Leukemia, Lymphocytic, Chronic, B-Cell clinical trials
The registry lists 2,036 studies for Leukemia, Lymphocytic, Chronic, B-Cell across more than 10 countries. 237 are recruiting or about to start. 1,010 of them are mainly about Leukemia, Lymphocytic, Chronic, B-Cell (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12.
ClinicalTrials.gov finds 2,258 studies for Leukemia, Lymphocytic, Chronic, B-Cell. How that becomes 2,036 here
This page counts the studies the registry files under Leukemia, Lymphocytic, Chronic, B-Cell, and those it files under no condition that list Leukemia, Lymphocytic, Chronic, B-Cellthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 2,258Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −21List Leukemia, Lymphocytic, Chronic, B-Cell as a condition, but the registry did not file them under itMost often written as “CLL (Chronic Lymphocytic Leukemia)” (8), “Chronic Lymphocytic Lymphoma” (2), and “B-Chronic Lymphocytic Leukemia” (1). The registry filed them under other conditions only, most often Leukemia, B-Cell (14) and Precursor Cell Lymphoblastic Leukemia-Lymphoma (6).
- −212Match it another way25 name it in the title, 5 in a keyword, and 182 by a synonym or other text the search reads.
- 2,025Counted here and found by its search7 of them list Leukemia, Lymphocytic, Chronic, B-Cell in their own words; the registry filed them under no condition.
- +11
Counted here, but its search does not find them
- Lisocabtagene Maraleucel, Nivolumab and Ibrutinib for the Treatment of Richter's TransformationNCT05672173
- STop and Restart Acalabrutinib In fRail Patients With Previously Untreated Chronic Lymphocytic LeukemiaNCT04963946
- A Prospective, Multicenter, Phase-II Trial of Ibrutinib Plus Venetoclax in Patients With Creatinine Clearance >= 30 ml/Min Who Have Relapsed or Refractory Chronic Lymphocytic Leukemia (RR-CLL) With or Without TP53 AberrationsNCT03226301
- Calquence CLL 1L Japan PMS _ Japan Post-Marketing Surveillance (PMS) StudyNCT05665374
- Evaluation of Risk-Adapted and MRD-Driven Strategy for Untreated Fit Patients With Intermediate Risk Chronic Lymphocytic LeukemiaNCT04010968
- Feasibility of a Whole-Food, Plant-Based Diet for Patients With Low-Risk Chronic Lymphocytic Leukemia (CLL)NCT06377501
- Study to Investigate the Use of Acalabrutinib in the Treatment of Patients With Chronic Lymphocytic LeukemiaNCT04178798
- Lenalidomide in Combination With Rituximab in Treating Participants With Stage III/IV Indolent Non-Hodgkin LymphomaNCT00695786
- Phase I/II Study of Different Doses and Dose Schedules of Milatuzumab (hLL1) in CLLNCT00603668
- A Multicenter Phase 2 Study of Ibrutinib in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) With 17p DeletionNCT01744691
- Combined Treatment With Fresh Frozen Plasma and Rituximab (Mabthera) in Patients With Advanced Refractory Chronic Lymphocytic LeukemiaNCT00892827
- 2,036The count on this page
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Who runs them
National Cancer Institute (NCI) (134) · M.D. Anderson Cancer Center (118) · Fred Hutchinson Cancer Center (82) · Mayo Clinic (45) · City of Hope Medical Center (40) · Memorial Sloan Kettering Cancer Center (39) · Hoffmann-La Roche (36) · Gilead Sciences (35)
What is being tested here
Drugs under test in Leukemia, Lymphocytic, Chronic, B-Cell studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Venetoclax | 21 | 15 | 67 |
| Obinutuzumab | 16 | 13 | 53 |
| Pirtobrutinib | 13 | 5 | 22 |
| Acalabrutinib | 11 | 8 | 38 |
| Zanubrutinib | 9 | 4 | 20 |
| Ibrutinib | 8 | 15 | 80 |
| Sonrotoclax | 8 | 4 | 11 |
| ARQ531 | 7 | 3 | 9 |
| Tacabrutideg | 7 | 3 | 8 |
| Fludarabine | 4 | 14 | 166 |
Drug classes tested here Tyrosine kinase inhibitors (TKIs) 56 open · Alkylating agents 6 open · Antimetabolites 6 open · Immune checkpoint inhibitors 2 open · mTOR inhibitors 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Dec 2026A Long-term Extension Study of PCI-32765 (Ibrutinib) · Phase 3 · Janssen Research & Development, LLC
- Apr 2027Study of Acalabrutinib (ACP-196) in Combination With Venetoclax (ABT-199), With and Without Obinutuzumab (GA101) Versus Chemoimmunotherapy for Previously Untreated CLL · Phase 3 · Acerta Pharma BV
- May 2027A Study of Nemtabrutinib vs Chemoimmunotherapy for Participants With Previously Untreated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) Without TP53 Aberrations (MK-1026-008, BELLWAVE-008) · Phase 3 · Merck Sharp & Dohme LLC
- Jul 2027A Study of Acalabrutinib Plus Venetoclax Versus Venetoclax Plus Obinutuzumab in Previously Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma · Phase 3 · AstraZeneca
- Aug 2027An Extension Study of Venetoclax for Subjects Who Have Completed a Prior Venetoclax Clinical Trial · Phase 3 · AbbVie
- Oct 2027A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL) · Phase 3 · Loxo Oncology, Inc.
