Low Anterior Resection Syndrome clinical trials
The registry lists 82 studies for Low Anterior Resection Syndrome across more than 10 countries. 38 are recruiting or about to start. 51 of them are mainly about Low Anterior Resection Syndrome (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-13.
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Who runs them
Seoul National University Hospital (5) · National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos (5) · Jewish General Hospital (4) · Sixth Affiliated Hospital, Sun Yat-sen University (4) · University Hospital, Ghent (3) · Peking University People's Hospital (2) · Hospital Universitari Vall d'Hebron Research Institute (2) · KU Leuven (2)
What is being tested here
Drugs under test in Low Anterior Resection Syndrome studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Ramosetron | 1 | 0 | 1 |
| Psyllium husk | 0 | 0 | 1 |
| Botulinum toxin type A | 0 | 0 | 1 |
| Melatonin | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Dec 2026Comparison of Transanal Irrigation and Glycerol Suppositories in Treatment of Low Anterior Resection Syndrome · Phase 3 · University of Aarhus
- Apr 2027Antegrade Intestinal Fluid Reinfusion for Prevention of Low Anterior Resection Syndrome After Low Anterior Resection: a Single-Center, Prospective Randomized Controlled Trial. · Phase 3 · Pei-Rong Ding
- Dec 2026A Randomised Clinical Investigation to Assess Efficacy of Low Volume Transanal Irrigation by Qufora® IrriSedo MiniGo Versus Conservative Treatment for Low Anterior Resection Syndrome Patients · Qufora A/S
- Dec 2026The Efficacy of Antegrade and Retrograde Enemas Management in Low Anterior Resection Syndrome and Improving the Rate of Ileostomy Reversal · Sichuan Cancer Hospital and Research Institute
- Dec 2026Retrograde and Antegrade Enema for Prevention of LARS After LAR: a Randomized Controlled Trial · Sichuan Cancer Hospital and Research Institute
- Dec 2026Aerobic Exercise and Guided Imagery in Low Anterior Resection Syndrome · Biruni University
- Dec 2026Understanding and Tailored Treatment of Low Anterior Resection Syndrome · Aalborg University Hospital
- May 2027Assessment of Quality of Life After Low Anterior Resection During Cytoreductive Surgery for Advanced Ovarian Cancer · Seoul National University Hospital
- Jul 2027Effect of Thread Embedding Acupuncture on Postoperative Ileus Recovery After Colorectal Cancer Surgery: A Multicenter Randomized Controlled Trial · Northern Jiangsu People's Hospital
- Aug 2027Comparison of Postoperative Anal Function Between Parks and Bacon Techniques in Low Rectal Cancer · Sixth Affiliated Hospital, Sun Yat-sen University
Who these studies take
Of the 25 Low Anterior Resection Syndrome studies recruiting now, 17 (68%) set no upper age limit and 4 (16%) stop at 75 or younger. 0 (0%) take children under 18. 1 (4%) are for women only and 0 (0%) for men only; 2 (8%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 22 (88%) | 21 (84%) |
| 30 | 25 (100%) | 24 (96%) |
| 40 | 25 (100%) | 24 (96%) |
| 50 | 25 (100%) | 24 (96%) |
| 65 | 25 (100%) | 24 (96%) |
| 75 | 24 (96%) | 23 (92%) |
| 85 | 19 (76%) | 18 (72%) |
Across all 82 studies, recruiting or not: 11% stop at 75 or younger and 1% at 65; 4% take children; 2% are for women only and 0% for men only; 6% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Low Anterior Resection Syndrome studies take
Of 29 interventional studies with no phase under Low Anterior Resection Syndrome, half reached primary completion within 33 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 33 mo21–66 · 29 studies | — | — |
| Observational | 31 mo21–34 · 18 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 15, 2026.
Newly registered1
Studies
Recruiting first, then most recently updated. Showing 50 of 82. Browse all 82 → or search them.
