Drug
Methotrexate clinical trials
Also written MTX, CL 14377, Mexate and Folex.
- studies test it
- 649
- open now
- 88
- in phase 3
- 172
- first study started
- 1990
Keep track of what changes. Save the Methotrexate studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Studies by the year they started
640 studies that test it; most in 2007 (34)
| Year | Studies |
|---|---|
| 1990 | 3 |
| 1991 | 2 |
| 1992 | 1 |
| 1993 | 2 |
| 1994 | 6 |
| 1995 | 6 |
| 1996 | 7 |
| 1997 | 8 |
| 1998 | 9 |
| 1999 | 14 |
| 2000 | 12 |
| 2001 | 13 |
| 2002 | 18 |
| 2003 | 20 |
| 2004 | 11 |
| 2005 | 28 |
| 2006 | 20 |
| 2007 | 34 |
| 2008 | 21 |
| 2009 | 32 |
| 2010 | 23 |
| 2011 | 26 |
| 2012 | 21 |
| 2013 | 29 |
| 2014 | 24 |
| 2015 | 32 |
| 2016 | 23 |
| 2017 | 24 |
| 2018 | 11 |
| 2019 | 12 |
| 2020 | 21 |
| 2021 | 24 |
| 2022 | 21 |
| 2023 | 19 |
| 2024 | 26 |
| 2025 | 21 |
| 2026 | 16 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 12
- Phase 1
- 83
- Phase 2
- 278
- Phase 3
- 172
- Phase 4
- 98
- No phase
- 47
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 147 · Other 502
Hoffmann-La Roche (30) · St. Jude Children's Research Hospital (22) · Children's Oncology Group (18) · National Cancer Institute (NCI) (15) · Fred Hutchinson Cancer Center (15) · M.D. Anderson Cancer Center (14) · Amgen (13) · Bristol-Myers Squibb (12)
Often tested with
Tested in the same studies.
Cyclophosphamide (121) · Cytarabine (85) · Vincristine (77) · Doxorubicin (60) · Dexamethasone (58) · Rituximab (55) · Mercaptopurine (50) · Etoposide (48)
Studies
Open first, then newest update. How each study uses Methotrexate is read from its arms, and is right about nine times in ten.
Testing it · 649
- A Study of Tacrolimus/Methotrexate/Ruxolitinib Versus Post-Transplant Cyclophosphamide/Tacrolimus/Mycophenolate Mofetil in Non-Myeloablative/Reduced Intensity Conditioning Allogeneic Peripheral Blood Stem Cell Transplantation (BMT CTN 2203)RecruitingPhase 3Incyte CorporationNCT06615050Written as Methotrexate (MTX)
- Graft Versus Host Disease-Reduction Strategies for Donor Blood Stem Cell Transplant Patients With Acute Leukemia or Myelodysplastic Syndrome (MDS)RecruitingPhase 2Fred Hutchinson Cancer CenterNCT03970096Written as Methotrexate
- Optimizing Treatment for Patients With Juvenile Idiopathic Arthritis in Sustained Remission: The MOVE-JIA TrialRecruitingPhase 4Oslo University HospitalNCT06653634Written as Methotrexate
- A Double-blind, Randomized Controlled Trial to Investigate the Efficacy, Safety, and Pharmacokinetics of Pegloticase Administration Via Subcutaneous and Intravenous Routes Both With Methotrexate in Participants With Uncontrolled GoutRecruitingPhase 3AmgenNCT07388498Written as Methotrexate
- Ruxolitinib With Tacrolimus and Methotrexate for the Prevention of Graft Versus Host Disease in Pediatric and Young Adult Patients Undergoing Allogeneic Hematopoietic Cell Transplant for Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Myelodysplastic SyndromeRecruitingPhase 2City of Hope Medical CenterNCT06128070Written as Methotrexate
- Testing the Addition of MEDI4736 (Durvalumab) to Chemotherapy Before Surgery for Patients With High-Grade Upper Urinary Tract CancerRecruitingPhase 2/3National Cancer Institute (NCI)NCT04628767Written as Methotrexate
- The CATSINDO Trial - Clinical and Translational Study in Newly Diagnosed OsteosarcomaRecruitingPhase 2Wake Forest University Health SciencesNCT07560826Written as High-dose Methotrexate
