Lupus Erythematosus, Systemic clinical trials
The registry lists 1,208 studies for Lupus Erythematosus, Systemic across more than 10 countries. 404 are recruiting or about to start. 920 of them are mainly about Lupus Erythematosus, Systemic (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12. Counting its narrower condition Lupus Nephritis too: 1,428 studies, 480 open.
ClinicalTrials.gov finds 1,505 studies for Lupus Erythematosus, Systemic. How that becomes 1,207 here
This page counts the studies the registry files under Lupus Erythematosus, Systemic, and those it files under no condition that list Lupus Erythematosus, Systemicthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 1,505Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −212Filed under a narrower condition, counted on its own pageLupus Nephritis 212
- −10List Lupus Erythematosus, Systemic as a condition, but the registry did not file them under itMost often written as “Juvenile Systemic Lupus Erythematosus” (3), “Neuropsychiatric Systemic Lupus Erythematosus” (1), and “Bullous Systemic Lupus Erythematosus” (1). The registry filed them under other conditions only, most often Dermatomyositis (2) and Arthritis, Juvenile (2).
- −76Match it another way61 name it in the title and 15 by a synonym or other text the search reads.
- 1,207The count on this page22 of them list Lupus Erythematosus, Systemic in their own words; the registry filed them under no condition.
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Status
Who runs them
AstraZeneca (39) · Assiut University (37) · GlaxoSmithKline (30) · Assistance Publique - Hôpitaux de Paris (21) · Amgen (20) · Sohag University (17) · Bristol-Myers Squibb (15) · National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) (15)
What is being tested here
Drugs under test in Lupus Erythematosus, Systemic studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Drug classes tested here Tyrosine kinase inhibitors (TKIs) 6 open · Antimetabolites 4 open · Alkylating agents 4 open · JAK inhibitors 3 open · Corticosteroids 2 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Nov 20263TR (Taxonomy, Treatment, Targets and Remission) Systemic Lupus Erithematosus Study Protocol · Phase 3 · University Hospital, Brest
- Dec 2026A Research Study to Evaluate the Efficacy and Safety of Cenerimod in Subjects Suffering From Systemic Lupus Erythematosus · Phase 3 · Viatris Innovation GmbH
- Feb 2027Phase 3 Study of Anifrolumab in Adult Patients With Active Proliferative Lupus Nephritis · Phase 3 · AstraZeneca
- Mar 2027Program to Assess Adverse Events and Change in Disease Activity of Oral Upadacitinib in Adult Participants With Moderate to Severe Systemic Lupus Erythematosus · Phase 3 · AbbVie
- Mar 2027Phase 3 Study to Evaluate Two Regimens of Ianalumab on Top of Standard-of-care Therapy in Patients With Systemic Lupus Erythematosus (SIRIUS-SLE 1) · Phase 3 · Novartis Pharmaceuticals
- Mar 2027A Research Study to Evaluate the Effects of a New Oral Medicine Called Cenerimod in Adults With Systemic Lupus Erythematosus · Phase 3 · Viatris Innovation GmbH
- Apr 2027Phase 3 Study to Evaluate Ianalumab on Top of Standard-of-care Therapy in Patients With Systemic Lupus Erythematosus (SIRIUS-SLE 2) · Phase 3 · Novartis Pharmaceuticals
- Sep 2027Safety, Efficacy and Tolerability of Ianalumab Versus Placebo, Combination With SoC Therapy, in Participants With Active Lupus Nephritis · Phase 3 · Novartis Pharmaceuticals
- Sep 2027Sirolimus in Patients With Systemic Lupus Erythematosus-Associated Immune Thrombocytopenia · Phase 3 · Chinese SLE Treatment And Research Group
