Rectal Diseases clinical trials
The registry lists 87 studies for Rectal Diseases across more than 10 countries. 14 are recruiting or about to start. 17 of them are mainly about Rectal Diseases (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its 17 narrower conditions too, such as Colorectal Neoplasms: 10,927 studies, 2,865 open.
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Who runs them
Exact Sciences Corporation (5) · Royal Marsden NHS Foundation Trust (4) · Medical University of Warsaw (3) · Pfizer (3) · Bausch Health Americas, Inc. (3) · Swedish Medical Center (2) · University Hospitals Cleveland Medical Center (2) · First Affiliated Hospital of Harbin Medical University (2)
What is being tested here
Drugs under test in Rectal Diseases studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 6, phase 3 first
- Dec 2026Iltamiocel Compared to Placebo for Chronic Fecal Incontinence in Females With Obstetric Injury · Phase 3 · Cook MyoSite
- Dec 2026Research on the Efficacy and Mechanism of Shouhui Tongbian Capsules in Treating Postoperative Constipation of Benign Anal and Rectal Diseases Based on Gut Microbiota Analysis · China-Japan Friendship Hospital
- Apr 2027GLP-1 Receptor Agonists and Early Proctologic Effects in Morbid Obesity · Gazi University
- Apr 2027Post-Market Study of the Signia Circular Stapler With Tri-Staple Technology in Left-sided Colon, Sigmoid, and Rectal Resections · Medtronic - MITG
- May 2027Understanding New Cachexia Subtypes Through Observational Epidemiological Research · Kaiser Permanente
- Aug 2027COLOFLOW: Laser Speckle Contrast Imaging Versus Near-infrared Fluorescence Imaging With Indocyanine Green · Leiden University Medical Center
Who these studies take
Of the 8 Rectal Diseases studies recruiting now, 6 (75%) set no upper age limit and 1 (13%) stop at 75 or younger. 2 (25%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (25%) | 2 (25%) |
| 18 | 8 (100%) | 8 (100%) |
| 30 | 7 (88%) | 7 (88%) |
| 40 | 7 (88%) | 7 (88%) |
| 50 | 7 (88%) | 7 (88%) |
| 65 | 7 (88%) | 7 (88%) |
| 75 | 7 (88%) | 7 (88%) |
| 85 | 6 (75%) | 6 (75%) |
Across all 87 studies, recruiting or not: 21% stop at 75 or younger and 13% at 65; 8% take children; 2% are for women only and 0% for men only; 20% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Rectal Diseases studies take
Of 16 interventional studies with no phase under Rectal Diseases, half reached primary completion within 35 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 35 mo11–57 · 16 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 87. Browse all 87 → or search them.
- Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal CancerRecruitingNCT07222800Phase 317 countries
- Post-Market Study of the Signia Circular Stapler With Tri-Staple Technology in Left-sided Colon, Sigmoid, and Rectal ResectionsRecruitingNCT07351071Not applicable1 country
- Understanding New Cachexia Subtypes Through Observational Epidemiological ResearchRecruitingNCT077763531 country
- COLOFLOW: Laser Speckle Contrast Imaging Versus Near-infrared Fluorescence Imaging With Indocyanine GreenNot yet recruitingNCT07720505
- Research on the Efficacy and Mechanism of Shouhui Tongbian Capsules in Treating Postoperative Constipation of Benign Anal and Rectal Diseases Based on Gut Microbiota AnalysisNot yet recruitingNCT07648394Phase 1/21 country
- GLP-1 Receptor Agonists and Early Proctologic Effects in Morbid ObesityNot yet recruitingNCT076687651 country
- Seattle Spatial Transcriptomic Research in Inflammatory Bowel Disease Evaluation (STRIDE)RecruitingNCT063151791 country
- Hemorrhoid Suture Mucopexy Combined With Laser HemorrhoidoplastyRecruitingNCT074047741 country
- Extra-Peritoneal Tunneling Versus Conventional Drain Fixation After Anterior or Low Anterior ResectionNot yet recruitingNCT07241143Not applicable1 country
- Physiotherapy Applications in Children With Bladder and Bowel Symptoms After Anorectal Malformation SurgeryNot yet recruitingNCT07075692Not applicable
- SCI-Pex Study - Safety and Performance of PexyEazy®, a Device for Treatment of HemorrhoidsRecruitingNCT05782010Not applicable1 country
- Clinical Observation of Drug Retention Enema in Preventing Acute Radiation-induced Rectal InjuryRecruitingNCT06325982Not applicable1 country
- The Efficacy of Aescin in Combination With MPFF in the Early Control of Bleeding From Acute Internal Hemorrhoids, A Randomized Controlled TrialNot yet recruitingNCT06363513Not applicable1 country
- Impact of Early Postoperative Treatment With Posterior Tibial Nerve Stimulation on the Incidence and Duration of Low Anterior Rectal Resection SyndromeRecruitingNCT05368168Not applicable1 country
- CRC Detection Reliable Assessment With BloodActive, not recruitingNCT055510521 country