- Oral B-Complex Vitamin (B6, B9 and B12) Prevents Low Anterior Resection Syndrome in Rectal Cancer Patients With HyperhomocysteinemiaNot yet recruitingNCT07928180Not applicable1 country
- The Effects of Kegel Exercise Combined With Biofeedback Therapy on Bowel Function Recovery, Emotional Distress, and Quality of Life in Patients Following Low Anterior Resection for Rectal CancerEnrolling by invitationNCT07253298Not applicable1 country
- Efficacy of a Novel High Intensive Percutaneous Tibial Nerve Stimulation on Faecal Incontinence in Patients With Low Anterior Resection Cancer Syndrome After Rectal Cancer SurgeryNot yet recruitingNCT07862673Not applicable1 country
- A Bowel Management Program (Retrograde Rectal Enema) for the Treatment of Low Anterior Resection Syndrome in Rectal Cancer PatientsRecruitingNCT06424522Not applicable1 country
- Transanal Irrigation for the Management of Early Low Anterior Resection Syndrome (LARS)Not yet recruitingNCT07219745Not applicable1 country
- Early Implementation of Sacral Neuromodulation in Patients With Low Anterior Resection Syndrome.Not yet recruitingNCT07761884Not applicable1 country
- Aerobic Exercise and Guided Imagery in Low Anterior Resection SyndromeRecruitingNCT07732894Not applicable1 country
- Evaluating the Optimal Timing of Trans-Anal Irrigation for Low Anterior Resection Syndrome Post-rectal Cancer SurgeryNot yet recruitingNCT07696689Not applicable
- Efficacy and Safety of Transcutaneous Posterior Tibial Nerve Stimulation on Fecal Continence in Patients Undergoing Surgery for Rectal NeoplasiaRecruitingNCT07632196Not applicable1 country
- Total Neoadjuvant Therapy and Organ Preservation Versus Surgery for Rectal Cancer.RecruitingNCT06758830Phase 2/31 country
- Understanding and Tailored Treatment of Low Anterior Resection SyndromeRecruitingNCT075733711 country
- Improving Functional Outcomes and Quality of Life in Patients With Rectal Cancer After Surgery With Intensified Follow-up & SurveillanceRecruitingNCT06936774Phase 31 country
- Antegrade Intestinal Fluid Reinfusion for Prevention of Low Anterior Resection Syndrome After Low Anterior Resection: a Single-Center, Prospective Randomized Controlled Trial.RecruitingNCT07537998Phase 2/31 country
- Personalized Care Pathways for Bowel Symptoms in Rectal Cancer patients_development of E-diaryRecruitingNCT06274190Not applicable1 country
- Personalized Care Pathways for Bowel Symptoms in Rectal Cancer Patients_contributing Factors (Treatable)RecruitingNCT06914245Not applicable1 country
- ProLARS Trial: Prospective Longitudinal Follow-up of Low Anterior Resection Syndrome (LARS) and COREFO Score After Rectum Surgery in Patients Undergoing Upfront Surgery or Different Neo-adjuvant Treatment RegimensRecruitingNCT07339904Not applicable1 country
- Comparison of Postoperative Anal Function Between Parks and Bacon Techniques in Low Rectal CancerRecruitingNCT05943444Not applicable1 country
- The Efficacy of Antegrade and Retrograde Enemas Management in Low Anterior Resection Syndrome and Improving the Rate of Ileostomy ReversalNot yet recruitingNCT07082699Not applicable
- Effect of Thread Embedding Acupuncture on Postoperative Ileus Recovery After Colorectal Cancer Surgery: A Multicenter Randomized Controlled TrialRecruitingNCT07071987Not applicable1 country
- Knowledge-enhanced Digital Intervention to Prevent Low Anterior Resection SyndromeNot yet recruitingNCT07041515Not applicable
- A Randomised Clinical Investigation to Assess Efficacy of Low Volume Transanal Irrigation by Qufora® IrriSedo MiniGo Versus Conservative Treatment for Low Anterior Resection Syndrome PatientsRecruitingNCT069231501 country
- Retrograde and Antegrade Enema for Prevention of LARS After LAR: a Randomized Controlled TrialNot yet recruitingNCT06717854Not applicable1 country
- Transanal Irrigation for Low Anterior Resection SyndromeNot yet recruitingNCT06796296Not applicable1 country
