An observational study in Critical Illness, Elevated Left Atrial Pressure and Left Ventricular Diastolic Dysfunction, sponsored by Queen Mary Hospital, Hong Kong. Recruiting at 1 site in Hong Kong. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-15.
Sponsored by Queen Mary Hospital, Hong Kong · Observational
This study evaluates a new single-beat echocardiographic technique (TE-e', the time difference between the onset of the mitral inflow E wave and the septal e' wave on tissue Doppler imaging) for estimating left atrial pressure (LAP) in critically ill patients, comparing it against the standard two-beat method. The goal is to determine whether the faster, single-beat method gives results as reliable as the conventional method, and whether it can help identify patients with elevated left atrial pressure without an invasive procedure.
Left atrial pressure (LAP) is an important measure in the care of critically ill patients but usually requires an invasive catheter to assess directly. Echocardiography offers a non-invasive alternative. One promising marker, TE-e' (the time difference between the onset of the mitral inflow E wave and the septal e' wave on tissue Doppler imaging), was recently incorporated into the 2025 American Society of Echocardiography (ASE) diastolic function guidelines. The conventional method for calculating TE-e' requires measurements from two separate heartbeats, introducing potential error from beat-to-beat heart rate variability - a common issue in the critically ill patients. This study assesses a novel single-beat method, in which both waveforms are captured on the same Doppler display within one cardiac cycle, eliminating that source of variability. Patients undergoing clinically indicated transthoracic echocardiography (TTE) in the Adult Intensive Care Unit of Queen Mary Hospital, Hong Kong will have TE-e' measured by both methods, along with other echocardiographic parameters associated with LAP, to evaluate correlation between the two methods and their relationship with clinically assessed LAP.
260 studies on the registry are indexed under Ventricular Dysfunction, Left; 57 are open to participants now.
This study's planned enrollment of 50 is below the median of 198 across 103 observational studies indexed under Ventricular Dysfunction, Left.
Browse Ventricular Dysfunction, Left studies →Queen Mary Hospital, Hong Kong is the lead sponsor of 24 studies on the registry; 11 are open to participants now.
Compared within Ventricular Dysfunction, Left, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Critical Illness. The counts are of registry records indexed under each term, refreshed daily. How we classify →
Patients admitted to Adult Intensive Care Unit requiring a TTE
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Exclusion Criteria:
each patient serves as their own comparison - conventional vs. novel method measured within the same transthoracic echocardiography study
Diagnostic Test: Echocardiography
Full echocardiogram performed on recruited patients.
Correlation between novel (single-beat) and conventional (two-beat) TE-e' values
Time frame: At the time of index TTE (single time point for each patient) during the course of ICU stay (from day 1 of ICU admission till ICU discharge, up to 1 month)
Correlation between novel and conventional methods in obtaining septal e' and s' velocities - At time of index TTE
Time frame: At the time of index TTE (single time point for each patient) during the course of ICU stay (from day 1 of ICU admission till ICU discharge, up to 1 month)
Correlation between clinical evaluation of LAP and TE-e' value
Time frame: At the time of index TTE (single time point for each patient) during the course of ICU stay (from day 1 of ICU admission till ICU discharge, up to 1 month)
Correlation between other echocardiographic parameters of LAP (E/A ratio, LAVi, TR Vmax, lung ultrasound 6-point protocol) and TE-e' value
Time frame: At the time of index TTE (single time point for each patient) during the course of ICU stay (from day 1 of ICU admission till ICU discharge, up to 1 month)
Plan to share: Undecided
Started Jul 2026 (actual). Primary completion is estimated for Dec 2026, 5 months after the start.
Of 45 non-industry observational studies under Ventricular Dysfunction, Left, half reached primary completion within 25 months of starting (the median), counting those still running; a quarter within 17 and three quarters within 51. This study's planned 5 months is below that.
Counting every sponsor, half of 50 studies reached it within 27 months; a quarter within 17 and three quarters within 51.
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Ventricular Dysfunction, Left →
Queen Mary Hospital, Hong Kong