Ventricular Dysfunction, Left clinical trials
The registry lists 260 studies for Ventricular Dysfunction, Left across more than 10 countries. 57 are recruiting or about to start. 97 of them are mainly about Ventricular Dysfunction, Left (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its narrower condition Takotsubo Cardiomyopathy too: 320 studies, 82 open.
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Status
Who runs them
Assistance Publique - Hôpitaux de Paris (6) · Bayer (5) · Yonsei University (4) · Medtronic Cardiac Rhythm and Heart Failure (4) · Mayo Clinic (4) · Eko Devices, Inc. (4) · The University of Texas Health Science Center, Houston (4) · National Defense Medical Center, Taiwan (4)
What is being tested here
Drugs under test in Ventricular Dysfunction, Left studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Finerenone | 2 | 2 | 2 |
| Dapagliflozin | 1 | 1 | 2 |
| Sotagliflozin | 1 | 0 | 1 |
| Maltodextrin | 1 | 0 | 1 |
| Prednisone | 1 | 1 | 1 |
| Cholecalciferol | 1 | 0 | 1 |
| Vericiguat | 1 | 1 | 1 |
| Midodrine | 1 | 1 | 1 |
| Sucrosomial iron | 1 | 0 | 1 |
| Simvastatin | 1 | 0 | 1 |
Drug classes tested here SGLT2 inhibitors 2 open · Mineralocorticoid receptor antagonists (MRAs) 2 open · Angiotensin receptor blockers (ARBs) 5 · Beta blockers 5 · PDE5 inhibitors 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Nov 2026PRE-DETERMINE Cohort Study · Brigham and Women's Hospital
- Nov 2026The C-MIC-II Follow-Up Study · Berlin Heals GmbH
- Dec 2026Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE) · Wake Forest University Health Sciences
- Dec 2026Preoperative Maltodextrin's Effect on Cardiac Function in Cardiac Surgery · Jewish General Hospital
- Dec 2026Assement of Left Ventricular Function Before Decannulation in Cardiac Surgery :Visual Estimation vs TEE · Ataturk University
- Dec 2026Sodium Lowering Vascular Effects Trial · Tulane University
- Dec 2026The Use of Single-Beat TE-e' in Evaluation of Left Atrial Pressure in Critically Ill Patients: The TELAP-ICU Trial · Queen Mary Hospital, Hong Kong
- Mar 2027Preoperative Gastric Ultrasound and Left Ventricular Function in Coronary Artery Bypass Surgery · Adiyaman University
- Apr 2027Sacubitril/Valsartan Versus Valsartan Alone on Left Atrial Volume Index in Hypertensive Patients · University of Health Sciences Lahore
- Jun 2027ECG Low Ejection Fraction Detection and Guiding in AI Navigated Treatment Era · National Defense Medical Center, Taiwan
Who these studies take
Of the 38 Ventricular Dysfunction, Left studies recruiting now, 21 (55%) set no upper age limit and 12 (32%) stop at 75 or younger. 5 (13%) take children under 18. 1 (3%) are for women only and 0 (0%) for men only; 7 (18%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 5 (13%) | 5 (13%) |
| 18 | 28 (74%) | 28 (74%) |
| 30 | 31 (82%) | 31 (82%) |
| 40 | 31 (82%) | 31 (82%) |
| 50 | 32 (84%) | 31 (82%) |
| 65 | 32 (84%) | 32 (84%) |
| 75 | 30 (79%) | 30 (79%) |
| 85 | 22 (58%) | 22 (58%) |
Across all 260 studies, recruiting or not: 15% stop at 75 or younger and 7% at 65; 7% take children; 2% are for women only and <1% for men only; 12% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Ventricular Dysfunction, Left studies take
Of 50 observational studies under Ventricular Dysfunction, Left, half reached primary completion within 27 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 36 mo24–86 · 34 studies | — | — |
| Observational | 27 mo17–51 · 50 studies | — | 25 mo17–51 · 45 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 11, 2026.
