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Enrolling by invitationNCT07108803ERGOSTEUpdated Aug 7, 2025

European Research Group on Outcomes of Surgical Treatment of Infective Endocarditis

An observational study in Infective Endocarditis (IE), sponsored by Azienda Sanitaria Universitaria Giuliano Isontina (ASU GI). Enrolling by invitation at 1 site in Italy. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-08-07.

Sponsored by Azienda Sanitaria Universitaria Giuliano Isontina (ASU GI) · Observational

From the registry’s dates

  • Primary completion was expected by Aug 2025, 1 year 2 months ago, but the record still lists the study as enrolling by invitation.
Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
2,500
Ages
18 Years and older
Sex
All
01

Study summary

The European Research Group on Outcomes of Surgical Treatment of Infective Endocarditis (ERGOSTE) is a nascent large surgical registry that would encompass most relevant aspects of IE in Europe in the contemporary era.

Read the detailed description

ERGOSTE, Purposes:

  • To create a European multicenter retrospective database including a large number of patients undergoing surgical treatment for infective endocarditis (IE).
  • To perform epidemiologic analyses of IE-patients and involved pathogens.
  • To find independent predictors of early post-operative death.
  • To test ALL the scoring systems specifically developed to predict early death after surgery for infective endocarditis.
  • To devise a specific risk score for early postoperative death.
  • To explore early and late outcomes of these very difficult patients in order to establish optimal indications, techniques and timing of surgery.
  • To carry out a number of sub-analyses concerning the demographic parameters and variable clinical presentation of patients, type and severity of cardiac structural involvement, adopted valve prostheses and surgical techniques, and different involved microbiologic agents.
  • To lay experiential foundations of a prospective database on the topic.
02

Conditions studied

  • Infective Endocarditis (IE)

Keywords

  • Infective endocarditis
  • Cardiac surgery
  • Outcomes
  • Risk score
  • Prediction
  • In-hospital mortality
  • Pathogen agents
  • Statistics
  • Sepsis
  • Surgical techniques
  • Epidemiology
03

In context

Endocarditis

173 studies on the registry are indexed under Endocarditis; 57 are open to participants now.

This study's planned enrollment of 2,500 is above the median of 225 across 82 observational studies indexed under Endocarditis.

Browse Endocarditis studies →

Lead sponsor

This is the only study on the registry with Azienda Sanitaria Universitaria Giuliano Isontina (ASU GI) as lead sponsor.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Patients undergoing cardiac surgery due to infective endocarditis

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Patients undergoing cardiac surgery due to infective endocarditis

Exclusion criteria

Exclusion Criteria:

  • Patients under 18 years
05

Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
2,500 participants (estimated)
Patient registry
No
06

What researchers measure

Primary outcomes

  1. Early post-operative mortality

    Time frame: Mortality at 1 year after surgery

07

Study locations

1 site
  • Cardiac Surgery Unit - ASUGI
    Trieste, TRIESTE 34151, Italy
08

References and documents

Individual participant data

Plan to share: Yes

Supporting information: Study protocol, Statistical analysis plan, Clinical study report

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 7, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07108803
Lead sponsor
Azienda Sanitaria Universitaria Giuliano Isontina (ASU GI)
Responsible party
Giuseppe Gatti (Principal Investigator, Azienda Sanitaria Universitaria Giuliano Isontina (ASU GI)) — Principal investigator
First posted
Aug 7, 2025
Start date
Jun 1, 2025
Primary completion
Aug 31, 2025 (estimated)
Completion
Aug 31, 2025 (estimated)
Last update
Aug 7, 2025

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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No contact was published for this record. The registry link below has the sponsor’s details.

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