- Nov 2026Clinical Study of EVM18001 in the Treatment of Refractory Autoimmune Diseases · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Who these studies take
Of the 283 Lupus Erythematosus, Systemic studies recruiting now, 92 (33%) set no upper age limit and 161 (57%) stop at 75 or younger. 54 (19%) take children under 18. 14 (5%) are for women only and 0 (0%) for men only; 33 (12%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 37 (13%) | 34 (12%) |
| 18 | 270 (95%) | 257 (91%) |
| 30 | 266 (94%) | 252 (89%) |
| 40 | 265 (94%) | 251 (89%) |
| 50 | 265 (94%) | 253 (89%) |
| 65 | 243 (86%) | 233 (82%) |
| 75 | 149 (53%) | 141 (50%) |
| 85 | 112 (40%) | 104 (37%) |
Across all 1,208 studies, recruiting or not: 53% stop at 75 or younger and 31% at 65; 18% take children; 9% are for women only and 1% for men only; 15% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Lupus Erythematosus, Systemic studies take
Of 147 phase 1 interventional studies under Lupus Erythematosus, Systemic, half reached primary completion within 28 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 28 mo16–36 · 147 studies | 28 mo13–35 · 108 studies | — |
| Phase 1/2 | 42 mo21–60 · 37 studies | — | — |
| Phase 2 | 36 mo27–56 · 95 studies | 32 mo25–48 · 67 studies | — |
| Phase 3 | 51 mo38–84 · 53 studies | — | — |
| Phase 4 | 33 mo30–42 · 33 studies | — | — |
| Interventional, no phase | 23 mo10–38 · 129 studies | — | 23 mo10–38 · 122 studies |
| Observational | 64 mo34–126 · 112 studies | — | 59 mo30–212 · 90 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 14, 2026.
Started recruiting4
- A Long-Term Extension (LTE) Study Of Enpatoran In Cutaneous Manifestations Of Lupus With Or Without Systemic Disease [Elowen-LTE]Nov 10, 2026NCT07840287
- Pain Phenotyping of Rheumatic Diseases - An Observational StudyNov 3, 2026NCT07829497
- A Study of ATG-201 in Adult Participants With Autoimmune DiseasesOct 28, 2026NCT07732309
- A Study to Test CRT-402 in Refractory Autoimmune DiseaseOct 22, 2026NCT07778446
Results posted1
Stopped3
- Study to Evaluate Safety, Tolerability and Pharmacodynamics of KP104 in Participants With Thrombotic Microangiopathy Secondary to Systemic Lupus ErythematosusWithdrawnNov 9, 2026NCT05504187
- Study of Efficacy and Safety of LNP023 in Participants With Active Lupus Nephritis Class III-IV, +/- VTerminatedOct 15, 2026NCT05268289
- Autologous CD19/BCMA Dual-Target CAR-T for Relapsed/Refractory Autoimmune DiseasesWithdrawnOct 15, 2026NCT07361094
Newly registered9
- Diagnostic Performance of Urinary CD163 as a Non-invasive Biomarker for Egyptian Lupus Nephritis Patients Versus Conventional BiomarkersNov 12, 2026NCT07930403
- An Ascending Dose Study of DKB903 in Participants With Rheumatoid Arthritis (RA) and Participants With Systemic Lupus Erythematosus (SLE)Nov 6, 2026NCT07923747
- Effect of Anifrolumab on Arterial Inflammation in Systemic Lupus Erythematosus StudyNov 3, 2026NCT07913919
- A Phase 1 Study of QLS2416 Injection in Participants With Autoimmune DiseasesOct 30, 2026NCT07906145
- Pakistan Arthritis and Connective Tissue Disease Network - Systemic Lupus ErythematosusOct 29, 2026NCT07902622
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- Association of Inflammatory Biomarkers and Ferritin With Severity of Pediatric Systemic Lupus Erythematosus PatientsOct 28, 2026NCT07901634
- MYTP01 for Immune-Mediated DiseasesOct 28, 2026NCT07901764
- MENA/Levant Epidemiological, Registry of Immunological & Clinical Traits (MERIT)Oct 23, 2026NCT07892651
- A Study of BMS-986553 in Participants With Refractory Autoimmune DiseasesOct 14, 2026NCT07873931
Studies
Recruiting first, then most recently updated. Showing 50 of 1,208. Browse all 1,208 → or search them.
- Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVORecruitingNCT03816345Phase 12 countries
- Pain Phenotyping of Rheumatic Diseases - An Observational StudyRecruitingNCT078294971 country
- A Study to Test Whether Different Doses of BI 3000202 Help People With Systemic Lupus Erythematosus (SLE)RecruitingNCT07409181Phase 221 countries
- Testing of an Educational Tool for Patients With Melanoma and Pre-Existing Autoimmune Disease Who Are Candidates for Immune Checkpoint InhibitorsRecruitingNCT047513961 country
- Deciphering the Genetic Architecture of Autoimmune DiseasesRecruitingNCT069481102 countries
- An Exploratory Study of CD19/CD22/BCMA CAR-T Cells (BZE2204) in Subjects With Relapsed or Refractory Autoimmune DiseasesRecruitingNCT07174843Early Phase 11 country
- Carotid Ultrasound-Based Strategy for Primary Prevention of Cardiovascular Events in Inflammatory Rheumatic Disease (PREVENER)RecruitingNCT07611747Phase 41 country
- Rollover Study for Participants Who Have Completed a Previous Clinical Study With Anifrolumab (Saphnelo) and Clinically Benefited From Continued TreatmentRecruitingNCT07691970Phase 335 countries
- Gonadotropin-releasing Hormone Agonist (GnRHa) in Ovarian Preservation in SLE Subjects Receiving Cyclophosphamide as Determined by QuestionnairesRecruitingNCT055671981 country
- A Long-Term Extension (LTE) Study Of Enpatoran In Cutaneous Manifestations Of Lupus With Or Without Systemic Disease [Elowen-LTE]RecruitingNCT07840287Phase 31 country
- A Study to Evaluate the Treatment Outcomes of Subcutaneous Anifrolumab in Immunosuppressant-naïve and Biologic-naïve Systemic Lupus ErythematosusRecruitingNCT07430306Phase 39 countries
- Phase 3 Extension Study to Evaluate Long-term Safety of Ianalumab in Participants With Systemic Lupus Erythematosus (SIRIUS-SLE Extension).RecruitingNCT06133972Phase 329 countries
- Electroencephalogram Recording in Patients With Systemic Lupus ErythematosusRecruitingNCT063787361 country
- An Ascending Dose Study of DKB903 in Participants With Rheumatoid Arthritis (RA) and Participants With Systemic Lupus Erythematosus (SLE)Not yet recruitingNCT07923747Phase 1
- A Trial in Healthy Adult Participants and Adults With Autoimmune Diseases to Test How HBM7020 is Tolerated and How it Behaves in the BodyRecruitingNCT07649265Phase 11 country
- To Evaluate the Effects of Cevostamab in Participants With Systemic Lupus Erythematosus With or Without Active Lupus NephritisRecruitingNCT07629583Phase 16 countries
- MYTP01 for Immune-Mediated DiseasesNot yet recruitingNCT07901764Not applicable1 country
- A Study of Enpatoran in Participants With Cutaneous Manifestations of Lupus With or Without Systemic Disease (ELOWEN-2)RecruitingNCT07355218Phase 320 countries
- A Study of Enpatoran in Participants With Cutaneous Manifestations of Lupus With or Without Systemic DiseaseRecruitingNCT07332481Phase 320 countries
- A Study of Nipocalimab in Adults With Moderate to Severe Systemic Lupus ErythematosusRecruitingNCT07438496Phase 333 countries
- Phase I/II Study of AD-PluReceptor Plus Tafasitamab-cxix and Lymphodepleting Chemotherapy in Patients With Autoimmune DisordersRecruitingNCT06434363Phase 1/21 country
- Effect of Anifrolumab on Arterial Inflammation in Systemic Lupus Erythematosus StudyRecruitingNCT07913919Not applicable1 country
- A Study in Participants With Active Systemic Lupus Erythematosus With Inadequate Response to Glucocorticoids and ≥2 ImmunosuppressantsRecruitingNCT0717528513 countries
- A Study to Investigate the Safety and Preliminary Efficacy of ALLO-329, an Allogeneic CAR T-cell Therapy, in Adults With Autoimmune DiseaseRecruitingNCT07085104Phase 12 countries
