Endocarditis clinical trials
The registry lists 173 studies for Endocarditis across more than 10 countries. 57 are recruiting or about to start. 129 of them are mainly about Endocarditis (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its narrower condition Endocarditis, Bacterial too: 182 studies, 60 open.
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Status
Who runs them
Assistance Publique - Hôpitaux de Paris (9) · Central Hospital, Nancy, France (6) · Assistance Publique Hopitaux De Marseille (5) · Assiut University (5) · University Hospital, Bordeaux (4) · University Hospital, Strasbourg, France (4) · Todd C. Lee MD MPH FIDSA (3) · Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) (3)
What is being tested here
Drugs under test in Endocarditis studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Nov 2026Percutaneous AngioVac Vegetation Extraction (PAVE) to Remove Right Heart Vegetations in Patients With Infective Endocarditis · Angiodynamics, Inc.
- Dec 2026Interest of Parametric Positron Emission Imaging in the Diagnosis of Infections on Cardiac Valve Prosthesis · Centre Henri Becquerel
- Dec 2026Oral Antimicrobial Treatment vs. Outpatient Parenteral for Infective Endocarditis · Fundacion Clinic per a la Recerca Biomédica
- Dec 2026French National Observatory on Infective Endocarditis · Central Hospital, Nancy, France
- Jan 2027Impact of Preoperative Dental Screening in Reducing Infective Endocarditis Risk in Transcatheter Aortic Valve Implantation Patients · Odense University Hospital
- Feb 2027Etiologic Diagnosis Algorithm in Infective Endocarditis · I.M. Sechenov First Moscow State Medical University
- Mar 2027Transthoracic Echocardiography in Assessing Patients With Suspected Endocarditis · Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Mar 2027Impact of Preoperative Dental Screening in Reducing Infective Endocarditis Risk in Surgical Valve Replacement Patients · Odense University Hospital
- Mar 2027Infective Endocarditis Surgery Using Conventional Prosthetic Valves Versus Cryopreserved Aortic Homograft · Centre Cardiologique du Nord
- Jun 2027Evolution of PET Fixation With FDG at the End of Antibiotic Treatment of Infective Endocarditis on Valvular Prosthesis · Assistance Publique - Hôpitaux de Paris
Who these studies take
Of the 38 Endocarditis studies recruiting now, 34 (89%) set no upper age limit and 1 (3%) stop at 75 or younger. 1 (3%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 2 (5%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 38 (100%) | 38 (100%) |
| 30 | 38 (100%) | 38 (100%) |
| 40 | 38 (100%) | 38 (100%) |
| 50 | 38 (100%) | 38 (100%) |
| 65 | 38 (100%) | 38 (100%) |
| 75 | 38 (100%) | 38 (100%) |
| 85 | 36 (95%) | 36 (95%) |
Across all 173 studies, recruiting or not: 6% stop at 75 or younger and 6% at 65; 12% take children; 0% are for women only and 0% for men only; 8% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Endocarditis studies take
Of 36 observational studies under Endocarditis, half reached primary completion within 62 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 35 mo22–59 · 34 studies | — | — |
| Observational | 62 mo36–… · 36 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 11, 2026.
Started recruiting1
Newly registered2
- Study of Fosfomycin-containing Antibiotic Regimens for the Treatment of Infective Endocarditis in Clinical PracticeNov 10, 2026NCT07930104
- Metabolic Profiling Among Patients Suspected of Infective Endocarditis - PPSIE Comparing Metabolomes of Bloodstream Infections Versus Infective EndocarditisNov 4, 2026NCT07917325
Studies
Recruiting first, then most recently updated. Showing 50 of 173. Browse all 173 → or search them.
- Study of Fosfomycin-containing Antibiotic Regimens for the Treatment of Infective Endocarditis in Clinical PracticeNot yet recruitingNCT07930104
- Metabolic Profiling Among Patients Suspected of Infective Endocarditis - PPSIE Comparing Metabolomes of Bloodstream Infections Versus Infective EndocarditisNot yet recruitingNCT07917325Not applicable1 country
- CBCT vs OPT on the Oral Health Status at 12 Months of Patients Hospitalized for Infective Endocarditis.RecruitingNCT06269679Not applicable1 country
- Rifampin-free Regimen Versus Rifampin-containing Regimen in the Treatment of Staphylococcal Prosthetic Valve EndocarditisRecruitingNCT07345325Phase 31 country
- Impact of Preoperative Dental Screening in Reducing Infective Endocarditis Risk in Transcatheter Aortic Valve Implantation PatientsRecruitingNCT063307661 country
- REVIVE-FR RegistryNot yet recruitingNCT07885761
- AngioVac Aspiration Therapy RegistryNot yet recruitingNCT077693201 country
- Impact of Preoperative Dental Screening in Reducing Infective Endocarditis Risk in Surgical Valve Replacement PatientsRecruitingNCT064038391 country
- From Commensalism to Pathogenicity: Exploring the Pathophysiology of Bacteremia to Better Understand Enterococcus Faecalis Infective EndocarditisRecruitingNCT07313865Not applicable1 country
- Clopidogrel vs. Aspirin for Cardiovascular Risk Reduction in Patients With S. Aureus BacteremiaRecruitingNCT06650488Phase 41 country