- Nov 2026A Study to Investigate Sonrotoclax Combined With Zanubrutinib Versus Zanubrutinib Alone in Participants With Previously Untreated Chronic Lymphocytic Leukemia · BeOne Medicines
- Nov 2026Study to Assess Change in Disease Activity and Adverse Events of Oral Venetoclax With Intravenous (IV) Obinutuzumab in Adult Participants With Recurring Chronic Lymphocytic Leukemia (CLL) · AbbVie
- Nov 2026MB-CART19.1 r/r CD19+ B-cell Malignancies (BCM) · Miltenyi Biomedicine GmbH
- Nov 2026Muscle Dysfunction in Patients With Hematological Diseases Referred to Stem Cell Transplant · Rigshospitalet, Denmark
Who these studies take
Of the 188 Leukemia, Lymphocytic, Chronic, B-Cell studies recruiting now, 150 (80%) set no upper age limit and 15 (8%) stop at 75 or younger. 17 (9%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 13 (7%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 11 (6%) | 11 (6%) |
| 18 | 181 (96%) | 181 (96%) |
| 30 | 183 (97%) | 183 (97%) |
| 40 | 185 (98%) | 185 (98%) |
| 50 | 185 (98%) | 185 (98%) |
| 65 | 186 (99%) | 186 (99%) |
| 75 | 185 (98%) | 185 (98%) |
| 85 | 166 (88%) | 166 (88%) |
Across all 2,036 studies, recruiting or not: 18% stop at 75 or younger and 7% at 65; 18% take children; <1% are for women only and <1% for men only; 3% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Leukemia, Lymphocytic, Chronic, B-Cell studies take
Of 249 phase 2 interventional studies under Leukemia, Lymphocytic, Chronic, B-Cell, half reached primary completion within 73 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 56 mo39–86 · 180 studies | 56 mo38–73 · 84 studies | 56 mo39–91 · 96 studies |
| Phase 1/2 | 78 mo51–103 · 90 studies | 80 mo51–104 · 50 studies | 76 mo53–103 · 40 studies |
| Phase 2 | 73 mo41–114 · 249 studies | 55 mo26–87 · 41 studies | 75 mo42–119 · 208 studies |
| Phase 3 | 59 mo43–76 · 83 studies | 53 mo41–73 · 57 studies | — |
| Interventional, no phase | 50 mo31–134 · 39 studies | — | 50 mo31–134 · 37 studies |
| Observational | 60 mo32–176 · 104 studies | 54 mo35–66 · 34 studies | 72 mo30–… · 70 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 14, 2026.
Started recruiting3
- Tafasitamab With Acalabrutinib and Venetoclax for the Treatment of Chronic Lymphocytic Leukemia/Small Lymphocytic LymphomaNov 6, 2026NCT07582159
- A Clinical Trial of MK-1045 in People With B-cell Cancer (MK-1045-006)Nov 4, 2026NCT07709000
- Nemtabrutinib and Venetoclax for the Treatment of Patients With Chronic Lymphocytic Leukemia or Small Lymphocytic LymphomaOct 15, 2026NCT07557056
Results posted2
- Double-blind, Randomized, Placebo-controlled, Prospective Phase III Study Evaluating Efficacy and Safety of Panzyga in Primary Infection Prophylaxis in Patients With Chronic Lymphocytic Leukemia ("PRO-SID" Study)Nov 2, 2026NCT04502030
- Study to Assess Change in Disease Activity and Adverse Events of Oral Venetoclax in Combination With Intravenous (IV) Obinutuzumab or Oral Ibrutinib in Adult Participants With Untreated Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)Oct 21, 2026NCT05105841
Stopped2
- Sorafenib and Bortezomib in Treating Patients With Advanced CancerTerminatedNov 12, 2026NCT00303797
- Anti-CD19 CAR-Engineered NK Cells in the Treatment of Relapsed/Refractory B-cell MalignanciesWithdrawnOct 15, 2026NCT05410041
Newly registered3
- huCART19-IL18-CD428z Cells for the Treatment of Patients With HIV With CD19+ CancersOct 23, 2026NCT07891468
- Tacabrutideg and Sonrotoclax, With Response-Guided Obinutuzumab, for the Treatment of Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)Oct 21, 2026NCT07887061
- RPM Signals in Outpatient CAR T TherapyOct 20, 2026NCT07882732
Studies
Recruiting first, then most recently updated. Showing 50 of 2,036. Browse all 2,036 → or search them.
