Otitis Media clinical trials
The registry lists 241 studies for Otitis Media across more than 10 countries. 32 are recruiting or about to start. 175 of them are mainly about Otitis Media (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-04. Counting its narrower condition Otitis Media with Effusion too: 296 studies, 38 open.
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Status
Who runs them
GlaxoSmithKline (11) · Alcon Research (10) · Integra LifeSciences Corporation (8) · University of Pittsburgh (8) · Pfizer (7) · Menzies School of Health Research (5) · Children's Hospital of Philadelphia (5) · Otonomy, Inc. (5)
What is being tested here
Drugs under test in Otitis Media studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Amoxicillin | 2 | 1 | 8 |
| Clavulanic Acid | 2 | 1 | 5 |
| Triamcinolone Acetonide | 1 | 1 | 1 |
| Triamcinolone | 1 | 1 | 1 |
| PHiD-CV vaccine | 0 | 4 | 5 |
| Azithromycin | 0 | 3 | 5 |
| Benzocaine | 0 | 2 | 4 |
| Moxifloxacin | 0 | 3 | 4 |
| Dexamethasone phosphate | 0 | 3 | 4 |
| Dexamethasone | 0 | 3 | 4 |
Drug classes tested here Beta-lactamase inhibitors 2 open · Corticosteroids 1 open · Local anesthetics 5
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Aug 2027Intranasal Corticosteroid Spray for Preventing Otitis Media With Effusion After Radiotherapy in Nasopharyngeal Carcinoma · Phase 3 · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Nov 2026Perspectives on Antibiotics and Tracking Symptoms in Children · Murdoch Childrens Research Institute
- Nov 2026Acetic Acid Ear Drops Versus 0.3 % Ciprofloxacin for Chronic Suppurative Otitis Media. · Dow University of Health Sciences
- Mar 2027Artificial Intelligence Diagnostic Decision Support to Reduce Antimicrobial Prescriptions in Young Children With Colds · Timothy Shope
- Mar 2027Digital Otoscopy Versus Standard Otoscopy on the Diagnosis and Treatment of Otitis Media in Young Children · Boston Children's Hospital
- Apr 2027RELAX: Reducing Length of Antibiotics for Children With Ear Infections · Intermountain Health Care, Inc.
- Apr 2027Coherent Optical Detection of Middle Ear Disease · Medical College of Wisconsin
- Apr 2027SWIR Otoscopy Study · Stanford University
- May 2027Utility of Advanced Ultrasound Otoscope In The Diagnosis of AOM · Baylor College of Medicine
- May 2027Parent-led Assessment and Recognition of AOM Using Digital Ear Imaging · Turku University Hospital
Who these studies take
Of the 20 Otitis Media studies recruiting now, 5 (25%) set no upper age limit and 15 (75%) stop at 75 or younger. 19 (95%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 4 (20%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 11 (55%) | 11 (55%) |
| 18 | 7 (35%) | 7 (35%) |
| 30 | 5 (25%) | 5 (25%) |
| 40 | 5 (25%) | 5 (25%) |
| 50 | 5 (25%) | 5 (25%) |
| 65 | 5 (25%) | 5 (25%) |
| 75 | 5 (25%) | 5 (25%) |
| 85 | 5 (25%) | 5 (25%) |
Across all 241 studies, recruiting or not: 80% stop at 75 or younger and 77% at 65; 85% take children; 2% are for women only and 0% for men only; 24% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Otitis Media studies take
Of 10 phase 3 interventional studies under Otitis Media, half reached primary completion within 15 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 3 | 15 mo11–35 · 10 studies | — | — |
| Interventional, no phase | 38 mo13–51 · 45 studies | — | 38 mo11–64 · 36 studies |
| Observational | 24 mo18–67 · 22 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 12, 2026.
Started recruiting1
Newly registered1
- Amoxicillin-clavulanate Versus Amoxicillin Versus Placebo in Acute Otitis Media in ChildrenOct 16, 2026NCT07878910
Studies
Recruiting first, then most recently updated. Showing 50 of 241. Browse all 241 → or search them.
