Drug
Amoxicillin clinical trials
Also written Amoxil, Amoxycillin and Trimox.
Counted the way a researcher would: Amoxicillin with its salts, dosage forms, brands and biosimilars. Looking for a trial to join? Including related medicines shows more you could take part in.
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How each study uses Amoxicillin is sorted by a rule, right about nine times in ten. Readers can ask us to read every study one by one.Ask us to read each study
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Approvals
The first approval found in each region, with its record
- United States
- 18 Jan 1974 · AMOXIL · NDA 050459 (FDA, Drugs@FDA)
- European Union
- Not in EMA's list of EU-wide authorisations
From FDA's Drugs@FDA and Purple Book (through openFDA) and the European Medicines Agency, files of Sept 2026 and 27 Oct 2026. National approvals in Europe and other countries are not included. How this is worked out
How studies write it
Studies that test it under each name
Other names
- Amoxycillin
- 4
In one entry with another drug
Given together, or one or the other
Studies by the year they started
283 studies that test it; most in 2018 (20); 1 more planned to start later
| Year | Studies |
|---|---|
| 1995 | 2 |
| 1996 | 2 |
| 1997 | 1 |
| 1998 | 1 |
| 1999 | 1 |
| 2000 | 1 |
| 2001 | 2 |
| 2002 | 5 |
| 2003 | 11 |
| 2004 | 6 |
| 2005 | 6 |
| 2006 | 15 |
| 2007 | 3 |
| 2008 | 6 |
| 2009 | 3 |
| 2010 | 8 |
| 2011 | 11 |
| 2012 | 9 |
| 2013 | 9 |
| 2014 | 9 |
| 2015 | 7 |
| 2016 | 14 |
| 2017 | 16 |
| 2018 | 20 |
| 2019 | 12 |
| 2020 | 10 |
| 2021 | 15 |
| 2022 | 15 |
| 2023 | 18 |
| 2024 | 19 |
| 2025 | 8 |
| 2026 | 18 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it, so a study counts once.
Who runs them
Industry 24 · Other 261
Shanghai Jiao Tong University School of Medicine (9) · Shandong University (5) · Aga Khan University (5) · Washington University School of Medicine (4) · Nanjing First Hospital, Nanjing Medical University (4) · Assistance Publique - Hôpitaux de Paris (4) · Abbott (4) · National Institute of Allergy and Infectious Diseases (NIAID) (3)
Often tested with
Tested in the same studies.
Clavulanic Acid (63) · Clarithromycin (43) · Metronidazole (36) · Vonoprazan (18) · Azithromycin (14) · Levofloxacin (14) · Omeprazole (12) · Rabeprazole (10)
Coming up
From the study records. Dates are the sponsors’ own estimates and often move.
Reaching primary completion within a year · 18, 7 in phase 3
Studies that test Amoxicillin, phase 3 first.
- Dec 2026Comparative Study Evaluating Safety and Effectiveness of ( Proton Pump Inhibitor Versus Vonoprazan ) Based Triple Therapy With or Without Zinc to Eradicate H. Pylori InfectionPhase 3 · Tanta University
- Dec 2026Prospective Clinical Investigation on Infection as a Cause of Chronic Subdural Hematoma.Phase 2/3 · University of Rostock
- Mar 2027Role of Antibiotic Therapy or Immunoglobulin On iNfections in hAematoLogy Immunoglobulin Stopping or Extension (Stop Ig)Phase 2/3 · Monash University
- Apr 2027Role of Antibiotic Therapy or Immunoglobulin On iNfections in hAematoLogy: Immunoglobulin Stopping or ExtensionPhase 2/3 · Monash University
- May 2027Amoxicillin Alone Versus Amoxicillin/Clavulanate for Community-acquired Pneumonia in Patients Aged 65 Years or Older, and Hospitalized in a Non-intensive Care Unit WardPhase 3 · Nantes University Hospital
- Jun 2027Twice Daily Treatment With Amoxicillin for Non-severe Community Acquired Pneumonia.Phase 2/3 · St. Justine's Hospital
- Aug 2027Efficacy of Antibiotic Treatment for Patients With Chronic Low Back Pain and Modic Type I Changes - Randomized Placebo-controlled TrialPhase 3 · Bart Koes
- Dec 2026Vonoprazan vs Proton Pump Inhibitor With Vitamin D or Probiotics Based Triple Therapy for Eradication of Helicobacter Pylori InfectionPhase 2 · Tanta University
- Dec 2026Comparison of Amoxicillin, Clindamycin and Azithromycin Single Doses Antibiotic Prophylaxis in Patient Undergoing Lower Third Molar ExtractionPhase 4 · Dow University of Health Sciences
- Dec 2026Oral Antimicrobial Treatment vs. Outpatient Parenteral for Infective EndocarditisPhase 4 · Fundacion Clinic per a la Recerca Biomédica
Studies
Open first, then newest update. How each study uses Amoxicillin is read from its arms, and is right about nine times in ten. Ask us to read each study. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.