- The Effects of Colorectal Prehabilitation Via Reinfusion or Retention Enema of Ileal Contents Filtrate on the Defecation Functions for the LAR Patients With Ileostomy Before Stoma ClosureRecruitingNCT06569966Not applicable1 country
- Effect of Pelvic Rehabilitation After Low Anterior Resection for Cancer Rectum. - A Randomised Controlled TrialNot yet recruitingNCT06524362Not applicable1 country
- Effectiveness of Pelvic Floor Exercise to Prevent LARS (Low Anterior Resection Syndrome)RecruitingNCT06519006Not applicable1 country
- Fecal Microbiota Transplantation in the Treatment of Major LARSNot yet recruitingNCT06475430Not applicable
- The Safety and Efficacy of Transanal Irrigation in Patients With Sleep Disturbance From Low Anterior Resection Syndrome After Rectal Cancer Surgery (TraLARS)RecruitingNCT06222255Not applicable1 country
- Patient Reported Outcomes Following Cancer of the RectumRecruitingNCT049365811 country
- Effect of Gelsectan® in the Treatment of Low Anterior Resection SyndromeRecruitingNCT061621431 country
- International Low Anterior Resection Score EvaluationRecruitingNCT040408421 country
- Transanal Irrigation - Best Treatment Possibility for Low Anterior Resection Syndrome? Multicenter, Randomized Clinical TrialRecruitingNCT05920681Not applicable1 country
- Impact of Early Postoperative Treatment With Posterior Tibial Nerve Stimulation on the Incidence and Duration of Low Anterior Rectal Resection SyndromeRecruitingNCT05368168Not applicable1 country
- Transanal Irrigation to Prevent Major Low Anterior Resection SyndromeRecruitingNCT04758195Not applicable1 country
- Assessment of Quality of Life After Low Anterior Resection During Cytoreductive Surgery for Advanced Ovarian CancerRecruitingNCT054315301 country
- HEM1036 Phase 2 Study in Low Anterior Resection SyndromeNot yet recruitingNCT05527301Phase 2
- Comparison of Transanal Irrigation and Glycerol Suppositories in Treatment of Low Anterior Resection SyndromeRecruitingNCT04087421Phase 31 country
- 5-HT3 Receptor Antagonist (Ramosetron) vs Loperamide for the Treatment of Low Anterior Resection Syndrome(RALARS)RecruitingNCT05577845Not applicable1 country
- Autologous Fecal Microbiota Transplantation for Anal Function Recovery After Ileostomy Reversal in Rectal CancerActive, not recruitingNCT07711509Not applicable1 country
- Transanal Irrigation for the Management of LARSActive, not recruitingNCT05007015Not applicable1 country
- Paula Method of Exercises in Patients With LARS Syndrome:Randomized Controlled TrialCompletedNCT05682157Not applicable1 country
- Bowel Dysfunction After Low Rectal Resection. An Pilot Study Using Psyllium Husk In Rectal Cancer Patients.CompletedNCT06724198Not applicable1 country
- Comparison of Six Different Machine Learning Methods With Traditional Model for Low Anterior Resection Syndrome After Minimally Invasive Surgery for Rectal Cancer -- Development and External Validation of a Nomogram : A Dual-center Cohort StudyCompletedNCT07267767
- Transanal Irrigation for Low Anterior Resection Syndrome.Active, not recruitingNCT05245331Not applicable1 country
- The Longitudinal Study of Low Anterior Resection Syndrome in Patients with Newly Diagnosed Rectal Cancer.CompletedNCT054452451 country
- Impact of a Patient-Centered Program for Low Anterior Resection Syndrome a Multicenter Randomized Controlled TrialCompletedNCT03828318Not applicable2 countries
- Interactive Online Informational and Peer Support App for Patients with Low Anterior Resection SyndromeCompletedNCT04469426Not applicable1 country
- Exploring the Effect of Colonic J-pouch in Anorectal Preservation Surgery for Ultra-low Rectal Cancer.Active, not recruitingNCT066019851 country
- Randomized Clinical Trial on Transanal IrrigationCompletedNCT04586634Not applicable1 country
- Evaluation of a Decision Aid Tool in Rectal Cancer patiëntsCompletedNCT049383361 country