An interventional study of Dietary intervention 1 and Dietary Intervention 2 in Dietary Habits and Endotoxemia, sponsored by University of Vienna. Completed at 1 site in Austria. Open to participants aged 18 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-11-01.
Sponsored by University of Vienna · Not applicable, Interventional, and Basic science
The aim of the present study is to determine the effect of non-nutritive sweeteners on intestinal barrier function and inflammatory markers in healthy subjects in comparison to mono- and disaccharides.
In the intervention study normal weight participants will receive beverages sweetened with non-nutritive sweeteners, mono- and disaccharides for a defined number of days. Before and after intervention parameters of intestinal barrier function will be assessed.
Exclusion Criteria:
Participants receive a beverage with a defined amount of non-nutritive sweetener.
Other: Dietary intervention 1
Participants receive a beverage with a defined amount of non-nutritive sweetener.
Other: Dietary Intervention 2
Participants receive a beverage with a defined amount of monosaccharide.
Other: Dietary Intervention 3
Participants receive a beverage with a defined amount of disaccharide.
Other: Dietary Intervention 4
Participants receive a beverage with a defined amount of non-nutritive sweetener.
Participants receive a beverage with a defined amount of non-nutritive sweetener and maltodextrin.
Participants receive a beverage with a defined amount of monosaccharide.
Participants receive a beverage with a defined amount of disaccharide.
Changes in parameters of intestinal barrier function.
Changes in plasma endotoxin levels.
Time frame: 1 week
Changes in inflammatory markers.
Changes in IL-6 plasma levels (ng/ml).
Time frame: 1 week
Changes in blood pressure.
Changes in systolic and diastolic blood pressure
Time frame: 1 week
Changes in markers for glucose metabolism.
Changes in fasting glucose (mg/dl) and fasting insulin levels (mU/l)
Time frame: 1 week
Changes in markers for glucose metabolism.
Changes in fasting insulin levels (mU/l).
Time frame: 1 week
Changes in blood lipid levels.
Changes in triglyceride levels.
Time frame: 1 week
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Oct 2023. You cannot join it, but the record below documents what was studied.
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University of Vienna