Testing it · 285
- Antibiotic Tissue Penetration and Tissue Response in Head and Neck Infection and Reconstructive SurgeryRecruitingPhase 4Tejs Ehlers KlugNCT07896239Written as Amoxicillin/Clavulanic Acid
- Comparison of Amoxicillin, Clindamycin and Azithromycin Single Doses Antibiotic Prophylaxis in Patient Undergoing Lower Third Molar ExtractionRecruitingPhase 4Dow University of Health SciencesNCT07894016Written as Amoxicillin 2g
- Oral Amoxicillin Compared to Penicillin G Benzathine for the Treatment of Acquired Syphilis.RecruitingPhase 3Hospital de Niños R. Gutierrez de Buenos AiresNCT06877351Written as Amoxicillin
- Comprehensive Ambulatory Antibiotics for the Treatment of Congenital SyphilisRecruitingPhase 2London School of Hygiene and Tropical MedicineNCT06921213Written as Amoxicillin
- Comparative Effectiveness of Available Treatments for Sinus and Ear Infections in Children (Acute Otitis Media)RecruitingPhase 4Nader ShaikhNCT07730814Written as Amoxicillin
- Comparative Effectiveness of Available Treatments for Sinus and Ear Infections in Children (Acute Sinusitis)RecruitingPhase 4Nader ShaikhNCT07732699Written as Amoxicillin
- Amoxicillin-clavulanate Versus Amoxicillin Versus Placebo in Acute Otitis Media in ChildrenNot yet recruitingPhase 4Kuopio University HospitalNCT07878910Written as Amoxicillin
- Antibiotic Prophylaxis After Simple Tooth Extraction in Immunosuppressed Patients With Autoimmune Rheumatic DiseasesRecruitingPhase 4University of Sao Paulo General HospitalNCT07275580Written as Amoxicillin
- Comparative Efficacy of Amoxicillin, Metronidazole, and Chlorhexidine in Preventing Alveolar OsteitisNot yet recruitingNot applicableKhyber Medical University PeshawarNCT07833176Written as Amoxicillin
- Comparison of Topical Antibiotics Versus Systemic Antibiotics in Preventing Burn Wound Infection in Pediatric Burn PatientsNot yet recruitingNot applicableabdul mateenNCT07870239Written as Amoxicillin and clavulanate
- Vonoprazan-Amoxicillin Dual Therapy for Helicobacter Pylori Infection in United States AdolescentsNot yet recruitingPhase 2Boston Children's HospitalNCT07860112Written as Amoxicillin
- Patient Choice Between Antibiotics and Appendectomy in Uncomplicated Appendicitis (FRENCH 47 - ALACARTE)Not yet recruitingPhase 2Assistance Publique - Hôpitaux de ParisNCT07857252Written as amoxicillin-clavulanate
- Antibiotics After Incision and Drainage to Prevent Fistula Formation After First Episode of Perianal AbscessNot yet recruitingPhase 4University of Illinois at ChicagoNCT07704359Written as Amoxicillin + Clavulanate
- Comparative Study Evaluating Safety and Effectiveness of ( Proton Pump Inhibitor Versus Vonoprazan ) Based Triple Therapy With or Without Zinc to Eradicate H. Pylori InfectionRecruitingPhase 3Tanta UniversityNCT07275827Written as Vonoprazan + amoxicillin + clarithromycin
- Vonoprazan vs Proton Pump Inhibitor With Vitamin D or Probiotics Based Triple Therapy for Eradication of Helicobacter Pylori InfectionRecruitingPhase 2Tanta UniversityNCT07293910Written as Amoxicillin
- Congenital Syphilis Treatment Trial (CONSISTENT) in NeonatesNot yet recruitingPhase 4University of Alabama at BirminghamNCT07457385Written as Amoxicillin
- Oral Antimicrobial Treatment vs. Outpatient Parenteral for Infective EndocarditisRecruitingPhase 4Fundacion Clinic per a la Recerca BiomédicaNCT05398679Written as Amoxicillin Capsules
- 3 vs. 5 Days of Amoxicillin for Childhood Pneumonia: An RCTNot yet recruitingEarly Phase 1Khyber Teaching HospitalNCT07647835Written as Amoxicillin
