An observational study in Chronic Pain, PERIPHERAL NEUROPATHY and Occipital Neuralgia, sponsored by Yale University. Recruiting at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-08-21.
Sponsored by Yale University · Observational
To prospectively describe patient-centered and health utilization outcomes through 12 months after cryoneurolysis performed as routine clinical care for chronic pain at Yale.
Adults aged 18 years or older with chronic pain localized to an anatomical region considered appropriate for cryoneurolysis by the treating physician and scheduled to undergo cryoneurolysis as standard clinical care.
Exclusion Criteria:
Participants undergoing cryoneurolysis for chronic pain as part of standard clinical care.
Percentage of participants with improvement in pain
Percentage of participants achieving a clinically meaningful improvement in pain. Pain improvement measured as a ≥2-point reduction on the 0-10 Numeric Rating Scale (NRS). NRS is a widely used, validated 0-10, tool for measuring subjective pain intensity, where 0 represents "no pain" and 10 represents "the worst pain imaginable".
Time frame: 6 and 12 months
Change in Pain Disability Index (PDI) score
PDI is a 7-item self-report questionnaire used to measure how chronic pain interferes with various aspects of a person's life, with total scores ranging from 0 (no disability) to 70 (maximum disability).
Time frame: 6 and 12 months
Number of pain-related hospital admissions
Number of pain-related hospital admissions in the 12 months before versus the 12 months after cryoneurolysis.
Time frame: up to 12 months post cryoneurolysis
Number of pain-related emergency department visits
Number of pain-related emergency department visits in the 12 months before versus the 12 months after cryoneurolysis.
Time frame: up to 12 months post cryoneurolysis
Number of pain-related medication refills
Number of pain-related medication refills in the 12 months before versus the 12 months after cryoneurolysis.
Time frame: up to 12 months post cryoneurolysis
Number of responders
Responders are participants reporting 'much improved' or 'very much improved' using the Patient Global Impression of Change (PGIC).
Time frame: 6 and 12 month
Plan to share: No
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Yale University