Syphilis clinical trials
The registry lists 126 studies for Syphilis across more than 10 countries. 34 are recruiting or about to start. 77 of them are mainly about Syphilis (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-09.
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Breast cancer · Recruiting: 2 came in, 3 changed
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A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
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· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
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Who runs them
National Institute of Allergy and Infectious Diseases (NIAID) (6) · University of Washington (4) · London School of Hygiene and Tropical Medicine (4) · National Taiwan University Hospital (3) · Peking Union Medical College Hospital (3) · University of North Carolina, Chapel Hill (3) · The University of Texas Health Science Center, Houston (3) · Population Council (3)
What is being tested here
Drugs under test in Syphilis studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Jan 2027Cefixime Clinical Trial · Phase 3 · University of Southern California
- Dec 2026This Study Evaluates the ALPCO Syphilis-T and Syphilis-NT CLIA Kits for Detecting Syphilis Antibodies in Serum and Plasma. Samples From At-risk, HIV-positive, Pregnant, and Healthy Individuals Will Assess Assay Performance Versus Established Comparator Tests. · American Laboratory Products Company
- Dec 2026The Feasibility of Implementing Syphilis Point-of-care Testing Into a Prenatal Clinic for People Facing Barriers to Care · McMaster University
- Dec 2026Peer Delivered HIV/Syphilis Self-Testing with Assisted Partner Notification Services · Makerere University
- Dec 2026MAGIA H3S Point of Care Test Performance for HIV, HBV, HCV, and Syphilis Screening in Pregnant Women in DR Congo · Gardiens de Vies
- Jan 2027Study of Ceftriaxone and Benzathine Penicillin G During Pregnancy · International Maternal Pediatric Adolescent AIDS Clinical Trials Group
- Jun 2027Pilot HIV Self-Testing And Self-collected STI Testing Strategy for Sex Worker Empowerment Study · University of North Carolina, Chapel Hill
- Jun 2027Treponemal Shedding, Load, and Viability, in Women and Men-who-have-sex-with-women-only With Early Infectious Syphilis: Implications for Transmission · Monash University
- Aug 2027Feasibility and Acceptability of Point of Care Rapid Syphilis Testing Among Patients Seeking Family Planning Services in Hawai'i · Queen's Medical Center
- Oct 2027Doxi-Rio: Study on the Use of Doxycycline to Prevent Sexually Transmitted Infections in Rio de Janeiro · Oswaldo Cruz Foundation
Who these studies take
Of the 22 Syphilis studies recruiting now, 15 (68%) set no upper age limit and 6 (27%) stop at 75 or younger. 12 (55%) take children under 18. 6 (27%) are for women only and 1 (5%) for men only; 13 (59%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 4 (18%) | 1 (5%) |
| 18 | 21 (95%) | 15 (68%) |
| 30 | 19 (86%) | 14 (64%) |
| 40 | 19 (86%) | 14 (64%) |
| 50 | 17 (77%) | 12 (55%) |
| 65 | 16 (73%) | 12 (55%) |
| 75 | 16 (73%) | 12 (55%) |
| 85 | 16 (73%) | 12 (55%) |
Across all 126 studies, recruiting or not: 21% stop at 75 or younger and 20% at 65; 34% take children; 20% are for women only and 22% for men only; 52% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Syphilis studies take
Of 25 interventional studies with no phase under Syphilis, half reached primary completion within 29 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 29 mo9–42 · 25 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 11, 2026.
Newly registered2
- Daily, Weekly, or Event-driven Doxycycline for STI Prevention Among Men Who Have Sex With Men (MSM) Engaging in Chemsex: The DOSE Non-inferiority TrialNov 9, 2026NCT07925255
- A Clinical Study to Assess the Efficacy of Weekly Doxycycline Prophylaxis to Reduce Bacterial Sexually Transmitted Infections (STI) in Young African WomenOct 20, 2026NCT07884240
Studies
Recruiting first, then most recently updated. Showing 50 of 126. Browse all 126 → or search them.
