Fissure in Ano clinical trials
The registry lists 84 studies for Fissure in Ano across more than 10 countries. 16 are recruiting or about to start. 66 of them are mainly about Fissure in Ano (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-28.
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Who runs them
Mansoura University (9) · State Scientific Centre of Coloproctology, Russian Federation (4) · RDD Pharma Ltd (3) · Zagazig University (2) · Biolab Sanus Farmaceutica (2) · Region Skane (2) · SB Istanbul Education and Research Hospital (2) · Gazi University (2)
What is being tested here
Drugs under test in Fissure in Ano studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Diltiazem | 1 | 1 | 3 |
| Botulinum toxin type A | 1 | 0 | 2 |
| Nitroglycerin | 0 | 2 | 4 |
| Polyethylene Glycols | 0 | 1 | 2 |
| Isosorbide mononitrate | 0 | 0 | 2 |
| Phenytoin | 0 | 0 | 1 |
| Metronidazole | 0 | 0 | 1 |
| Minoxidil | 0 | 0 | 1 |
| Centella asiatica | 0 | 0 | 1 |
| Gabapentin | 0 | 0 | 1 |
Drug classes tested here Calcium channel blockers 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 5
- Dec 2026Percutaneous Tibial Nerve Stimulation (PTNS) for the Treatment of Chronic Anal Fissure · Region Skane
- Dec 2026E-CEL UVEC Treatment for Anal Fissures · Weill Medical College of Cornell University
- Dec 2026AI-Assisted Written Information in Chronic Anal Fissure · Sanliurfa Education and Research Hospital
- Apr 2027GLP-1 Receptor Agonists and Early Proctologic Effects in Morbid Obesity · Gazi University
- Apr 2027Effect of Listening to Standardized Music Sequences on Preventing Postoperative Pain in Proctologic Surgery · Clinique Saint-Vincent
Who these studies take
Of the 12 Fissure in Ano studies recruiting now, 6 (50%) set no upper age limit and 5 (42%) stop at 75 or younger. 1 (8%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 2 (17%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 12 (100%) | 12 (100%) |
| 30 | 12 (100%) | 12 (100%) |
| 40 | 12 (100%) | 12 (100%) |
| 50 | 12 (100%) | 12 (100%) |
| 65 | 12 (100%) | 12 (100%) |
| 75 | 7 (58%) | 7 (58%) |
| 85 | 7 (58%) | 7 (58%) |
Across all 84 studies, recruiting or not: 54% stop at 75 or younger and 31% at 65; 12% take children; 2% are for women only and 0% for men only; 13% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Fissure in Ano studies take
Of 25 interventional studies with no phase under Fissure in Ano, half reached primary completion within 12 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 12 mo5–30 · 25 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered1
- Topical Nitroglycerin Versus Lateral Internal Sphincterotomy for Chronic Anal FissureOct 21, 2026NCT07884916
Studies
Recruiting first, then most recently updated. Showing 50 of 84. Browse all 84 → or search them.
- Ultrasound Assessment After Surgery for Chronic Anal FissureRecruitingNCT078097111 country
- AI-Assisted Written Information in Chronic Anal FissureRecruitingNCT07701811Not applicable1 country
- Female Sexual Function After Surgery for Benign Perianal DiseasesNot yet recruitingNCT07666035
- Comparative Outcomes of Inj Botox Alone vs Inj Botox Combined With Fissurectomy and Anoplasty in the Management of Chronic Anal FissureRecruitingNCT07665528Not applicable1 country
- GLP-1 Receptor Agonists and Early Proctologic Effects in Morbid ObesityNot yet recruitingNCT076687651 country
- The Impact of Perianal Disease on Patient's Sex LifeRecruitingNCT075198501 country
- E-CEL UVEC Treatment for Anal FissuresRecruitingNCT06456073Phase 11 country
- Combined Method of Surgical Treatment of Anal FissureRecruitingNCT07268261Not applicable1 country
- Effect of Listening to Standardized Music Sequences on Preventing Postoperative Pain in Proctologic SurgeryRecruitingNCT06798155Not applicable1 country
- Effect of Enhanced Recovery After Surgery for Benign Anorectal ConditionsRecruitingNCT06803550Not applicable1 country
- Comparative Evaluation of MEBO Ointment and Topical Diltiazem Ointment in the Treatment of Acute Anal FissureRecruitingNCT04153032Phase 21 country
- Percutaneous Tibial Nerve Stimulation (PTNS) for the Treatment of Chronic Anal FissureNot yet recruitingNCT04604483Not applicable1 country
- Pudendal Nerve Block With Bupivacaine Alone and Bupivacaine With Methylene Blue for Postoperative AnalgesiaRecruitingNCT05990569Not applicable1 country
- Could Preoperative Assessment of Physical and Psychological Status Help Predict Pain After Anorectal Surgery?Not yet recruitingNCT060495241 country
