Polyneuropathies clinical trials
The registry lists 133 studies for Polyneuropathies across more than 10 countries. 33 are recruiting or about to start. 61 of them are mainly about Polyneuropathies (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-06. Counting its 6 narrower conditions too, such as Polyradiculoneuropathy, Chronic Inflammatory Demyelinating: 497 studies, 154 open.
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A study of drug A after surgery for early breast cancer
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· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
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Who runs them
Pfizer (5) · Eidos Therapeutics, a BridgeBio company (4) · Alnylam Pharmaceuticals (4) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (4) · Assistance Publique - Hôpitaux de Paris (3) · Odense University Hospital (3) · AstraZeneca (3) · Intellia Therapeutics (2)
What is being tested here
Drugs under test in Polyneuropathies studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 9, phase 3 first
- Jul 2027A Phase 3 Study of NTLA-2001 in ATTRv-PN · Phase 3 · Intellia Therapeutics
- Sep 2027Clinical Trial With Aconite Pain Oil in Oncology Patients Under Chemotherapy to Prevent CIPN, to Reduce Symptoms and to Improve the Quality of Life of Patients With CIPN · Phase 3 · WALA Heilmittel GmbH
- Nov 2026Metabolomics Study on Postoperative Intensive Care Acquired Muscle Weakness · Technical University of Munich
- Dec 2026Polyneuropathy, Impairments and Physical Activity - The PolyImPAct Study · Rigshospitalet, Denmark
- Dec 2026Accuracy of the Polymerase Chain Reaction of Ulnar Perineural Subcutaneous Aspirate Guided by Ultrasound for the Diagnosis and Monitoring of Leprosy Cure · University of Brasilia
- Dec 2026Diagnostic Feasibility of 100 Hz Tetanic Stimulation · University of Debrecen
- Jan 2027Exploring the Genetics of Neuropathic Pain · Oslo University Hospital
- Jun 2027Shear Wave Elastography of Peripheral Nerves for Early Diagnosis of ICU-acquired Weakness · First Affiliated Hospital of Wannan Medical College
- Jun 2027Using the EHR to Advance Genomic Medicine Across a Diverse Health System · University of Pennsylvania
Who these studies take
Of the 24 Polyneuropathies studies recruiting now, 11 (46%) set no upper age limit and 8 (33%) stop at 75 or younger. 8 (33%) take children under 18. 1 (4%) are for women only and 0 (0%) for men only; 4 (17%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 6 (25%) | 5 (21%) |
| 18 | 20 (83%) | 19 (79%) |
| 30 | 20 (83%) | 19 (79%) |
| 40 | 20 (83%) | 19 (79%) |
| 50 | 20 (83%) | 19 (79%) |
| 65 | 21 (88%) | 20 (83%) |
| 75 | 18 (75%) | 17 (71%) |
| 85 | 15 (63%) | 14 (58%) |
Across all 133 studies, recruiting or not: 24% stop at 75 or younger and 10% at 65; 12% take children; 3% are for women only and 0% for men only; 14% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Polyneuropathies studies take
Of 26 observational studies under Polyneuropathies, half reached primary completion within 54 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 28 mo14–41 · 19 studies | — | — |
| Observational | 54 mo26–93 · 26 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 133. Browse all 133 → or search them.
- Zanubritnib and Anti-MAG NeuropathyRecruitingNCT07392229Phase 21 country
- ConTTRibute: A Global Observational Study of Patients With Transthyretin (TTR)-Mediated Amyloidosis (ATTR Amyloidosis)RecruitingNCT0456151812 countries
- TRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Hereditary Transthyretin Amyloidosis With PolyneuropathyRecruitingNCT07223203Phase 322 countries
- Patisiran-Lipid Nanoparticle (LNP) Pregnancy Surveillance ProgramRecruitingNCT050403737 countries
- Clinical, Electrophysiological and Genetic Characteristics of Hereditary and Inflammatory Polyneuropathies in FranceNot yet recruitingNCT078518441 country
- Non-interventional Study of Patients With Transthyretin (ATTR) AmyloidosisRecruitingNCT064658106 countries
- Clinical Trial With Aconite Pain Oil in Oncology Patients Under Chemotherapy to Prevent CIPN, to Reduce Symptoms and to Improve the Quality of Life of Patients With CIPNRecruitingNCT06186479Phase 31 country
- Using the EHR to Advance Genomic Medicine Across a Diverse Health SystemRecruitingNCT06377033Not applicable1 country
- To Evaluate the Long-term Safety and Tolerability of Acoramidis in Participants With Newly Diagnosed ATTR-CM (ACT-EARLY OLE)Not yet recruitingNCT07116473Phase 3
- Study to Evaluate Safety and Efficacy of Different PANZYGA Dose Regimens in Pediatric Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) PatientsRecruitingNCT04929236Phase 31 country
- Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR VariantRecruitingNCT06563895Phase 324 countries
- Is Serum Irisin Level a Biomarker in Diabetic Polyneuropathy?Not yet recruitingNCT077345971 country
- Single-Center Study Evaluating the Impact of Age on the Diagnostic Performance of the Sural-to-Radial Sensory Amplitude Ratio in Length-Dependent and Non-Length-Dependent Peripheral PolyneuropathiesNot yet recruitingNCT077251201 country