- Dabigatran vs. Oral Anti-Xa Inhibitors in S. Aureus BacteremiaRecruitingNCT06650501Phase 41 country
- A Prospective Diagnostic Trial of Al[¹⁸F]F-NOTA-folate PET in Patients With Suspected Cardiac Sarcoidosis and Infective EndocarditisRecruitingNCT07814222Not applicable1 country
- Daptomycin vs. Vancomycin for the Treatment of Methicillin Resistant S. Aureus BacteremiaRecruitingNCT06637332Phase 43 countries
- Reducing Risk for Infective EndocarditisRecruitingNCT05721781Not applicable1 country
- Barts Endocarditis Research RegistryRecruitingNCT064340121 country
- Dalbavancin Therapy for Infective EndocarditisNot yet recruitingNCT07699211Phase 31 country
- Oral Antimicrobial Treatment vs. Outpatient Parenteral for Infective EndocarditisRecruitingNCT05398679Phase 41 country
- Etiologic Diagnosis Algorithm in Infective EndocarditisRecruitingNCT07682389Not applicable1 country
- Study of the Prognosis of Infectious Endocarditis (EPEI)RecruitingNCT032119751 country
- Anemia Therapy in Patients With Infective EndocarditisRecruitingNCT07523646Phase 41 country
- The Study Tests if Preoperative Dental Screening is Superior to no Preoperative Dental Screening in Improving the Outcome of Patients Undergoing Surgical Cardiac Valve Replacement or Transcatheter Cardiac Valve Implantation.RecruitingNCT07511673Not applicable1 country
- Oritavancin for Treatment of Serious Cardiac InfectionsNot yet recruitingNCT07550595Phase 21 country
- Percutaneous AngioVac Vegetation Extraction (PAVE) to Remove Right Heart Vegetations in Patients With Infective EndocarditisNot yet recruitingNCT07282002Not applicable
- INfectious DIsease REgistry BIObankRecruitingNCT064180481 country
- Healthrelated Quality of Life and Experiences of a Heart Rehabilitation Programme After Care for Infective Endocarditis.RecruitingNCT06704048Not applicable1 country
- Evaluation of the Benefits of Hypnosis During Transoesophageal EchocardiographyRecruitingNCT07512830Not applicable1 country
- Bacteriophages in Addition to Antibiotics for the Treatment of Patients With Infective EndocarditisRecruitingNCT06870409Phase 31 country
- Transthoracic Echocardiography in Assessing Patients With Suspected EndocarditisNot yet recruitingNCT07415369
- San Matteo Endocarditis Registry STEADYRecruitingNCT073462221 country
- Interest of Parametric Positron Emission Imaging in the Diagnosis of Infections on Cardiac Valve ProsthesisRecruitingNCT05146180Not applicable1 country
- Betalactam Pharmacokinetics in Endocarditis PatientsRecruitingNCT046473311 country
- Echocardiography Versus no Echocardiography in S. Aureus Bacteraemia and VIRSTA Score < 3RecruitingNCT06457386Not applicable1 country
- Prospective Cohort Study of Patients With Infective Endocarditis at Pitié-Salpêtrière HospitalRecruitingNCT049929231 country
- French National Observatory on Infective EndocarditisRecruitingNCT032727241 country
- Belgian Infective Endocarditis RegistryNot yet recruitingNCT06745440
- European Research Group on Outcomes of Surgical Treatment of Infective EndocarditisEnrolling by invitationNCT071088031 country
- Evolution of PET Fixation With FDG at the End of Antibiotic Treatment of Infective Endocarditis on Valvular ProsthesisRecruitingNCT05989152Not applicable1 country
- Ampicillin and Ceftriaxone for the Treatment of Enterococcus Faecalis Infective Endocarditis.RecruitingNCT06423898Phase 41 country
- Evaluation of the Impact of a Patient Education Protocol on the Quality of 18F-FDG PET Imaging Indicated for Investigation of Cardiac InflammationNot yet recruitingNCT07029295Not applicable1 country
- Oritavancin for CIED Infections With MDR Gram-positive CocciNot yet recruitingNCT07013552Not applicable1 country
- Study of Leukocyte Immunophenotype and the Lipid Transport System as Predictive Biomarkers of Severe Bacterial InfectionsEnrolling by invitationNCT041789151 country
- Impact of FDG-PET/CT on Management of Patients with Native Valve Infective EndocarditisRecruitingNCT047922811 country
- Antibiotics Vs Antibiotics and Surgical ThERapy for Infective EndocarditisRecruitingNCT05061355Not applicable4 countries
- Cytokine REmoval in CRitically Ill PAtients Requiring Surgical Therapy for Infective Endocarditis (RECReATE)RecruitingNCT03892174Not applicable1 country
- Management of Anemia in Patients with EndocaRditis Infectious Candidates for Cardiac Surgery: the AMERICA StudyNot yet recruitingNCT065839021 country
- Prognosis of Patients With Infective Endocarditis and Risk Stratification Value of Biomarkers (ENDEAVOR)RecruitingNCT059653621 country
- An Oral Doxycycline Regimen to Prevent Bacteremia Following Dental ProceduresNot yet recruitingNCT06422221Phase 41 country
- PREhabilitation in Patients Awaiting Acute Inpatient Cardiac SurgEryRecruitingNCT06275100Not applicable1 country
- Partial Oral Antimicrobials to Treat Infective Endocarditis in People Who Inject DrugsRecruitingNCT04544306Not applicable1 country
- The Predictive Value of Lubricin in Patients With Infective EndocarditisEnrolling by invitationNCT062667411 country