- Natural History Study of Monoclonal B Cell Lymphocytosis (MBL), Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL), Lymphoplasmacytic Lymphoma (LPL)/Waldenstrom Macroglobulinemia (WM), and Splenic Marginal Zone Lymphoma (SMZL)RecruitingNCT009235071 country
- ROCKET-CLL Global Phase 3 Study: Rocbrutinib vs Pirtobrutinib in cBTKi-Pretreated R/R CLL/SLLRecruitingNCT07342478Phase 32 countries
- A Study of Tacabrutideg (BGB-16673) Compared to Investigator's Choice in Participants With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Previously Exposed to Both Bruton Tyrosine Kinase (BTK) and B-cell Leukemia/Lymphoma 2 Protein (BCL2) InhibitorsRecruitingNCT06846671Phase 314 countries
- Phase II Study of Combined Pirtobrutinib, Venetoclax and Obinutuzumab (PVO) Time-limited Treatment for Patients With Recurrent Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL).RecruitingNCT06967610Phase 21 country
- Effects of Nicotinamide in Patients With Chronic Lymphocytic Leukemia With History of Non-melanoma Skin CancersRecruitingNCT04844528Phase 21 country
- Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL StudyRecruitingNCT04269902Phase 32 countries
- A Study to Evaluate Efficacy, Safety, and PK of XEMBIFY®+Standard Medical Treatment (SMT) Compared to Placebo+SMT to Prevent Infections in Participants With HGG and Recurrent or Severe Infections Associated With B-cell Chronic Lymphocytic Leukemia, Multiple Myeloma, and Non-Hodgkin LymphomaRecruitingNCT05645107Phase 38 countries
- Collection of Human Samples to Study Hairy Cell and Other Leukemias, and to Develop Recombinant Immunotoxins for Cancer TreatmentRecruitingNCT010873331 country
- Nemtabrutinib for Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Leukemia (SLL) Refractory to Covalent Bruton Tyrosine Kinase Inhibitor or Pirtobrutinib and Previously Treated With a BCL2 InhibitorNot yet recruitingNCT07796373Phase 21 country
- Immune Profiling of CLL/SLL Treated With First-Line PirtobrutinibRecruitingNCT07428707Early Phase 11 country
- A Clinical Trial of MK-1045 in People With B-cell Cancer (MK-1045-006)RecruitingNCT07709000Phase 23 countries
- Epcoritamab as Consolidation Therapy for High-Risk Pts w/CLL on BTKINot yet recruitingNCT07819214Phase 21 country
- Venetoclax Plus Zanubrutinib for the Treatment of Chronic Lymphocytic Leukemia and Small Lymphocytic LymphomaRecruitingNCT07734038Phase 21 country
- Tafasitamab With Acalabrutinib and Venetoclax for the Treatment of Chronic Lymphocytic Leukemia/Small Lymphocytic LymphomaRecruitingNCT07582159Phase 21 country
- A Study of Nemtabrutinib Plus Venetoclax vs Venetoclax + Rituximab (VR) in Second-line (2L) + Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) (MK-1026-010/BELLWAVE-010).RecruitingNCT05947851Phase 323 countries
- HPC Offered for PRESERVE ExpansionRecruitingNCT071454111 country
- A Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Mosunetuzumab and a Combined Regimen of Mosunetuzumab and Venetoclax in Participants With Relapsed or Refractory Chronic Lymphocytic LeukemiaRecruitingNCT05091424Phase 110 countries
- PICAROS - Acalabrutinib RWE on 1L CLL in SpainRecruitingNCT059998771 country
- A Rollover Study for Continued Study Treatment and Ongoing Safety MonitoringEnrolling by invitationNCT06788509Phase 115 countries
- A Study of Pirtobrutinib (LY3527727) in Participants With Chronic Lymphocytic Leukemia/Small Lymphocytic LymphomaRecruitingNCT07218341Phase 417 countries
- A Study Evaluating the Efficacy and Safety of Pirtobrutinib in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic LymphomaRecruitingNCT06588478Phase 218 countries
- Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer DetectionRecruitingNCT053340691 country
- Study of NX-5948 in Combination With Other Agents in Adults With B-cell MalignanciesRecruitingNCT07520006Phase 1/21 country
- A Real-world Study of Ibrutinib and Venetoclax (I+V) First-Line Treatment Given for Fixed-duration of Time in Participants With Chronic Lymphocytic LeukemiaRecruitingNCT076020881 country
