An observational study in Infective Endocarditis, sponsored by Central Hospital, Nancy, France. Recruiting at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-09-23.
Sponsored by Central Hospital, Nancy, France · Observational
The objective of this observatory is to provide a national database of infective endocarditis, informed by all volunteer centers, using a standardized case report forms.
Such an observatory will describe the clinical profile, microbiological, therapeutic and evolving of infective endocarditis (IE); analyze the risk factors for the disease and its prognosis factors of evolution; describe management practices; evaluate and compare in the real drug treatment strategies (including antibiotics) and surgical.
All the clinical, biological, microbiological and laboratory describing the history of patients and their evolution during hospitalization for infective endocarditis will be obtained from physicians supporting patients and recorded in an electronic case report form. Will include collected clinical characteristics (site, pre-existing heart disease underlying symptoms, complications), biological characteristics (dosage on admission and diagnosis), microbiological characteristics (identifying the genus and species of the microorganism responsible, sensitivity to antibiotics susceptibility testing and evaluated by determination of minimal inhibiting concentration (MIC), exhaustive search of the rare forms of endocarditis uncultivated microorganisms), an analysis of the gateways based on the causative organism; echocardiographic characteristics (number and size of vegetations, valvular damage, scalable: surgery, lethality) and therapeutic characteristics (antibiotic treatment, surgical).
173 studies on the registry are indexed under Endocarditis; 57 are open to participants now.
This study's planned enrollment of 5,000 is above the median of 225 across 82 observational studies indexed under Endocarditis.
Browse Endocarditis studies →Central Hospital, Nancy, France is the lead sponsor of 798 studies on the registry; 186 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Adult hospitalized patients, suspected of infective endocarditis
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
history of heart disease
status of heart valves, pre-existing heart conditions
Time frame: inclusion
risk factors, medical history
associated diseases
Time frame: inclusion
origin of infection
high risk procedures
Time frame: period of 3 months before infective endocarditis
weight
kg
Time frame: inclusion
height
cm
Time frame: inclusion
clinical symptoms
cardiac, peripheral and neurological symptoms
Time frame: inclusion
biological outcomes
blood count
Time frame: inclusion
microbiological outcomes
identification of infecting organisms
Time frame: inclusion
diagnostic imaging
description of tyhe imaging tests performed
Time frame: inclusion
antibiotic therapy
antibiotic treatment: type and duration
Time frame: from inclusion to recovery
surgical procedures
description of surgical procedures
Time frame: from inclusion to recovery
biologic collection (optional)
plasma and serum collection
Time frame: inclusion
Plan to share: No
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
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