- MethMax Trial: MAXimising the METHotrexate Therapy Potential in Patients With Active Rheumatoid ArthritisRecruitingPhase 4Medical University of ViennaNCT06649136Written as Methotrexate
- Prospective Evaluation Of High-Dose Systemic Methotrexate In Patients With Breast Cancer And Leptomeningeal MetastasisRecruitingPhase 2Wake Forest University Health SciencesNCT02422641Written as High-dose Methotrexate (8 gm/m2; HD-MTX)
- Methotrexate, Erlotinib, and Celecoxib for the Treatment of Recurrent/Metastatic Head and Neck Cancer in a Rural Midwest United States PopulationRecruitingPhase 2Mayo ClinicNCT06997068Written as Methotrexate
- A Study to Investigate the Clinical Effect and the Safety of PRX-115 Infused Intravenously at Different Dosing Regimens, With and Without Methotrexate, Versus Placebo in Adults Gout Patients (RELEASE)RecruitingPhase 2ProtalixNCT07280156Written as Methotrexate (MTX)
- Methotrexate Treatment in Hand Osteoarthritis Refractory to Usual TreatmentsRecruitingPhase 2/3Centre Hospitalier Universitaire de NiceNCT07501507Written as Methotrexate Injectable Solution
- Molecular and Clinical Risk-Directed Therapy for Infants and Young Children With Newly Diagnosed MedulloblastomaRecruitingPhase 2St. Jude Children's Research HospitalNCT05535166Written as Methotrexate
- ZR-MTX for PIOL Phase II TrialRecruitingPhase 2Peking Union Medical College HospitalNCT06973811Written as Methotrexate
- Pragmatic, Open-Label Study to Pilot Evaluation for Clinical Trials in Relapsing PolychondritisRecruitingPhase 2University of PennsylvaniaNCT06941376Written as Methotrexate (MTX)
- Chemoimmunotherapy and Allogeneic Stem Cell Transplant for NK T-cell Leukemia/LymphomaRecruitingEarly Phase 1New York Medical CollegeNCT03719105Written as Methotrexate
- BRIDGE-NK: Immunotherapy Versus Chemotherapy Induction Followed by Autologous HSCT in Advanced NKTCLRecruitingPhase 3Rong TaoNCT07678229Written as High-dose methotrexate
- A Trial to Examine the Interaction of Repinatrabit With Ethinyl Estradiol/Norethindrone, Metformin,Carbamazepine, Rosuvastatin, and Methotrexate When Administered TogetherRecruitingPhase 1Otsuka Pharmaceutical Development & Commercialization, Inc.NCT07446400Written as Methotrexate
- Treatment of Newly Diagnosed Standard Risk Acute Lymphoblastic Leukemia in ChildrenRecruitingPhase 2Hee Young JuNCT06099366Written as induction: vincristine, L-asparaginase, dexamethasone, intrathecal Ara-C, intrathecal Methotrexate
- Therapy for Newly Diagnosed Patients With B-Cell Precursor Acute Lymphoblastic Leukemia and LymphomaRecruitingPhase 2St. Jude Children's Research HospitalNCT06533748Written as Methotrexate
See all 649 studies that test Methotrexate →
Given in every arm · 472 — Methotrexate is usual care beside what is tested
- A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)RecruitingPhase 2National Cancer Institute (NCI)NCT06124157Written as Methotrexate
- Pembrolizumab + Chemotherapy in Newly Diagnosed PCNSLRecruitingPhase 1Dana-Farber Cancer InstituteNCT06475235Written as Methotrexate
- Study of Revumenib, Azacitidine, and Venetoclax in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid LeukemiaRecruitingPhase 1St. Jude Children's Research HospitalNCT06177067Written as Methotrexate
- Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged LeukemiaRecruitingPhase 2National Cancer Institute (NCI)NCT06317662Written as Methotrexate