- Daily, Weekly, or Event-driven Doxycycline for STI Prevention Among Men Who Have Sex With Men (MSM) Engaging in Chemsex: The DOSE Non-inferiority TrialNot yet recruitingNCT07925255Phase 41 country
- Pilot HIV Self-Testing And Self-collected STI Testing Strategy for Sex Worker Empowerment StudyNot yet recruitingNCT07829133Not applicable1 country
- A Clinical Study to Assess the Efficacy of Weekly Doxycycline Prophylaxis to Reduce Bacterial Sexually Transmitted Infections (STI) in Young African WomenNot yet recruitingNCT07884240Phase 34 countries
- Doxycycline Prophylaxis for Prevention of Sexually Transmitted InfectionsRecruitingNCT06738407Phase 41 country
- A Seek, Test, and Treat Intervention to Reduce Chlamydia Trachomatis DisparitiesRecruitingNCT06428643Not applicable1 country
- Feasibility and Acceptability of Point of Care Rapid Syphilis Testing Among Patients Seeking Family Planning Services in Hawai'iRecruitingNCT073589491 country
- This Study Evaluates the ALPCO Syphilis-T and Syphilis-NT CLIA Kits for Detecting Syphilis Antibodies in Serum and Plasma. Samples From At-risk, HIV-positive, Pregnant, and Healthy Individuals Will Assess Assay Performance Versus Established Comparator Tests.RecruitingNCT070898361 country
- Strengthening, Guidance, Health, EmpowermentNot yet recruitingNCT07788599Not applicable1 country
- Improving Maternal and Child Health Through Point-of-care STI TestingRecruitingNCT07290439Not applicable1 country
- Rapid HIV, Hep C, and Syphilis Screening in a Rural Street Medicine ClinicRecruitingNCT073176871 country
- Study of Ceftriaxone and Benzathine Penicillin G During PregnancyRecruitingNCT072078762 countries
- Comparisons of Treatment Responses of Early Syphilis to Benzathine Penicillin G With or Without DoxycyclineRecruitingNCT06069141Not applicable1 country
- A Randomized Controlled Trial of Doxycycline Post Exposure Prophylaxis to Prevent Incident Bacterial STIs Among Women in the United StatesNot yet recruitingNCT07704957Phase 4
- The Feasibility of Implementing Syphilis Point-of-care Testing Into a Prenatal Clinic for People Facing Barriers to CareRecruitingNCT06829602Not applicable1 country
- Offering Routine and Rapid Point of Care (POC) Syphilis Testing in Pregnant Patients Presenting to the Emergency DepartmentRecruitingNCT06645106Not applicable1 country
- Cefixime Clinical TrialRecruitingNCT04958122Phase 31 country
- Integrated Care Versus Usual Care for Opioid Use Disorder and Infectious Diseases in VeteransNot yet recruitingNCT06766331Not applicable1 country
- Evaluation of Free STI Testing Pilot Projects in Lucerne and Zurich, SwitzerlandNot yet recruitingNCT07516912
- Treponemal Shedding, Load, and Viability, in Women and Men-who-have-sex-with-women-only With Early Infectious Syphilis: Implications for TransmissionRecruitingNCT073002544 countries
- Doxi-Rio: Study on the Use of Doxycycline to Prevent Sexually Transmitted Infections in Rio de JaneiroRecruitingNCT07500415Not applicable1 country
- The Efficacy of Doxycycline Post Exposure Prophylaxis for Preventing STIs Among MSM in Bangkok, Thailand.RecruitingNCT07397403Phase 41 country
- MAGIA H3S Point of Care Test Performance for HIV, HBV, HCV, and Syphilis Screening in Pregnant Women in DR CongoNot yet recruitingNCT07388979
- Clinical Performance Evaluation of MagIA IVD-MD Multiplex Testing (HIV/HBV/HCV/Syphilis)RecruitingNCT071707482 countries
