Drug
Doxycycline clinical trials
Also written Vibramycin, Oracea and Doxy-100.
Includes 3 studies of Doxycycline hydrochloride and 1 study of Doxycycline anhydrous.
How each study uses Doxycycline is sorted by a rule, right about nine times in ten. Readers can ask us to read every study one by one.Ask us to read each study
Get an email when these change. Save the Doxycycline studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Approvals
The first approval found in each region, with its record
- United States
- 5 Dec 1967 · VIBRAMYCIN · NDA 050007 (FDA, Drugs@FDA)
- European Union
- Not in EMA's list of EU-wide authorisations
From FDA's Drugs@FDA and Purple Book (through openFDA) and the European Medicines Agency, files of Sept 2026 and 27 Oct 2026. National approvals in Europe and other countries are not included. How this is worked out
How studies write it
Studies that test it under each name
Name
Development codes
- Doxy-100
- 2
Studies by the year they started
252 studies that test it; most in 2020 (19); 2 more planned to start later
| Year | Studies |
|---|---|
| 1996 | 1 |
| 1997 | 1 |
| 1999 | 3 |
| 2000 | 1 |
| 2002 | 4 |
| 2003 | 3 |
| 2004 | 6 |
| 2005 | 10 |
| 2006 | 10 |
| 2007 | 11 |
| 2008 | 11 |
| 2009 | 11 |
| 2010 | 11 |
| 2011 | 10 |
| 2012 | 10 |
| 2013 | 12 |
| 2014 | 14 |
| 2015 | 8 |
| 2016 | 8 |
| 2017 | 7 |
| 2018 | 18 |
| 2019 | 9 |
| 2020 | 19 |
| 2021 | 9 |
| 2022 | 9 |
| 2023 | 6 |
| 2024 | 10 |
| 2025 | 8 |
| 2026 | 12 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it, so a study counts once.
Who runs them
Industry 31 · Other 227
National Institute of Allergy and Infectious Diseases (NIAID) (8) · University Medical Centre Ljubljana (8) · University of Washington (5) · Galderma R&D (5) · Par Pharmaceutical, Inc. (5) · University of California, San Francisco (4) · Emory University (4) · Sun Yat-sen University (4)
Often tested with
Tested in the same studies.
Azithromycin (18) · Metronidazole (9) · Rifampin (7) · Ceftriaxone (6) · Levofloxacin (6) · Ciprofloxacin (5) · Trimethoprim, Sulfamethoxazole Drug Combination (5) · Clindamycin (5)
Coming up
From the study records. Dates are the sponsors’ own estimates and often move.
Reaching primary completion within a year · 15
Studies that test Doxycycline.
- Nov 2026Treatment Results for Patients With Central Centrifugal Cicatricial Alopecia (CCCA): a Multicenter Prospective StudyPhase 4 · Wake Forest University Health Sciences
- Dec 2026These Studies That Evaluated the Efficacy of Antibiotics for Leptospirosis Treatment.Phase 4 · Chulalongkorn University
- Dec 2026Characterization of Tuberculosis Associated Lung Fibrosis and Respiratory Impairment, and Prevention Using DoxycyclinePhase 2 · Makerere University
- Dec 2026Doxycycline in Cutaneous Schwannoma (NF2)Phase 1/2 · Massachusetts Eye and Ear Infirmary
- Dec 2026MMP-9 Inhibition for Recalcitrant Wet AMDPhase 2 · University of Iowa
- Dec 2026Doxycycline Intervention for Bacterial STI ChemoprOphylaxis (DISCO)Not applicable · Jonathan Troy Grennan
- Jan 2027Lipidome and Microbiome Profile of AcnePhase 1/2 · University of California, Davis
- Jan 2027Antibiotic Prophylaxis in High-Risk Arthroplasty PatientsPhase 4 · Mayo Clinic
- Jan 2027Effects of Treatments on Atopic DermatitisPhase 2 · National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
- Feb 2027Doxycycline for Emphysema in People Living With HIV (The DEPTH Trial)Phase 2 · Weill Medical College of Cornell University
Studies
Open first, then newest update. How each study uses Doxycycline is read from its arms, and is right about nine times in ten. Ask us to read each study. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.