- Evaluation of an Oral Microbiota-based Therapeutic as a Treatment Option for PSCRecruitingEarly Phase 1University of MinnesotaNCT06197308Written as oral vancomycin and oral amoxicillin
- Prospective Clinical Investigation on Infection as a Cause of Chronic Subdural Hematoma.RecruitingPhase 2/3University of RostockNCT07556991Written as Amoxicillin + clavulanic acid
See all 285 studies that test Amoxicillin →
Given beside what is tested · 106 — Amoxicillin is usual care or a partner of the new treatment
- Safety of Vonoprazan-Amoxicillin Dual Therapy Versus Concomitant Quadruple Therapy for H. Pylori EradicationRecruitingPhase 4Ignacio MoratorioNCT07924098Written as Amoxicillin
- Keverprazan-Minocycline Dual Therapy of Different Durations Versus Bismuth Quadruple Therapy for Helicobacter Pylori Eradication.RecruitingPhase 3Nanjing First Hospital, Nanjing Medical UniversityNCT07904429Written as Amoxicillin
- Optimizing H. Pylori Eradication Regimen Under Intensified Acid SuppressionNot yet recruitingPhase 4Qilu Hospital of Shandong UniversityNCT07750938Written as Amoxicillin 1000 mg
- Comparison of PRF and Corticosteroids in Impacted Third Molar SurgeryRecruitingNot applicableFinal International UniversityNCT07742826Written as Amoxicillin/Clavulanic Acid
- Optimization of Keverprazan-amoxicillin Dual Therapy for Eradicating Helicobacter Pylori InfectionRecruitingPhase 3Eighth Affiliated Hospital, Sun Yat-sen UniversityNCT06734260Written as Keverprazan Hydrochloride tablets + high dose amoxicillin
- Combination Study of Antibiotics With Enzalutamide (PROMIZE)RecruitingPhase 1/2Institute of Cancer Research, United KingdomNCT06126731Written as Amoxicillin 500mg
- Head-to-head Study of Tegoprazan 50 mg BID Plus Amoxicillin 1 g TID vs. Vonoprazan 20 mg BID Plus Amoxicillin 1 g TID for H. Pylori EradicationRecruitingPhase 2/3First People's Hospital of HangzhouNCT07242456Written as Amoxicillin
- Efficacy Comparison of Vonoprazan Combined With Different Antibiotics in Dual Therapy for Helicobacter Pylori Eradication: A Prospective, Randomized Controlled Clinical TrialRecruitingPhase 4Yongquan ShiNCT07068607Written as Amoxicillin
- Comparison of Omeprazole vs Vonoprazon in Treatment of H Pylori InfectionNot yet recruitingPhase 4Rehman Medical Institute - RMINCT07040839Written as Amoxicillin 1 g
- The Effect of Vitamin D Supplement as Adjuvant Therapy in Eradication of Helicobacter Pylori InfectionNot yet recruitingPhase 3Assiut UniversityNCT06964334Written as amoxicillin
- Zuojin Wan Combined with Vonoprazan-Amoxicillin Dual Therapy in H.Pylori EradicationNot yet recruitingEarly Phase 1Nanjing First Hospital, Nanjing Medical UniversityNCT06901375Written as Amoxicillin
- The Efficacy and Safety of Keverprazan for Helicobacter Pylori EradicationNot yet recruitingEarly Phase 1Nanjing First Hospital, Nanjing Medical UniversityNCT06777732Written as Amoxicillin
- Comparison of Keverprazan Hydrochloride-Amoxicillin Dual Therapy and Susceptibility-Guided Quadruple Therapy for Helicobacter Pylori Rescue TreatmentNot yet recruitingPhase 3Sixth Affiliated Hospital, Sun Yat-sen UniversityNCT06760065Written as Keverprazan Hydrochloride tablets + high dose amoxicillin
- Modified Dosage for Severe Acute MalnutritionRecruitingNot applicableAction Against Hunger USANCT06061484Written as Amoxicillin
- Pivmecillinam With Amoxicillin/Clavulanic Acid for Step Down Oral Therapy in ESBL UTIsRecruitingPhase 3Lund UniversityNCT05224401Written as Pivmecillinam and amoxicillin/clavulanic acid
- Comparison of Two Dual Therapies in the First-line Treatment of Helicobacter Pylori Infection （SHARE2301）RecruitingNot applicableYanqing LiNCT05870683Written as Amoxicillin
