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Cyclophosphamide clinical trials

Also written Cytoxan, Endoxan, cytophosphane and NSC-26271.

studies test it
1,537
open now
241
in phase 3
209
first study started
1990
Related medicines add 6 studies

Counted the way a researcher would: Cyclophosphamide with its salts, dosage forms, brands and biosimilars. Looking for a trial to join? Including related medicines shows more you could take part in.

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How each study uses Cyclophosphamide is sorted by a rule, right about nine times in ten. Readers can ask us to read every study one by one.Ask us to read each study

Get an email when these change. Save the Cyclophosphamide studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.

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Approvals

The first approval found in each region, with its record

United States
16 Nov 1959 · CYTOXAN · NDA 012141 (FDA, Drugs@FDA)
European Union
Not in EMA's list of EU-wide authorisations

From FDA's Drugs@FDA and Purple Book (through openFDA) and the European Medicines Agency, files of Sept 2026 and 27 Oct 2026. National approvals in Europe and other countries are not included. How this is worked out

How studies write it

Studies that test it under each name

Name

Cyclophosphamide
1,241
CTX
109
CPM
70
Endoxana
63
Cy
25

Brand

Cytoxan
423
Endoxan
116
Neosar
96
Procytox
24
Revimmune
22
Cycloblastin
6
Cyclostin
1

Development codes

NSC-26271
4
EACODD-14
1
WTX221
1

Other names

cytophosphane
22
Cyclophosphamidum
1

In one entry with another drug

Given together, or one or the other

CHOP
15
Cyclophosphamide,Fludarabine
4
Prednisone,Vincristine, Cyclophosphamide
2
CARFILZOMIB, CYCLOPHOSPHAMIDE, DEXAMETHASONE
2
Adriamycin/Cytoxan
2
docetaxel, cyclophosphamide
2
Fludarabine, Cyclophosphamide
2
Cyclophosphamide and Sirolimus
2

Studies by the year they started

1,525 studies that test it; most in 2007 (67); 4 more planned to start later

Studies that test Cyclophosphamide, by start year
YearStudies
19905
19918
19925
19939
199410
199514
199621
199714
199835
199935
200033
200131
200242
200339
200448
200557
200659
200767
200861
200958
201055
201152
201241
201357
201454
201567
201658
201764
201847
201954
202047
202155
202240
202358
202431
202541
202653

By phase

A phase 1/2 study counts in both.

Early Phase 1
40
Phase 1
426
Phase 2
945
Phase 3
209
Phase 4
33
No phase
84

What it is tested for

Each study’s main condition, where its own words name it, so a study counts once.

Breast Neoplasms
193
Multiple Myeloma
102
Precursor Cell Lymphoblastic Leukemia-Lymphoma
79
Leukemia
61
Leukemia, Lymphocytic, Chronic, B-Cell
55
Leukemia, Myeloid, Acute
50
Lymphoma
47
Lymphoma, Large B-Cell, Diffuse
38
Hematologic Neoplasms
29
Melanoma
29
Hodgkin Disease
28
Anemia, Aplastic
27

Who runs them

Industry 110 · Other 1,427

National Cancer Institute (NCI) (73) · M.D. Anderson Cancer Center (71) · Fred Hutchinson Cancer Center (54) · Children's Oncology Group (53) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (46) · Memorial Sloan Kettering Cancer Center (44) · St. Jude Children's Research Hospital (41) · City of Hope Medical Center (37)

Often tested with

Tested in the same studies.

Fludarabine (393) · Doxorubicin (271) · Etoposide (203) · Vincristine (202) · Rituximab (162) · Prednisone (150) · Dexamethasone (129) · Methotrexate (117)

Related medicines

As reviewed, each with the page that says it.

Coming up

From the study records. Dates are the sponsors’ own estimates and often move.

Tested against it · 24 phase 3 studies under way

Cyclophosphamide is the comparator. A study of two new drugs counts under both.

  • 3Cytarabine · The Affiliated People's Hospital of Ningbo University, University of Birmingham · next primary completion Dec 2026
  • 3Carboplatin · Fudan University · next primary completion Jun 2029
  • 2Lenalidomide · The Lymphoma Academic Research Organisation, Ruijin Hospital · next primary completion Nov 2028
  • 2Ibrutinib · National Cancer Institute (NCI), University College, London · next primary completion Mar 2030
  • 2Rituximab · University Hospital, Rouen, University College, London · next primary completion Mar 2027
  • 2Paclitaxel · Fudan University, Weiguo Lv
  • 2Etoposide · The Affiliated People's Hospital of Ningbo University · next primary completion Dec 2026
  • 1Datopotamab deruxtecan · AstraZeneca · next primary completion Nov 2028
Reaching primary completion within a year · 111, 9 in phase 3

Studies that test Cyclophosphamide, phase 3 first.

Studies

Open first, then newest update. How each study uses Cyclophosphamide is read from its arms, and is right about nine times in ten. Ask us to read each study. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.

Testing it · 1,537

See all 1,537 studies that test Cyclophosphamide →

Given beside what is tested · 1,497 — Cyclophosphamide is usual care or a partner of the new treatment

Showing 20 of 1,497.

As the comparator · 124 — what is tested is compared with Cyclophosphamide

Showing 20 of 124.

Codes

What other systems call Cyclophosphamide · ClinicalTrials.gg INT007282

  • MeSH (NLM) D003520CyclophosphamideConfirmed ClinicalTrials.gov, NLM, Wikidata
  • UNII (FDA) 8N3DW7272PCYCLOPHOSPHAMIDEConfirmed FDA, NLM, Wikidata
  • RxNorm 3002One source FDA
  • Wikidata Q27106287cyclophosphamide hydrateConfirmed FDA, NLM, Wikidata
  • NCI Thesaurus C405CyclophosphamideOne source FDA
  • DrugBank DBSALT001814One source Wikidata

Also registered as cyclophosphamide anhydrous (UNII 6UXW23996M · RxNorm 1545988).

“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.