- Botulinum Toxin Type A in the Treatment of Chronic Anal FissureRecruitingNCT05598164Not applicable1 country
- Complex Treatment of a Chronic Anal FissureRecruitingNCT03855046Phase 41 country
- Low Versus High Dose OnabotulinumtoxinA for Chronic Anal FissureCompletedNCT075433151 country
- Topical Nitroglycerin Versus Lateral Internal Sphincterotomy for Chronic Anal FissureCompletedNCT07884916Not applicable1 country
- Comparison of Botulinum Toxin Injection and Lateral Internal Sphincterotomy in Chronic Anal Fissure ManagementCompletedNCT07568314Not applicable1 country
- Pulsed Electromagnetic Field on Chronic Anal Fissure HealingCompletedNCT07729709Phase 31 country
- Closed Versus Open Lateral Internal Sphincterotomy for Chronic Anal FissureCompletedNCT07496216Not applicable1 country
- War-Drill Model Guided Treatment of Hemorrhoids With Nimsai Herbal (NAJ)CompletedNCT07034820Not applicable1 country
- Short-Term Outcome of Medical Vs. Surgical Management Of Chronic Anal FissureCompletedNCT06617026Phase 1/21 country
- Effect of Phenytoin Cream on Wound Healing After Anal Fissure Surgery.CompletedNCT06633185Phase 11 country
- The Efficacy of Botulinum Toxin Alone Versus Combined Botulinum Toxin and Topical Diltiazem in Chronic Anal FissureCompletedNCT057972201 country
- Comparative Analysis of Hypobaric Versus Hyperbaric Bupivacaine for Spinal Anesthesia in Day-Case Anorectal SurgeryCompletedNCT054098201 country
- Laser Versus Surgery in Anal Diseases in Inflammatory Bowel PatientsCompletedNCT06216223Not applicable1 country
- Efficacy and Safety of CONAN® Proctological Cream for Treatment of Haemorrhoidal DiseaseCompletedNCT05984641Not applicable1 country
- Use of Fototherapy in the Treatment of Fissure in AnoCompletedNCT05993793Not applicable1 country
- Efficacy of Polyethylene Glycol vs Lactulose With Isabgol in Acute Fissure-in-Ano: PEGASIS TrialCompletedNCT05341180Phase 2/31 country
- The Use of Platelet-rich Plasma in the Treatment of Chronic Anal FissureCompletedNCT05837403Phase 31 country
- Comparison of Injections of Botulinum Toxin and Topical Nitroglycerin Ointment for the Treatment of Chronic Anal FissureStatus unknownNCT05590520Not applicable1 country
- Anal Fissure Among Survivors of COVID-19 Virus Infection.CompletedNCT057369261 country
- Regenerative Therapy With Autologous Stromal Vascular Fraction Derived Mesenchymal Stem Cells and Platelet-rich Plasma to Treat Complex Perianal DiseasesStatus unknownNCT057097171 country
- Efficacy and Safety of Propionibacterium Extract Gel Versus 0.4% Glyceryl Trinitrate Ointment in the Treatment of Chronic Anal Fissure: a Randomised Controlled TrialCompletedNCT05616455Phase 41 country
- Microbiota in Chronic Anal Fissure and Its Association With PrognosisStatus unknownNCT05405634
- Short Term Results of Platelet-rich Plasma in the Treatment of Chronic Anal FissureCompletedNCT04320498Phase 41 country
- Surgical Treatment of a Chronic Anal FissureStatus unknownNCT05117697Not applicable1 country
- The Efficacy of Asacol (Mesalazine) Suppository on the Treatment of Diarrhea-Induced Acute FissureCompletedNCT05091775Phase 1/21 country
- Topical vs Oral Metronidazole After Benign Anorectal SurgeryCompletedNCT05038605Not applicable1 country
- Diltiazem Ointment With Lidocaine vs. Nifedipine Ointment With Lidocaine Ointment for Treatment of Chronic Anal FissureStatus unknownNCT04887818Phase 2/31 country
- Effectiveness of Anal Enlargement by Dilators as a Therapeutic Physical Tool in Acute Anal FissureStatus unknownNCT04828889Not applicable
- Effect of Shock Waves Therapy on Chronic Anal FissureStatus unknownNCT04793347Not applicable1 country
- Pharmacokinetics Trial of Isosorbide Mononitrate 0.5% Gel for Intra Anal Application in Healthy SubjectsWithdrawnNCT04729088Phase 1
- The Role of Fitostimoline Proctogel in Symptoms Relief and Healing in Patients Affected by Anal FissureStatus unknownNCT04714684Not applicable
- Monocentric Feasibility Study for a New Medical Device for the Treatment of Anal Fissure With Botulinum ToxinCompletedNCT04173130Not applicable1 country
- Sungurtekin Technique vs. Closed Lateral Internal Sphincterotomy TechniqueStatus unknownNCT04428697Not applicable
- Postero-lateral Internal Sphincterotomy vs Botulinum Toxin Injection in the Treatment of Chronic Anal FissureStatus unknownNCT03920449Not applicable1 country
- Efficacy Study of Dysport® in the Treatment of Anal Fissure.CompletedNCT00210444Phase 24 countries
- Treatment Of Chronic Anal FissureTerminatedNCT02158013Not applicable1 country