- Benefits of Individual Physical Activity Intervention on Health-related Quality of Life in Participants With Chronic Lymphocytic LeukemiaRecruitingNCT062995401 country
- Testing the Addition of Anti-Cancer Drug Sonrotoclax, to the Standard Treatment Zanubrutinib, for Previously Untreated CLL/SLLRecruitingNCT07321652Phase 31 country
- A Study of NX-5948 in Adults With CLL/SLL Previously Treated With a Bruton's Tyrosine Kinase Inhibitor and a B-cell Lymphoma-2 Inhibitor (DAYBreak CLL-201)RecruitingNCT07221500Phase 25 countries
- Family Study of Lymphoproliferative DisordersRecruitingNCT006264961 country
- huCART19-IL18-CD428z Cells for the Treatment of Patients With HIV With CD19+ CancersNot yet recruitingNCT07891468Phase 11 country
- Sonrotoclax, Rituximab, and Zanubrutinib in Treating Participants With Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, and Mantle Cell LymphomaRecruitingNCT06839053Phase 21 country
- A Randomized Phase II Study Of Bruton Tyrosine Kinase Inhibitor With Or Without Venetoclax In Veterans With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)RecruitingNCT06520098Phase 21 country
- Observational Study of Cardiac Arrhythmias During Treatment With BTK Inhibitors or VenetoclaxRecruitingNCT057241211 country
- Phase Ib Clinical Study of KeynatinibRecruitingNCT04807881Phase 11 country
- A Phase 2 Trial Of The Bruton Tyrosine Kinase Degrader BGB-16673 In Combination With BCL-2 Inhibitor Sonrotoclax For Patients With Treatment-Naive Chronic Lymphocytic Leukemia (CLL)RecruitingNCT07508995Phase 21 country
- Cancer Experience Registry (CER) for Cancer Patients and CaregiversRecruitingNCT023336041 country
- Nemtabrutinib and Lisocabtagene Maraleucel for the Treatment of Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic LymphomaRecruitingNCT07194980Phase 21 country
- Tissue, Blood, and Body Fluid Sample Collection From Patients With Hematologic CancerRecruitingNCT011376431 country
- A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell MalignanciesRecruitingNCT06564038Phase 1/213 countries
- AQUALIS:QoL of CLL Patients Treated With Acalabrutinib in France, Retrospective Study Based on Data From PLATON DatabaseRecruitingNCT065481521 country
- A Study to Investigate the Safety of Novel Dose Ramp-up Schedule(s) When Initiating Sonrotoclax in Participants Treated for Blood Cancers.RecruitingNCT06697184Phase 1/26 countries
- Acalabrutinib With or Without Obinutuzumab in Treating Patients With Early-Stage Chronic Lymphocytic Leukemia or Small Lymphocytic LymphomaRecruitingNCT03516617Phase 21 country
- Anti-CD19 Chimeric Antigen Receptor T Cells for Treatment of Relapsed or Refractory Non-Hodgkin LymphomaRecruitingNCT04545762Phase 11 country
- Gene Therapy for CD19-Positive Hematologic Malignancies (SENTRY-CD19)RecruitingNCT06533579Phase 1/21 country
- A Vaccine (CMV-MVA Triplex Vaccine) for the Enhancement of CMV-Specific Immunity and the Prevention of CMV Viremia in Patients Undergoing Haploidentical Hematopoietic Stem Cell TransplantRecruitingNCT07020533Phase 11 country
- A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)RecruitingNCT06943872Phase 321 countries
- Acalabrutinib in Combination With Venetoclax for the Treatment of Refractory or Recurrent Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma, The AVENUE-2 TrialRecruitingNCT04941716Phase 21 country
- CMV-MVA Triplex Vaccination in HLA-Matched Related Stem Cell Donors for the Prevention of CMV Infection in Patients Undergoing Hematopoietic Stem Cell TransplantRecruitingNCT06059391Phase 21 country
- MAVRiC Studies 2L Treatment With AV in Patients With CLL/SLL Who Have Relapsed After a Course of BTKi + BCL2i Combination, With or Without ObinutuzumabRecruitingNCT07024706Phase 29 countries
- Treatment of Chinese Participants With B-Cell Malignancies With BGB-16673, a Bruton Tyrosine Kinase-Targeted Protein-DegraderRecruitingNCT05294731Phase 1/21 country
- Tacabrutideg and Sonrotoclax, With Response-Guided Obinutuzumab, for the Treatment of Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)Not yet recruitingNCT07887061Phase 21 country