Started recruiting2
- Preoperative Gastric Ultrasound and Left Ventricular Function in Coronary Artery Bypass SurgeryNov 6, 2026NCT07898215
- AI-Based Cardiac Analysis Using 12-Lead and 1-Lead ECGOct 30, 2026NCT07844434
Newly registered1
Studies
Recruiting first, then most recently updated. Showing 50 of 260. Browse all 260 → or search them.
- Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)RecruitingNCT05714085Phase 2/330 countries
- Preoperative Gastric Ultrasound and Left Ventricular Function in Coronary Artery Bypass SurgeryRecruitingNCT078982151 country
- Importance of Point-of-Care Ultrasound for Early Detection of Valvular and Cardiac Diseases (IMPROVE)Not yet recruitingNCT07756398Not applicable1 country
- Monitoring for CardioToxicity Using WeArable deVices While Undergoing cancEr Treatments (MCT-WAVE)Not yet recruitingNCT07776964Not applicable1 country
- AI-Based Cardiac Analysis Using 12-Lead and 1-Lead ECGRecruitingNCT078444341 country
- A Study to Learn More About How Safe Finerenone is, When it is Taken for a Longer Time With Standard Treatment, in Children and Young Adults With Heart Failure and Left Ventricular Systolic DysfunctionRecruitingNCT07192952Phase 323 countries
- The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy Trial (STICH3C)RecruitingNCT05427370Not applicable16 countries
- A Study to Learn More About How Well Finerenone Works, How Safe it is, and How it Moves Into, Through, and Out of the Body Compared to Placebo When Taken With Standard Treatment in Children With Heart Failure and Left Ventricular Systolic DysfunctionRecruitingNCT07188805Phase 323 countries
- Sacubitril/Valsartan Versus Valsartan Alone on Left Atrial Volume Index in Hypertensive PatientsNot yet recruitingNCT07853625Not applicable
- The Use of Single-Beat TE-e' in Evaluation of Left Atrial Pressure in Critically Ill Patients: The TELAP-ICU TrialRecruitingNCT078203191 country
- Midodrine in Heart Failure With Reduced Ejection Fraction With HypotensionRecruitingNCT06405555Phase 2/31 country
- Assement of Left Ventricular Function Before Decannulation in Cardiac Surgery :Visual Estimation vs TEERecruitingNCT072862271 country
- STEPwise De-escalation and Optimizing Withdrawal of ARNI and SGLT2i in Normalized Heart FailureRecruitingNCT07631156Phase 41 country
- Federated Learning for Point-of-Care Cardiac UltrasoundEnrolling by invitationNCT078009621 country
- Menopausal Hormone Therapy And Left Ventricular FunctionRecruitingNCT072423911 country
- Micro-axial Flow Pump-Supported PCI in Complex Coronary Artery Disease With Ischemic LV DysfunctionNot yet recruitingNCT07678021Not applicable1 country
- AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable MonitorRecruitingNCT066990561 country
- PASCAL Precision-GDMT RegistryNot yet recruitingNCT07578129
- CHIP-CC Registry: A Prospective Multicenter Registry of Complex High-Risk PCI in ChinaNot yet recruitingNCT075572381 country
- Sotagliflozin as Prevention of Anthracycline-Related CardiotoxicityNot yet recruitingNCT07572175Phase 21 country
- Multimodality Evaluation of Left Ventricular Remodeling In Mitral Regurgitation: A Pilot StudyRecruitingNCT067700621 country
- London Valvular Heart Disease and Reduced Ejection Fraction Detection in a Multi-ethnic Community Using Cardiac UltrasoundRecruitingNCT052085671 country
- Effect of Left Ventricle Diastolic Dysfunction on Outcomes in Female Cardiac Surgery PatientsRecruitingNCT059723561 country
