Sinusitis clinical trials
The registry lists 256 studies for Sinusitis across more than 10 countries. 23 are recruiting or about to start. 191 of them are mainly about Sinusitis (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its narrower condition Rhinosinusitis too: 490 studies, 91 open.
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Who runs them
Integra LifeSciences Corporation (8) · St. Paul's Hospital, Canada (7) · Intersect ENT (7) · Entellus Medical, Inc. (5) · GlaxoSmithKline (5) · Bayer (4) · University of Chicago (4) · STS Medical (3)
What is being tested here
Drugs under test in Sinusitis studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Amoxicillin | 2 | 1 | 8 |
| Azithromycin | 1 | 1 | 6 |
| Clavulanic Acid | 1 | 1 | 5 |
| Budesonide | 1 | 1 | 5 |
| Dupilumab | 1 | 0 | 4 |
| Amoxicillin-Potassium Clavulanate Combination | 1 | 1 | 4 |
| Omalizumab | 1 | 1 | 3 |
| Moxifloxacin | 0 | 1 | 3 |
| Telithromycin | 0 | 1 | 3 |
| Camtarkibart | 0 | 1 | 2 |
Drug classes tested here Beta-lactamase inhibitors 2 open · Corticosteroids 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 9, phase 3 first
- Nov 2027Evaluation of the Efficacy of Azithromycin in Idiopathic Purulent Oedematous Sinusitis in Adults · Phase 3 · Centre Hospitalier Intercommunal Creteil
- Dec 2026Diagnostics of Mycotic Sinusitis in ENT Patients · University Hospital Ostrava
- Dec 2026High Resolution Micro OCT Imaging · University of Alabama at Birmingham
- Dec 2026How OMT Benefits Newly Diagnosed Patients With Respiratory Illness When Given Alongside Other Standard Care. · Geisinger Clinic
- Dec 2026Balloon Sinuplasty Efficiency in Maxillary Rhinosinusitis. · Tampere University Hospital
- Dec 2026A Study Evaluating the Efficacy of Endoscope Ethmoid Infundibulum Expansion Surgery (EEIES) Combined With Stapokibart in the Treatment of Type 2 Chronic Rhinosinusitis · China-Japan Union Hospital
- Jan 2027Endotypic Stability in CRS · Thomas Jefferson University
- Sep 2027Complicated Infections in Otorhinolaryngology · University Medical Centre Ljubljana
- Oct 2027Efficacy of Bee Venom Phonophoresis in Treating Chronic Sinusitis: · Sinai University
Who these studies take
Of the 15 Sinusitis studies recruiting now, 6 (40%) set no upper age limit and 6 (40%) stop at 75 or younger. 2 (13%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (13%) | 2 (13%) |
| 18 | 13 (87%) | 13 (87%) |
| 30 | 13 (87%) | 13 (87%) |
| 40 | 13 (87%) | 13 (87%) |
| 50 | 13 (87%) | 13 (87%) |
| 65 | 14 (93%) | 14 (93%) |
| 75 | 11 (73%) | 11 (73%) |
| 85 | 7 (47%) | 7 (47%) |
Across all 256 studies, recruiting or not: 36% stop at 75 or younger and 20% at 65; 21% take children; 0% are for women only and 0% for men only; 16% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Sinusitis studies take
Of 29 interventional studies with no phase under Sinusitis, half reached primary completion within 19 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 19 mo9–63 · 29 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 11, 2026.
Started recruiting1
Studies
Recruiting first, then most recently updated. Showing 50 of 256. Browse all 256 → or search them.
- Biologics in Chronic Rhinosinusitis With Nasal PolyposisRecruitingNCT06824649Phase 41 country
- Comparative Effectiveness of Available Treatments for Sinus and Ear Infections in Children (Acute Sinusitis)RecruitingNCT07732699Phase 41 country
- Effect of Probiotic Nasal Irrigation on the Postoperative Care of Chronic RhinosinusitisNot yet recruitingNCT07865715Not applicable1 country
- How OMT Benefits Newly Diagnosed Patients With Respiratory Illness When Given Alongside Other Standard Care.RecruitingNCT06495021Not applicable1 country
- Efficacy of Bee Venom Phonophoresis in Treating Chronic Sinusitis:Not yet recruitingNCT07151313Not applicable1 country
- Study on Drug Interactions Affecting the Pharmacokinetics of RSS0343 TabletNot yet recruitingNCT07696091Phase 11 country
- Complicated Infections in OtorhinolaryngologyRecruitingNCT060235501 country
- Nasal Steroids, Irrigation, Oral Antibiotics, and Subgroup Targeting for Effective Management of Acute SinusitisRecruitingNCT06076304Phase 41 country
- Harnessing Digital Medicine to Improve Allergic Rhinitis Management in Primary Care (DMAR)Enrolling by invitationNCT06603935Not applicable1 country
- In-clinic Endoscopic Polypectomy for Chronic Sinusitis With Nasal PolypsRecruitingNCT02975310Not applicable1 country
- A Study to Evaluate the Efficacy and Safety of HTMC0658 Tablets in the Treatment of Chronic Rhinosinusitis Without Nasal PolypsRecruitingNCT07174115Phase 21 country
- Evaluation of the Efficacy of Azithromycin in Idiopathic Purulent Oedematous Sinusitis in AdultsRecruitingNCT05157685Phase 31 country
