Amyloid Neuropathies, Familial clinical trials
The registry lists 188 studies for Amyloid Neuropathies, Familial across more than 10 countries. 94 are recruiting or about to start. 115 of them are mainly about Amyloid Neuropathies, Familial (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12. Counting its narrower condition Amyloidosis, Hereditary, Transthyretin-Related too: 241 studies, 112 open.
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Status
Who runs them
Eidos Therapeutics, a BridgeBio company (9) · Pfizer (9) · Alnylam Pharmaceuticals (9) · Brigham and Women's Hospital (6) · University Hospital Center of Martinique (5) · University Hospital, Essen (5) · Steen Hvitfeldt Poulsen (4) · IRCCS Azienda Ospedaliero-Universitaria di Bologna (3)
What is being tested here
Drugs under test in Amyloid Neuropathies, Familial studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Dec 2026Molecular Imaging of Myocardial Fibrosis in Cardiac Amyloidosis · Phase 3 · Brigham and Women's Hospital
- Mar 2027[64Cu]FBP8 PET for Early Detection of Intracardiac Thrombus in Amyloid Cardiomyopathy · Phase 3 · Brigham and Women's Hospital
- Jul 2027A Phase 3 Study of NTLA-2001 in ATTRv-PN · Phase 3 · Intellia Therapeutics
- Nov 2026AI Echocardiographic Screening of Cardiac Amyloidosis · Cedars-Sinai Medical Center
- Dec 2026Determining the Association of TTR Stabilizing Therapy With Circulating TTR Amyloid Aggregates Over Time in Patients With ATTR-CM: Longitudinal Biomarker Study · University of Texas Southwestern Medical Center
- Dec 2026Elevated Rate Pacing of Cardiac Amyloidosis · University of Minnesota
- Dec 2026Amyloidosis TTR Flow Reserve Evaluation · Centre Hospitalier Régional d'Orléans
- Dec 2026Analysis of the Evolution of SUVmax by Quantitative Analysis Method of Bisphosphonate Scintigraphy · GCS Ramsay Santé pour l'Enseignement et la Recherche
- Jan 2027An Observational Study Using Artificial Intelligence (AI) Algorithms on Electrocardiography (ECG), Point-of-care Ultrasound (POCUS), and Transthoracic Echocardiophy (TTE) to Estimate the Under-diagnosis of Transthyretin Amyloid Cardiomyopathy (ATTR-CM) Across a Diverse Range of US Health Systems. · Yale University
- Jan 2027Artificial Intelligence Guided Echocardiographic Screening of Rare Diseases (EchoNet-Screening) · Cedars-Sinai Medical Center
Who these studies take
Of the 69 Amyloid Neuropathies, Familial studies recruiting now, 53 (77%) set no upper age limit and 1 (1%) stop at 75 or younger. 7 (10%) take children under 18. 1 (1%) are for women only and 1 (1%) for men only; 9 (13%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 6 (9%) | 5 (7%) |
| 18 | 49 (71%) | 48 (70%) |
| 30 | 53 (77%) | 52 (75%) |
| 40 | 56 (81%) | 55 (80%) |
| 50 | 60 (87%) | 59 (86%) |
| 65 | 67 (97%) | 67 (97%) |
| 75 | 67 (97%) | 67 (97%) |
| 85 | 61 (88%) | 61 (88%) |
Across all 188 studies, recruiting or not: 4% stop at 75 or younger and 1% at 65; 9% take children; 1% are for women only and 1% for men only; 12% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Amyloid Neuropathies, Familial studies take
Of 74 observational studies under Amyloid Neuropathies, Familial, half reached primary completion within 65 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 35 mo18–67 · 30 studies | — | — |
| Observational | 65 mo30–110 · 74 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 188. Browse all 188 → or search them.
- Elevated Rate Pacing of Cardiac AmyloidosisRecruitingNCT07583823Not applicable1 country
- Quantitative Analysis of Myocardial Uptake of Bone Radiopharmaceuticals in Patients With Cardiac ATTR AmyloidosisRecruitingNCT04535349Not applicable1 country
- Essen Amyloidosis RegistryRecruitingNCT068872831 country
- Swiss Cardiac Amyloidosis REgistry (Swiss-CARE)RecruitingNCT047768241 country
- PET Imaging Study Using Evuzamitide to Detect Cardiac Amyloidosis in Patients With Inconclusive Nuclear Scans and Elevated TAD1 LevelsNot yet recruitingNCT075385181 country
- ConTTRibute: A Global Observational Study of Patients With Transthyretin (TTR)-Mediated Amyloidosis (ATTR Amyloidosis)RecruitingNCT0456151812 countries
- Patisiran-Lipid Nanoparticle (LNP) Pregnancy Surveillance ProgramRecruitingNCT050403737 countries
- Impact of a Cardiac Rehabilitation Program on Patients With Cardiac AmyloidosisRecruitingNCT07494942Not applicable1 country
- BE.Amycon Biobank & Data Registry UZ LeuvenRecruitingNCT071722431 country
- Non-interventional Study of Patients With Transthyretin (ATTR) AmyloidosisRecruitingNCT064658106 countries
- Individualized Exercise Training in Cardiac AmyloidosisNot yet recruitingNCT07835867Not applicable