- A Study of Encorafenib Plus Cetuximab With or Without Chemotherapy in People With Previously Untreated Metastatic Colorectal CancerActive, not recruitingNCT04607421Phase 329 countries
- Iltamiocel Compared to Placebo for Chronic Fecal Incontinence in Females With Obstetric InjuryActive, not recruitingNCT05776277Phase 31 country
- Influence of Body Position on the Defecation Model During Anorectal Manometry.TerminatedNCT069249571 country
- Drainage After Rectal Excision for Rectal CancerCompletedNCT01269567Phase 31 country
- ctDNA-guided Surveillance for Stage III CRC, a Randomized Intervention TrialActive, not recruitingNCT04084249Not applicable1 country
- A Prospective, Multicenter Randomized Controlled Study of the Application of Preoperative FOLFOXIRI Chemotherapy Combined With Lateral Lymph Node Dissection in Low- and Medium-lying Rectal Cancer With Lateral Lymph Node MetastasisCompletedNCT06048146Not applicable1 country
- Anorectal Dysfunction in Patients Suffering From Spina Bifida : From Clinic to Neuro-epithelial Function (ANOSPIN)CompletedNCT02440984Not applicable1 country
- A Study to Learn About How Different Amounts of the Study Medicine PF-07826390 Act in the Body of People With Cancer When Taken Alone or With Other Anti-cancer Medicines.TerminatedNCT06546553Phase 11 country
- Prevention of Colorectal Cancer Through Multiomics Blood TestingCompletedNCT043690532 countries
- Impact Of The Nurse Enhanced Recovery After Surgery Coordinator On The Compliance In Colorectal Surgery (nursERAS-BCN)CompletedNCT05231473Not applicable1 country
- Effects of an Anal Insert Device in Fecal IncontinenceCompletedNCT03898778Not applicable1 country
- Prediction of Postoperative Outcomes After Rectal Resection by the Comprehensive Complication Index (CCI)CompletedNCT070376931 country
- Efficacy and Safety of GTN vs. Nifedipine in Acute Anal Fissure: A Clinical TrialCompletedNCT06859554Phase 41 country
- Research Study of IV Vitamin C in Combination With Irinotecan vs Irinotecan Alone for Advanced Colorectal CATerminatedNCT01550510Phase 1/21 country
- Descriptive and Prospective Study of Sphincter Disorders in the Severe Traumatic Brain Injury PopulationTerminatedNCT05163262Not applicable1 country
- Comparative Analysis of Hypobaric Versus Hyperbaric Bupivacaine for Spinal Anesthesia in Day-Case Anorectal SurgeryCompletedNCT054098201 country
- Pelvic Floor Dysfunction and Its Influence on Body Image and Sexual FunctionCompletedNCT03591393Not applicable1 country
- Phase I/II Study of KRN330 Plus Irinotecan in Patients With Metastatic Colorectal CancerTerminatedNCT00838578Phase 1/21 country
- Autologous Cell Therapy for Treatment of Fecal IncontinenceCompletedNCT01600755Phase 1/22 countries
- Evaluation of Ocoxin®-Viusid® in Metastatic Colorectal AdenocarcinomaCompletedNCT03559543Phase 21 country
- Intrathecal Hydromorphone for Postoperative Pain of Anorectal SurgeryCompletedNCT05579223Phase 21 country
- Prospective Randomized Controlled Trial of an Enhanced Recovery Protocol for Anorectal SurgeryCompletedNCT03738904Phase 41 country
- A Study of Napabucasin (BBI-608) in Combination With FOLFIRI in Adult Patients With Previously Treated Metastatic Colorectal CancerCompletedNCT02753127Phase 316 countries
- Urine Retention Rate Between Spinal and General Anesthesia for Anorectal SurgeryCompletedNCT055712021 country
- The Effect of Pain Education on Pain and ComfortCompletedNCT05692193Not applicable1 country
- Anlotinib Hydrochloride Capsules Combined With CAPEOX in RAS and BRAF Wild-type mCRC PatientsCompletedNCT04080843Phase 21 country
- Palliative Primary Tumor Resection in Minimally Symptomatic Patients With Colorectal Cancer and Synchronous Unresectable MetastasesStatus unknownNCT053224861 country
- The Guarding Reflex Anal, Study of the Modulation Function of Rectal DistensionCompletedNCT044090541 country
- Single-incision Versus Conventional Laparoscopic Surgery for Colorectal CancerWithdrawnNCT03633539Not applicable1 country
- Diltiazem Ointment With Lidocaine vs. Nifedipine Ointment With Lidocaine Ointment for Treatment of Chronic Anal FissureStatus unknownNCT04887818Phase 2/31 country
- SGI-110 in Combination With an Allogeneic Colon Cancer Cell Vaccine (GVAX) and Cyclophosphamide (CY) in Metastatic Colorectal Cancer (mCRC)CompletedNCT01966289Phase 11 country
- Comparison of Rubber Band Ligation and Haemorrhoidectomy in Patients With Symptomatic Haemorrhoids Grade IIIStatus unknownNCT04621695Not applicable1 country
- Study of GVAX (With CY) and Pembrolizumab in MMR-p Advanced Colorectal CancerCompletedNCT02981524Phase 21 country
- Multitarget Stool FIT-DNA Study for Colorectal Cancer Early Screening in ChinaCompletedNCT042873351 country
- An Extended Feasibility Phase I/II Study of Methylenetetrahydrofolate (Arfolitixorin) and Pemetrexed Single Agent, Given as Neoadjuvant Treatment in Patients With Resectable Rectal CancerCompletedNCT01397305Phase 1/21 country