- AI-Enabled Electrocardiogram-Guided Guideline-Directed Medical Therapy on Incident Left Ventricular Dysfunction: A Target Trial Emulation StudyRecruitingNCT07355023Not applicable1 country
- DAPAgliflozine to Attenuate Cardiac RemOdeling afTEr aCuTe myOcardial InfarctionRecruitingNCT05764057Phase 31 country
- Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE)RecruitingNCT047522931 country
- Effect of Oral sucRosomIal Iron on exerciSE Capacity and Quality of Life in Patients With Heart FailureRecruitingNCT06270498Phase 41 country
- Human Embryonic Stem Cell-Derived Cardiomyocyte Therapy for Chronic Ischemic Left Ventricular DysfunctionRecruitingNCT05068674Phase 11 country
- Prevalence and Risk Factors asSOciated With CArdiac comorbiDIty in psoriAsisRecruitingNCT049502181 country
- Conventional Biventricular Versus Left Bundle Branch Pacing on Outcomes in Heart Failure PatientsRecruitingNCT05769036Not applicable1 country
- The Predictive Value of Dobutamine Echo-stress in the Clinical Response to CCM Therapy in Advanced HFRecruitingNCT069739021 country
- Flecainide in Idiopathic Premature Ventricular Contractions and Related CardiomyopathyRecruitingNCT069497481 country
- External Validation of Artificial Intelligence-enabled Electrocardiography (AI-ECG) for the Detection of Left Ventricular Dysfunction (LVD)Not yet recruitingNCT070380181 country
- Carvedilol + Simvastatin vs. Carvedilol Alone for Cirrhosis and Cirrhotic Cardiomyopathy and Impact on Hepatic Decompensation and SurvivalRecruitingNCT06431919Not applicable1 country
- The C-MIC-II Follow-Up StudyRecruitingNCT05189860Not applicable4 countries
- ECG Low Ejection Fraction Detection and Guiding in AI Navigated Treatment EraEnrolling by invitationNCT06968533Not applicable1 country
- AI-based Prediction of Cardiac Function Using Echocardiography and Body Composition Data (ECHO-FIT Study)RecruitingNCT068115191 country
- Preoperative Maltodextrin's Effect on Cardiac Function in Cardiac SurgeryNot yet recruitingNCT05188222Phase 41 country
- COR-INSIGHT: Optimizing Cardiovascular and Cardiopulmonary Outcomes with AI-Driven Multiplexed Indications Using COR ECG WearableEnrolling by invitationNCT067635491 country
- Apixaban Prophylaxis for Prevention of Left Ventricular Thrombus Following Anterior Myocardial InfarctionRecruitingNCT06742567Phase 31 country
- Study to Assess Safety and Efficacy of Treating Symptomatic, Ischemic, Chronic Congestive Heart Failure Patients with an LVEF of ≤40% with Fresh, Uncultured, Autologous, Adipose-derived Regenerative Cells Isolated from Lipoaspirate.RecruitingNCT06705023Phase 21 country
- Left Bundle Branch Pacing on Outcomes and Ventricular Remodeling in Biventricular CRT NonrespondersRecruitingNCT05760924Not applicable1 country
- Reducing Cognitive Impairment by Management of Heart Failure as a Modifiable Risk FactorRecruitingNCT06088212Not applicable1 country
- Corticoid Therapy in Acute MyocarditisNot yet recruitingNCT06522100Phase 3
- Pharmacokinetics of Inhaled LevosimendanRecruitingNCT06387862Phase 21 country
- Early Evaluation of Left Ventricular Systolic Function Impairment in Patients With Chronic Kidney Disease by Multimodal UltrasonographyRecruitingNCT062218911 country
- The COLchicine HEART Failure PRESERVED Trial (COLHEART-PRESERVED)RecruitingNCT06081049Phase 21 country
- Sex Differences in Myocardial Steatosis Induced Left Ventricular DysfunctionRecruitingNCT04671966Phase 41 country
- Ivabradine in Cirrhotic CardiomyopathyRecruitingNCT04111133Not applicable1 country
- AI-ECG Screening for Left Ventricular Systolic DysfunctionNot yet recruitingNCT06231797