Drug
Hydrochlorothiazide clinical trials
Also written HCTZ, Hydrodiuril and Microzide.
- studies test it
- 191
- open now
- 11
- in phase 3
- 52
- first study started
- 1997
Keep track of what changes. Save the Hydrochlorothiazide studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Name
Brand
Studies by the year they started
188 studies that test it; most in 2006 (22)
| Year | Studies |
|---|---|
| 1997 | 1 |
| 1998 | 2 |
| 1999 | 4 |
| 2000 | 3 |
| 2001 | 2 |
| 2002 | 2 |
| 2003 | 4 |
| 2004 | 11 |
| 2005 | 21 |
| 2006 | 22 |
| 2007 | 14 |
| 2008 | 11 |
| 2009 | 14 |
| 2010 | 9 |
| 2011 | 6 |
| 2012 | 4 |
| 2013 | 9 |
| 2014 | 10 |
| 2015 | 6 |
| 2016 | 5 |
| 2017 | 6 |
| 2018 | 4 |
| 2019 | 3 |
| 2020 | 1 |
| 2021 | 3 |
| 2022 | 1 |
| 2024 | 5 |
| 2025 | 2 |
| 2026 | 3 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 4
- Phase 1
- 18
- Phase 2
- 11
- Phase 3
- 52
- Phase 4
- 80
- No phase
- 28
What it is tested for
Each study’s main condition, where its own words name it.
- Hypertension
- 104
Who runs them
Industry 103 · Other 88
Novartis (36) · Boehringer Ingelheim (16) · Daiichi Sankyo (6) · Sanofi (5) · Novartis Pharmaceuticals (5) · Damanhour University (4) · Merck Sharp & Dohme LLC (3) · University of Florida (3)
Often tested with
Tested in the same studies.
Amlodipine (35) · Valsartan (34) · Telmisartan (20) · Losartan (20) · Aliskiren (13) · Irbesartan (11) · Lisinopril (10) · Olmesartan Medoxomil (8)
Studies
Open first, then newest update. How each study uses Hydrochlorothiazide is read from its arms, and is right about nine times in ten.
Testing it · 191
- HYDROchlorothiazide to PROTECT Polycystic Kidney Disease Patients and Improve Their Quality of LifeRecruitingPhase 3University Medical Center GroningenNCT05373264Written as Hydrochlorothiazide 25 mg
- Comparative Effectiveness of Dual Antihypertensive Regimens in Patients After Percutaneous Coronary InterventionRecruitingNot applicableNational Medical Research Center for Therapy and Preventive MedicineNCT07683585Written as Losartan + Hydrochlorothiazide
- TACTIC-HF: Sequential Diuretic Strategies in Ambulatory Worsening Heart FailureNot yet recruitingPhase 4Lucrecia Maria BurgosNCT07593612Written as Hydrochlorothiazide (HCT)
- Indapamide and Chlorthalidone to Reduce Urine Supersaturation for Kidney Stone PreventionRecruitingPhase 2Insel Gruppe AG, University Hospital BernNCT06111885Written as Hydrochlorothiazide 50Mg
- POcus INTERvention for Tailoring Diuretic Strategy in Acute Decompensated Heart FailureNot yet recruitingPhase 2/3Hospital de Clinicas de Porto AlegreNCT07469722Written as Hydrochlorothiazide (HCTZ) 25 milligrams.
