Lyme Disease clinical trials
The registry lists 97 studies for Lyme Disease across more than 10 countries. 26 are recruiting or about to start. 67 of them are mainly about Lyme Disease (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-09. Counting its narrower condition Post-Lyme Disease Syndrome too: 106 studies, 29 open.
Get an email when these change. Save the Lyme Disease studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
University Medical Centre Ljubljana (14) · National Institute of Allergy and Infectious Diseases (NIAID) (12) · Pfizer (8) · University Hospital, Strasbourg, France (7) · Research Foundation for Mental Hygiene, Inc. (3) · National Institute of Neurological Disorders and Stroke (NINDS) (2) · Tarsus Pharmaceuticals, Inc. (2) · Children's National Research Institute (2)
What is being tested here
Drugs under test in Lyme Disease studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Dec 2026A Study to Learn About the Safety, Tolerability, and Immunogenicity of a Fifth Dose of 6-Valent OspA-Based Lyme Disease Vaccine · Phase 3 · Pfizer
- Nov 2026taVNS for Persistent Symptoms From Lyme Disease · Columbia University
- Nov 2026Borrelia B-cell Diagnostics · University Children's Hospital, Zurich
- Dec 2026Effectiveness of an Intervention Combining Adapted Physical Activity and Therapeutic Education in Patients With Chronic Symptoms Attributed to Lyme Borreliosis. · Centre Hospitalier Universitaire de Saint Etienne
- Dec 2026Pregnancy and Early Neurodevelopmental Outcomes Following In Utero Lyme Disease Exposure · Children's National Research Institute
- Dec 2026Lumbrokinase for Adults With Long Covid, Post-treatment Lyme Disease Syndrome, and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome · Icahn School of Medicine at Mount Sinai
- Dec 2026Effect of Saccharomyces Boulardii CNCM I-745 on Gut Microbiota in Patients Undergoing Antibiotic Therapy (in the Context of Erythema Migrans (Early Skin Form of Lyme Borreliosis)) · Biocodex
- Dec 2026Navigating Pregnancy and Parenthood With Lyme Disease · Children's National Research Institute
- Dec 2026Clinicaly Manifested Reinfections with Borrelia Burgdorferi Sensu Lato · University Medical Centre Ljubljana
- Jun 2027Transcranial Direct Current Stimulation for Post Treatment Lyme Disease · Columbia University
Who these studies take
Of the 18 Lyme Disease studies recruiting now, 11 (61%) set no upper age limit and 3 (17%) stop at 75 or younger. 7 (39%) take children under 18. 1 (6%) are for women only and 0 (0%) for men only; 5 (28%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 6 (33%) | 6 (33%) |
| 18 | 17 (94%) | 16 (89%) |
| 30 | 17 (94%) | 16 (89%) |
| 40 | 17 (94%) | 16 (89%) |
| 50 | 17 (94%) | 16 (89%) |
| 65 | 17 (94%) | 16 (89%) |
| 75 | 15 (83%) | 14 (78%) |
| 85 | 15 (83%) | 14 (78%) |
Across all 97 studies, recruiting or not: 31% stop at 75 or younger and 24% at 65; 33% take children; 1% are for women only and 0% for men only; 42% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered2
- FINtick - a Prospective Multicenter Study on Tick-borne Infections in FinlandOct 27, 2026NCT07897825
- Experiences and Care Pathways Shared on Social Media Regarding 5 Conditions Causing Chronic PainOct 13, 2026NCT07871578
Studies
Recruiting first, then most recently updated. Showing 50 of 97. Browse all 97 → or search them.
- Evaluation, Treatment, and Follow-up of Patients With Lyme DiseaseRecruitingNCT000280801 country
- Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at SanfordRecruitingNCT017931681 country
- FINtick - a Prospective Multicenter Study on Tick-borne Infections in FinlandRecruitingNCT078978251 country
- A Comprehensive Clinical, Microbiological and Immunological Assessment of Patients With Suspected Post Treatment Lyme Disease Syndrome and Selected Control PopulationsRecruitingNCT000015391 country
- The Precision Mito- Mito Map COMPASS StudyNot yet recruitingNCT078561211 country
- Effectiveness of an Intervention Combining Adapted Physical Activity and Therapeutic Education in Patients With Chronic Symptoms Attributed to Lyme Borreliosis.RecruitingNCT05641116Not applicable1 country
- Human Immune Response to Ixodes Scapularis Tick BitesRecruitingNCT05036707Phase 1/21 country
- Flow Cytometric Immune Monitoring of B. Afzelii-Specific T LymphocytesNot yet recruitingNCT077037871 country
- Navigating Pregnancy and Parenthood With Lyme DiseaseRecruitingNCT063977941 country
- Pregnancy and Early Neurodevelopmental Outcomes Following In Utero Lyme Disease ExposureRecruitingNCT060269691 country
- Transcranial Direct Current Stimulation for Post Treatment Lyme DiseaseRecruitingNCT06915324Not applicable1 country
- taVNS for Persistent Symptoms From Lyme DiseaseRecruitingNCT05776251Not applicable1 country
