Hypertrophy, Left Ventricular clinical trials
The registry lists 162 studies for Hypertrophy, Left Ventricular across more than 10 countries. 28 are recruiting or about to start. 49 of them are mainly about Hypertrophy, Left Ventricular (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-27.
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Who runs them
National Heart, Lung, and Blood Institute (NHLBI) (5) · Novartis Pharmaceuticals (4) · Massachusetts General Hospital (4) · University of Dundee (4) · Medical University of Vienna (3) · Washington University School of Medicine (3) · Unity Health Toronto (3) · University of Aarhus (3)
What is being tested here
Drugs under test in Hypertrophy, Left Ventricular studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Eplerenone | 1 | 0 | 4 |
| Colchicine | 1 | 0 | 2 |
| Chlorthalidone | 1 | 0 | 1 |
| Potassium | 1 | 0 | 1 |
| Valsartan | 0 | 2 | 7 |
| Tadalafil | 0 | 0 | 4 |
| Everolimus | 0 | 0 | 3 |
| Allopurinol | 0 | 0 | 3 |
| Amlodipine | 0 | 1 | 3 |
| Paricalcitol | 0 | 2 | 3 |
Drug classes tested here Angiotensin receptor blockers (ARBs) 1 open · Mineralocorticoid receptor antagonists (MRAs) 1 open · Diuretics 1 open · Calcium channel blockers 5 · SGLT2 inhibitors 4
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 4
- Dec 2026Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE) · Wake Forest University Health Sciences
- Dec 2026Sodium Lowering Vascular Effects Trial · Tulane University
- Dec 2026Predictors of Poor Prognosis in HFpEF · National Medical Research Center for Cardiology, Ministry of Health of Russian Federation
- Apr 2027Mineralocorticoid Receptor, Coronary Microvascular Function, and Cardiac Efficiency in Hypertension · Brigham and Women's Hospital
Who these studies take
Of the 20 Hypertrophy, Left Ventricular studies recruiting now, 13 (65%) set no upper age limit and 2 (10%) stop at 75 or younger. 4 (20%) take children under 18. 0 (0%) are for women only and 1 (5%) for men only; 7 (35%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 3 (15%) | 4 (20%) |
| 18 | 14 (70%) | 15 (75%) |
| 30 | 14 (70%) | 15 (75%) |
| 40 | 17 (85%) | 18 (90%) |
| 50 | 17 (85%) | 18 (90%) |
| 65 | 18 (90%) | 19 (95%) |
| 75 | 18 (90%) | 19 (95%) |
| 85 | 16 (80%) | 17 (85%) |
Across all 162 studies, recruiting or not: 25% stop at 75 or younger and 13% at 65; 14% take children; 1% are for women only and 2% for men only; 17% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Hypertrophy, Left Ventricular studies take
Of 14 phase 4 interventional studies under Hypertrophy, Left Ventricular, half reached primary completion within 30 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 4 | 30 mo25–44 · 14 studies | — | — |
| Observational | 38 mo32–58 · 18 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered1
Studies
Recruiting first, then most recently updated. Showing 50 of 162. Browse all 162 → or search them.
- Therapeutic Implications of CMR Low Native T1 in Non-treated Non-hypertrophic Females With Fabry Disease (FD)Not yet recruitingNCT07872852Not applicable1 country
- A Gene Therapy Study of RP-A501 in Male Patients With Danon DiseaseRecruitingNCT06092034Phase 24 countries
- Can Exercise Electrocardiography Discriminate Hypertensive Heart Disease From Obstructive Coronary Artery Disease? A Multimodality Imaging StudyRecruitingNCT078474631 country
- Study of LX2006 Gene Therapy in Friedreich Ataxia CardiomyopathyRecruitingNCT07721025Phase 21 country
- Detection of Cardiac Amyloidosis Using Right Ventricular Sensing Amplitude in Patients With Left Ventricular HypertrophyNot yet recruitingNCT07734285Not applicable
- Angiotensin Receptor Blocker After TAVR in Severe Aortic Stenosis With Left Ventricular Hypertrophy (ARBITAR)Not yet recruitingNCT07735130Phase 41 country
- AI-based Echocardiography for Detection of Cardiac AmyloidosisNot yet recruitingNCT07529860Not applicable
- Triple Combination Therapy (ARNI, SGLT2i, MRA) in Advanced HFpEFRecruitingNCT06655480Phase 21 country
- Predictors of Poor Prognosis in HFpEFRecruitingNCT068440321 country
- Mineralocorticoid Receptor, Coronary Microvascular Function, and Cardiac Efficiency in HypertensionRecruitingNCT05593055Phase 41 country
- Left Ventricular Hypertrophy in CKD PatientsNot yet recruitingNCT07380893
