Syphilis clinical trials
The registry lists 120 studies for Syphilis across more than 10 countries. 34 are recruiting or about to start. Per ClinicalTrials.gov, last updated 2026-09-21.
Status
- Completed
- 58
- Recruiting
- 23
- Status unknown
- 13
- Not yet recruiting
- 10
- Active, not recruiting
- 9
- Terminated
- 4
Phase
- Phase 4
- 16
- Phase 2
- 9
- Phase 3
- 9
- Phase 1
- 3
Where
- United States
- 36
- Canada
- 11
- China
- 7
- Uganda
- 6
- United Kingdom
- 5
- Argentina
- 5
Who runs them
National Institute of Allergy and Infectious Diseases (NIAID) (5) · University of Washington (5) · Hospital de Niños R. Gutierrez de Buenos Aires (4) · London School of Hygiene and Tropical Medicine (4) · The University of Texas Health Science Center, Houston (3) · Peking Union Medical College Hospital (3) · National Taiwan University Hospital (3) · University of North Carolina, Chapel Hill (3)
Studies
Recruiting first, then most recently updated. Showing 50 of 120 — search for more.
- A Seek, Test, and Treat Intervention to Reduce Chlamydia Trachomatis DisparitiesRecruitingNCT06428643Not applicable1 country
- Pilot HIV Self-Testing And Self-collected STI Testing Strategy for Sex Worker Empowerment StudyNot yet recruitingNCT07829133Not applicable1 country
- This Study Evaluates the ALPCO Syphilis-T and Syphilis-NT CLIA Kits for Detecting Syphilis Antibodies in Serum and Plasma. Samples From At-risk, HIV-positive, Pregnant, and Healthy Individuals Will Assess Assay Performance Versus Established Comparator Tests.RecruitingNCT070898361 country
- Strengthening, Guidance, Health, EmpowermentNot yet recruitingNCT07788599Not applicable1 country
- Improving Maternal and Child Health Through Point-of-care STI TestingRecruitingNCT07290439Not applicable1 country
- Rapid HIV, Hep C, and Syphilis Screening in a Rural Street Medicine ClinicRecruitingNCT073176871 country
- Comparisons of Treatment Responses of Early Syphilis to Benzathine Penicillin G With or Without DoxycyclineRecruitingNCT06069141Not applicable1 country
- Study of Ceftriaxone and Benzathine Penicillin G During PregnancyRecruitingNCT072078762 countries
- The Feasibility of Implementing Syphilis Point-of-care Testing Into a Prenatal Clinic for People Facing Barriers to CareRecruitingNCT06829602Not applicable1 country
- Doxycycline Prophylaxis for Prevention of Sexually Transmitted InfectionsRecruitingNCT06738407Phase 41 country
- Offering Routine and Rapid Point of Care (POC) Syphilis Testing in Pregnant Patients Presenting to the Emergency DepartmentRecruitingNCT06645106Not applicable1 country
- Cefixime Clinical TrialRecruitingNCT04958122Phase 31 country
- Integrated Care Versus Usual Care for Opioid Use Disorder and Infectious Diseases in VeteransNot yet recruitingNCT06766331Not applicable1 country
- Evaluation of Free STI Testing Pilot Projects in Lucerne and Zurich, SwitzerlandNot yet recruitingNCT07516912
- Treponemal Shedding, Load, and Viability, in Women and Men-who-have-sex-with-women-only With Early Infectious Syphilis: Implications for TransmissionRecruitingNCT073002544 countries
- Doxi-Rio: Study on the Use of Doxycycline to Prevent Sexually Transmitted Infections in Rio de JaneiroRecruitingNCT07500415Not applicable1 country
- The Efficacy of Doxycycline Post Exposure Prophylaxis for Preventing STIs Among MSM in Bangkok, Thailand.RecruitingNCT07397403Phase 41 country
- MAGIA H3S Point of Care Test Performance for HIV, HBV, HCV, and Syphilis Screening in Pregnant Women in DR CongoNot yet recruitingNCT07388979
- Clinical Performance Evaluation of MagIA IVD-MD Multiplex Testing (HIV/HBV/HCV/Syphilis)RecruitingNCT071707482 countries
- Periodic Presumptive Treatment vs. doxyPEP for STI Control in Kenyan MSMRecruitingNCT06468462Phase 41 country