- Biofunctionalization of a Volume-stable Collagen Matrix (VCMX) for the Treatment of Single Gingival RecessionRecruitingNot applicableUniversidade Estadual Paulista Júlio de Mesquita FilhoNCT05916742Written as Amoxicillin 500mg
- Vonoprazan-containing Triple Therapy Versus Empiric Bismuth Quadruple Therapy for First-line Helicobacter Pylori Treatment: a Randomized Clinical TrialNot yet recruitingPhase 4Shanghai East HospitalNCT05726734Written as Amoxicillin, Metronidazole
- Milk Fat Globule Membrane-Enhanced RUTF for Children With Severe Acute MalnutritionActive, not recruitingNot applicableWashington University School of MedicineNCT06869850Written as Amoxicillin
- Efficacy and Safety of Black Seed Oil With Vonoprazan Based Triple Therapy in Treatment of Helicobacter PyloriActive, not recruitingPhase 2Ain Shams UniversityNCT05957432Written as Vonoprazan, Amoxicillin and Clarithromycin
Showing 20 of 106.
As the comparator · 53 — what is tested is compared with Amoxicillin
- Safety and PK of Ceftibuten-ledaborbactam Etzadroxil Fixed-dose CombinationRecruitingPhase 1Basilea PharmaceuticaNCT06733675Written as amoxicillin-clavulanate
- APLAUD Trial (Antibiotics vs PLacebo for Acute Uncomplicated Diverticulitis)RecruitingPhase 2Vanderbilt University Medical CenterNCT07492134Written as Amoxicillin-Clavulanate 875 Mg-125 Mg Oral Tablet
- Improvement of PPROM Management With Prophylactic Antimicrobial Therapy (iPROMPT)RecruitingPhase 4Ohio State UniversityNCT06396078Written as Amoxicillin 250 MG
- Azithromycin as Adjunctive Treatment for Uncomplicated Severe Acute MalnutritionRecruitingPhase 4University of California, San FranciscoNCT06010719Written as Amoxicillin
- Optimizing Care for Children Hospitalized With Community-acquired Pneumonia: Short-course TherapyRecruitingPhase 4JeffreyNCT06125340Written as Amoxicillin
- Study on the Efficacy and Safety of Berberine, Minocycline, Esomeprazole, and Colloidal Bismuth Quadruple Therapy in the Initial Treatment of Helicobacter Pylori.RecruitingPhase 4Xijing Hospital of Digestive DiseasesNCT06603688Written as Amoxicillin
- Non-antibiotic Management in Acute Uncomplicated DiverticulitisWithdrawnPhase 4Montefiore Medical CenterNCT07625267Written as Amoxicillin-clavulanate
- Effectiveness of the Eradication of Helicobacter Pylori and an Inhibitor of Pump With Proton Versus ControlWithdrawnPhase 4Assistance Publique - Hôpitaux de ParisNCT00713947Written as during one week for the active treatments
- Efficacy and Safety of Tegoprazan and Minocycline Dual Therapy for Helicobacter Pylori Initial TreatmentActive, not recruitingPhase 4Xijing Hospital of Digestive DiseasesNCT06523764Written as Amoxicillin
- Azithromycin for Severe Acute Malnutrition in CMAM, NigeriaTerminatedPhase 3University of California, San FranciscoNCT05473234Written as Amoxicillin
- Oral Sulopenem Versus Amoxicillin/Clavulanate for Uncomplicated Urinary Tract Infection in Adult WomenCompletedPhase 3Iterum Therapeutics, International LimitedNCT05584657Written as Amoxicillin/clavulanate
- Effectiveness and Safety of Once or Twice Daily Mometasone Nasal Spray Versus Amoxicillin Versus Placebo for Treatment of Acute Rhinosinusitis (Study P02683)CompletedPhase 2Organon and CoNCT00750750Written as Amoxicillin
- Effectiveness and Safety of Once or Twice Daily Mometasone Nasal Spray Versus Amoxicillin Versus Placebo for Treatment of Acute Rhinosinusitis (Phase 3 Study)(Study P02692)CompletedPhase 3Organon and CoNCT00751075Written as Amoxicillin
- Study to Compare the Efficacy of Pristinamycin (Pyostacine ®) Versus Amoxicillin in the Treatment of Acute Community Acquired PneumoniaTerminatedPhase 4SanofiNCT02332577Written as Amoxicillin
