Arginine clinical trials
Also written Arg.
Counted the way a researcher would: Arginine with its salts, dosage forms, brands and biosimilars. Looking for a trial to join? Including related medicines shows more you could take part in.
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How each study uses Arginine is sorted by a rule, right about nine times in ten. Readers can ask us to read every study one by one.Ask us to read each study
Get an email when these change. Save the Arginine studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Approvals
The first approval found in each region, with its record
- United States
- 28 Feb 1973 · R-GENE 10 · NDA 016931 (FDA, Drugs@FDA)
- European Union
- 25 Jul 2019 · LysaKare · EMEA/H/C/004541 (EMA; in a combination)
From FDA's Drugs@FDA and Purple Book (through openFDA) and the European Medicines Agency, files of Sept 2026 and 27 Oct 2026. National approvals in Europe and other countries are not included. How this is worked out
How studies write it
Studies that test it under each name
Studies by the year they started
123 studies that test it; most in 2016 (11)
| Year | Studies |
|---|---|
| 1997 | 1 |
| 1998 | 1 |
| 2000 | 3 |
| 2001 | 2 |
| 2002 | 2 |
| 2003 | 4 |
| 2004 | 4 |
| 2005 | 6 |
| 2006 | 4 |
| 2007 | 4 |
| 2008 | 4 |
| 2009 | 6 |
| 2010 | 3 |
| 2011 | 6 |
| 2012 | 4 |
| 2013 | 2 |
| 2014 | 2 |
| 2015 | 3 |
| 2016 | 11 |
| 2017 | 4 |
| 2018 | 8 |
| 2019 | 5 |
| 2020 | 2 |
| 2021 | 6 |
| 2022 | 3 |
| 2023 | 6 |
| 2024 | 9 |
| 2025 | 5 |
| 2026 | 3 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it, so a study counts once.
Who runs them
Industry 5 · Other 119
Ain Shams University (4) · Emory University (4) · Maastricht University Medical Center (4) · UCSF Benioff Children's Hospital Oakland (3) · Menzies School of Health Research (3) · The University of Texas at Arlington (2) · Texas A&M University (2) · Colgate Palmolive (2)
Often tested with
Tested in the same studies.
Nitrates (3) · Glutamine (3) · Sildenafil (3) · Creatine (2) · Leucine (2) · Citrulline (2) · Nitrites (2) · Ascorbic Acid (2)
Coming up
From the study records. Dates are the sponsors’ own estimates and often move.
Reaching primary completion within a year · 4
Studies that test Arginine.
- Nov 2026NON-SURGİCAL PERİODONTAL THERAPY WİTH L-ARGİNİNENot applicable · Alanya Alaaddin Keykubat University
- Dec 2026L-arginine to Reduce Sympathetic Nerve Activity in CKD PatientsPhase 4 · The University of Texas at Arlington
- Dec 2026An Exploratory Study of Arginine Supplementation and the Postoperative Immune REsponseNot applicable · University of Liverpool
- Mar 2027Effect of Add-on L-Arginine Therapy on Heart Failure PatientsPhase 2 · German University in Cairo
Studies
Open first, then newest update. How each study uses Arginine is read from its arms, and is right about nine times in ten. Ask us to read each study. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.
Testing it · 124
- Study of Supplemental Arginine With Chemotherapy and Immunotherapy in Platinum Resistant Ovarian, Fallopian Tube, and Peritoneal CancerNot yet recruitingPhase 1Rebecca ArendNCT07772882Written as (Arginaid®) Oral Arginine
- Arginine and Whole Brain Radiation Therapy for the Treatment of Patients With Brain MetastasesRecruitingEarly Phase 1Emory UniversityNCT06328686Written as Arginine
- Arginine Therapy for the Treatment of Pain in Children With Sickle Cell DiseaseRecruitingPhase 1/2Emory UniversityNCT02447874Written as Arginine
- Arginine Replacement Therapy in COVID-19RecruitingPhase 2Emory UniversityNCT05855330Written as Arginine Hydrochloride
- An Exploratory Study of Arginine Supplementation and the Postoperative Immune REsponseRecruitingNot applicableUniversity of LiverpoolNCT05306925Written as Arginine
- Effect of Add-on L-Arginine Therapy on Heart Failure PatientsNot yet recruitingPhase 2German University in CairoNCT07394270Written as L-Arginine Powder
- Evaluation of the Effect of L-Arginine on the Cognitive Function in Geriatric PatientsRecruitingPhase 2German University in CairoNCT07338682Written as L-Arginine
- Comparison Between Treatments of OligohydramniosRecruitingPhase 2Kafrelsheikh UniversityNCT07135037Written as L-Arginine, 1000 Mg Oral Tablet
- L-arginine for Knee Osteoarthritis PatientsRecruitingNot applicableXiangya Hospital of Central South UniversityNCT06054633Written as L-arginine tablet
- The Effects of L-arginine Supplementation on Anaerobic Exercise PerformanceRecruitingNot applicableUniversity of ManitobaNCT06475391Written as L-arginine
- EFFECTS OF L-ARGININE SUPPLEMENTATION ON THE RECOVERY OF CARDIORESPIRATORY PARAMETERS AFTER SUBMAXIMAL EXERCISE TESTRecruitingNot applicableUniversidade Estadual Paulista Júlio de Mesquita FilhoNCT06405477Written as L-arginine