- A Cross-sectional Investigational Study to Evaluate the Sensitivity, Specificity, and Utility of the MedMira Inc. Multiplo® Complete Syphilis (TP/nTP) Antibody Test (POCT) to Diagnose Infectious Syphilis in Participants Attending the Sexual Health Clinic in Ottawa, Ontario.RecruitingNCT06586905Not applicable1 country
- Modernizing Perinatal Syphilis TestingRecruitingNCT06082453Not applicable1 country
- Congenital and Maternal Point of Care Rapid Testing for Syphilis Study, UgandaNot yet recruitingNCT071737641 country
- Daily Doxycycline for Early SyphillisRecruitingNCT06683638Phase 21 country
- LIMIT Trial - Lidocaine With Intramuscular Injection of Benzathine Penicillin G for Treponema Pallidum TreatmentRecruitingNCT06391125Phase 31 country
- Peer Delivered HIV/Syphilis Self-Testing with Assisted Partner Notification ServicesEnrolling by invitationNCT06791928Phase 21 country
- Evaluation of the Diagnostic Sensitivity and Specificity of the Determine™ Syphilis Advanced Test.Not yet recruitingNCT06584214Not applicable1 country
- The TRIple Elimination Model Of Mother-to-child Transmission Program (TRI-MOM)RecruitingNCT05951751Not applicable2 countries
- MENJAGA: Continuous Quality Improvement for Antenatal HIV, Syphilis and Hepatitis B Testing in IndonesiaNot yet recruitingNCT06058286Not applicable1 country
- Syphilis and HIV Point of Care Testing (POCT) in SaskatchewanRecruitingNCT05863117Not applicable1 country
- Vienna HIV Infection Via Sex StudyRecruitingNCT053260611 country
- Linezolid for Syphilis Pilot StudyCompletedNCT05548426Phase 21 country
- Periodic Presumptive Treatment vs. doxyPEP for STI Control in Kenyan MSMActive, not recruitingNCT06468462Phase 41 country
- Validation of Self Testing Using the INSTI Multiplex HIV1/2 Syphilis Antibody TestTerminatedNCT06953024Not applicable1 country
- Investigational Study to Evaluate the DPP® Syphilis Screen & Confirm Antibody Point-of-care Test (POCT) to Diagnose Infectious SyphilisCompletedNCT069278431 country
- HPV Infection, Sexually Transmitted Infections and Anal Dysplasia in the Transgender PopulationCompletedNCT059818071 country
- Spotting Syphilis: A Dual Point-of-Care Syphilis Screening Initiative in a Low-Resource Healthcare SettingCompletedNCT07498153Not applicable1 country
- Alternative Antibiotics for SyphilisCompletedNCT05069974Phase 32 countries
- Superiority of On-demand PrEP Versus PEP on Using Doxycycline for Preventing STI in MSMActive, not recruitingNCT06188442Phase 41 country
- Ending the HIV Epidemic Through Point-of-Care Technologies (EHPOC)CompletedNCT04793750Not applicable1 country
- Treatment Responses of Early Syphilis to Ceftriaxone Plus DoxycyclineTerminatedNCT05980871Phase 41 country
- Combination Primary Care and Prevention Services for Women Who Inject Drugs and Exchange Sex in Seattle, WashingtonCompletedNCT06187064Not applicable1 country
- Evaluation of the Sensitivity, Specificity, and Utility of the Reveal® TP (Syphilis) Antibody POCTCompletedNCT05831098Not applicable1 country
- Clinical Trial of Doxycycline VS BPG for Early Syphilis (SY-DOXY)CompletedNCT04838717Phase 31 country
- Investigating Point-of-care Diagnostics for Sexually Transmitted Infections and Antimicrobial Resistance in Primary Care in ZimbabweCompletedNCT05541081Not applicable1 country
- Building Mobile HIV Prevention and Mental Health Support in Low-resource SettingsCompletedNCT03912753Not applicable1 country
- Impact of Covid-19 on SyphilisActive, not recruitingNCT071508711 country