- Shear Wave Elastography of Peripheral Nerves for Early Diagnosis of ICU-acquired WeaknessNot yet recruitingNCT075942491 country
- Effectiveness of a Structured Multidimensional Tele-rehabilitation Intervention in Cardiac Patients With Post-Intensive Care Syndrome (CARDIO-PICS)RecruitingNCT07599306Not applicable1 country
- Two Dose Levels of Privigen in Pediatric CIDPRecruitingNCT03684018Phase 41 country
- Accuracy of the Polymerase Chain Reaction of Ulnar Perineural Subcutaneous Aspirate Guided by Ultrasound for the Diagnosis and Monitoring of Leprosy CureRecruitingNCT07515989Not applicable1 country
- Critical Illness Weakness Outside the Intensive Care Unit.RecruitingNCT074783671 country
- Metabolomics Study on Postoperative Intensive Care Acquired Muscle WeaknessRecruitingNCT038107682 countries
- Effects of Resistance Exercises in Hereditary Sensory-Motor Neuropathy (Charcot-Marie-Tooth Disease)RecruitingNCT07152197Not applicable1 country
- Investigation of Ultrasonographic Measurements of Lower Extremity Nerves in Type 2 Diabetes Patients With Peripheral PolyneuropathyRecruitingNCT067780051 country
- Ultrasound Evaluation of Hematoma Risk After Needle EMG in Patient on DOAC TherapyRecruitingNCT071663021 country
- Prevalence of Wild-type TTR Cardiac Amyloidosis in Patients With Polyneuropathy of Unknown Cause.RecruitingNCT05950867Not applicable1 country
- A New Cancer Rehabilitation Process for Chemotherapy-Induced Foot Neuropathy Using Orthopedic DevicesRecruitingNCT06904989Not applicable1 country
- Diagnostic Feasibility of 100 Hz Tetanic StimulationRecruitingNCT067549951 country
- Improved Recovery of Walking in Acquired Muscle WeaknessRecruitingNCT06786390Not applicable1 country
- Prodromal Model of Parkinson's Disease Confined to The Peripheral Nervous SystemEnrolling by invitationNCT067450111 country
- Assessment of Effectiveness and Stimulation Coverage of Closed-loop Spinal Cord Stimulation (CL-SCS) Therapy in Patients with Cervical Lead PlacementEnrolling by invitationNCT063595611 country
- A Phase I/IIa，Open-label, Single Ascending Dose and Dose-expansion Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of YOLT-201 in Patients With Transthyretin Amyloidosis Polyneuropathy (ATTR-PN) or Transthyretin Amyloidosis Cardiomyopathy (ATTR-CM)RecruitingNCT06539208Phase 1/21 country
- Ultrasonography in Diagnosis of PolyneuropathyNot yet recruitingNCT06390527
- Prognostic Value of Biomarkers in Polyneuropathy.RecruitingNCT060446621 country
- IVIG in Painful Sensory NeuropathyNot yet recruitingNCT06183008Phase 4
- Exploring the Genetics of Neuropathic PainRecruitingNCT038623651 country
- A Phase 3 Study of NTLA-2001 in ATTRv-PNActive, not recruitingNCT06672237Phase 36 countries
- FOot CAre and Exercises ImplementatioN for People With Diabetes in Primary CareCompletedNCT05639478Not applicable1 country
- Comparative Effectiveness of Nursing Interventions: Using Buerger-Allen Exercises Versus Mechanical Compression Therapy on Lower Limb Perfusion and Peripheral Neuropathy Among Patients Undergoing Chemotherapy.Active, not recruitingNCT07842237Not applicable1 country
- Effect of Exercise and Surgical Weight Loss on PolyneuropathyCompletedNCT03617185Not applicable1 country
- Polyneuropathy, Impairments and Physical Activity - The PolyImPAct StudyActive, not recruitingNCT060405671 country
- AI Based Muscular Ultrasound to Assess Intensive Care Unit-acquired WeaknessCompletedNCT067655511 country
- Paclitaxel-induced Polyneuropathy in Breast Cancer: Early Detection, Risk Factors, Quality of Life and Lifestyle OutcomesWithdrawnNCT060523451 country
- Prevalence of Thiamine Deficiency in Hospitalized Non-Alcoholic VeteransCompletedNCT054809431 country
- Hereditary Transthyretin Amyloidosis Polyneuropathy in Patients With Carpal Tunnel Syndrome in RussiaCompletedNCT064147461 country
- CPAx: Responsiveness and Minimal Clinically Important DifferenceActive, not recruitingNCT064196992 countries
- Spectrum of Peripheral and Autonomic Neuropathies in Patients With aTTRwt Amyloidosis and Response to Patisiran TherapyCompletedNCT05023889Early Phase 11 country
- Effects of Four-Cell Galvanic Therapy on Pain and Balance in Diabetic Peripheral NeuropathyCompletedNCT07590011Not applicable1 country
- ChatGPT in the Diagnosis and Management of Complex Polyneuropathies: Comparative Analysis With Neurologists Using Real-World CasesCompletedNCT074936811 country
- Turkish Validation and Reliability of the John Hopkins In-Room Independence ScaleCompletedNCT072502431 country
- Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of NTLA-2001 in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy (ATTRv-PN) and Patients With Transthyretin Amyloidosis-Related Cardiomyopathy (ATTR-CM)CompletedNCT04601051Phase 14 countries
- Individual Patient Expanded Access IND to Treat PolyneuropathyNo longer availableNCT040649831 country
- TRAMmoniTTR Study Genetic Screening of an At-risk Population for hATTR and Monitoring of TTR Positive SubjectsCompletedNCT032374943 countries