- A Study to Learn About the Safety, Tolerability, and Immunogenicity of a Fifth Dose of 6-Valent OspA-Based Lyme Disease VaccineRecruitingNCT07500506Phase 32 countries
- Borrelia B-cell DiagnosticsRecruitingNCT060454161 country
- Lumbrokinase for Adults With Long Covid, Post-treatment Lyme Disease Syndrome, and Myalgic Encephalomyelitis/Chronic Fatigue SyndromeRecruitingNCT06511050Phase 1/21 country
- Rheumatology Patient Registry and BiorepositoryRecruitingNCT044020861 country
- Borrelia Arthritis - a Hidden Cause of Arthritis in Danish Patients?Not yet recruitingNCT07351721
- A Multicenter Real-life Study of Disseminated Borreliosis Cases Occurring in Patients Receiving Anti-CD20 Treatment in FranceRecruitingNCT073430891 country
- Effect of Saccharomyces Boulardii CNCM I-745 on Gut Microbiota in Patients Undergoing Antibiotic Therapy (in the Context of Erythema Migrans (Early Skin Form of Lyme Borreliosis))RecruitingNCT06451913Phase 41 country
- Safety and Effectiveness of the BlinkER System in Participants With Facial Nerve PalsyNot yet recruitingNCT06542289Not applicable1 country
- Anti-phospolipid Antibodies in Lyme BorreliosisNot yet recruitingNCT069295461 country
- Serological Measurement of Montpellier Professionals' Contacts with Infectious Agents Responsible for Animal-borne DiseasesNot yet recruitingNCT06859619Not applicable1 country
- Quest to Analyze One Thousand Humans MeditatingEnrolling by invitationNCT065833951 country
- Risk of Exposure and Prevention of Ticks and Tick-borne Diseases Among Foresters in AlsaceRecruitingNCT064926681 country
- Central Nervous System Infections in DenmarkRecruitingNCT034184411 country
- Lyme Disease Diagnostic Assay - Collection of Whole BloodEnrolling by invitationNCT050415951 country
- Searching for Persistence of Infection in Lyme DiseaseCompletedNCT01143558Early Phase 11 country
- Experiences and Care Pathways Shared on Social Media Regarding 5 Conditions Causing Chronic PainCompletedNCT078715781 country
- A Non-Interventional Pilot Study to Explore the Role of Gut Flora in DiseaseSuspendedNCT040314691 country
- Phase 2 Study Of VLA15, A Vaccine Candidate Against Lyme Borreliosis, In A Healthy Pediatric And Adult Study PopulationCompletedNCT04801420Phase 21 country
- A Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of mRNA-1982 to Prevent Lyme Disease in Healthy Participants (18 to 70 Years of Age)Active, not recruitingNCT07561294Phase 21 country
- A Study to Evaluate the Safety and Immunogenicity of mRNA-1975 and mRNA-1982 Against Lyme Disease in Participants 18 Through 70 Years of AgeCompletedNCT05975099Phase 1/21 country
- A Study to Evaluate Safety and Efficacy of TP-05 in Healthy Participants With Tick ExposureActive, not recruitingNCT07562087Phase 21 country
- An Efficacy, Safety, Tolerability, Immunogenicity, and Lot-Consistency Clinical Trial of a 6-Valent OspA-Based Lyme Disease Vaccine (VLA15)CompletedNCT05477524Phase 37 countries
- Safety Study of a Vaccine to Help Protect Against Lyme Disease in Healthy ChildrenCompletedNCT05634811Phase 31 country
- A Study to Learn About Different Dosing Schedules of a Lyme Disease Vaccine in Healthy AdultsActive, not recruitingNCT07226882Phase 31 country
- Symptomatic Management of Lyme ArthritisTerminatedNCT04038346Phase 31 country
- A School-Based Intervention to Reduce Lyme DiseaseCompletedNCT00594997Not applicable
- A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Lyme DiseaseWithdrawnNCT041482221 country
- Clinicaly Manifested Reinfections with Borrelia Burgdorferi Sensu LatoActive, not recruitingNCT068350751 country
- Disulfiram: A Test of Symptom Reduction Among Patients With Previously Treated Lyme DiseaseCompletedNCT03891667Phase 1/21 country
- BOrrelia BUrgdorferi IN Children and AdolescentsCompletedNCT058568121 country
- A Human Tick Kill Study to Investigate the Safety, Tolerability, and Whole Blood Concentration of TP-05CompletedNCT05387083Phase 21 country
- Perceptions,Social Representations and Experience of Lyme Borreliosis and Ticks in Adolescents Likely to be Infected and Their ParentsCompletedNCT056784781 country
- Xenodiagnosis After Antibiotic Treatment for Lyme DiseaseCompletedNCT02446626Not applicable1 country
- Feasibility of Teleyoga for Treatment of Lyme DiseaseCompletedNCT04867473Not applicable1 country
- Evaluation and Follow-up of People With Tick-borne DiseasesWithdrawnNCT043189251 country
- Place of Intrathecal CXCL-13 in the Diagnosis of Lyme NeuroborreliosisStatus unknownNCT056251001 country
- Meditation and Stretching for Post Treatment Lyme Disease SyndromeTerminatedNCT02344537Not applicable1 country
- Alternative Schedule Study For VLA15, a Vaccine Candidate Against Lyme BorreliosisCompletedNCT03970733Phase 21 country