- Reduction of Dentine Hypersensitivity After Use of Different DentifricesRecruitingPhase 1Armed Forces Institute of Dentistry, PakistanNCT06273930Written as 8% Arginine
- An Exploratory Study of Increased Preterm Arginine INTake (PAINT18)RecruitingNot applicableLiverpool Women's NHS Foundation TrustNCT05299112Written as Arginine
- Prevention of Cancer Development and ProgressionNot yet recruitingPhase 3Zujiang YUNCT03940053Written as Arginine hydrochloride
- Myoinositol, L-arginine and Chromium With Letrozole for Ovulation Induction in Polycystic Ovarian Syndrome PatientsCompletedPhase 3Beni-Suef UniversityNCT06405243Written as l-arginine
- Efficacy Of Supplemental L-Arginine in Preventing Preeclampsia in Pregnant WomenCompletedNot applicableQuaid-e-Azam Medical CollegeNCT07912866Written as L-Arginine
- NON-SURGİCAL PERİODONTAL THERAPY WİTH L-ARGİNİNEActive, not recruitingNot applicableAlanya Alaaddin Keykubat UniversityNCT07892638Written as L-arginine 0.8% subgingival irrigation
- Sickle Cell Disease Treatment With Arginine Therapy (STArT) TrialCompletedPhase 3Claudia R. MorrisNCT04839354Written as L-Arginine Hydrochloride
- L-arginine to Reduce Sympathetic Nerve Activity in CKD PatientsActive, not recruitingPhase 4The University of Texas at ArlingtonNCT03982160Written as L-Arginine
- Improving Quality of Life and Daily Life Activities With Bioarginine in Patients With COPDCompletedNot applicableUniversity of MilanNCT05412160Written as Arginine
See all 124 studies that test Arginine →
Given beside what is tested · 7 — Arginine is usual care or a partner of the new treatment
- Human Albumin Infusion in Liver Cirrhosis and Overt Hepatic Encephalopathy (HACHE)RecruitingNot applicableGeneral Hospital of Shenyang Military RegionNCT06483737Written as Arginine
- The Effects of ATLAS Therapy on Nitric Oxide Bioavailability in Patients With Intermittent ClaudicationActive, not recruitingPhase 1Louis MessinaNCT04800692Written as L-Arginine
- Pressure Ulcers in Patients Receiving Enteral Nutrition Therapy and Their Relationship With Gut MicrobiotaStatus unknownNot applicableFondazione Don Carlo Gnocchi OnlusNCT03627910Written as zinc and arginine
- A Specialized Amino Acid Mixture on Body Composition and Skin State in Overweight and Obese Class I Postmenopausal WomenCompletedNot applicableAzienda di Servizi alla Persona di PaviaNCT04701463Written as L-glutamine, L-arginine and calcium beta-hydroxy-beta-methylbutyrate
- Novel Treatment of Advanced Hepatocellular CarcinomaStatus unknownPhase 3The First Affiliated Hospital of Zhengzhou UniversityNCT03950518Written as Arginine hydrochloride
- Treatment of Supine Hypertension in Autonomic FailureCompletedPhase 1Vanderbilt UniversityNCT00223717Written as L-arginine
- Assessing the Effects of a Topically Applied Cream to Clitoral Blood FlowStatus unknownNot applicableEast Suburban Ob GynNCT01085981Written as arginine 20%, nicotinamide .01%, niacin.1%, in LipodermPG 50%
As the comparator · 4 — what is tested is compared with Arginine
- Phase 1 Trial of Arginine Hydrochloride for the Management of Diabetic Ketoacidosis in Type 2 DiabetesRecruitingPhase 1/2David K CarrollNCT07167693Written as Arginine hydrochloride
- Investigation of a New, Oral Growth Hormone Secretagogue, AEZS-130 as a Growth Hormone Stimulation Test.CompletedPhase 3AEterna ZentarisNCT00448747Written as L-ARG+GHRH
- Role of Nitric Oxide in the Impact of Aging on Myocardial RemodelingCompletedNot applicableWashington University School of MedicineNCT00603720Written as L-Arginine
- Intervention With Lupin Protein-enriched Foods in Hypercholesterolemic SubjectsCompletedNot applicableUniversity of JenaNCT01598649Written as Arginine
What changed recently
From the registry's own updates since Oct 15, 2026.
Newly registered2
- Efficacy Of Supplemental L-Arginine in Preventing Preeclampsia in Pregnant WomenNov 3, 2026NCT07912866
- NON-SURGİCAL PERİODONTAL THERAPY WİTH L-ARGİNİNEOct 23, 2026NCT07892638
Codes
What other systems call Arginine · ClinicalTrials.gg INT007019
- MeSH (NLM) D001120ArginineConfirmed NLM, Wikidata
- UNII (FDA) 94ZLA3W45FARGININEConfirmed FDA, NLM, Wikidata
- RxNorm 1091Confirmed FDA, Wikidata
- Wikidata Q173670L-arginineConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C62008ArginineConfirmed FDA, Wikidata
- DrugBank DB00125One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D001120 | Arginine | Confirmed NLM, Wikidata |
| UNII (FDA) | 94ZLA3W45F | ARGININE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 1091 | — | Confirmed FDA, Wikidata |
| Wikidata | Q173670 | L-arginine | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C62008 | Arginine | Confirmed FDA, Wikidata |
| DrugBank | DB00125 | — | One source Wikidata |
Also registered as arginine hydrochloride (UNII F7LTH1E20Y · RxNorm 89918).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.