- Blood Pressure Control With Thiazide Diuretics in Peritoneal Dialysis PatientsRecruitingPhase 4Chinese University of Hong KongNCT07271420Written as Hydrochlorothiazide 25mg once per day
- The Role of Skin Sodium Accumulation in Chronic Kidney DiseaseRecruitingNot applicableAcademisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)NCT07020104Written as Hydrochlorothiazide
- Mitigating the Pro-inflammatory Phenotype of ObesityRecruitingPhase 1University of Kansas Medical CenterNCT04934228Written as Hydrochlorothiazide 12.5Mg Tab
- Comparison of the Role of Losartan Alone vs Hydrochlorothiazide Plus LosartanNot yet recruitingNot applicableRESnTEC, Institute of ResearchNCT06491940Written as Losartan + Hydrochlorothiazide
- Multi-Omics to Predict the Blood Pressure Response to AntihypertensivesRecruitingPhase 4Radboud University Medical CenterNCT05917275Written as Hydrochlorothiazide
- Dapagliflozin and Hydrochlorothiazide in Recurring Kidney Stone PatientsNot yet recruitingPhase 4Medical University of ViennaNCT05443932Written as Hydrochlorothiazide
- Improving Pain Management Via Spinal Cord Stimulation and Blood Pressure ReductionActive, not recruitingEarly Phase 1University of Kansas Medical CenterNCT04676399Written as Hydrochlorothiazide 12.5mg
- Postpartum Management of Hypertension in Pregnancy With HydrochlorothiazideTerminatedPhase 3The University of Texas Medical Branch, GalvestonNCT03298802Written as Hydrochlorothiazide 50mg Tablet
- Effectiveness of Valsartan Alone vs Combination Therapy in Hypertensive Heart DiseaseCompletedPhase 1Shaikh Zayed Hospital, LahoreNCT07544888Written as Valsartan + Hydrochlorothiazide
- Protocol of Diuretics Use in Congestive Therapy in Heart FailureCompletedPhase 4University Hospital, Clermont-FerrandNCT03892148Written as Hydrochlorothiazide
- Study to Evaluate the Influence of Hydrochlorothiazide on Dermal Photosensitivity and DNA Stability - a Pilot Study (HCTox Study)CompletedPhase 1Universität des SaarlandesNCT04654312Written as Hydrochlorothiazide
- INTERVENCION TrialCompletedPhase 4PrevencionNCT02373163Written as Hydrochlorothiazide
- ACES - ACE Inhibitors Combined With Exercise for Seniors With HypertensionCompletedPhase 2University of Alabama at BirminghamNCT03295734Written as HCTZ
- Diuretic Comparison ProjectCompletedPhase 3VA Office of Research and DevelopmentNCT02185417Written as Hydrochlorothiazide (HCTZ)
- Fasting Study of Hydrochlorothiazide Tablets 50 mg to Hydrochlorothiazide Tablets 50 mgCompletedEarly Phase 1Mylan Pharmaceuticals IncNCT00649324Written as Hydrochlorothiazide Tablets 50 mg
See all 191 studies that test Hydrochlorothiazide →
Given in every arm · 27 — Hydrochlorothiazide is usual care beside what is tested
- Determinants of Warfarin MetabolismRecruitingNot applicableHadassah Medical OrganizationNCT00162474Written as Losartan & Hydrochlorothiazide
- LAAS (Losartan Anti-Atherosclerosis Study)(0954-330)(COMPLETED)CompletedPhase 4Organon and CoNCT00496834Written as Comparator: losartan (+) hydrochlorothiazide (HCTZ)
- Safety, Tolerability and Pharmacokinetics of Single Rising and Multiple Oral Doses of Telmisartan / Hydrochlorothiazide (HCTZ) in Healthy Male VolunteersCompletedPhase 1Boehringer IngelheimNCT02262780Written as HCTZ
- Efficacy and Tolerability of an Aliskiren-based Treatment Algorithm in Patients With Mild to Moderate HypertensionCompletedPhase 4NovartisNCT00765947Written as Hydrochlorothiazide