- CLIKX® Tympanostomy Tube Delivery System for the Placement of Tympanostomy TubesRecruitingNCT07625657Not applicable1 country
- Comparative Effectiveness of Available Treatments for Sinus and Ear Infections in Children (Acute Otitis Media)RecruitingNCT07730814Phase 41 country
- Amoxicillin-clavulanate Versus Amoxicillin Versus Placebo in Acute Otitis Media in ChildrenNot yet recruitingNCT07878910Phase 41 country
- Artificial Intelligence Diagnostic Decision Support to Reduce Antimicrobial Prescriptions in Young Children With ColdsRecruitingNCT06876259Not applicable1 country
- Perspectives on Antibiotics and Tracking Symptoms in ChildrenRecruitingNCT07093749Not applicable1 country
- Safety and Efficacy of wSp Vaccine in Young ChildrenRecruitingNCT07216430Phase 21 country
- Does Adding a Fascial Layer to the Cartilage in Tympanoplasty for Large Tympanic Membrane Perforation Affect the Overall Results?Not yet recruitingNCT07834892Not applicable
- Acetic Acid Ear Drops Versus 0.3 % Ciprofloxacin for Chronic Suppurative Otitis Media.Not yet recruitingNCT07835425Not applicable1 country
- Parent-led Assessment and Recognition of AOM Using Digital Ear ImagingRecruitingNCT07640568Not applicable1 country
- Post-Market Clinical Follow-Up Study of the Solo+ Tympanostomy Tube DeviceRecruitingNCT070299971 country
- SWIR Otoscopy StudyRecruitingNCT06944795Not applicable1 country
- Comparative Study of Adherence to Antibiotic Therapy Among Pediatric Patients: Hospital Emergency Department vs. Primary Care CenterNot yet recruitingNCT07711756
- Osteopathic Manipulative Treatment for Children With Chronic or Recurrent Otitis MediaNot yet recruitingNCT07639775Not applicable1 country
- The ROOT Study: Scaling the 'Standard of Care Plus' Obstetric Nutrition Model to Optimize Maternal and Infant HealthNot yet recruitingNCT07559773Not applicable
- Evaluation of the Medentum Diagnostik Platform for Pediatric ENT Conditions and AsthmaRecruitingNCT07500532Not applicable1 country
- Evaluating Laser Otoscope for Middle Ear Effusion DetectionNot yet recruitingNCT074545121 country
- Spectroscopic Evaluation of Middle Ear InfectionRecruitingNCT048120931 country
- Impact of a Multimodal Intervention on Antibiotic Prescribing for Respiratory Infections in Primary CareRecruitingNCT07359287Not applicable1 country
- Coherent Optical Detection of Middle Ear DiseaseRecruitingNCT05353569Not applicable1 country
- Gamified Training and AI Support for Improving Ear Infection Diagnosis in Primary CareNot yet recruitingNCT07246551Not applicable
- Validating and AI Software for Assessment of Children With Ear ConcernsNot yet recruitingNCT07243093
- Intranasal Corticosteroid Spray for Preventing Otitis Media With Effusion After Radiotherapy in Nasopharyngeal CarcinomaNot yet recruitingNCT07189572Phase 3
- Interventions to De-implement Unnecessary Antibiotic Prescribing for Children With Ear InfectionsRecruitingNCT06034080Not applicable1 country
- Comparison of Amoxicillin and Amoxicillin + Clavulanic Acid in Treating Acute Otitis Media in ChildrenNot yet recruitingNCT06895135Not applicable
- Effect of Chitodex Gel in Tympanoplasty SurgeryRecruitingNCT06260618Not applicable1 country
- Evaluation of Outcomes Following In-office Tympanostomy Using the Tula® System: a Prospective, Multi-center RegistryRecruitingNCT059150781 country
- Respiratory Tract Microbiome and Probiotics in Children With Cleft PalateRecruitingNCT06505330Not applicable1 country
- Chronic Suppurative Otitis Media MicrobiologyNot yet recruitingNCT064247041 country
- Microplastics in Otitis Media With Effusion MaterialRecruitingNCT063166351 country
- Mastoid Obliteration Using S53P4 Bioactive Glass Versus Mastoidectomy Alone for Chronic Suppurative Otitis MediaRecruitingNCT061605051 country
- Pneumococcal Carriage and Serotype Distribution in Children With Otitis Media in Malaysia.RecruitingNCT054295411 country
- Effect of Ventilation Tubes in Otitis-prone ChildrenRecruitingNCT05348291Not applicable1 country
- In-Office Clinical Study of the Solo+ TTDActive, not recruitingNCT05741333Not applicable1 country
- Safety Study of a Single Dose of Pneumococcal Whole-Cell Vaccine in Healthy AdultsCompletedNCT07059182Phase 11 country
- Dynamic Change and Immune Response to Nasopharyngeal Carriage and Acute Otitis Media PathogensActive, not recruitingNCT04946084Not applicable1 country
- Evaluate Pathogens and Immunity to Acute Otitis Media in Healthy Children.Active, not recruitingNCT025915631 country
- Does Topical Otic Drop Use at Time of Tympanostomy Tube Surgery Improve Outcomes When no Middle Ear Effusion is PresentTerminatedNCT03655665Phase 41 country
- Effects of Saccharomyces Boulardii CNCM I-745 on Antibiotic-Associated Perturbation in Children Treated for Acute Respiratory Infections (RESTORE Study)CompletedNCT07015736Phase 41 country
- Study the Impact of the Mastoid and Middle Ear Volume on the Success of Type 1 Tympanoplasty in Pediatric Age, With Comparing Using Cartilage and Fascial Grafts Through This, Strength the Hypothesis of That Total Tympanometry Volume Correlates With Ventilated Mastoid Air Cells Volume on CT ScansCompletedNCT078064611 country
- Hearing for Learning Initiative - a Health Facilitator Model for Otitis MediaCompletedNCT03916029Not applicable1 country
- Surveillance of Non-invasive Streptococcus Pneumoniae Infections in BelgiumCompletedNCT044475211 country
- Analgesic Ear Drops for Children With Acute Otitis MediaTerminatedNCT05651633Phase 31 country
- The Effects of Chronic Otitis Surgery on SVVActive, not recruitingNCT043961451 country
- Utility of Advanced Ultrasound Otoscope In The Diagnosis of AOMActive, not recruitingNCT064297091 country
- Effect of Platelet-Rich Plasma on Eardrum Healing and Hearing After Tympanoplasty in AdultsCompletedNCT07664319Not applicable1 country
- Treatment of Clogged Tympanostomy Tubes: An Off-Label Use of Dornase Alfa (Pulmozyme®)CompletedNCT00419380Phase 41 country
- Digital Otoscopy Versus Standard Otoscopy on the Diagnosis and Treatment of Otitis Media in Young ChildrenActive, not recruitingNCT07328555Not applicable1 country
- Digital Otoscope Versus Education and Feedback for Otitis Media in Young ChildrenCompletedNCT06731660Not applicable1 country
- Otitis Treatment With OtoSight™ - Modification of Antibiotic Treatment Intervention in ChildrenActive, not recruitingNCT062858121 country
- Systematic Search for Primary Immunodeficiency in Adults With InfectionsCompletedNCT02972281Not applicable1 country