- A Study Evaluating the Efficacy of Endoscope Ethmoid Infundibulum Expansion Surgery (EEIES) Combined With Stapokibart in the Treatment of Type 2 Chronic RhinosinusitisEnrolling by invitationNCT07073664Not applicable1 country
- Rhinosinusitis Italian Network: the Italian Registry for Severe, Uncontrolled Chronic RhinosinusitisRecruitingNCT059356831 country
- Steroid-eluting Sinus Stent for Chronic Rhinosinusitis Patients With Uncontrolled Postoperative SymptomsRecruitingNCT06198894Not applicable1 country
- Auriculotherapy for Intraoperative Blood Pressure ControlNot yet recruitingNCT06182982Not applicable1 country
- A Clinical Study to Evaluate the Safety and Effectiveness of Novabel Bioabsorbable Steroid-releasing Stent for the Chronic SinusitisRecruitingNCT06020690Not applicable1 country
- Diagnostics of Mycotic Sinusitis in ENT PatientsRecruitingNCT05955859Not applicable1 country
- Maxillary Sinus Membrane Perforation Incidence During OsseodensificationEnrolling by invitationNCT059542731 country
- "Association of Peri-implantitis and Maxillary Sinusitis: a Case-control Study".RecruitingNCT059247111 country
- Endoscopic Sinus Surgery in Recurrent Acute RhinosinusitisRecruitingNCT04241016Not applicable1 country
- Implementation Of Physical Therapy Protocol In Management Of Chronic Maxillary SinusitisNot yet recruitingNCT05875298Not applicable
- Balloon Sinuplasty Efficiency in Maxillary Rhinosinusitis.RecruitingNCT04645511Not applicable1 country
- A Clinical Study of TQH2722 Injection in the Treatment of Chronic Sinusitis With or Without Nasal Polyps.CompletedNCT06089278Phase 21 country
- Craniosacral Osteopathic Treatment for Chronic SinusitisCompletedNCT07542444Not applicable1 country
- Endotypic Stability in CRSActive, not recruitingNCT062721231 country
- A Study to Investigate the Efficacy and Safety of Verekitug (UPB-101) in Participants With Chronic Rhinosinusitis With Nasal PolypsCompletedNCT06164704Phase 25 countries
- Efficacy of Two Nasal Products Based on Diluted Seawater in the Treatment of Upper Respiratory Infections/ConditionsCompletedNCT06498843Not applicable1 country
- Dupilumab in CRSsNPCompletedNCT04678856Phase 213 countries
- High Resolution Micro OCT ImagingActive, not recruitingNCT032567731 country
- Prospective Study on the Efficacy of Exclusive Odontological and Medical Treatment in Chronic Dental Maxillary SinusitisTerminatedNCT04085536Not applicable1 country
- Post-radiotherapy Rhinosinusitis in ChildrenWithdrawnNCT05454163
- Clinical Outcomes and Patient Satisfaction With Velnez Versus Nasopore in Nasal SurgeryCompletedNCT07560254Not applicable1 country
- Endoscopic Assessment of Schneiderian Membrane Perforation During Osseodensification-mediated Transcrestal Sinus Floor Elevation With Graftless Immediate Implant Placement in Subsinus Bone Height of 4-6 mm: A Pilot Study.CompletedNCT07542275Not applicable1 country
- Evaluation of Nitric Oxide Nasal Spray (NONS) for Treatment of Recurrent Acute RhinosinusitisCompletedNCT06264141Phase 21 country
- Reducing Antibiotic Use by Implementation of Stewardship in Primary and Urgent CareActive, not recruitingNCT072170021 country
- Best Practice in the Management of Concha Bullosa in FESS OperationCompletedNCT06687629Not applicable1 country
- Microbiota Transfer for Chronic RhinosinusitisActive, not recruitingNCT05454072Not applicable1 country
- Genetic Factors in Chronic SinusitisActive, not recruitingNCT008805161 country
- Application of Ectoin® Rhinitis Nasal Spray in Patients With Acute RhinosinusitisCompletedNCT016845401 country
- Pilot Study of The EPIC TrialActive, not recruitingNCT02533206Not applicable1 country
- A Study to Evaluate 611 in Patients With Chronic Rhinosinusitis With Nasal PolypsActive, not recruitingNCT06639295Phase 31 country
- Efficacy of Dupilumab for Patients With Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP)CompletedNCT04362501Phase 21 country
- Using ChatGPT to Help Guide Treatment for Sinus and Nasal ProblemsCompletedNCT07140250Not applicable1 country
- Use of Perioperative Antibiotics in Endoscopic Sinus SurgeryTerminatedNCT03369717Phase 41 country
- Aggravated Airway Inflammation: Research on Genomics and Optimal Operative Treatment (AirGOs Operative)CompletedNCT03704415Not applicable2 countries
- Brain Structural Abnormalities in Patients with VertigoCompletedNCT068487121 country
- Dupilumab Severe Eosinophilic Chronic Sinusitis Without Nasal PolyposisActive, not recruitingNCT04430179Phase 21 country
- Dupixent Study for Alternate AdministrationActive, not recruitingNCT06750471Phase 41 country
- Clinical and Radiographic Evidence of Alleviation of Preoperative Chronic Sinusitis After Open Sinus Allogeneic Bone Augmentation Surgery: A Retrospective Observational StudyCompletedNCT067734941 country