- Efficacy and Safety of Valsartan and Amlodipine (± HCTZ) in Adults With Moderate, Inadequately Controlled HypertensionCompletedPhase 3NovartisNCT00523744Written as Hydrochlorothiazide
- A Dose Escalation Study of a Combination Antihypertensive Drug in the Treatment of Various Groups of Patients Who do Not Respond to Single Drug Treatment of Their High Blood PressureCompletedPhase 4Daiichi SankyoNCT00791258Written as hydrochlorothiazide tablets
- Aldosterone and the Metabolic SyndromeCompletedPhase 1Vanderbilt University Medical CenterNCT01103245Written as Hydrochlorothiazide (HCTZ)
- Pharmacologic Treatment of Congenital Nephrogenic Diabetes InsipidusCompletedNot applicableUniversity of Colorado, DenverNCT00478335Written as hydrochlorothiazide/amiloride
- A Phase III Long-term Study of TAK-536TCH in Participants With Essential HypertensionCompletedPhase 3TakedaNCT02277691Written as HCTZ 12.5 mg tablet
- Randomized Controlled Trial of Renal Denervation for Resistant HypertensionStatus unknownPhase 3Shanghai WiseGain Medical Devices Co., Ltd.NCT02900729Written as Amlodipine, losartan potassium and hydrochlorothiazide
- Safety and Tolerability of Valsartan in Children 6 to 17 Years of AgeCompletedPhase 3Novartis PharmaceuticalsNCT01365481Written as Hydrochlorothiazide
- Study of the Safety and Efficacy of LCZ696 on Arterial Stiffness in Elderly Patients With HypertensionCompletedPhase 2Novartis PharmaceuticalsNCT01692301Written as hydrochlorothiazide
- Compare Efficacy and Safety of Telmisartan/Hydrochlorothiazide With Telmisartan/Hydrochlorothiazide Plus AmlodipineCompletedPhase 3Boehringer IngelheimNCT01911780Written as telmisartan + HCTZ
- Stratification of Blood Pressure Control Against Progress of Cerebral Small Vessel Diseases in Poststroke PatientsStatus unknownPhase 4Yining HuangNCT01819441Written as hydrochlorothiazide
- A Long-term (12 Months) Safety, Tolerability and Efficacy Study of LCZ696 in Patients With Essential HypertensionCompletedPhase 2Novartis PharmaceuticalsNCT01256411Written as Hydrochlorothiazide (HCTZ)
- A Study to Investigate the Magnitude and Duration of Response of MK0954 Compared to Placebo in Patients With Hypertension (0954-021)(COMPLETED)CompletedPhase 3Merck Sharp & Dohme LLCNCT00886600Written as hydrochlorothiazide (HCTZ)
- Aliskiren Study of Safety and Efficacy in Senior HypertensivesWithdrawnPhase 4Novartis PharmaceuticalsNCT01922141Written as Hydrochlorothiazide
- Influence of Food on the Bioavailability of Two Doses of Telmisartan/HCTZ Fixed-dose Combination in Japanese Healthy Male VolunteersCompletedPhase 1Boehringer IngelheimNCT02276378Written as Hydrochlorothiazide (HCTZ)
- ALiskiren or Losartan Effects on bioMARKers of Myocardial RemodelingCompletedPhase 4Novartis PharmaceuticalsNCT01176032Written as Hydrochlorothiazide (HCTZ)
- To Study the Effects of Aliskiren on Albuminuria and Various Biomarkers in Patients With NephropathyTerminatedPhase 2Novartis PharmaceuticalsNCT01302899Written as Hydrochlorothiazide (HCTZ)
Showing 20 of 27.
As the comparator · 45 — what is tested is compared with Hydrochlorothiazide
- SPIRO-First: A Pragmatic Primary Care-Embedded Pilot Trial of Renin-Guided First-Line Antihypertensive TherapyNot yet recruitingPhase 4Ottawa Hospital Research InstituteNCT07687160Written as Hydrochlorothiazide (HCTZ) 25 milligrams.