Testing it · 258
- Effects of Treatments on Atopic DermatitisRecruitingPhase 2National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)NCT01631617Written as Doxycycline
- Fluoroquinolone-Doxycycline Oral Treatments for Adults With Uncomplicated BrucellosisNot yet recruitingNot applicableThe First Affiliated Hospital of Shihezi UniversityNCT07887126Written as Doxycycline + Rifampicin
- A Clinical Study to Assess the Efficacy of Weekly Doxycycline Prophylaxis to Reduce Bacterial Sexually Transmitted Infections (STI) in Young African WomenNot yet recruitingPhase 3National Institute of Allergy and Infectious Diseases (NIAID)NCT07884240Written as Doxycycline hyclate
- Rickettsia Clearance StudyRecruitingPhase 2/3Lao-Oxford-Mahosot Hospital Wellcome Trust Research UnitNCT05972772Written as Doxycyclin
- Or v IV Antibiotics for InfectionEnrolling by invitationPhase 3Rothman Institute OrthopaedicsNCT04723940Written as Doxycycline Hcl
- These Studies That Evaluated the Efficacy of Antibiotics for Leptospirosis Treatment.Not yet recruitingPhase 4Chulalongkorn UniversityNCT07865156Written as Doxycycline
- Regenerative Medicine for Joint Hypermobility and InstabilityNot yet recruitingPhase 1/2Manhattan Pain Medicine, PLLCNCT07688096Written as Doxycycline Hyclate Injectable (Investigational)
- Azithromycin Versus Doxycycline in Hospitalized Adult Patients With Community Acquired Pneumonia Treated With Beta-lactamsRecruitingPhase 4Mayo ClinicNCT07164131Written as Doxycycline
- AUTOP 2: Screen-and-treat Strategy for Vaginal Flora Abnormalities by Molecular Biology in Pregnant Women at High Risk of Preterm BirthNot yet recruitingPhase 3Assistance Publique Hopitaux De MarseilleNCT06349122Written as Doxycyclin
- Comparisons of Treatment Responses of Early Syphilis to Benzathine Penicillin G With or Without DoxycyclineRecruitingNot applicableNational Taiwan University HospitalNCT06069141Written as Doxycycline Capsule
- A Randomized Controlled Trial of Doxycycline Post Exposure Prophylaxis to Prevent Incident Bacterial STIs Among Women in the United StatesNot yet recruitingPhase 4Tulane UniversityNCT07704957Written as Doxycycline
- Doxycycline Use in Post-Operative SeromasRecruitingPhase 2University of MiamiNCT07498010Written as Doxycycline
- Antibiotic Prophylaxis in High-Risk Arthroplasty PatientsEnrolling by invitationPhase 4Mayo ClinicNCT04297592Written as Doxycycline
- Doxycycline Host-directed Therapy to Improve Lung Function and Decrease Tissue Destruction in Pulmonary TuberculosisRecruitingPhase 3National University Hospital, SingaporeNCT05473520Written as Doxycycline
- Isotretinoin vs. Doxycycline for Acneiform Rash in Patients Receiving Drugs That Target the MAPK PathwayNot yet recruitingPhase 2University of California, San FranciscoNCT07629167Written as Doxycycline
- Adjunctive Doxycycline for Central Nervous System TuberculosisRecruitingPhase 2National University Hospital, SingaporeNCT06446245Written as Doxycycline
- Finding the Optimal Regimen for Mycobacterium Abscessus TreatmentRecruitingPhase 2/3The University of QueenslandNCT04310930Written as Doxycycline
- Got Doxy- 'Flipping the Script' on STI PEPRecruitingPhase 4Emory UniversityNCT07215325Written as Doxycycline monohydrate 200 mg
- Comparing Sarecycline and Doxycycline Effects on the Skin and Gut Bacteria in Acne.RecruitingPhase 4Integrative Skin Science and ResearchNCT07544251Written as Doxycycline
- MMP-9 Inhibition for Recalcitrant Wet AMDRecruitingPhase 2University of IowaNCT04504123Written as Doxycycline Hyclate
See all 258 studies that test Doxycycline →
Given beside what is tested · 25 — Doxycycline is usual care or a partner of the new treatment
- Doxycycline Boosted Therapy in Lyme Borreliosis: DoBo Study.Not yet recruitingPhase 4Radboud University Medical CenterNCT07230028Written as Doxycycline