- Inotuzumab Ozogamicin and Frontline Chemotherapy in Treating Young Adults With Newly Diagnosed B Acute Lymphoblastic LeukemiaRecruitingPhase 3Alliance for Clinical Trials in OncologyNCT03150693Written as Methotrexate
- Ruxolitinib Before, During and After Hematopoietic Cell Transplant in Older Patients With Myelofibrosis and Myelodysplastic Syndrome/Myeloproliferative Neoplasm Overlap SyndromesRecruitingPhase 2Fred Hutchinson Cancer CenterNCT07228624Written as Methotrexate
- Safety and Efficacy of Asciminib in Pediatrics and Young Adults With Relapse/Refractory (r/r) Philadelphia Positive (Ph+) or ABL-class Ph-like Acute Lymphoblastic Leukemia (ALL)RecruitingPhase 1/2Novartis PharmaceuticalsNCT07387926Written as Methotrexate (intrathecal)
- Intrathecal Chemoprophylaxis to Prevent Neurotoxicity Associated With Blinatumomab Therapy for Acute Lymphoblastic LeukemiaRecruitingPhase 2Northside Hospital, Inc.NCT05519579Written as Methotrexate
- Testing Blinatumomab With or Without Revumenib in Patients With B-cell Acute Lymphoblastic Leukemia With a Genetic Change Requiring More TreatmentNot yet recruitingPhase 2SWOG Cancer Research NetworkNCT07636564Written as Methotrexate
- Asparaginase Erwinia Chrysanthemi With Chemotherapy for the Treatment of High-Risk Adults With Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoblastic LymphomaRecruitingPhase 2City of Hope Medical CenterNCT06918431Written as Methotrexate
- Evaluation of Dapagliflozin and Empagliflozin as Adjunctive Therapy to Methotrexate in Patients With Rheumatoid ArthritisNot yet recruitingPhase 2Al-Azhar UniversityNCT07864688Written as Methotrexate
- Combination Chemotherapy and Nelarabine in Treating Patients With T-cell Acute Lymphoblastic Leukemia or Lymphoblastic LymphomaRecruitingPhase 2M.D. Anderson Cancer CenterNCT00501826Written as Methotrexate
- Perioperative Durvalumab With Neoadjuvant ddMVAC in Patients With Muscle-Invasive Bladder Cancer (NIAGARA-2)RecruitingPhase 2AstraZenecaNCT06960577Written as Methotrexate
- Eflornithine (DFMO) for Ewing Sarcoma and OsteosarcomaRecruitingPhase 2Milton S. Hershey Medical CenterNCT07321912Written as Methotrexate
- Pentoxifylline as Anti-Inflammatory in Patients With Rheumatoid ArthritisRecruitingPhase 2Tanta UniversityNCT06998628Written as Methotrexate
- Arsenic Trioxide Combined With Chemotherapy for Relapsed SHH-Activated and/or TP53-Mutant MedulloblastomaNot yet recruitingPhase 2Sun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityNCT07856069Written as Methotrexate
- A Study of the Efficacy and Safety of Lisocabtagene Maraleucel (Liso-cel) as First-Line Therapy in Adults With Transplant-Ineligible Primary Central Nervous System LymphomaRecruitingPhase 2Juno Therapeutics, Inc., a Bristol-Myers Squibb CompanyNCT07015242Written as Methotrexate
- Study of Pedi-cRIB: Mini-Hyper-CVD With Condensed Rituximab, Inotuzumab Ozogamicin and Blinatumomab (cRIB) for Relapsed Therapy for Pediatric With B-Cell Lineage Acute Lymphocytic LeukemiaRecruitingPhase 2M.D. Anderson Cancer CenterNCT05645718Written as Methotrexate
- A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 MutationsRecruitingPhase 3Children's Oncology GroupNCT04293562Written as Methotrexate
- The Effect of Nicorandil on Rheumatoid Arthritis PatientsRecruitingPhase 2/3Ain Shams UniversityNCT07730723Written as conventional synthetic antirheumatic drugs (cDMARDs)
Showing 20 of 472.