- A Cross-sectional Investigational Study to Evaluate the Sensitivity, Specificity, and Utility of the MedMira Inc. Multiplo® Complete Syphilis (TP/nTP) Antibody Test (POCT) to Diagnose Infectious Syphilis in Participants Attending the Sexual Health Clinic in Ottawa, Ontario.RecruitingNCT06586905Not applicable1 country
- Modernizing Perinatal Syphilis TestingRecruitingNCT06082453Not applicable1 country
- Congenital and Maternal Point of Care Rapid Testing for Syphilis Study, UgandaNot yet recruitingNCT071737641 country
- Daily Doxycycline for Early SyphillisRecruitingNCT06683638Phase 21 country
- Validation of Self Testing Using the INSTI Multiplex HIV1/2 Syphilis Antibody TestNot yet recruitingNCT06953024Not applicable
- LIMIT Trial - Lidocaine With Intramuscular Injection of Benzathine Penicillin G for Treponema Pallidum TreatmentRecruitingNCT06391125Phase 31 country
- Peer Delivered HIV/Syphilis Self-Testing with Assisted Partner Notification ServicesEnrolling by invitationNCT06791928Phase 21 country
- Evaluation of the Diagnostic Sensitivity and Specificity of the Determine™ Syphilis Advanced Test.Not yet recruitingNCT06584214Not applicable1 country
- The TRIple Elimination Model Of Mother-to-child Transmission Program (TRI-MOM)RecruitingNCT05951751Not applicable2 countries
- Central Nervous System Infections in DenmarkRecruitingNCT034184411 country
- GUM Remote Testing v4.0Not yet recruitingNCT06244966Not applicable1 country
- MENJAGA: Continuous Quality Improvement for Antenatal HIV, Syphilis and Hepatitis B Testing in IndonesiaNot yet recruitingNCT06058286Not applicable1 country
- Syphilis and HIV Point of Care Testing (POCT) in SaskatchewanRecruitingNCT05863117Not applicable1 country
- Vienna HIV Infection Via Sex StudyRecruitingNCT053260611 country
- HPV Infection, Sexually Transmitted Infections and Anal Dysplasia in the Transgender PopulationCompletedNCT059818071 country
- Spotting Syphilis: A Dual Point-of-Care Syphilis Screening Initiative in a Low-Resource Healthcare SettingCompletedNCT07498153Not applicable1 country
- Alternative Antibiotics for SyphilisCompletedNCT05069974Phase 32 countries
- Superiority of On-demand PrEP Versus PEP on Using Doxycycline for Preventing STI in MSMActive, not recruitingNCT06188442Phase 41 country
- Investigational Study to Evaluate the DPP® Syphilis Screen & Confirm Antibody Point-of-care Test (POCT) to Diagnose Infectious SyphilisActive, not recruitingNCT069278431 country
- Ending the HIV Epidemic Through Point-of-Care Technologies (EHPOC)CompletedNCT04793750Not applicable1 country
- Linezolid for Syphilis Pilot StudyActive, not recruitingNCT05548426Phase 21 country
- Treatment Responses of Early Syphilis to Ceftriaxone Plus DoxycyclineTerminatedNCT05980871Phase 41 country
- Combination Primary Care and Prevention Services for Women Who Inject Drugs and Exchange Sex in Seattle, WashingtonCompletedNCT06187064Not applicable1 country
- Evaluation of the Sensitivity, Specificity, and Utility of the Reveal® TP (Syphilis) Antibody POCTCompletedNCT05831098Not applicable1 country
- Clinical Trial of Doxycycline VS BPG for Early Syphilis (SY-DOXY)CompletedNCT04838717Phase 31 country
- Investigating Point-of-care Diagnostics for Sexually Transmitted Infections and Antimicrobial Resistance in Primary Care in ZimbabweCompletedNCT05541081Not applicable1 country
- Building Mobile HIV Prevention and Mental Health Support in Low-resource SettingsCompletedNCT03912753Not applicable1 country
- Impact of Covid-19 on SyphilisActive, not recruitingNCT071508711 country
- The University of Zimbabwe College of Health Science (UZ-CHS) BIRTH COHORT StudyActive, not recruitingNCT04087239
- Zenyth: Motivational Interviewing-based Telehealth Intervention for Bacterial Sexually Transmitted Infection ScreeningCompletedNCT06100250Not applicable1 country