- The Efficacy and Safety of Anti-inflammation Treatment (Hirudoid Introduction Followed by Yellow Light Therapy) Combined With Tofacitinib and Doxycycline in Chinese Adult Patients With Mild to Moderate Erythematous Telangiectatic RosaceaRecruitingNot applicableThe Fourth Affiliated Hospital of Zhejiang University School of MedicineNCT07343635Written as Doxycycline
- Testing a Novel Combination Treatment (Arm D) Versus Standard of Care for Intensive Phase Treatment for Mycobacterium Abscessus Pulmonary Disease in People With or Without Cystic Fibrosis in the Finding the Optimal Regimen for Mycobacterium Abscessus Treatment (FORMaT) Adaptive Platform TrialNot yet recruitingPhase 2The University of QueenslandNCT07485010Written as Doxycycline
- Combination Therapy Between Doxycycline, Pentoxifylline, and Nitazoxanide in Sexually Active MenNot yet recruitingPhase 2/3Tanta UniversityNCT05897034Written as Doxycyclin
- Enhanced Dermatological Care to Reduce Rash and Paronychia in Epidermal Growth Factor Receptor (EGRF)-Mutated Non-Small Cell Lung Cancer (NSCLC) Treated First-line With Amivantamab Plus LazertinibActive, not recruitingPhase 2Janssen Research & Development, LLCNCT06120140Written as Doxycycline
- Pembrolizumab With Intratumoral Injection of Clostridium Novyi-NTCompletedPhase 1M.D. Anderson Cancer CenterNCT03435952Written as Doxycycline
- Parrying the Pitfalls of PrEP: Project PEACHCompletedPhase 4Emory UniversityNCT05072093Written as Offering of STI PEP
- Treatment Responses of Early Syphilis to Ceftriaxone Plus DoxycyclineTerminatedPhase 4National Taiwan University HospitalNCT05980871Written as Doxycycline
- Combined Diagnostic Approach for Refractory Mycoplasma Pneumonia in ChildrenCompletedNot applicableChildren's Hospital of Hebei ProvinceNCT07064278Written as Azithromycin, Doxycycline, Prednisone
- Lefamulin for M. Genitalium Treatment FailuresTerminatedPhase 1/2University of WashingtonNCT05111002Written as Doxycycline
- Tenofovir/Emtricitabine With Doxycycline for Combination HIV and Syphilis Pre-exposure Prophylaxis in HIV-negative MSMCompletedPhase 4British Columbia Centre for Disease ControlNCT02844634Written as Doxycycline 100mg PO daily x 12 months
- Cefixime Plus Doxycycline Compared to Ceftriaxone Plus Azithromycin for Treatment of GonorrhoeaCompletedPhase 4Bulovka HospitalNCT06090565Written as Doxycyclin
- A Treatment for Severe Inflammatory Acne SubjectsCompletedPhase 4Galderma R&DNCT02899000Written as Oral doxycycline hyclate
- A Study to Compare Efficacy and Safety of Trifarotene Cream When Used With an Oral Antibiotic for the Treatment of Severe Acne Vulgaris (AV)CompletedPhase 4Galderma R&DNCT04451330Written as Doxycycline hyclate
- Effect of Antimalarial Drugs to Rabies Vaccine for Post-exposure Prophylaxis.CompletedPhase 4State University of New York - Upstate Medical UniversityNCT02564471Written as Doxycycline
- Oracea Soolantra Association in Participants With Severe RosaceaCompletedPhase 4Galderma R&DNCT03075891Written as Doxycycline 40 mg MR (30 mg Immediate Release & 10 mg Delayed Release beads) capsules
- Efficacy of Topical Azelaic Acid 15% Gel Plus Anti-inflammatory Dose Doxycycline or Metronidazole Gel 1% Plus Anti-inflammatory Dose Doxycycline in Moderate Papulopustular RosaceaCompletedPhase 4LEO PharmaNCT00855595Written as Doxycycline (Oracea)
- Pre-emptive Cycline Treatment on Cetuximab Induced Skin Toxicity in Colorectal CancerTerminatedNot applicableInstitut Cancerologie de l'OuestNCT01317433Written as Doxycycline
- Persistent Methicillin Resistant Staphylococcus Aureus Eradication Protocol (PMEP)CompletedPhase 2Johns Hopkins UniversityNCT01594827Written as Doxycycline
- Study Of Dacomitinib (PF-00299804) In Advanced NSCLC Patients (Post Chemo Or Select First Line) To Evaluate Prophylactic Intervention On Derm And GI AEs And PROCompletedPhase 2PfizerNCT01465802Written as Doxycycline
Showing 20 of 25.