- Prevalence of Cardiac Thrombi in Cardiac AmyloidosisRecruitingNCT07648303Not applicable1 country
- Multimodal Radiomics Model (18F-FAPI PET/CT + CMR) for AL Cardiac Amyloidosis PrognosisEnrolling by invitationNCT071038631 country
- Safety and Efficacy Study of GEB-101 Injection in Subjects With TGFBI-related Corneal DystrophyNot yet recruitingNCT07750678Phase 1/22 countries
- [18F]FT8 PET Imaging in Immunoglobulin Light Chain AmyloidosisRecruitingNCT072324591 country
- Pan-Amyloid PET/CT in Various Amyloid-Related DiseaseRecruitingNCT071305651 country
- Echocardiographic Characterization of Cardiac AmyloidosisRecruitingNCT057602871 country
- Non-Interventional Study on the Prevalence of Cardiac Amyloidosis in Patients With Higher-Grade Aortic Valve Stenosis - Evaluation Using Echocardiography, Computed Tomography, Tc99-SPECT/CT and Cardiac Magnetic Resonance Imaging (CMR)RecruitingNCT077527321 country
- Subclinical Transthyretin Cardiac Amyloidosis in V122I TTR CarriersRecruitingNCT054895491 country
- Right Ventricular Septal Biopsy to Detect Cardiac AmyloidosisNot yet recruitingNCT07784712
- Ultrasound Therapy In Cardiac AmyloidosisRecruitingNCT04667494Phase 41 country
- Analysis of the Evolution of SUVmax by Quantitative Analysis Method of Bisphosphonate ScintigraphyRecruitingNCT04849754Not applicable1 country
- PET Imaging With [18F]Fluselenamyl in People With Cardiac AmyloidosisEnrolling by invitationNCT07771621Phase 11 country
- Liver and Coagulation Disorders in Cardiac Transthyretin AmyloidosisRecruitingNCT077661351 country
- ATTR Cardiac Amyloidosis in a Selected PopulationRecruitingNCT064583741 country
- To Evaluate the Long-term Safety and Tolerability of Acoramidis in Participants With Newly Diagnosed ATTR-CM (ACT-EARLY OLE)Not yet recruitingNCT07116473Phase 3
- Cardiovascular Multimodality Imaging StudyRecruitingNCT066100191 country
- Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR VariantRecruitingNCT06563895Phase 324 countries
- Long-Term Follow-Up (LTFU) of Subjects Dosed With NTLA-2001Enrolling by invitationNCT056978614 countries
- Detection of Cardiac Amyloidosis Using Right Ventricular Sensing Amplitude in Patients With Left Ventricular HypertrophyNot yet recruitingNCT07734285Not applicable
- Cardiac Magnetic Resonance and Echocardiography Study With AcoramidisRecruitingNCT07695701Phase 41 country
- Artificial Intelligence Guided Echocardiographic Screening of Rare Diseases (EchoNet-Screening)RecruitingNCT051397971 country
- AI Echocardiographic Screening of Cardiac AmyloidosisEnrolling by invitationNCT06664866Not applicable1 country
- 124I-Evuzamitide PET/CT Imaging In Patients With Lumbar Spinal Stenosis and Carpal Tunnel SyndromeEnrolling by invitationNCT06907849Phase 21 country
- CAPACITY (Cardiac Amyloidosis and Physical ACtivITY) StudyRecruitingNCT06096675Not applicable1 country
- [64Cu]FBP8 PET for Early Detection of Intracardiac Thrombus in Amyloid CardiomyopathyRecruitingNCT07560306Phase 31 country
- Hungarian National Systemic Amyloidosis RegistryRecruitingNCT076893311 country
- Enavogliflozin for the Management of Patients With Amyloid CardiomyopaThyRecruitingNCT07240844Phase 41 country
- PATHWAY-RCT: Preventing Admission To Hospital With Attr cardiomyopathYRecruitingNCT05098665Not applicable1 country
- AI-based Echocardiography for Detection of Cardiac AmyloidosisNot yet recruitingNCT07529860Not applicable
- Analysis of Lumbar Spine Stenosis Specimens for Identification of Transthyretin Cardiac AmyloidosisRecruitingNCT060344051 country
- Haemodynamic Effects of Dobutamine in Patients With Wild-type Transthyretin Amyloid Cardiomyopathy (ATTRwt)RecruitingNCT06318260Phase 1/21 country
- Retrospective Identification of Scintigraphic Cardiac Amyloidosis (RISCA)Not yet recruitingNCT06921408
- Early Screening for Cardiac Amyloid Using a History of Bilateral Carpal Tunnel SyndromeNot yet recruitingNCT07580872Not applicable
- Screening, Characterization, and Longitudinal Follow-up of Patients With Cardiac AmyloidosisNot yet recruitingNCT075774661 country
- Early Detection of Concealed Cardiac Amyloidosis Using AI-ECG and CT-Derived Extracellular Volume in Patients With Atrial FibrillationNot yet recruitingNCT07567508Not applicable1 country
- Cardiac Amyloidosis pRevaleNce of in OLDer Subjects Affected by Heart FailureRecruitingNCT064273041 country
- NatiOnal Referral cenTEr Study of Transthyretin Amyloid Cardiomyopathy(ATTR) Patients on TafamidisRecruitingNCT062517781 country
- A Study Of Deep Learning For Echo Analysis, Tracking, And EvaluationRecruitingNCT073087041 country
- CHEST-CA: Study of Chest Pain and Hidden Cardiac AmyloidosisRecruitingNCT07435168Not applicable1 country