB08931 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.