As the comparator · 19 — what is tested is compared with Doxycycline
- All-Oral Fluoroquinolone-Based Triple Therapies for Adults With Imaging-Confirmed Osteoarticular BrucellosisNot yet recruitingNot applicableThe First Affiliated Hospital of Shihezi UniversityNCT07887152Written as Doxycycline + Rifampicin + Ceftriaxone (intravenous therapy for 4 weeks)
- Randomized Double-blind Study on the Benefit of Spironolactone for Treating Acne of Adult Woman.CompletedPhase 3Nantes University HospitalNCT03334682Written as Doxycycline
- Comparative Effectiveness Study of Spironolactone Versus Doxycycline for AcneActive, not recruitingPhase 4University of PennsylvaniaNCT04582383Written as Doxycycline Hyclate
- Clinical Effectiveness of Tigecycline for Scrub Typhus.CompletedNot applicableJin Soo LeeNCT07513103Written as doxycycline
- Efficacy of Oral Metformin vs Oral Doxycycline in Treating Acne VulgarisCompletedPhase 4Ghurki Trust and Teaching HospitalNCT07357337Written as Oral doxycycline
- Effect of Topical Azithromycin on Tear Film Thickness in Patients With Meibomian Gland DysfunctionCompletedPhase 4Medical University of ViennaNCT03162497Written as Doxycycline
- A Randomized, Double-Blind Study to Assess the Safety, Efficacy and Tolerability of Oral DFD-29 Capsules for the Treatment of Rosacea.CompletedPhase 3Journey Medical CorporationNCT05296629Written as Doxycycline
- A Study to Assess the Safety, Efficacy and Tolerability of Oral DFD-29 Capsules for the Treatment of Rosacea (MVOR-2)CompletedPhase 3Journey Medical CorporationNCT05343455Written as Doxycycline
- Tenofovir/Emtricitabine With Doxycycline for Combination HIV and Syphilis Pre-exposure Prophylaxis in HIV-negative MSMCompletedPhase 4British Columbia Centre for Disease ControlNCT02844634Written as Doxycycline 100mg PO daily x 12 months
- Antimicrobial Therapy for Ulcerative Colitis (UC)TerminatedPhase 2Wolfson Medical CenterNCT03986996Written as amoxicillin, metronidazole and doxycycline
- Placebo Controlled Efficacy and Safety Study of CD2475/101 40 mg Tablets vs. Placebo and Doxycycline 100 mg Capsules Once Daily in the Treatment of Inflammatory Lesions of Acne VulgarisCompletedPhase 2Galderma R&DNCT01320033Written as Doxycycline 100 mg
- Safety and Efficacy of Ivermectin and Doxycycline in Treatment of Covid-19Status unknownPhase 2Bangladesh Medical Research Council (BMRC)NCT04551755Written as Ivermectin and Doxycycline
- Spironolactone in Preventing Rash in Patients With Advanced Cancer Receiving Panitumumab and CetuximabCompletedPhase 2Academic and Community Cancer Research UnitedNCT01867294Written as Doxycycline
- Indwelling Pleural Catheter With Either Doxycycline or Saline at Day 7 for PleurodesisTerminatedPhase 4M.D. Anderson Cancer CenterNCT02623959Written as Doxycycline
- Comparison of Two Preemptive Treatment Strategies of Panitumumab Mediated Skin Toxicity and Assessment of QoL in Patient With Ras-wt Colorectal CancerCompletedPhase 2AIO-Studien-gGmbHNCT01668498Written as Doxycycline
- A Clinical Trial of YH14642 in Patients With Chronic Periodontal DiseaseCompletedPhase 2Yuhan CorporationNCT01499225Written as DENTISTA[Doxycycline hyclate] 20mg Cap
- Oral Azithromycin Versus Doxycycline in Posterior BlepharitisCompletedPhase 2Tehran University of Medical SciencesNCT01783860Written as Doxycycline
- Azithromycin/Bicillin SyphilisCompletedPhase 3National Institute of Allergy and Infectious Diseases (NIAID)NCT00031499Written as Doxycycline
- the Comparison Efficacy of Azithromycin With Doxycycline in the Treatment of Acne VulgarisStatus unknownPhase 2Shahid Beheshti University of Medical SciencesNCT00419848Written as Doxycycline
What changed recently
From the registry's own updates since Oct 15, 2026.
Stopped1
- Efficacy & Safety of Fluoroquinolone-Based Brucellosis Regimens (BRUCE)WithdrawnOct 27, 2026NCT07779629
Newly registered2
Codes
What other systems call Doxycycline · ClinicalTrials.gg INT007400
- MeSH (NLM) D004318DoxycyclineConfirmed ClinicalTrials.gov, NLM
- UNII (FDA) N12000U13ODOXYCYCLINEConfirmed FDA, NLM, Wikidata
- RxNorm 203122Confirmed FDA, Wikidata
- Wikidata Q27128318doxycycline monohydrateConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C457DoxycyclineConfirmed FDA, Wikidata
- DrugBank DBSALT001956One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D004318 | Doxycycline | Confirmed ClinicalTrials.gov, NLM |
| UNII (FDA) | N12000U13O | DOXYCYCLINE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 203122 | — | Confirmed FDA, Wikidata |
| Wikidata | Q27128318 | doxycycline monohydrate | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C457 | Doxycycline | Confirmed FDA, Wikidata |
| DrugBank | DBSALT001956 | — | One source Wikidata |
Also registered as doxycycline calcium (UNII 8ZL07I20SB · RxNorm 82012) and doxycycline hyclate (UNII 19XTS3T51U · RxNorm 23663).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.