An interventional study of Probiotics and Standard management in Probiotic, Ventilator Associated Pneumonia and Critically- Ill Children, sponsored by Tanta University. Recruiting at 1 site in Egypt. Open to participants aged 1 Month to 18 Years. Per ClinicalTrials.gov, last updated 2026-09-29.
Sponsored by Tanta University · Not applicable, Interventional, and Treatment
The aim of the work is to evaluate the impact of Probiotics supplementation on prevention of ventilator associated pneumonia in critically ill children admitted at Pediatric Intensive Care Unit at Tanta University Hospitals.
Critically ill children are the children whom requiring, or potentially requiring, high reliance or serious consideration whether in medical, surgical or trauma-related fields.
Based on the time of onset of Ventilator Associated Pneumonia (VAP), it can be divided into two types. Early-onset VAP occurs during the first four days of mechanical ventilation and is usually caused by antibiotic sensitive bacteria. Late-onset VAP develops five or more days after initiation of MV and is caused by multidrug-resistant (MDR) pathogens .VAP is associated with a high rate of all-cause mortality and a prolonged duration of mechanical ventilation and intensive care unit stay.
Exclusion Criteria:
Critically ill ventilated children will receive standard management plus probiotics.
Drug: Probiotics
Critically ill ventilated children will receive standard management only.
Other: Standard management
Critically ill ventilated children will receive standard management plus probiotics.
Critically ill ventilated children will receive standard management only.
Incidence of ventilator-associated pneumonia
Incidence of ventilator-associated pneumonia (VAP) diagnosed according to predefined CDC/NHSN pediatric criteria
Time frame: During the first 28 days after initiation of mechanical ventilation
Duration of mechanical ventilation
Duration of invasive mechanical ventilation will be measured in days from initiation of mechanical ventilation until successful extubation.
Time frame: Up to 28 days
Pediatric intensive care unit length of stay
Pediatric intensive care unit (PICU) length of stay will be measured in days from PICU admission until PICU discharge.
Time frame: Up to 28 days
Incidence of mortality
Incidence of mortality will be recorded.
Time frame: Up to 28 days
Plan to share: Yes — The data will be available upon a reasonable request from the corresponding author after the end of study for one year.
Supporting information: Study protocol
No publications or documents are linked to this record.
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Pneumonia, Ventilator-Associated→
Tanta University