SupplementDrug
Citrulline clinical trials
Includes 5 studies of Citrulline malate.
- studies test it
- 68
- open now
- 12
- in phase 3
- 6
- first study started
- 2001
Keep track of what changes. Save the Citrulline studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Studies by the year they started
68 studies that test it; most in 2016 (7)
| Year | Studies |
|---|---|
| 2001 | 1 |
| 2003 | 1 |
| 2006 | 1 |
| 2008 | 2 |
| 2009 | 1 |
| 2010 | 3 |
| 2011 | 2 |
| 2012 | 4 |
| 2013 | 4 |
| 2014 | 1 |
| 2015 | 5 |
| 2016 | 7 |
| 2017 | 3 |
| 2018 | 4 |
| 2019 | 1 |
| 2020 | 5 |
| 2021 | 5 |
| 2022 | 3 |
| 2023 | 7 |
| 2024 | 3 |
| 2025 | 2 |
| 2026 | 3 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 3
- Phase 1
- 17
- Phase 2
- 15
- Phase 3
- 6
- Phase 4
- 1
- No phase
- 33
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 8 · Other 60
Asklepion Pharmaceuticals, LLC (7) · Texas Tech University (6) · Vanderbilt University (4) · Florida State University (3) · University of Colorado, Denver (3) · University of Pittsburgh (3) · Nantes University Hospital (2) · Baylor College of Medicine (2)
Often tested with
Tested in the same studies.
Nitrates (2) · Arginine (2) · Glutathione (1) · Whey Proteins (1) · Leucine (1) · Metformin (1) · Glycine (1) · Caffeine (1)
Studies
Open first, then newest update. How each study uses Citrulline is read from its arms, and is right about nine times in ten.
Testing it · 68
- Effects of Pre-Run Nutritional Supplements During a Fixed-Pace 5 km Treadmill RunRecruitingNot applicableSt. Louis UniversityNCT07854223Written as L-Citrulline
- L-Citrulline and Tadalafil for Mild to Moderate Erectile DysfunctionRecruitingPhase 4Beni-Suef UniversityNCT07642505Written as L-Citrulline
- L-Citrulline Versus Tamsulosin for Medical Expulsive Therapy of Distal Ureteral StonesRecruitingPhase 2Beni-Suef UniversityNCT07617909Written as L-Citrulline
- Safety and PK-PD Study of Oral L-CIT in Preterm Infants With BPD±PH and NECRecruitingNot applicableThe Hospital for Sick ChildrenNCT05636397Written as L-Citrulline
- Novel Approaches for Improving Vascular Function in Veterans With HFpEFRecruitingPhase 1VA Office of Research and DevelopmentNCT06312748Written as L-Citrulline
- Intravenous L-Citrulline for Vaso-occlusive Pain Episode in Sickle Cell DiseaseRecruitingPhase 2Suvankar MajumdarNCT06635902Written as L-citrulline
- L-citrulline to Improve Adverse Outcomes in Admitted Children (EChiLiBRiST, Clinical Trial 2, Inpatients)RecruitingNot applicableBarcelona Institute for Global HealthNCT06426147Written as L-citrulline
- L-ArGinine to pRevent advErse prEgnancy Outcomes (AGREE)RecruitingNot applicableLiverpool School of Tropical MedicineNCT05934318Written as L-citrulline
- Supplementing L-citrulline to Overweight Late Asthma oNset PhenotypesRecruitingPhase 2University of Colorado, DenverNCT03885245Written as L-ctirulline
- A Study of Intravenous L-Citrulline in Patients Aged 6-21 Years Old With Sickle Cell Disease Presenting to Emergency Departments in Acute Vaso-Occlusive CrisisNot yet recruitingPhase 3Asklepion Pharmaceuticals, LLCNCT06989567Written as L-citrulline
- Oral Citrulline Supplementation in COPD Patients With MalnutritionNot yet recruitingPhase 3University Hospital, GrenobleNCT06212765Written as L-citrulline
- Study to Improve Deployment Related Asthma by Using L-Citrulline SupplementationRecruitingPhase 2University of Colorado, DenverNCT05259904Written as L-citrulline
- Role of L-citrulline in Prevention of Pregnancy Associated HypertensionTerminatedPhase 1The University of Texas Medical Branch, GalvestonNCT04979793Written as L-citrulline
- "Effects of Oral Citrulline on Protein Metabolism in Healthy Humans: a Prospective, Randomized, Double-blind , Cross-over Study" (Citrugrêle)CompletedPhase 1Nantes University HospitalNCT00756080Written as citrulline
- Evaluation of the Efficacy of Citrulline Supplementation on the Delay of Delivery for Women Hospitalized for Pre-eclampsia (CITRUPE)CompletedPhase 2/3Nantes University HospitalNCT02801695Written as Citrulline
- L-Citrulline and Endothelial FunctionCompletedPhase 1University of OklahomaNCT05722860Written as L-Citrulline, capsule
- The Effect of 4 Weeks of L-Citrulline Supplementation on Macro- and Microvascular Function in Type 2 DiabetesCompletedNot applicableTexas Tech UniversityNCT06016478Written as L-citrulline
- 2 Weeks of Citrulline Supplementation on Arterial Function in Postmenopausal Women With Elevated Blood Pressure or HypertensionCompletedNot applicableTexas Tech UniversityNCT06025383Written as L-Citrulline
- Effect of L-citrulline and HIIT on Arterial Stiffness, Body Composition, and Lipid Profile in Adolescents with Steatosis Associated with Metabolic Dysfunction (MASLD)CompletedNot applicableUniversidad de GuanajuatoNCT05778266Written as L-citrulline
- L-citrulline Injection in Patients Aged 6-21 Years Old with Sickle Cell Disease Presenting with Vaso-Occlusive Crisis (VOC)TerminatedPhase 1/2Asklepion Pharmaceuticals, LLCNCT04852172Written as L-citrulline
See all 68 studies that test Citrulline →
Given in every arm · 1 — Citrulline is usual care beside what is tested
Codes
What other systems call Citrulline · ClinicalTrials.gg INT007225
- MeSH (NLM) D002956CitrullineConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 29VT07BGDACITRULLINEConfirmed FDA, NLM, Wikidata
- RxNorm 2567Confirmed FDA, Wikidata
- Wikidata Q106345633L-citrulline zwitterionConfirmed FDA, NLM, Wikidata
- Wikidata Q408641L-citrullineConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C53406CitrullineConfirmed FDA, Wikidata
- DrugBank DB00155One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D002956 | Citrulline | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 29VT07BGDA | CITRULLINE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 2567 | — | Confirmed FDA, Wikidata |
| Wikidata | Q106345633 | L-citrulline zwitterion | Confirmed FDA, NLM, Wikidata |
| Wikidata | Q408641 | L-citrulline | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C53406 | Citrulline | Confirmed FDA, Wikidata |
| DrugBank | DB00155 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.