Nephrolithiasis clinical trials

The registry lists 324 studies for Nephrolithiasis across more than 10 countries. 90 are recruiting or about to start. 170 of them are mainly about Nephrolithiasis (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its narrower condition Kidney Calculi too: 711 studies, 193 open.

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Status

Completed: 172
Recruiting: 51
Not yet recruiting: 36
Status unknown: 34
Terminated: 10
Withdrawn: 10

Phase

Phase 4: 27
Phase 2: 25
Phase 3: 18
Phase 1: 7
Early Phase 1: 1

Where

United States: 99
Egypt: 63
Turkey: 26
Canada: 22
China: 14
France: 14

Who runs them

Ain Shams University (14) · Mansoura University (10) · Assiut University (10) · Indiana Kidney Stone Institute (6) · Icahn School of Medicine at Mount Sinai (6) · VA New York Harbor Healthcare System (5) · Al-Azhar University (5) · Benha University (5)

What is being tested here

Drugs under test in Nephrolithiasis studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

Drug	Open	Phase 3	All
Potassium Citrate	2	1	4
Citric Acid	2	1	4
Chlorthalidone	2	0	3
Sodium Bicarbonate	2	0	2
Empagliflozin	2	2	2
Tamsulosin	1	1	6
Hydrochlorothiazide	1	2	4
Bupivacaine	1	0	2
Levofloxacin	1	0	2
Ketamine	1	0	1

Drug classes tested here Diuretics 2 open · Thiazide diuretics 2 open · Local anesthetics 1 open · Opioids 5

Coming up

4phase 3 studies under way

35studies finish main data collection within a year1 of them phase 3

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

The 10 nearest, phase 3 first

Oct 2027Spinal Morphine or Intravenous Lidocaine in Robot-assisted Upper Urologic Surgery · Phase 3 · Hans Bahlmann
Nov 2026Efficacy & Safety of High Power vs. Low Power Holmium Laser in Mini-PCNL for Large Renal Stones · Mansoura University
Nov 2026Evaluation of the LithoVue Elite Ureteroscope With Intra-Renal Pressure Monitoring Technology: Examination of Surgeon Behavior and Post-operative Outcomes · University of Kansas Medical Center
Nov 2026Comparison of Different Ventilation Modes for Reducing Kidney Motion During Retrograde Intrarenal Surgery · Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Nov 2026Comparative Study Between Spinal Anesthesia Versus General Anesthesia in Supine Percutaneous Nephrolithotomy Operation · Tanta University
Dec 2026Novel Antimicrobial Solution to Prevent Infections · Ohio State University
Dec 2026Dexamethasone for Ureteral STent Symptoms (DUSTS) · The Methodist Hospital Research Institute
Dec 2026Management of Medium Sized Renal Stones · Assiut University
Jan 2027FANS-FURS vs Suction Mini-PCNL for 2-3 cm Renal Stones: A Multicenter Randomized Trial · Mansoura University
Feb 2027Nebulized Glubran 2-Assisted Tubeless PCNL Versus Conventional PCNL · Benha University

Who these studies take

Of the 51 Nephrolithiasis studies recruiting now, 30 (59%) set no upper age limit and 14 (27%) stop at 75 or younger. 2 (4%) take children under 18. 0 (0%) are for women only and 1 (2%) for men only; 7 (14%) take healthy volunteers.

Recruiting studies that take each age, of 51
Age	Women	Men
10	2 (4%)	2 (4%)
18	45 (88%)	46 (90%)
30	47 (92%)	48 (94%)
40	48 (94%)	49 (96%)
50	48 (94%)	49 (96%)
65	47 (92%)	48 (94%)
75	38 (75%)	38 (75%)
85	31 (61%)	31 (61%)

Across all 324 studies, recruiting or not: 27% stop at 75 or younger and 15% at 65; 13% take children; 0% are for women only and 1% for men only; 14% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Nephrolithiasis studies take

Of 17 phase 4 interventional studies under Nephrolithiasis, half reached primary completion within 43 months of starting, counting those still running.

Start to primary completion	Every sponsor	Industry	Non-industry
Phase 4	43 mo23–67 · 17 studies	—	—
Interventional, no phase	24 mo12–38 · 140 studies	—	25 mo12–40 · 134 studies
Observational	23 mo10–54 · 27 studies	—	—

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

What changed recently

From the registry's own updates since Oct 11, 2026.

Show 1 more

Flexible Ureteroscopy Versus Mini- Percutaneous Nephrolithotomy in Management of Pediatric Renal Stones Less Than 2 cmOct 13, 2026NCT07870200

Studies

Recruiting first, then most recently updated. Showing 50 of 324. Browse all 324 → or search them.