- ILTHPI - Comparison of Medicament Containing Tetracycline, Metronidazole, Bismuth Versus Amoxicillin, Metronidazole, ClarithromycinCompletedPhase 4Mackay Memorial HospitalNCT04853875Written as Amoxicillin, Metronidazole, Clarithromycin
- Effects of Phenoximethylpenicillin, Amoxicillin and Amoxicillin-clavulanic Acid on the Gut MicrobiotaCompletedPhase 4Uppsala UniversityNCT04084106Written as Amoxicillin
- Azithromycin for Uncomplicated Severe Acute Malnutrition in Burkina Faso (Pilot)CompletedPhase 3University of California, San FranciscoNCT03568643Written as Amoxicillin
- Antimicrobial Therapy for Ulcerative Colitis (UC)TerminatedPhase 2Wolfson Medical CenterNCT03986996Written as amoxicillin, metronidazole and doxycycline
- Multicentral Preventive Antibiotics With Cystectomy Within Enhanced Recovery After SurgeryStatus unknownPhase 3N.N. Petrov National Medical Research Center of OncologyNCT05392634Written as Amoxicillin+clavulanic acid 1200 mg or Cefuroksim 1500mg
- An Oral Amoxicillin-Clavulanate Regimen to Prevent Bacteremia Following Dental ProceduresTerminatedPhase 4University of Santiago de CompostelaNCT02783404Written as Amoxicillin
Showing 20 of 53.
What changed recently
From the registry's own updates since Oct 15, 2026.
Started recruiting6
- Antibiotic Tissue Penetration and Tissue Response in Head and Neck Infection and Reconstructive SurgeryNov 4, 2026NCT07896239
- Comparison of Amoxicillin, Clindamycin and Azithromycin Single Doses Antibiotic Prophylaxis in Patient Undergoing Lower Third Molar ExtractionNov 2, 2026NCT07894016
- Oral Amoxicillin Compared to Penicillin G Benzathine for the Treatment of Acquired Syphilis.Oct 27, 2026NCT06877351
- Comparative Effectiveness of Available Treatments for Sinus and Ear Infections in Children (Acute Otitis Media)Oct 20, 2026NCT07730814
- Comparative Effectiveness of Available Treatments for Sinus and Ear Infections in Children (Acute Sinusitis)Oct 20, 2026NCT07732699
Show 1 moreShow fewer
Results posted1
- "Is Antibiotic Therapy Necessary for Patients Undergoing Extraction of Teeth With Abscess?"Oct 26, 2026NCT07694531
Newly registered3
- Comparison of Amoxicillin, Clindamycin and Azithromycin Single Doses Antibiotic Prophylaxis in Patient Undergoing Lower Third Molar ExtractionOct 26, 2026NCT07894016
- Antibiotic Tissue Penetration and Tissue Response in Head and Neck Infection and Reconstructive SurgeryOct 26, 2026NCT07896239
- Amoxicillin-clavulanate Versus Amoxicillin Versus Placebo in Acute Otitis Media in ChildrenOct 16, 2026NCT07878910
Codes
What other systems call Amoxicillin · ClinicalTrials.gg INT006961
- MeSH (NLM) D000658AmoxicillinConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 804826J2HUAMOXICILLINConfirmed FDA, NLM, Wikidata
- RxNorm 133008One source FDA
- Wikidata Q27122483amoxicillin trihydrateConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C237AmoxicillinConfirmed FDA, Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D000658 | Amoxicillin | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 804826J2HU | AMOXICILLIN | Confirmed FDA, NLM, Wikidata |
| RxNorm | 133008 | — | One source FDA |
| Wikidata | Q27122483 | amoxicillin trihydrate | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C237 | Amoxicillin | Confirmed FDA, Wikidata |
Also registered as amoxicillin anhydrous (UNII 9EM05410Q9 · RxNorm 1297882), amoxicillin sodium (UNII 544Y3D6MYH · RxNorm 267360) and clamoxyquin hydrochloride (UNII SQ922M93PI).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.