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RecruitingNCT06221891Updated Apr 11, 2024

Early Evaluation of Left Ventricular Systolic Function Impairment in Patients With Chronic Kidney Disease by Multimodal Ultrasonography

An observational study in Chronic Kidney Diseases and Left Ventricular Systolic Dysfunction, sponsored by Fifth Affiliated Hospital, Sun Yat-Sen University. Recruiting at 1 site in China. Open to participants aged 18 Years to 75 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-04-11.

Sponsored by Fifth Affiliated Hospital, Sun Yat-Sen University · Observational

From the registry’s dates

  • Primary completion was expected by Dec 2024, 1 year 10 months ago, but the record still lists the study as recruiting.
  • Started Oct 2023; still recruiting 3 years 1 month later.
Study type
Observational
Model
Case-control
Time perspective
Cross-sectional
Enrollment
500
Ages
18 Years to 75 Years
Sex
All
01

Study summary

The goal of this observational study is to learn about the value of multimodal ultrasound in early detection of left ventricular systolic dysfunction in patients with chronic kidney disease(CKD). The main questions it aims to answer are:

  1. If first-phase ejection fraction(EF1)could early detect the left ventricular systolic dysfunction in patients with CKD.
  2. Whether EF1 can detect left ventricular systolic dysfunction in patients with CKD more sensitively than speckle-tracking echocardiography and myocardial work.

Participants will need to cooperate to do an echocardiography. Researchers will compare healthy volunteers and patients with CKD to see if EF1 could early detect the left ventricular systolic dysfunction.

02

Conditions studied

  • Chronic Kidney Diseases
  • Left Ventricular Systolic Dysfunction

Keywords

  • first phase ejection fraction;left ventricular systolic dysfunction;echocardiography;chronic kidney disease
03

In context

Renal Insufficiency, Chronic

3,090 studies on the registry are indexed under Renal Insufficiency, Chronic; 698 are open to participants now.

This study's planned enrollment of 500 is above the median of 213 across 834 observational studies indexed under Renal Insufficiency, Chronic.

Browse Renal Insufficiency, Chronic studies →

Lead sponsor

Fifth Affiliated Hospital, Sun Yat-Sen University is the lead sponsor of 59 studies on the registry; 21 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 75 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Probability sample

Study population

Patients with chronic kidney disease who are hospitalized in The Fifth Affiliated Hospital of Sun Yat-sen University.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Patients with chronic kidney disease who are hospitalized in The Fifth Affiliated Hospital of Sun Yat-sen University.
  • ≥50%.

Exclusion criteria

Exclusion Criteria:

  • Patients with primary hypertension, diabetes and congenital heart disease.
  • Patients who are pregnant or lactating.
  • Patients with the blurry ultrasound images.
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

LVEF (left ventricular ejection fraction)

The share of blood the heart’s main pumping chamber (the left ventricle) pushes out with each beat, measured by an echocardiogram (heart ultrasound) or a MUGA scan. About 50–70% is normal.

05

Study design

Observational model
Case-control
Time perspective
Cross-sectional
Enrollment
500 participants (estimated)
Patient registry
No

Groups and cohorts

  • case group

    This group contains the patients with chronic kidney disease.

  • control group

    This group contains the healthy adults.

06

What researchers measure

Primary outcomes

  1. first-phase ejection fraction

    an ultrasound indicator used to assess early left ventricular systolic function

    Time frame: 1 hour

07

Study locations

1 of 1 sites recruiting
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 11, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT06221891
Lead sponsor
Fifth Affiliated Hospital, Sun Yat-Sen University
Responsible party
Sponsor
First posted
Jan 24, 2024
Start date
Oct 1, 2023
Primary completion
Dec 31, 2024 (estimated)
Completion
Dec 31, 2025 (estimated)
Last update
Apr 11, 2024

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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No contact was published for this record. The registry link below has the sponsor’s details.

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