- Sympathetic Regulation of Large Artery Stiffness in Humans With ISHCompletedEarly Phase 1University of IowaNCT04423627Written as Hydrochlorothiazide
- Efficacy and Safety of a Single-pill Fixed Combination of Sufficient Losartan/Hydrochlorothiazide in Chinese Hypertensive PatientsCompletedPhase 4Shanghai Jiao Tong University School of MedicineNCT03946514Written as amlodipine/hydrochlorothiazide
- Use of Nanotechnology Structured Water for the Prevention of Recurrent Stone FormationCompletedNot applicableALI KAMAL M. SAMINCT06681116Written as Hydrochlorothiazide (HCTZ)
- Anxiety-mediated Impairments in Large Elastic Artery Function and the Autonomic Nervous SystemTerminatedPhase 4University of IowaNCT03109795Written as Hydrochlorothiazide
- Fed Study of Benazepril HCl and Hydrochlorothiazide Tablets 20 mg/25 mg to Lotensin HCT® Tablets 20 mg/25 mgCompletedPhase 1Mylan Pharmaceuticals IncNCT00649038Written as Lotensin HCT® Tablets 20 mg/25 mg
- Fasting Study of Benazepril HCl and Hydrochlorothiazide Tablets 20 mg/25 mg to Lotensin HCT® Tablets 20 mg/25 mgCompletedPhase 1Mylan Pharmaceuticals IncNCT00649597Written as Lotensin HCT® Tablets 20 mg/25 mg
- Peripheral Vascular Effects of Sulfhydryl-containing Antihypertensive Pharmacotherapy on Microvessels in HumansTerminatedPhase 1/2Penn State UniversityNCT03179163Written as Hydrochlorothiazide
- Vascular Dysfunction in Human Obesity HypertensionTerminatedPhase 2Gary L. PierceNCT01983462Written as Hydrochlorothiazide
- Bioequivalence of Losartan and Hydrochlorothiazide (HCTZ) Combination Tablet and Coadministration of Its Components (0954A-306)CompletedPhase 1Organon and CoNCT00953680Written as losartan potassium (+) hydrochlorothiazide (HCTZ)
- Safety and Effect Study of SHR0532 (Drug Code) Tablets in Patients With Mild HypertensionCompletedPhase 1Jiangsu HengRui Medicine Co., Ltd.NCT03971929Written as Hydrochlorothiazide 25 mg
- A New Application of Amiloride in the Treatment of Patient With Chronic Kidney Disease In Reducing Urinary PROteinCompletedPhase 4Guangdong Provincial People's HospitalNCT03170336Written as Hydrochlorothiazide
- Ertugliflozin Versus Hydrochlorothiazide in Reducing Sympathetic Neural Overactivity in Patients With Hypertension and Recently-diagnosed Type 2 Diabetes.WithdrawnPhase 4Cedars-Sinai Medical CenterNCT03640221Written as Hydrochlorothiazide 12.5mg
- Efficacy of Chlorthalidone and Hydrochlorothiazide Combined With Amiloride on Blood Pressure in Primary Hypertension.Status unknownPhase 3Hospital de Clinicas de Porto AlegreNCT03928145Written as Hydrochlorothiazide 50 mg
- Safety and Efficacy Study of a Triple Combination Therapy in Subjects With HypertensionCompletedPhase 3Daiichi SankyoNCT00649389Written as Hydrochlorothiazide
- A Study of MK-7145 Compared to Placebo and Hydrochlorothiazide for Lowering Blood Pressure in Male Participants With Hypertension (MK-7145-009)CompletedPhase 1Merck Sharp & Dohme LLCNCT01370655Written as Hydrochlorothiazide (HCTZ)
- Study of Safety and Efficacy Of Ertugliflozin (PF-04971729, MK-8835) In Participants With Type 2 Diabetes And Hypertension (MK-8835-042)CompletedPhase 2Merck Sharp & Dohme LLCNCT01096667Written as HCTZ 12.5mg
- Epithelial Sodium Channel (ENaC) as a Novel Mechanism for Hypertension and Volume Expansion in Type 2 DiabetesTerminatedEarly Phase 1University of New MexicoNCT01804777Written as HCTZ
- Evaluating the Effect of Aliskiren Versus HCTZ on Coronary Flow Reserve in Hypertensive Type II DiabeticsWithdrawnPhase 4William Beaumont HospitalsNCT00994253Written as Hydrochlorothiazide
- Role of Mineralocorticoid Receptor in Diabetic Cardiovascular DiseaseCompletedNot applicableBrigham and Women's HospitalNCT00865124Written as Hydrochlorothiazide + potassium
Showing 20 of 45.
Codes
What other systems call Hydrochlorothiazide · ClinicalTrials.gg INT007626
- MeSH (NLM) D006852HydrochlorothiazideConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 0J48LPH2THHYDROCHLOROTHIAZIDEConfirmed FDA, NLM, Wikidata
- RxNorm 5487Confirmed FDA, Wikidata
- Wikidata Q423930hydrochlorothiazideConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C29098HydrochlorothiazideOne source FDA
- DrugBank DB00999One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D006852 | Hydrochlorothiazide | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 0J48LPH2TH | HYDROCHLOROTHIAZIDE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 5487 | — | Confirmed FDA, Wikidata |
| Wikidata | Q423930 | hydrochlorothiazide | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C29098 | Hydrochlorothiazide | One source FDA |
| DrugBank | DB00999 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.