- Evaluation of Left Ventricular Ejection Fraction Using an Accelerated Cardiac Cine-MRI Sequence With Deep Learning-based Image ReconstructionsRecruitingNCT07061821Not applicable1 country
- Diffusion MRI in Heart FailureRecruitingNCT02973633Early Phase 11 country
- Imaging Histone Deacetylase in the HeartRecruitingNCT03549559Not applicable1 country
- Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE)RecruitingNCT047522931 country
- Austrian Hypertrophic Cardiomyopathy RegistryRecruitingNCT063685181 country
- AI-Enabled Diagnosis and Prognosis of Hypertrophic CardiomyopathyRecruitingNCT072632041 country
- US Benchmarking Clinical StudyRecruitingNCT072157151 country
- Postnatal Steroids Effects on Cardiac Function in Extremely PretermRecruitingNCT046440941 country
- Echocardiographic Analysis by Artificial Intelligence in HypertensionRecruitingNCT066809861 country
- The COLchicine HEART Failure PRESERVED Trial (COLHEART-PRESERVED)RecruitingNCT06081049Phase 21 country
- A Study to Evaluate Accuracy and Validity of the Chang Gung ECG Abnormality Detection SoftwareEnrolling by invitationNCT059033131 country
- Screening Patients With Fabry Disease in Patients With Hypertrophic Cardiomyopathy or Left Ventricular HypertrophyRecruitingNCT061693581 country
- Response of the Myocardium to Hypertrophic Conditions in the Adult PopulationRecruitingNCT026700311 country
- Etiological DiagnOsis of caRdiac Diseases Based on echoCardiograpHIc Images and Clinical Data.RecruitingNCT059427291 country
- Effect of Azilsartan on Atrial Fibrillation in Patients With HypertensionNot yet recruitingNCT05841654Phase 41 country
- Multi-Modality Echocardiographic Techniques in Pathological Left Ventricular Hypertrophy AdultsRecruitingNCT057193371 country
- Assessment and Digital-health Based Intervention on Subclinical Organ Damage and Cardiovascular Risk in ChineseNot yet recruitingNCT054358981 country
- Early Valve Replacement Guided by Biomarkers of LV Decompensation in Asymptomatic Patients With Severe ASActive, not recruitingNCT03094143Not applicable1 country
- Sodium Lowering Vascular Effects TrialActive, not recruitingNCT05388032Not applicable1 country
- Point-of-care Ultrasound and Treatment Disparities for Left Ventricular HypertrophyCompletedNCT05730309Not applicable1 country
- CMR T1 Mapping for Diagnosis of Cardiac AmyloidosisCompletedNCT048622731 country
- SGLT2 Inhibition in HemodialysisCompletedNCT05179668Phase 21 country
- ReNEW Clinic Cohort StudyCompletedNCT038164621 country
- Towards Understanding the Phenotype of Cardiovascular Disease in CKD - TRUE-Type-CKD StudyCompletedNCT037495511 country
- The COlchicine HypERtENsion TrialActive, not recruitingNCT04916522Phase 21 country
- LCZ696 in Advanced LV Hypertrophy and HFpEFCompletedNCT03928158Phase 21 country
- Assessment of Bioimpedance and Vitamin D and LV Mass in PD Patients (FLUID Study)CompletedNCT01045980Phase 21 country
- Pediatric Primary Hypertension and the Renin-Angiotensin System (PHRAS)CompletedNCT033106841 country
- Assessment of Efficacy of Mirabegron, a New beta3-adrenergic Receptor in the Prevention of Heart FailureCompletedNCT02599480Phase 28 countries
- Antihypertensive Treatment in Masked HypertensionCompletedNCT02893358Phase 41 country
- Effect of a Targeted Notification and Clinical Support Pathway on Individuals With Left Ventricular HypertrophyCompletedNCT05713916Not applicable1 country
- A Noninterventional, Single-Center Feasibility Study to Evaluate Measures of Heart Failure RiskCompletedNCT056460561 country
- Screening of Fabry Disease in Patients With Left Ventricular Hypertrophy Detected in EchocardiographyCompletedNCT022211411 country
- Mechanism of Decompensation Evaluation - Aortic StenosisCompletedNCT033327451 country
- Investigation of Dietary Nitrate Effects in Hypertension-induced Target Organ DamageCompletedNCT03088514Phase 21 country
- The Effects of Sacubitril/Valsartan on Cardiac Oxygen Consumption and Efficiency of Cardiac Work in Heart Failure PatientsCompletedNCT03300427Phase 41 country
- Dietary Sodium Intake in Children on Chronic DialysisStatus unknownNCT061656401 country
- Access Creation for Hemodialysis: Association With Structural Changes of the HeartCompletedNCT003681471 country
- Transcatheter Aortic Valve Implantation in Western NORwayCompletedNCT04417829