- A Clinical Study of MK-1045 in People With Lupus or Rheumatoid Arthritis (MK-1045-004)RecruitingNCT07363590Phase 111 countries
- A Study to Evaluate the Efficacy and Safety of Dapirolizumab Pegol in Study Participants With Moderately to Severely Active Systemic Lupus ErythematosusRecruitingNCT06617325Phase 323 countries
- A Phase 1 Study of QLS2416 Injection in Participants With Autoimmune DiseasesNot yet recruitingNCT07906145Phase 1
- Obe-cel in Severe, Refractory Systemic Lupus Erythematosus (SLE) With Active Lupus Nephritis (LN)RecruitingNCT07053800Phase 25 countries
- CD19-Directed CAR-T Cell Therapy in Refractory Systemic Lupus ErythematosusNot yet recruitingNCT07659704Phase 1/21 country
- Pakistan Arthritis and Connective Tissue Disease Network - Systemic Lupus ErythematosusRecruitingNCT079026221 country
- Study of Systemic Lupus ErythematosusRecruitingNCT000013721 country
- A Study of ATG-201 in Adult Participants With Autoimmune DiseasesRecruitingNCT07732309Phase 11 country
- Association of Inflammatory Biomarkers and Ferritin With Severity of Pediatric Systemic Lupus Erythematosus PatientsNot yet recruitingNCT07901634
- Safety of the Herpes Zoster Subunit Vaccine in LupusRecruitingNCT05559671Phase 41 country
- Study Evaluating Safety, Tolerability, PK/PD of Surovatamig in Adult RA or SLE ParticipantsRecruitingNCT07201558Phase 110 countries
- A Study to Investigate Pharmacokinetics, Pharmacodynamics, and Safety of Subcutaneous Anifrolumab in Pediatric Participants 5 to < 18 Years of Age With Systemic Lupus ErythematosusRecruitingNCT07630714Phase 210 countries
- Dose Escalation Study With Bispecific Antibodies in Adult Participants With Lupus NephritisRecruitingNCT06975787Phase 16 countries
- A Safety and Efficacy Study Evaluating CTX112 in Adult Subjects With Refractory Autoimmune DiseaseRecruitingNCT06925542Phase 13 countries
- A Study of CLN-978, a Subcutaneously Administered CD19-directed T Cell Engager, in Subjects With Systemic Lupus ErythematosusRecruitingNCT06613360Phase 19 countries
- MENA/Levant Epidemiological, Registry of Immunological & Clinical Traits (MERIT)Not yet recruitingNCT078926511 country
- A Study of Outcomes in Chinese Patients Treated With Anifrolumab Who Have Active Mod-severe Systemic Lupus ErythematosusRecruitingNCT07751848Phase 31 country
- A Study to Test CRT-402 in Refractory Autoimmune DiseaseRecruitingNCT07778446Phase 1/21 country
- An Clinical Study of YTS109 Cell Injection in Subjects With Recurrent/Refractory Autoimmune DiseaseRecruitingNCT06379646Not applicable1 country
- A Clinical Study of YTS109 Cells for the Treatment of R/R Autoimmune DiseasesRecruitingNCT07123519Phase 11 country
- A Clinical Study of YTS109 Cell for R/R Autoimmune DiseasesRecruitingNCT07104721Phase 11 country
- A Clinical Study of YTS109 Cell in R/R Autoimmune DiseasesRecruitingNCT06978647Phase 11 country
- A Study to Evaluate the Safety and Activity of SAR448501/DR-0201 in Patients With Autoimmune Rheumatic DiseasesRecruitingNCT06647069Phase 15 countries
- A Study to Assess the Safety and PK/PD of LBL-047 in Healthy Adults and Patients With Systemic Lupus ErythematosusRecruitingNCT07323173Phase 11 country
- A Study to Assess Adverse Events, How the Drug Moves Through the Body and Effectiveness of Intravenous Infusions and Subcutaneous Injections of ABBV-519 in Adult Participants With Systemic Lupus Erythematosus (SLE) or Rheumatoid Arthritis (RA)RecruitingNCT07607964Phase 12 countries
- A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD5492 in Adult Participants With Systemic Lupus Erythematosus or Idiopathic Inflammatory Myopathies or Rheumatoid Arthritis.RecruitingNCT06916806Phase 110 countries