As the comparator · 97 — what is tested is compared with Methotrexate
- Study of Hysteroscopic Repeat Curettage as the First-line Treatment in Low-risk Postmolar Gestational Trophoblastic NeoplasiaRecruitingPhase 2Women's Hospital School Of Medicine Zhejiang UniversityNCT03703271Written as Methotrexate
- A Study to Evaluate MRG003 vs Cetuximab/Methotrexate in in the Treatment of Patients With RM-SCCHNRecruitingPhase 3Lepu Biopharma Co., Ltd.NCT05751512Written as Methotrexate Injection
- Treatment Strategy for Patients With RA-ILDNot yet recruitingPhase 4Chinese SLE Treatment And Research GroupNCT07643038Written as Methotrexate
- Study to Improve OS in 18 to 60 Year-old Patients, Comparing Daunorubicin Versus High Dose Idarubicin Induction Regimens, High Dose Versus Intermediate Dose Cytarabine Consolidation Regimens, and Standard Versus MMF Prophylaxis of GvHD in Allografted Patients in First CRRecruitingPhase 2/3University Hospital, AngersNCT02416388Written as Methotrexate
- Anti-CD25 Monoclonal Antibody for Prevention of Acute GVHD After Haploidentical HSCTRecruitingPhase 3Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyNCT07689630Written as Methotrexate
- Methotrexate Combined With Tofacitinib in Rheumatoid ArthritisRecruitingNot applicableSun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityNCT06301373Written as Methotrexate
- EFFICACY OF ROFLUMILAST IN THE TREATMENT OF FLEXURAL AND/OR GENITAL PSORIASIS: A RANDOMIZED CONTROLLED TRIAL.Not yet recruitingPhase 2Eman Raafat SaidNCT07543640Written as Methotrexate
- Cyclophosphamide and Etoposide as a Metronomic Therapy in Advanced Head and Neck Squamous Cell CancerNot yet recruitingPhase 2National Cancer Institute, EgyptNCT07361133Written as Methotrexate
- Tofacitinib vs Methotrexate for Severe Alopecia Areata (TOFA-MTX-AA)Not yet recruitingPhase 4Hayat Abad Medical Complex, PeshawarNCT07406204Written as Methotrexate
- Evaluation of Rovadicitinib Compared to the Protocol Selected by Researchers in Third Line and Subsequent Studies of Moderate to Severe Chronic Graft-versus-host DiseaseRecruitingPhase 3Chia Tai Tianqing Pharmaceutical Group Co., Ltd.NCT06682169Written as Methotrexate
- Microbiome and Clinical Response to Probiotics and Methotrexate in Early Psoriasis: a Pilot StudyRecruitingEarly Phase 1Alexandria UniversityNCT07169019Written as Methotrexate
- Efficacy and Safety of Resveratrol in Patients With Rheumatoid Arthritis.RecruitingNot applicableAin Shams UniversityNCT07089381Written as Methotrexate
- Lenalidomide vs Methotrexate in Difficult-to-treat Cutaneous Lupus ErythematosusNot yet recruitingPhase 3Assistance Publique - Hôpitaux de ParisNCT06965244Written as Methotrexate (MTX)
- Comparing Post-Transplant Cyclophosphamide As GVHD Prophylaxis to Standard of Care for Acute Leukemia PatientsRecruitingPhase 3King Faisal Specialist Hospital & Research CenterNCT04314219Written as Methotrexate
- Comparison of Tofacitinib and Methotrexate in Takayasu's ArteritisRecruitingPhase 4Shanghai Zhongshan HospitalNCT05102448Written as Methotrexate
- Use of Letrozole for Ectopic PregnancyRecruitingPhase 4Hospital de Clinicas de Porto AlegreNCT06354439Written as Methotrexate Sodium
- Methotrexate Versus Triamcinilone Acetonide in Treatment of Recalcitrant Alopecia AreataNot yet recruitingNot applicableAl-Azhar UniversityNCT06088147Written as Methotrexate
- Modified Zhiwang Decoction Combined With Methotrexate in the Treatment of Early Rheumatoid ArthritisRecruitingEarly Phase 1Beijing University of Chinese MedicineNCT05508815Written as Methotrexate
- Outcomes With Treatment and Withdraw of Secukinumab in Patients With Plaque PsoriasisNot yet recruitingPhase 4Singapore General HospitalNCT04239859Written as Methotrexate
- Outcomes With Treatment and Withdraw of Ixekizumab in Patients With Plaque PsoriasisRecruitingPhase 4Singapore General HospitalNCT04537689Written as Methotrexate
Showing 20 of 97.
Codes
What other systems call Methotrexate · ClinicalTrials.gg INT007807
- MeSH (NLM) D008727MethotrexateConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) YL5FZ2Y5U1METHOTREXATEConfirmed FDA, NLM, Wikidata
- RxNorm 6851Confirmed FDA, Wikidata
- Wikidata Q422232methotrexateConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C642MethotrexateOne source FDA
- DrugBank DB00563One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D008727 | Methotrexate | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | YL5FZ2Y5U1 | METHOTREXATE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 6851 | — | Confirmed FDA, Wikidata |
| Wikidata | Q422232 | methotrexate | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C642 | Methotrexate | One source FDA |
| DrugBank | DB00563 | — | One source Wikidata |
Also registered as methotrexate sodium (UNII 3IG1E710ZN · RxNorm 287734).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.